Transition Metal Ion Complexes of Schiff-bases. Synthesis, Characterization and Antibacterial Properties.

Metal-Based Drugs Pub Date : 2001-01-01 DOI:10.1155/MBD.2001.137

Z H Chohan, A Munawar, C T Supuran

引用次数: 120

Abstract

Some novel transition metal [Co(II), Cu(II), Ni(II) and Zn(II)] complexes of substituted pyridine Schiff-bases have been prepared and characterized by physical, spectral and analytical data. The synthesized Schiff-bases act as deprotonated tridentate for the complexation reaction with Co(II), Ni(II) and Zn(II) ions. The new compounds, possessing the general formula [M(L)(2)] where [M=Co(II), Cu(II), Ni(II) and Zn(II) and HL=HL(1), HL(2), HL(3) and HL(4)] show an octahedral geometry. In order to evaluate the effect of metal ions upon chelation, the Schiff bases and their complexes have been screened for antibacterial activity against the strains such as Escherichia coli,Staphylococcus aureus, and Pseudomonas aeruginosa. The complexed Schiff bases have shown to be more antibacterial against one more bacterial species as compared to uncomplexed Schiff-bases.

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席夫碱的过渡金属离子配合物。合成、表征及抗菌性能研究

本文制备了几种新型的取代吡啶席夫碱过渡金属[Co(II)， Cu(II)， Ni(II)和Zn(II)]配合物，并用物理、光谱和分析数据对其进行了表征。合成的席夫碱与Co(II)、Ni(II)和Zn(II)离子进行去质子化络合反应。新化合物具有通式[M(L)(2)]，其中[M=Co(II)， Cu(II)， Ni(II)和Zn(II)， HL=HL(1)， HL(2)， HL(3)和HL(4)]为八面体结构。为了评价金属离子对螯合作用的影响，对希夫碱及其配合物进行了抑菌活性筛选，对大肠杆菌、金黄色葡萄球菌、铜绿假单胞菌等菌株进行了抑菌活性研究。与未络合的席夫碱相比，络合的席夫碱对一种以上的细菌具有更强的抗菌作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Metal-Based Drugs

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