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Studies on Some New Ru(III) Complexes Using aryl-azo Pentane- 2,4-dione and 2,6-bis (2'-Benzimidazolyl) Pyridine as Ligands: Synthesis, Spectroscopic, Luminescent, Electrochemical and Biological Activities. 以芳基偶氮戊烷- 2,4-二酮和2,6-双(2′-苯并咪唑)吡啶为配体的新型Ru(III)配合物的合成、光谱、发光、电化学和生物活性研究
Metal-Based Drugs Pub Date : 2001-01-01 DOI: 10.1155/MBD.2001.65
L Mishra, A K Yadaw, R S Phadke, C S Choi, K Araki
{"title":"Studies on Some New Ru(III) Complexes Using aryl-azo Pentane- 2,4-dione and 2,6-bis (2'-Benzimidazolyl) Pyridine as Ligands: Synthesis, Spectroscopic, Luminescent, Electrochemical and Biological Activities.","authors":"L Mishra,&nbsp;A K Yadaw,&nbsp;R S Phadke,&nbsp;C S Choi,&nbsp;K Araki","doi":"10.1155/MBD.2001.65","DOIUrl":"https://doi.org/10.1155/MBD.2001.65","url":null,"abstract":"<p><p>Some ruthenium(III) complexes with aryl-azo 2,4-pentanedione as co-ligands (L(1)H - L(3)H(2)) have been synthesized and characterized spectroscopically IR, (1)H NMR, UV/Vis, ESR, conductimetric) along with elemental analysis and FAB-mass data. Their luminescent and redox properties have been studied. The antibacterial, anti-HIV and antitmnour activities have also been reported.</p>","PeriodicalId":18452,"journal":{"name":"Metal-Based Drugs","volume":"8 2","pages":"65-71"},"PeriodicalIF":0.0,"publicationDate":"2001-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/MBD.2001.65","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27438073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 16
Targeting Estrogen Receptor Sites in Human Breast Cancer Cell Line T47D With Copper Conjugates of Nonsteriodal Anti-inflammatory Drug Derivatives: Antiproliferative Activity of Ketoprofen Derivative and its Copper Complex. 非甾体抗炎药衍生物铜缀合物靶向人乳腺癌细胞系T47D雌激素受体位点:酮洛芬衍生物及其铜配合物的抗增殖活性
Metal-Based Drugs Pub Date : 2001-01-01 DOI: 10.1155/MBD.2001.73
D K Saha, S Padhye, S Padhye
{"title":"Targeting Estrogen Receptor Sites in Human Breast Cancer Cell Line T47D With Copper Conjugates of Nonsteriodal Anti-inflammatory Drug Derivatives: Antiproliferative Activity of Ketoprofen Derivative and its Copper Complex.","authors":"D K Saha,&nbsp;S Padhye,&nbsp;S Padhye","doi":"10.1155/MBD.2001.73","DOIUrl":"https://doi.org/10.1155/MBD.2001.73","url":null,"abstract":"<p><p>A square planar copper complex of derivatized NSAID drug (Ketoprofen thiosemicarbazone [3-benzoyl-alpha-methyl benzene acetic acid thiosemicarbazone]), is characterized by elemental analysis, spectroscopy, electrochemistry and magnetic susceptibility studies which exhibits dose-dependent and enhanced antiproliferative effects on human breast cancer cell line T47D rich in progesterone receptors.</p>","PeriodicalId":18452,"journal":{"name":"Metal-Based Drugs","volume":"8 2","pages":"73-7"},"PeriodicalIF":0.0,"publicationDate":"2001-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/MBD.2001.73","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27438074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 12
Cytotoxicity of triorganophosphinegold(i) complexes of thiobenzoate. 硫苯甲酸盐三有机膦金(i)配合物的细胞毒性。
Metal-Based Drugs Pub Date : 2001-01-01 DOI: 10.1155/MBD.2001.79
B R Vincent, D J Clarke, D R Smyth, D de Vos, E R Tiekink
{"title":"Cytotoxicity of triorganophosphinegold(i) complexes of thiobenzoate.","authors":"B R Vincent,&nbsp;D J Clarke,&nbsp;D R Smyth,&nbsp;D de Vos,&nbsp;E R Tiekink","doi":"10.1155/MBD.2001.79","DOIUrl":"https://doi.org/10.1155/MBD.2001.79","url":null,"abstract":"<p><p>The preparation and characterization of two triorganophosphinegold(I) complexes containing the anion derived from thiobenzoic acid are described. The cytotoxicity of these complexes has been investigated along with that of triphenylphosphinegold(I) mercaptopurinate, a known anti-tumor compound, against a variety of human cell lines. The complexes showed moderate to high cytotoxicity (ID(50) 250 - 2500 ng/ml).</p>","PeriodicalId":18452,"journal":{"name":"Metal-Based Drugs","volume":"8 2","pages":"79-84"},"PeriodicalIF":0.0,"publicationDate":"2001-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/MBD.2001.79","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27438075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Synthesis, Characterization and in Vitro Antifungal Effect of Some Butyltin(IV) N-substituted 2-aminoethanethiolates. 几种丁基锡(IV) n -取代2-氨基乙硫代酸酯的合成、表征及体外抑菌作用。
Metal-Based Drugs Pub Date : 2001-01-01 DOI: 10.1155/MBD.2001.165
A Smicka, V Buchta, K Handlir
{"title":"Synthesis, Characterization and in Vitro Antifungal Effect of Some Butyltin(IV) N-substituted 2-aminoethanethiolates.","authors":"A Smicka,&nbsp;V Buchta,&nbsp;K Handlir","doi":"10.1155/MBD.2001.165","DOIUrl":"https://doi.org/10.1155/MBD.2001.165","url":null,"abstract":"<p><p>Six new N-substituted di- and tributyltin 2-aminoethanethiolates (cysteaminates) have been prepared and characterised by (1)H, (13)C and (119)Sn NMR spectroscopy. All these compounds exhibit a good in vitro antifungal effect against selected types of human pathogenic fungi (Candida albicans, Candida krusei, Candida tropicalis, Candida glabrata, Trichosporon beigelii, Aspergillus fumigatus, Absidia corymbifera, Trichophyton mentagrophytes) and their activity is comparable with that of some antifungal drugs commonly used in the clinical use like ketoconazole. The structure-activity relationships in these compounds are discussed.</p>","PeriodicalId":18452,"journal":{"name":"Metal-Based Drugs","volume":"8 3","pages":"165-9"},"PeriodicalIF":0.0,"publicationDate":"2001-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/MBD.2001.165","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27437381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Activity of Pt(II) and Ru(III) Triazolopyrimidine Complexes Against Parasites of the Genus Leishmania, Trypanosomas and Phytomonas. Pt(II)和Ru(III)三唑嘧啶配合物对利什曼原虫、锥虫和植物单胞菌的抑制作用。
Metal-Based Drugs Pub Date : 2001-01-01 DOI: 10.1155/MBD.2001.119
J M Salas, M Quirós, M Abul Haj, R Magán, C Marín, M Sáchez-Moreno, R Faure
{"title":"Activity of Pt(II) and Ru(III) Triazolopyrimidine Complexes Against Parasites of the Genus Leishmania, Trypanosomas and Phytomonas.","authors":"J M Salas,&nbsp;M Quirós,&nbsp;M Abul Haj,&nbsp;R Magán,&nbsp;C Marín,&nbsp;M Sáchez-Moreno,&nbsp;R Faure","doi":"10.1155/MBD.2001.119","DOIUrl":"https://doi.org/10.1155/MBD.2001.119","url":null,"abstract":"<p><p>The synthesis and characterization of two Pt(II) Complexes with the isomeric ligands 4,5-dihydro-5-oxo- [1,2,4]triazolo-[ 1,5-a]pyrimidine (5HtpO) and 4,7-dihydro-7-oxo-[ 1,2,4]-triazolo-[ 1,5-a]pyrimidine (7HtpO) are described, as well as a Ru(III) complex with 7HtpO. The crystal structure of cis-[PtCl(2)(7HtpO)(2)].2H(2)O has been solved by X-ray diffraction analysis. In vitro activity of the new isolated complexes against the epimastigote form of T. cruzi, procyclic form of T. b. brucei and promastigote form of L. donnovani and P. characias has also been studied. The three complexes markedly affect the growth of the parasites and none of them shows cytotoxicity against macrophage of the J774.2 line at the heaviest dosages used.</p>","PeriodicalId":18452,"journal":{"name":"Metal-Based Drugs","volume":"8 3","pages":"119-24"},"PeriodicalIF":0.0,"publicationDate":"2001-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/MBD.2001.119","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27438048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 19
Characterization and Antimicrobial Activity of Erbium(III) Complexes of C-3 Substituted 2-hydroxy-1,4-naphthalenedione-1-oxime Derivatives. C-3取代2-羟基-1,4-萘二酮-1-肟衍生物铒配合物的表征及抗菌活性
Metal-Based Drugs Pub Date : 2001-01-01 DOI: 10.1155/MBD.2001.159
S B Jagtap, N N Patil, B P Kapadnis, B A Kulkarni
{"title":"Characterization and Antimicrobial Activity of Erbium(III) Complexes of C-3 Substituted 2-hydroxy-1,4-naphthalenedione-1-oxime Derivatives.","authors":"S B Jagtap,&nbsp;N N Patil,&nbsp;B P Kapadnis,&nbsp;B A Kulkarni","doi":"10.1155/MBD.2001.159","DOIUrl":"https://doi.org/10.1155/MBD.2001.159","url":null,"abstract":"<p><p>Erbium(III) complexes of 2-hydroxy-l,4-naphthalenedione-1-oxime and its C-3 substituted derivatives are synthesized and characterized by elemental analysis, thermogravimetric analysis, infrared spectroscopy, magnetic susceptibility measurements 2-hydroxy-1,4-naphthalenedione-1-oxime derivatives are analysed using (1)H and (13)C NMR spectroscopy. The molecular composition of the synthesized complexes is found to be [ML(3)(H(2)O)(2)]. The antimicrobial activity of these complexes is determined by well diffusion method against the target microorganisms- Staphylococcus aureus, Xanthomonas campestris, Pseudomonas aeruginosa, Candida albicans and Aspergillus niger. The antimicrobial activities of 2- hydroxy-1,4-naphthalenedione-1-oximes and their complexes are compared. It is observed that 2-hydroxy-1,4-naphthalenedione-l-oximes exhibit higher antifungal activity as compared to antibacterial activity. These activities are reduced upon complexation of these oximes with Erbium.</p>","PeriodicalId":18452,"journal":{"name":"Metal-Based Drugs","volume":"8 3","pages":"159-64"},"PeriodicalIF":0.0,"publicationDate":"2001-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/MBD.2001.159","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27438053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
High In-Vitro Antitumour Activity of Triphenyltin Coumarin 3-Carboxylate and its Coordination Complexes With Monodentate Oxygen Donor Ligands Against the Epstein Barr Virus (EBV)-DNA Positive Raji and the P-388 Murine Leukaemia Cell Lines, and Evidence for the Suppression by Organotin of the Early Antigen Complex in the EBV Lytic Cycle. 三苯基锡香豆素3-羧酸酯及其单齿供氧配体配合物对eb病毒(EBV)-DNA阳性Raji和P-388小鼠白血病细胞系的体外高抗肿瘤活性，以及有机锡抑制EBV裂解周期早期抗原复合物的证据
Metal-Based Drugs Pub Date : 2000-01-01 DOI: 10.1155/MBD.2000.245
J Koshy, V G Das, S Balabaskaran, S W Ng, N Wahab
{"title":"High In-Vitro Antitumour Activity of Triphenyltin Coumarin 3-Carboxylate and its Coordination Complexes With Monodentate Oxygen Donor Ligands Against the Epstein Barr Virus (EBV)-DNA Positive Raji and the P-388 Murine Leukaemia Cell Lines, and Evidence for the Suppression by Organotin of the Early Antigen Complex in the EBV Lytic Cycle.","authors":"J Koshy,&nbsp;V G Das,&nbsp;S Balabaskaran,&nbsp;S W Ng,&nbsp;N Wahab","doi":"10.1155/MBD.2000.245","DOIUrl":"https://doi.org/10.1155/MBD.2000.245","url":null,"abstract":"<p><p>Triphenyltin coumarin-3-carboxylate and its coordination complexes with ethanol, triphenylphosphine oxide, triphenylarsine oxide, diphenylcyclopropenone and quinoline N-oxide exhibited high in vitro cytotoxicity (LC(50) values in the range 0.25-3.4 mug/mL) when tested against EBV-DNA positive Raji cells and P-388 leukaemia cells, compared to the standard drug 5-Fluorouracil, which showed LC(50) values of 11 and >50 mug/mL, respectively, against these cells. Additional tests performed on the Raji cells incubated with the quinoline N-oxide complex in the presence of the tumour promoters, TPA and sodium butyrate, revealed that the diffused and restricted protein components of the early antigen complex were suppressed relative to the control containing only the promoters, indicating impaired function of the genes involved as transactivators in the early lytic cycle of the EBV. The failure of the restriction enzymes Eco R1 and Hind III to cleave the extracted DNA from such treated cells in contrast to the control, coupled with the amplification of the BMLF-1 gene by the PCR technique which was realised only with the DNA of the control and not of the treated sample, point to a punitive interaction of the organotin with the nuclear DNA of the Raji cells.</p>","PeriodicalId":18452,"journal":{"name":"Metal-Based Drugs","volume":"7 5","pages":"245-51"},"PeriodicalIF":0.0,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/MBD.2000.245","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27437679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interaction of [Rh(2)(O(2)CCH(3))(4)(H(2)O)(2)] and [Rh(2)(O(2)CCH(OH)Ph)(2)(phen)(2)(H(2)O)(2)](O(2)C-CH(OH)Ph)(2) With Sulfhydryl Compounds and Ceruloplasmin. 交互(Rh (2) (O (2) CCH) (3) (4) (H (2) O)(2)]和[Rh (2) (O (2) CCH (OH) Ph值)(2)(苯酚的)(2)(H (2) O) (2)] (O (2) C-CH (OH) Ph值)与巯基化合物和血浆铜蓝蛋白(2)。
Metal-Based Drugs Pub Date : 2000-01-01 DOI: 10.1155/MBD.2000.201
P Jakimowicz, L Ostropolska, F P Pruchnik
{"title":"Interaction of [Rh(2)(O(2)CCH(3))(4)(H(2)O)(2)] and [Rh(2)(O(2)CCH(OH)Ph)(2)(phen)(2)(H(2)O)(2)](O(2)C-CH(OH)Ph)(2) With Sulfhydryl Compounds and Ceruloplasmin.","authors":"P Jakimowicz,&nbsp;L Ostropolska,&nbsp;F P Pruchnik","doi":"10.1155/MBD.2000.201","DOIUrl":"https://doi.org/10.1155/MBD.2000.201","url":null,"abstract":"<p><p>The interaction of binuclear rhodium(II) complexes [Rh(2)(OOCCH(3))(4)(H(2)O)(2)], [Rh(2){OOCCH(OH)Ph}(2)(phen)(2)(H(2)O)(2)] {OOCCH(OH)Ph}(2), [Rh(2)(OOCCH(3))(2)(bpy)(2)(H(2)O)(2)](OOCCH(3))(2) and [Rh(2)Cl(2)(OOCMe)(2)(bpy)(2)](3H(2)O) with ceruloplasmin, cysteine, glutathione and coenzyme A have been investigated using. UV-Vis and CD spectroscopies. The complexes containing phen or bpy at pH = 7.4 and 4.0 are readily reduced with sulfhydryl compounds, while rhodium(II) acetate is relatively stable in these conditions. Complex [Rh(2){OOCCH(OH)Ph}(2)(phen)(2)(H(2)O)(2)] strongly changes structure of ceruloplasmin leading to the decrease of of alpha-helix content and loss of oxidase activity.</p>","PeriodicalId":18452,"journal":{"name":"Metal-Based Drugs","volume":"7 4","pages":"201-9"},"PeriodicalIF":0.0,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/MBD.2000.201","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27437787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 14
Carbonic anhydrase inhibitors. Part 91. Metal complexes of heterocyclic sulfonamides as potential pharmacological agents in the treatment of gastric Acid secretion imbalances. 碳酸酐酶抑制剂。91年一部分。杂环磺胺类金属配合物治疗胃酸分泌失衡的潜在药理作用。
Metal-Based Drugs Pub Date : 2000-01-01 DOI: 10.1155/MBD.2000.57
M A Ilies, C T Supuran, A Scozzafava
{"title":"Carbonic anhydrase inhibitors. Part 91. Metal complexes of heterocyclic sulfonamides as potential pharmacological agents in the treatment of gastric Acid secretion imbalances.","authors":"M A Ilies,&nbsp;C T Supuran,&nbsp;A Scozzafava","doi":"10.1155/MBD.2000.57","DOIUrl":"https://doi.org/10.1155/MBD.2000.57","url":null,"abstract":"<p><p>Zinc, magnesium, aluminum and copper complexes of several potent, clinically used carbonic anhydrase (CA) sulfonamide inhibitors, such as acetazolamide, methazolamide, ethoxzolamide and benzolamide were tested for their possible applications as antacids, in experimental animals. Gastric acid secretion parameters 3 days after treatment with these CA inhibitors (2 x 500 mg, twice a day), in dogs with chronic gastric fistulas, led to the observation that the gastric acid parameters BAO (the basal acid output), and MAO (the maximal acid output after stimulation with histamine) were drastically reduced, as compared to the same parameters in animals that did not receive these enzyme inhibitors. These are promising results for the possible use of metal complexes of heterocyclic sulfonamides as treatment alternatives (alone or in combination with other drugs) for gastric acid secretion imbalances.</p>","PeriodicalId":18452,"journal":{"name":"Metal-Based Drugs","volume":"7 2","pages":"57-62"},"PeriodicalIF":0.0,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/MBD.2000.57","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27437885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 16
Developing Carrier Complexes for "Caged NO": RuCl(3)(NO)(H(2)O)(2) Complexes of Dipyridylamine, (dpaH), N,N,N'N'-Tetrakis (2-Pyridyl) Adipamide, (tpada), and (2-Pyridylmethyl) Iminodiacetate, (pida). 开发“笼化NO”载体配合物:RuCl(3)(NO)(H(2)O)(2)二吡啶胺(dpaH)， N,N,N'N'-四(2-吡啶基)己二酰胺(tpada)和(2-吡啶基甲基)亚氨基二乙酸酯(pida)配合物。
Metal-Based Drugs Pub Date : 2000-01-01 DOI: 10.1155/MBD.2000.67
J M Slocik, R A Kortes, R E Shepherd
{"title":"Developing Carrier Complexes for \"Caged NO\": RuCl(3)(NO)(H(2)O)(2) Complexes of Dipyridylamine, (dpaH), N,N,N'N'-Tetrakis (2-Pyridyl) Adipamide, (tpada), and (2-Pyridylmethyl) Iminodiacetate, (pida).","authors":"J M Slocik,&nbsp;R A Kortes,&nbsp;R E Shepherd","doi":"10.1155/MBD.2000.67","DOIUrl":"https://doi.org/10.1155/MBD.2000.67","url":null,"abstract":"<p><p>Delivery agents which can carry the {Ru(NO)}(6) chromophore (\"caged NO\") are desired for vasodilation and for photodynamic therapy of tumors. Toward these goals, complexes derived from [RuCl(3)(NO)(H(2)O)(2)]= (1) have been prepared using dipyridylamine (dpaH) as mono and bis adducts, [Ru(NO)Cl(3)(dpaH)] = (2) and [Ru(NO)Cl(dpaH)(2)]Cl(2) = (3). The dpaH ligands coordinate cis to the Ru(NO) axis.The mono derivative is a model for a potential DNA groove-spanning binuclear complex {[RuNO)Cl(3)](2)(tpada)} = (4) which has two DNA-coordinating Ru(II) centers, photo-labile {Ru(NO)}(6) sites, and a groove-spanning tether moiety.The binuclear assembly is prepared from the tethered dipyridylamine ligand N,N,N',N'-tetrakis(2-pyridylmethyl)adipamide (tpada) which has recently been shown to provide a binuclear carrier complex suited to transporting Ru(II) and Pd(II) agents. A related complex, [Ru(NO)Cl(pida)] = (5) with the {Ru(NO)}(6) moiety bound to (2-pyridylmethyl) iminodiacetate (pida(2-)) is also characterized as a potential \"caged NO\" carrier. Structural information concerning the placement of the pyridyl donor groups relative to the {Ru(NO)}(6) unit has been obtained from (1)H and (13)C NMR and infrared methods, noting that a pyridyl donor trans to NO+ causes \"trans strengthening\" of this ligand for [Ru(NO)Cl(pida)], whereas placement of pyridyl groups cis to NO+ causes a weakening of the N-O bond and a lower NO stretching frequency in the dpa-based complexes.</p>","PeriodicalId":18452,"journal":{"name":"Metal-Based Drugs","volume":"7 2","pages":"67-75"},"PeriodicalIF":0.0,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/MBD.2000.67","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27437887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
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