Menopause: The Journal of The North American Menopause Society最新文献

{"title":"Dietary supplements for menopausal symptoms and health: a bibliometric analysis of US research (2000-2024).","authors":"Maria C Canino, Barbara Cohen, Coretté Byrd, Jaime J Gahche","doi":"10.1097/GME.0000000000002853","DOIUrl":"https://doi.org/10.1097/GME.0000000000002853","url":null,"abstract":"<p><strong>Objective: </strong>To visualize the research landscape and evolution of dietary supplements investigated for menopausal symptom management and associated health outcomes.</p><p><strong>Methods: </strong>A Web of Science search yielded 4,434 English-language articles limited to published literature from the years 2000-2024. Inclusion criteria were studies conducted in the United States, or in collaboration with the United States, that were dietary supplement-based interventions. R's Bibliometrix package was used to conduct all bibliometric analyses.</p><p><strong>Results: </strong>The final data set included 253 publications and showed a low annual scientific productivity growth rate (3.89%), with most articles focused on postmenopause (n = 234). Over 80 unique ingredients were assessed, with calcium, vitamin D, and isoflavones as the most studied. Limited collaboration was observed among the most productive authors, indicated by the limited number of connections between research groups. Cardiovascular-related outcomes and bone health were prominent research themes. Author keywords co-word analysis identified 14 thematic clusters that encompass multiple disciplines. Recent important topics included nitric oxide, aging, and inflammation, whereas emerging themes were related to (1) vitamin D and musculoskeletal health, and (2) calcium, blood pressure, and weight loss.</p><p><strong>Conclusion: </strong>Dietary supplement research during the menopause transition has remained limited over the last two decades, with perimenopause notably underrepresented. The large number of distinct ingredients, coupled with limited collaborations among researchers, suggests dispersed research efforts and few replication studies. The imbalance between the number of ingredients studied and supporting studies may hinder the development of evidence-based guidance, but also presents an opportunity to harmonize research efforts and produce stronger science.</p>","PeriodicalId":18435,"journal":{"name":"Menopause: The Journal of The North American Menopause Society","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148604948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiorespiratory fitness, physical activity, and vasomotor symptoms of menopause.","authors":"Abbi D Lane, Catherine Kim, Marnie K McLean, Kelley Pettee Gabriel, Barbara Sternfeld, Pamela J Schreiner","doi":"10.1097/GME.0000000000002850","DOIUrl":"https://doi.org/10.1097/GME.0000000000002850","url":null,"abstract":"<p><strong>Objectives: </strong>Vasomotor symptoms of menopause (VMS) are purportedly linked to cardio-autonomic dysfunction. Higher cardiorespiratory fitness and moderate-vigorous intensity physical activity (MVPA) protect against cardio-autonomic dysfunction and might protect against VMS. Our purpose was to determine associations of fitness and MVPA with severe VMS (sVMS).</p><p><strong>Methods: </strong>CARDIA participants with evidence of menopause transition by the year 30 examination (Y30) who completed a baseline fitness test and attended the Y30 examination were included. MVPA was determined with accelerometry at Y20. sVMS were identified using surveys. The proportion of participants with sVMS according to quartiles of baseline fitness was determined with χ2 tests. Differences in baseline and Y20 fitness and Y20 MVPA between sVMS groups were evaluated with Wilcoxon tests. Associations of fitness and MVPA with sVMS were evaluated using Poisson regression with robust SEs, adjusted for age, race, study center, smoking, body mass index, Y30 self-reported total PA, and Y30 hormone use.</p><p><strong>Results: </strong>Of 1,808 participants (median age=56 y [IQR: 53, 58], 49.5% Black race), 32.2% had sVMS. sVMS prevalence decreased as baseline fitness quartile increased: Q1: 38%, Q2: 37%, Q3: 28%, and Q4: 25%. Participants with sVMS had lower baseline fitness (480 [398, 570s] vs. 496 [420, 600 s]) and Y20 fitness, both P<0.001. Y20 MVPA was lower (22 [13, 38min/day] vs. 26 [16, 43 min/day]) in those with sVMS, P<0.02. After adjustment, neither baseline nor Y20 fitness nor MVPA was associated with sVMS.</p><p><strong>Conclusions: </strong>Fitness and MVPA in young or mid-adulthood were not independently associated with severe VMS. Other mitigation strategies seem necessary.</p>","PeriodicalId":18435,"journal":{"name":"Menopause: The Journal of The North American Menopause Society","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148604919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychological symptoms during perimenopause: a global perspective.","authors":"Adam C Cunningham, Mary S Hedges, Yella Hewings-Martin, Regina Castaneda, Jana Karam, Liudmila Zhaunova, Stephanie S Faubion, Chrisandra L Shufelt","doi":"10.1097/GME.0000000000002872","DOIUrl":"https://doi.org/10.1097/GME.0000000000002872","url":null,"abstract":"<p><strong>Objectives: </strong>Psychological health changes are known to occur during perimenopause, but the extent to which these differ from premenopause remains unclear. This study aimed to assess psychological symptoms during perimenopause compared with premenopause and evaluate differences by country.</p><p><strong>Methods: </strong>Flo app users aged 35 years or above not taking hormonal contraception or hormone therapy were included. The psychological domain of the Menopause Rating Scale (range 0-16) and symptoms within this domain of depressive mood, irritability, anxiety, and exhaustion (range 0-4 each) were evaluated. Participants in perimenopause were compared with those in premenopause (self-reported not in perimenopause or postmenopause).</p><p><strong>Results: </strong>A total of 7,975 women were included, with 2,353 in perimenopause (mean age 45 years [SD±4.5]) and 5,622 in premenopause (39 y [SD±4.0]). Psychological Menopause Rating Scale scores in the perimenopause group were significantly higher (7.3 [SD±3.56]) than in the premenopause group (4.8 [SD±3.56]; P<0.001). The individual symptoms of depressive mood, irritability, anxiety, and exhaustion were also higher in the perimenopause group (P<0.001, for all respectively), with the largest difference being exhaustion. These findings remained after adjusting for known confounders, including an existing diagnosis of anxiety or depression. Geographic analysis included 20 countries across 6 continents, with significant differences identified between countries for the overall psychological symptom domain score and all individual symptoms.</p><p><strong>Conclusion: </strong>Significantly greater psychological symptom burden was identified in the perimenopause group compared with the premenopause group, with the greatest difference noted for the individual symptom of exhaustion. Differences in symptom burden were also identified by country.</p>","PeriodicalId":18435,"journal":{"name":"Menopause: The Journal of The North American Menopause Society","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148604976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Weight loss interventions and sexual function in midlife women: the emerging role of glucagon-like peptide-1 receptor agonists.","authors":"Regina Castaneda, Diego Sepulveda, Maria D Hurtado Andrade, Chrisandra L Shufelt, Stephanie S Faubion","doi":"10.1097/GME.0000000000002854","DOIUrl":"https://doi.org/10.1097/GME.0000000000002854","url":null,"abstract":"<p><strong>Importance and objective: </strong>Sexual health is a multidimensional aspect of women's well-being. It is particularly vulnerable during midlife, when the physiological and psychosocial changes of the menopause transition intersect with the growing burden of obesity. Glucagon-like peptide-1 (GLP-1) receptor agonists have emerged as highly effective pharmacologic treatments for obesity, yet their effects on female sexual function remain largely uncharacterized. This review aims to discuss the interplay among obesity, midlife, obesity treatments, and female sexual health, with a focused synthesis of available evidence on GLP-1-based therapies and sexual outcomes in women.</p><p><strong>Methods: </strong>This narrative review synthesizes preclinical studies, case reports, observational data, and clinical trials identified through PubMed searches from inception through March 2026, examining female sexual function in the context of obesity, the menopause transition, obesity treatments, and GLP-1 receptor agonist therapy.</p><p><strong>Discussion and conclusion: </strong>Obesity impairs female sexual function through hormonal, vascular, and psychosocial mechanisms. Accordingly, lifestyle interventions and bariatric surgery have demonstrated meaningful improvements in sexual function. In contrast, GLP-1 receptor agonists, despite conferring substantial weight loss and favorable metabolic effects, may paradoxically suppress sexual desire and arousal through central neuroendocrine mechanisms, including the modulation of dopaminergic reward and serotonergic signaling. While emerging case reports and preclinical data support this concern, systematic clinical evidence remains limited, highlighting the need for prospective studies with longitudinal sexual function endpoints. In this context, clinicians should proactively assess sexual function before and during GLP-1 therapy using validated instruments and integrate sexual health into comprehensive obesity care for midlife women.</p>","PeriodicalId":18435,"journal":{"name":"Menopause: The Journal of The North American Menopause Society","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148604992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perception of prolapse-associated symptoms by age: a cross-sectional study.","authors":"Faith Dunn, Katelyn Donaldson, Sarah Stevens, Kelly Rutherford, Paul J Nietert, Valentín Manríquez, Giuseppe Alessandro Digesu, Autumn Edenfield, Steven Swift","doi":"10.1097/GME.0000000000002865","DOIUrl":"10.1097/GME.0000000000002865","url":null,"abstract":"<p><strong>Objective: </strong>We sought to determine if age affects how women with pelvic organ prolapse (POP) perceive associated symptoms.</p><p><strong>Methods: </strong>A secondary analysis was performed on a previously published cross-sectional study of participants presenting for POP to three urogynecology centers in the United States, the United Kingdom, and Chile. Participants completed a questionnaire regarding the presence and bother of associated symptoms. Statistical analysis was performed using Mantel-Haenszel χ2 tests or Fisher's exact tests.</p><p><strong>Results: </strong>Of 202 participants, 25 were under 50 years, 38 were aged 50-59 years, 71 were aged 60-69 years, and 68 were aged 70 years and above. The majority of participants below 50 and 50-59 years had POP-Q stage 2 prolapse (60% and 53%, respectively), and the majority of participants 60-69 years and 70 years and above had POP-Q stage 3 prolapse (70% and 51%, respectively). The most common symptom was bulge (80.2%). Only three symptoms, stress urinary incontinence, back pain, and pelvic pain, significantly varied in the degree of bother among the three groups, with pelvic pain and back pain almost twice as common in those below 50 years old (64.0% and 64.0%) compared with those 70 years and above (39.7% and 33.8%, P=0.04 and <0.01).</p><p><strong>Conclusions: </strong>Vaginal bulge is the most common prolapse-associated symptom. POP-associated pelvic floor symptoms are experienced similarly across study participants, regardless of age, with the exception of stress urinary incontinence and pain.</p>","PeriodicalId":18435,"journal":{"name":"Menopause: The Journal of The North American Menopause Society","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148437440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Premature menopause and risk of kidney stone disease: evidence from the UK biobank and National Health and Nutrition Examination Survey.","authors":"Muhammad Usman, Chunnuan Deng, Jintao Hu, Cong Lai, Zhikai Wu, Zhihan Yuan, Junyi Xie, Cheng Liu, Hao Yu, Kuiqing Li, Kang He, Chuanchuan Yu, Ge Sun, Rijia Su, Wang He, Weiming Liang, Zhuang Tang, Kewei Xu","doi":"10.1097/GME.0000000000002852","DOIUrl":"https://doi.org/10.1097/GME.0000000000002852","url":null,"abstract":"<p><strong>Objective: </strong>Kidney stone disease (KSD) is a global health burden. Premature menopause (PM) may increase the likelihood of KSD, but the influence of hormone therapy (HT) and genetic predisposition is unclear. We examined the association between PM and KSD in two large cohorts and evaluated potential modification by HT and polygenic risk scores (PRS).</p><p><strong>Methods: </strong>We conducted cross-sectional analyses in 7,112 women from the National Health and Nutrition Examination Survey and 189,900 women from UK Biobank (UKB), with PM defined as menopause before age 40 years. Logistic regression estimated odds ratios (ORs) for prevalent KSD, and Cox models estimated hazard ratios (HRs) for incident KSD over a mean follow-up of ∼15 years in UKB. Sensitivity analyses and PRS stratification were performed to assess robustness and potential effect modification. Statistical analyses were conducted using R software.</p><p><strong>Results: </strong>In National Health and Nutrition Examination Survey (N = 7,112), KSD prevalence was higher in women with PM compared with women without PM (13.4% vs. 8.4%), with logistic regression showing 50% higher odds (OR: 1.54, 95% CI: 1.11-2.13). In the UKB baseline analysis (N = 189,900), PM was associated with higher odds of KSD (OR: 1.55, 95% CI: 1.32-1.83). In the prospective cohort (N = 188,282), women with PM had a 29%-55% higher hazard of incident KSD (HR: 1.29-1.55). Cumulative hazard curves showed early divergence (P < 0.001). PRS analyses demonstrated increasing hazards of KSD with higher genetic predisposition (HR: 1.22-1.80). HT use partially attenuated, but did not eliminate, the elevated association.</p><p><strong>Conclusion: </strong>PM was consistently associated with KSD across two large cohorts. This association remained robust across multiple analytical approaches. Genetic predisposition was associated with higher hazards of KSD, whereas HT did not meaningfully modify these associations. These findings suggest a clinically relevant link that warrants further investigation in prospective and mechanistic studies.</p>","PeriodicalId":18435,"journal":{"name":"Menopause: The Journal of The North American Menopause Society","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148437566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring prevalence and drivers of perimenopause uncertainty among US Women: a mixed-methods study.","authors":"Yihan Xu, Deirbhle Fergus, Yella Hewings-Martin, Mary Hedges, Carley Prentice, Adam Cunningham, Liudmila Zhaunova, Chrisandra Shufelt, Stephanie Faubion","doi":"10.1097/GME.0000000000002837","DOIUrl":"https://doi.org/10.1097/GME.0000000000002837","url":null,"abstract":"<p><strong>Objective: </strong>Perimenopause is an under-recognized life stage that is often accompanied by complex and fluctuating symptoms. We aimed to quantify the prevalence of perimenopause uncertainty and explore the underlying drivers.</p><p><strong>Methods: </strong>We conducted a mixed-methods study using a cross-sectional survey of US women aged 35 years and above (N=7,640). We estimated the prevalence of perimenopause uncertainty and examined subgroup differences by age and symptom severity. Content analysis of free-text responses (n=409) identified key uncertainty drivers.</p><p><strong>Results: </strong>Overall, 34% (95% CI: 33%-35%) of participants reported being unsure of their reproductive stage. Uncertainty varied by age and symptom severity (P < 0.001), peaking at 42% (95% CI: 41%-43%) among those aged 40-44 and 37% (95% CI: 36%-38%) among those with severe symptom burden. Content analysis revealed three main uncertainty drivers. Symptom confusion and attribution were the most common (56%), reflecting difficulties interpreting bodily changes and distinguishing perimenopause from other causes. Knowledge gaps and information seeking accounted for 28% of responses, highlighting limited health literacy, age-based assumptions, and active searches for evidence. Barriers to confirmation and care (16%) described dismissive health care encounters and reluctance to acknowledge perimenopause. Younger women (35-39 y) were more likely to cite knowledge gaps, while health care barriers peaked in the 40-44 age group (P = 0.05).</p><p><strong>Conclusion: </strong>Perimenopause uncertainty is a prevalent and clinically meaningful phenomenon. Conceptually distinct from illness-focused uncertainty, this universal transition frequently involves ambiguity and limited validation. Clarifying symptom patterns, addressing knowledge gaps, and reducing barriers to confirmation may support women during perimenopause.</p>","PeriodicalId":18435,"journal":{"name":"Menopause: The Journal of The North American Menopause Society","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148437401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cumulative social determinants of health and reproductive lifespan among US women: a NHANES 1999-2018 analysis.","authors":"Bei Li, Meidi Yang","doi":"10.1097/GME.0000000000002860","DOIUrl":"10.1097/GME.0000000000002860","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the associations of individual and cumulative social determinants of health (SDoH) with reproductive lifespan among US women using nationally representative National Health and Nutrition Examination Survey (NHANES) data.</p><p><strong>Methods: </strong>This cross-sectional study used data from the NHANES 1999-2018. A total of 8,576 women aged ≥45 years were included. Reproductive lifespan was defined as the interval between age at menarche and menopause. SDoH indicators included socioeconomic status, education, marital status, employment, food security, health care access, insurance, and housing. Weighted linear regression models were used to examine associations between individual SDoH indicators and reproductive lifespan. Weighted quantile sum regression was applied to assess the joint effects of multiple SDoH factors.</p><p><strong>Results: </strong>In weighted linear regression analyses, lower education level, lower poverty income ratio (PIR), and renting a home were significantly associated with a shorter reproductive lifespan. Weighted quantile sum analysis further showed that higher cumulative social disadvantage was significantly associated with a shorter reproductive lifespan (β=-3.06, 95% CI: -3.92 to -2.19, P<0.001). Food security contributed the highest weight to the mixture (0.34), followed by housing status (0.25), education level (0.17), and PIR (0.16). Sensitivity analyses supported the main findings.</p><p><strong>Conclusions: </strong>Higher cumulative social disadvantage was associated with a shorter reproductive lifespan among women. Food security, housing status, education level, and PIR were important contributors within the SDoH mixture, highlighting the potential relevance of SDoH in reproductive aging.</p>","PeriodicalId":18435,"journal":{"name":"Menopause: The Journal of The North American Menopause Society","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148437484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Group-based compassionate mind training for low mood and anxiety in the menopause transition: a feasibility randomized controlled trial.","authors":"Simone Saidel, Kate Robinson, Helen Donovan, Rachel Evans, Meena Khatwa, Aimee Spector","doi":"10.1097/GME.0000000000002826","DOIUrl":"https://doi.org/10.1097/GME.0000000000002826","url":null,"abstract":"<p><strong>Objective: </strong>The menopause transition (MT) can present with a range of biopsychosocial challenges, including peaks in anxiety and depression. Compassionate Mind Training (CMT), a psychological intervention focused on improving distress and wellbeing, has shown promising results in supporting depression in clinical populations. This study examined the feasibility and preliminary effects of a six-session online CMT group intervention for women in MT, with mild to moderate anxiety and/or mild to moderately severe depression.</p><p><strong>Methods: </strong>This was a mixed-methods feasibility study. 38 participants were randomized to either CMT plus treatment as usual (TAU) or TAU alone. Feasibility and acceptability outcomes included recruitment, retention, attendance, and measure completion. Exploratory analyses examined changes in psychological outcomes. Qualitative interviews (n=16) were analyzed thematically to explore participant experiences.</p><p><strong>Results: </strong>Recruitment targets were met, with retention rates of 89.5% for CMT, and 73.7% for TAU. Attendance was high, and outcome measures showed 100% completion among those at follow-up. Exploratory analyses suggested improvements following CMT for depression (Patient Health Questionnaire-9, d=0.73), anxiety (Generalized Anxiety Disorder-7, d=0.53), and anxiety/depressive symptoms (Women's Health Questionnaire, d=1.12), alongside reductions in fears of compassion and self-criticism. Thematic analysis generated five themes: motivation and engagement, perceptions of trial processes, structure, support, and group experience, intervention content and skill-building, and personal outcomes, impact, and the future.</p><p><strong>Conclusions: </strong>The study supports the feasibility and acceptability of CMT for women in MT. Quantitative and qualitative findings suggest potential benefits for mental health and quality of life, warranting a fully powered trial of effectiveness and cost-effectiveness.</p>","PeriodicalId":18435,"journal":{"name":"Menopause: The Journal of The North American Menopause Society","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148405184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evolution of health-related quality of life after breast cancer surgery: longitudinal follow-up of climacteric symptoms.","authors":"Silvia Cortell-Aznar, Nicolás Ruiz-Robledillo, Rosario Ferrer-Cascales, Manuel Fernández-Alcántara, Natalia Albaladejo-Blázquez, Silvia Delgado-García","doi":"10.1097/GME.0000000000002849","DOIUrl":"https://doi.org/10.1097/GME.0000000000002849","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate longitudinal changes in climacteric symptom burden and health-related quality of life between 6 and 12 months after breast cancer surgery and to assess whether symptom trajectories differ according to age or clinical and treatment-related factors using the minimal clinically important difference (MCID).</p><p><strong>Methods: </strong>Prospective longitudinal cohort study including women surgically treated for breast cancer at Hospital General Universitario Dr. Balmis (Alicante, Spain) between April 2023 and April 2024. Of the 196 women assessed at 6 months, 181 completed the 12-month follow-up and were included in the final longitudinal analysis. Climacteric symptoms were assessed at 6 and 12 months post-surgery using the 16-item Cervantes Scale. Within-participant changes were analyzed using the Wilcoxon signed-rank test, estimating the Hodges-Lehmann shift and effect size. Subgroup comparisons were performed using nonparametric tests with Bonferroni correction. Age-stratified analyses were conducted across five predefined age groups. Clinical relevance was evaluated against the MCID.</p><p><strong>Results: </strong>The 16-item Cervantes Scale total score showed a statistically significant change between 6 and 12 months; however, the magnitude of this change was small and remained below the MCID, indicating overall symptom stability. Age-stratified analyses identified statistically significant changes in women aged 40-49, 50-59, and 60-69 years, but these remained below the MCID thresholds, and did not reflect clinically meaningful improvement. No clinical, lifestyle, or treatment-related variables were associated with differential symptom trajectories.</p><p><strong>Conclusions: </strong>Between 6 and 12 months after surgery, climacteric symptom burden in breast cancer survivors showed minimal change. Although statistically significant differences were observed, these remained below the MCID and are therefore unlikely to represent clinically meaningful changes. These findings support the need for early, proactive, and multidisciplinary management strategies to optimize health-related quality of life during survivorship in this population.</p>","PeriodicalId":18435,"journal":{"name":"Menopause: The Journal of The North American Menopause Society","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148405192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}