硫苯甲酸盐三有机膦金(i)配合物的细胞毒性。

Metal-Based Drugs Pub Date : 2001-01-01 DOI:10.1155/MBD.2001.79

B R Vincent, D J Clarke, D R Smyth, D de Vos, E R Tiekink

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引用次数: 4

摘要

描述了两种含硫代苯甲酸阴离子的三有机膦金配合物的制备和表征。这些复合物与已知的抗肿瘤化合物三苯基磷金(I)巯基嘌呤酸酯一起对多种人类细胞系的细胞毒性进行了研究。该配合物具有中高的细胞毒性(ID(50) 250 ~ 2500 ng/ml)。

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Cytotoxicity of triorganophosphinegold(i) complexes of thiobenzoate.

The preparation and characterization of two triorganophosphinegold(I) complexes containing the anion derived from thiobenzoic acid are described. The cytotoxicity of these complexes has been investigated along with that of triphenylphosphinegold(I) mercaptopurinate, a known anti-tumor compound, against a variety of human cell lines. The complexes showed moderate to high cytotoxicity (ID(50) 250 - 2500 ng/ml).

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Metal-Based Drugs

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