Metal-Based Drugs最新文献_第8页

Evaluation of antibacterial properties of triorganotin carboxylates containing functionalised ester groups in tests against some pathogenic bacteria. 含官能化酯基羧酸三有机锡对某些致病菌抗菌性能的评价。

Metal-Based Drugs Pub Date : 2001-01-01 DOI: 10.1155/MBD.2001.107

J Koshy, A Ansary, K M Lo, V G Das

{"title":"Evaluation of antibacterial properties of triorganotin carboxylates containing functionalised ester groups in tests against some pathogenic bacteria.","authors":"J Koshy, A Ansary, K M Lo, V G Das","doi":"10.1155/MBD.2001.107","DOIUrl":"https://doi.org/10.1155/MBD.2001.107","url":null,"abstract":"Bacterial screening employing the agar diffusion test on triphenyltin carboxylates containing various functional residues in the ester moiety revealed appreciable differences in their activities relative to triphenyltin acetate. Among these, [3-(Diethylphosphono)propionato] triphenyltin (1) and [N-cyclohexylcarbamoyl) glycinato] triphenyltin displayed activities comparable to tri-n-butyltin cinnamate (2) towards both Gram-positive and Gram-negative bacteria; the latter compound was the most active among the eleven triorganotin compounds tested, which included cyclopentyldiphenyltin hydroxide (3) and its methacrylate derivative. Applying the more quantitative plate count and optical density tests on compounds 1-3, it was shown that their inhibitory activity ranked in the order 2 > 3 >1. Significantly, 3 caused around 90% inhibition of both Eschechia coli (-) and Pseudomonas aeruginosa (-) when incubated for 24 h at 37+/-1 at the 10.0 mug/ mL concentration level. Compound 2 was less effective against P.aeruginosa than against E.coli. While the Gram-positive bacteria were all readily inhibited, Bacillus subtilis (+) appeared to the most susceptible among them towards the test compounds.","PeriodicalId":18452,"journal":{"name":"Metal-Based Drugs","volume":"8 2","pages":"107-11"},"PeriodicalIF":0.0,"publicationDate":"2001-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/MBD.2001.107","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27438046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Synthesis, properties and biological activity of organotitanium substituted heteropolytungstates. 有机钛取代杂多钨酸盐的合成、性质及生物活性。

Metal-Based Drugs Pub Date : 2001-01-01 DOI: 10.1155/MBD.2001.179

X Wang, J Li, J He, J Liu

引用次数: 10

Synthesis, Characterization and Antiproliferative Activity of the Co(II), Ni(II), Cu(II), Pd(II) and Pt(II) Complexes of 2-(4-Thiazolyl)Benzimidazole (Thiabendazole). 2-(4-噻唑基)苯并咪唑(噻苯达唑)Co(II)、Ni(II)、Cu(II)、Pd(II)和Pt(II)配合物的合成、表征和抗增殖活性

Metal-Based Drugs Pub Date : 2001-01-01 DOI: 10.1155/MBD.2001.189

M Z Wisniewski, T Glowiak, A Opolski, J Wietrzyk

引用次数: 19

Cytotoxicity of Co(III) Complexes of Arginine. 精氨酸Co(III)配合物的细胞毒性。

Metal-Based Drugs Pub Date : 2001-01-01 DOI: 10.1155/MBD.2001.195

P Genova, T Varadinova, R Alexandrova, S Trifunovic, P Radivojsa

引用次数: 1

Cellular Uptake, DNA Binding and Apoptosis Induction of Cytotoxic Trans-[PtCl(2)(N,N-dimethylamine)(Isopropylamine)] in A2780cisR Ovarian Tumor Cells. A2780cisR卵巢肿瘤细胞中细胞毒性Trans-[PtCl(2)(N,N-二甲胺)(异丙胺)]的细胞摄取、DNA结合和凋亡诱导

Metal-Based Drugs Pub Date : 2001-01-01 DOI: 10.1155/MBD.2001.29

J M Pérez, E I Montero, A G Quiroga, M A Fuertes, C Alonso, C Navarro-Ranninger

{"title":"Cellular Uptake, DNA Binding and Apoptosis Induction of Cytotoxic Trans-[PtCl(2)(N,N-dimethylamine)(Isopropylamine)] in A2780cisR Ovarian Tumor Cells.","authors":"J M Pérez, E I Montero, A G Quiroga, M A Fuertes, C Alonso, C Navarro-Ranninger","doi":"10.1155/MBD.2001.29","DOIUrl":"https://doi.org/10.1155/MBD.2001.29","url":null,"abstract":"Trans-[PtCl(2)(N,N-dimethylamine)(isopropylamine)] is a novel trans-platinum compound that shows cytotoxic activity in several cisplatin resistant cell lines. The aim of this paper was to analyse, by means of molecular cell biology techniques and total reflection X-ray fluorescence (TXRF), the cytotoxic activity, the induction of apoptosis, the cellular uptake and the DNA binding of trans-[PtCl(2)(N,N-dimethylamine)(isopropylamine)] in the cisplatin resistant cell line A2780cisR. The results show that this drug is more cytotoxic and induces a higher amount of apoptotic cells than cisplatin in A2780cisR cells. However, the intracellular accumulation and extent of binding to DNA of trans-[PtCl(2)(N,N-dimethylamine)( isopropylamine)] is lower than that of cis-DDP. Moreover, trans-[PtCl(2)(N,N-dimethylamine)(isopropylaminae)] is partially inactivated by intracellular levels of glulathione. The result suggest that circumvention of ciplatin resistance by trans-[PtCl(2)(N,N-dimethylamine)(isopropylamine)] in A2780cisR cells might be related with the ability of this drug to induce apoptosis.","PeriodicalId":18452,"journal":{"name":"Metal-Based Drugs","volume":"8 1","pages":"29-37"},"PeriodicalIF":0.0,"publicationDate":"2001-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/MBD.2001.29","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27438069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Copper (II) Acylhydrazinates. Their Synthesis and Characterization. 铜(II)酰基肼酯。它们的合成与表征。

Metal-Based Drugs Pub Date : 2001-01-01 DOI: 10.1155/MBD.2001.171

Z H Chohan, M A Farooq, C T Supuran

引用次数: 5

Knigth's Move in the Periodic Table, From Copper to Platinum, Novel Antitumor Mixed Chelate Copper Compounds, Casiopeinas, Evaluated by an in Vitro Human and Murine Cancer Cell Line Panel. 奈特在元素周期表中的移动，从铜到铂，新型抗肿瘤混合螯合铜化合物，Casiopeinas，通过体外人和小鼠癌细胞系小组评估。

Metal-Based Drugs Pub Date : 2001-01-01 DOI: 10.1155/MBD.2001.19

I Gracia-Mora, L Ruiz-Ramírez, C Gómez-Ruiz, M Tinoco-Méndez, A Márquez-Quiñones, L R Lira, A Marín-Hernández, L Macías-Rosales, M E Bravo-Gómez

{"title":"Knigth's Move in the Periodic Table, From Copper to Platinum, Novel Antitumor Mixed Chelate Copper Compounds, Casiopeinas, Evaluated by an in Vitro Human and Murine Cancer Cell Line Panel.","authors":"I Gracia-Mora, L Ruiz-Ramírez, C Gómez-Ruiz, M Tinoco-Méndez, A Márquez-Quiñones, L R Lira, A Marín-Hernández, L Macías-Rosales, M E Bravo-Gómez","doi":"10.1155/MBD.2001.19","DOIUrl":"https://doi.org/10.1155/MBD.2001.19","url":null,"abstract":"We synthesized a novel anticancer agents based on mixed chelate copper (II) complexes, named Casiopeínas((R)) has of general formula [Cu(N-N)(N-O)H(2)O]NO(3) (where, N-N = diimines as 1,10- phenanthroline, 2,2-bipyridine, or substituted and N-O=aminoeidate or [Cu(N-N)(O-O)H(2)O]NO(3) (where NN= diimines as 10-phenanthroline, 2,2-bipyridine or substituted Casiopeínas I, II, IV, V, VI, VII VIII and O-O=acetylacetonate, salicylaldehidate Casiopínas III). We evaluated the in vitro antitumor activity using a human cancer cell panel and some nurine cancer cells. Eleven Casiopeinas are evaluated in order to acquire some structure-activity correlations and some monodentated Casiopeinäs analogues; cisplatinum was used as control drug. The 50% growth inhibition observed is, in all cases reach with concentrations of Casiopeina's 10 or 100 times lower than cisplatinum. In a previous work we reported the induction of apoptosis by Casiopeina II. The results indicate that Casiopeinass are a promising new anticancer drug candidates to be developed further toward clinical trials.","PeriodicalId":18452,"journal":{"name":"Metal-Based Drugs","volume":"8 1","pages":"19-28"},"PeriodicalIF":0.0,"publicationDate":"2001-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/MBD.2001.19","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27438068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 69

Synthesis, Characterization and Antiviral Properties of Pd(II) Complexes With Penciclovir. 喷昔洛韦Pd(II)配合物的合成、表征及抗病毒性能

Metal-Based Drugs Pub Date : 2001-01-01 DOI: 10.1155/MBD.2001.57

A Garoufis, K Karidi, N Hadjiliadis, S Kasselouri, J Kobe, J Balzarini, E De Clercq

引用次数: 2

Synthesis of silicon and germanium containing heteroaromatic sulfides as cholesterol level lowering and vasodilating agents. 含杂芳香硫化物的硅锗的合成及其降胆固醇和血管舒张剂的研究。

Metal-Based Drugs Pub Date : 2001-01-01 DOI: 10.1155/MBD.2001.85

K Rubina, E Abele, P Arsenyan, R Abele, M Veveris, E Lukevics

引用次数: 11

Enhanced antioxidant activities of metal conjugates of curcumin derivatives. 姜黄素衍生物金属缀合物的抗氧化活性增强。

Metal-Based Drugs Pub Date : 2001-01-01 DOI: 10.1155/MBD.2001.183

S Dutta, A Murugkar, N Gandhe, S Padhye

引用次数: 36