交互(Rh (2) (O (2) CCH) (3) (4) (H (2) O)(2)]和[Rh (2) (O (2) CCH (OH) Ph值)(2)(苯酚的)(2)(H (2) O) (2)] (O (2) C-CH (OH) Ph值)与巯基化合物和血浆铜蓝蛋白(2)。

Metal-Based Drugs Pub Date : 2000-01-01 DOI:10.1155/MBD.2000.201

P Jakimowicz, L Ostropolska, F P Pruchnik

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引用次数: 14

摘要

研究了双核铑(II)配合物[Rh(2)(OOCCH(3))(4)(H(2)O)(2)]、[Rh(2){OOCCH(OH)Ph}(2)(phen)(2)(H(2)O)(2)] {OOCCH(OH)Ph}(2)、[Rh(2)(OOCCH(3))(2)(H(2)O)(2)](OOCCH(3))(2) (H(2)O)(2)](OOCCH(3))(2))和[Rh(2)Cl(2)(OOCMe)(2)(bpy)(2)](3H(2)O))与铜蓝蛋白、半胱氨酸、谷胱甘肽和辅酶A的相互作用。紫外-可见和CD光谱。在pH = 7.4和pH = 4.0时，含苯乙酯或苯乙酯的配合物很容易被巯基化合物还原，而乙酸铑在这些条件下相对稳定。配合物[Rh(2){OOCCH(OH)Ph}(2)(phen)(2)(H(2)O)(2)]强烈改变铜蓝蛋白的结构，导致α -螺旋含量降低，氧化酶活性丧失。

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Interaction of [Rh(2)(O(2)CCH(3))(4)(H(2)O)(2)] and [Rh(2)(O(2)CCH(OH)Ph)(2)(phen)(2)(H(2)O)(2)](O(2)C-CH(OH)Ph)(2) With Sulfhydryl Compounds and Ceruloplasmin.

The interaction of binuclear rhodium(II) complexes [Rh(2)(OOCCH(3))(4)(H(2)O)(2)], [Rh(2){OOCCH(OH)Ph}(2)(phen)(2)(H(2)O)(2)] {OOCCH(OH)Ph}(2), [Rh(2)(OOCCH(3))(2)(bpy)(2)(H(2)O)(2)](OOCCH(3))(2) and [Rh(2)Cl(2)(OOCMe)(2)(bpy)(2)](3H(2)O) with ceruloplasmin, cysteine, glutathione and coenzyme A have been investigated using. UV-Vis and CD spectroscopies. The complexes containing phen or bpy at pH = 7.4 and 4.0 are readily reduced with sulfhydryl compounds, while rhodium(II) acetate is relatively stable in these conditions. Complex [Rh(2){OOCCH(OH)Ph}(2)(phen)(2)(H(2)O)(2)] strongly changes structure of ceruloplasmin leading to the decrease of of alpha-helix content and loss of oxidase activity.

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Metal-Based Drugs

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