J M Salas, M Quirós, M Abul Haj, R Magán, C Marín, M Sáchez-Moreno, R Faure
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引用次数: 19
摘要
描述了两种Pt(II)与4,5-二氢-5-氧-[1,2,4]三唑-[1,5-a]嘧啶(5HtpO)和4,7-二氢-7-氧-[1,2,4]-三唑-[1,5-a]嘧啶(7HtpO)的异构体配合物的合成和表征，以及Ru(III)与7HtpO的配合物。用x射线衍射分析了顺式-[PtCl(2)(7HtpO)(2)]. 2h (2)O的晶体结构。研究了新分离的配合物对克氏托氏菌(T. cruzi)、布氏托氏菌(T. b. bruei)、多诺瓦氏菌(L. donnovani)和P.性状的体外活性。三种复合物均能显著影响疟原虫的生长，且在最大剂量下均未表现出对巨噬细胞的细胞毒性。
Activity of Pt(II) and Ru(III) Triazolopyrimidine Complexes Against Parasites of the Genus Leishmania, Trypanosomas and Phytomonas.
The synthesis and characterization of two Pt(II) Complexes with the isomeric ligands 4,5-dihydro-5-oxo- [1,2,4]triazolo-[ 1,5-a]pyrimidine (5HtpO) and 4,7-dihydro-7-oxo-[ 1,2,4]-triazolo-[ 1,5-a]pyrimidine (7HtpO) are described, as well as a Ru(III) complex with 7HtpO. The crystal structure of cis-[PtCl(2)(7HtpO)(2)].2H(2)O has been solved by X-ray diffraction analysis. In vitro activity of the new isolated complexes against the epimastigote form of T. cruzi, procyclic form of T. b. brucei and promastigote form of L. donnovani and P. characias has also been studied. The three complexes markedly affect the growth of the parasites and none of them shows cytotoxicity against macrophage of the J774.2 line at the heaviest dosages used.
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