Menopause: The Journal of The North American Menopause Society最新文献

{"title":"Oncofertility and female fertility preservation: a clinical update.","authors":"Mindy S Christianson","doi":"10.1097/GME.0000000000002558","DOIUrl":"10.1097/GME.0000000000002558","url":null,"abstract":"<p><p>Certain cancer and medical treatments can be harmful to fertility by depleting the egg supply. The risk to fertility is dependent on the patient's age, ovarian reserve before treatment, specific medication, or treatment and dosage. For women at risk of developing ovarian insufficiency because of gonadotoxic treatment, fertility preservation options include embryo, oocyte, and ovarian-tissue cryopreservation. Surgical procedures that can protect fertility for patients facing pelvic radiation therapy include ovarian transposition and uterine transposition. This Practice Pearl will focus on fertility preservation options for women facing medical treatment, a core component of oncofertility.</p>","PeriodicalId":18435,"journal":{"name":"Menopause: The Journal of The North American Menopause Society","volume":"32 7","pages":"655-657"},"PeriodicalIF":2.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144528684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of menopausal status and hormone use with bladder health and lower urinary tract symptoms in US women: results from the RISE FOR HEALTH study.","authors":"Camille P Vaughan, Alayne D Markland, Gerald McGwin, Emily S Lukacz, Sonya S Brady, Yvette D Lacoursiere, Jean F Wyman, Siobhan Sutcliffe, Ariana L Smith, Kimberly Kenton, Ann Stapleton, Linda Brubaker, Bernard L Harlow","doi":"10.1097/GME.0000000000002541","DOIUrl":"10.1097/GME.0000000000002541","url":null,"abstract":"<p><strong>Objectives: </strong>Most previous studies of genitourinary symptoms associated with menopause focus on comparisons of postmenopausal to premenopausal women and less is known about bladder health during menopause. We evaluated associations of menopause status and hormone use with bladder health and lower urinary tract symptoms (LUTS).</p><p><strong>Methods: </strong>Data were collected from May 2022 to December 2023 from a regionally representative cohort of community-dwelling adult women in the United States. Bladder health and LUTS were measured using validated questionnaires. Analyses included multivariable linear and logistic regression models.</p><p><strong>Results: </strong>Of 3,423 eligible participants, 3,126 responded to menopause and hormone use questions. Of these, 1,226 were premenopausal, 260 perimenopausal, and 1,640 postmenopausal. Premenopausal women reported hormone use more often than perimenopausal or postmenopausal women (38.3% vs. 21.5% and 13.2%). Across multiple bladder health scales (BHS, range 0-100) and bladder function indices (BFI, range 0-100), perimenopause and postmenopause status were associated with worse scores compared with premenopause status. Perimenopausal women were more likely to report urgency UI [OR 2.27, (95% CI: 1.49-3.46)] and other LUTS compared to premenopausal women. Hormone use was associated with worse bladder health in postmenopausal women [postmenopause/hormone -6.0 Overall BHS, (95% CI: -9.8 to -2.2)] and BFI [postmenopause/hormone BFI -4.8, (95% CI: -7.4 to -2.2)].</p><p><strong>Conclusions: </strong>Promotion of bladder health and LUTS prevention is important as women approach the menopause transition. Hormone use was infrequently reported in perimenopausal and postmenopausal women and was associated with worse bladder health postmenopause.</p>","PeriodicalId":18435,"journal":{"name":"Menopause: The Journal of The North American Menopause Society","volume":" ","pages":"583-591"},"PeriodicalIF":3.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12395369/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144006914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation between equol production and intestinal microbiota after treatment with isoflavone, isoflavone plus probiotic and hormonal therapy in postmenopausal women: a pilot study.","authors":"Ana Elisa Ribeiro, Naice Eleidiane Santana Monteiro, Lucia Helena Simões da Costa Paiva, Adriana Orcesi Pedro","doi":"10.1097/GME.0000000000002544","DOIUrl":"10.1097/GME.0000000000002544","url":null,"abstract":"<p><strong>Objectives: </strong>To correlate the urinary excretion of equol with intestinal microbiota in response to isoflavone supplementation alone or in combination with probiotics, and to compare these results with those of hormone therapy in postmenopausal women.</p><p><strong>Methods: </strong>A pilot study was conducted on 47 postmenopausal women aged 40-60 years. Participants were randomly assigned to one of three groups: (A) oral isoflavone (150 mg dry extract of Glycine max); (B) isoflavone plus probiotic (Lactobacillus acidophilus, Lactobacillus casei, Lactococcus lactis, Bifidobacterium bifidum, and Bifidobacterium lactis); or (C) hormone therapy (1 mg estradiol/0.5 mg norethisterone acetate). Fecal samples were collected to extract bacterial DNA, and equol and its intermediates were measured using gas chromatography coupled with mass spectrometry at baseline and after 16 weeks of treatment.</p><p><strong>Results: </strong>In the isoflavone alone and isoflavone plus probiotic groups, no statistically significant correlations were found between bacterial phyla or genera and the urinary excretion of equol or its intermediate after 16 weeks of treatment. In the hormone therapy group, directly proportional correlation between Bacteroidetes (Spearman R=0.83, Pa=0.01), Cyanobacteria (Spearman R=0.89, Pa=0.002), Alistipes (Spearman R=0.81, Pa=0.04), Catenibacterium (Spearman R=0.81, Pa=0.04), Clostridium (Spearman R=0.84, Pa=0.02), Barnesiella (Spearman R=0.84, Pa=0.02), and the urinary excretion of the equol intermediate were observed.</p><p><strong>Conclusions: </strong>Only the hormone therapy group showed a significant increase in bacterial abundance involved in isoflavone metabolism.</p>","PeriodicalId":18435,"journal":{"name":"Menopause: The Journal of The North American Menopause Society","volume":"32 7","pages":"610-620"},"PeriodicalIF":2.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144528682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letters to the Editor.","authors":"Susan R Davis, Rodney Baber, Paula Briggs, Haitham Hamoda, Martha Hickey, Rossella E Nappi, Tommaso Simoncini","doi":"10.1097/GME.0000000000002581","DOIUrl":"10.1097/GME.0000000000002581","url":null,"abstract":"","PeriodicalId":18435,"journal":{"name":"Menopause: The Journal of The North American Menopause Society","volume":" ","pages":"665-667"},"PeriodicalIF":2.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144022219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Palpitations in midlife women: the Menopause Racing Heart Pilot Study.","authors":"Janet S Carpenter, Heather A Jaynes, Mofareh A Alzahrani, Peng-Sheng Chen, Richard J Kovacs, James E Tisdale","doi":"10.1097/GME.0000000000002538","DOIUrl":"10.1097/GME.0000000000002538","url":null,"abstract":"<p><strong>Objective: </strong>Although palpitations are common in midlife women and may have long-term effects on cardiovascular health and longevity, little is known about underlying electrocardiogram findings, real-time palpitations reporting, or correlates. This hypothesis-generating pilot study compared midlife perimenopausal and postmenopausal women with and without palpitations on electrocardiogram findings, real-time palpitations reporting, and potential correlates.</p><p><strong>Methods: </strong>In this prospective, longitudinal, descriptive, comparative pilot study, 15 midlife women with and 15 without palpitations provided data. They wore an ambulatory electrocardiogram patch for 14-28 days, prospectively recorded palpitations via event button presses and daily diaries, recorded vasomotor symptoms in daily diaries, provided blood samples, and completed questionnaires.</p><p><strong>Results: </strong>There were no group differences in age [Md (IQR) = 56 (50, 59) vs. 55 (53, 57) with an age range of 46 to 62 in both groups] or menopausal status. The palpitations group had significantly lower heart rate variability and longer runs of atrial tachycardia. Button press data indicated that 50% of the palpitations group experienced palpitations (1) one third or more of all nights on the study, (2) nearly half of all days on the study, or (3) once or more per 24 hours on the study. Symptoms occurred during altered rhythms and normal sinus rhythm, though the latter seemed more common at night. Palpitations reporting was not related to demographics, clinical variables, biomarkers, anxiety, or somatosensory awareness but was related to having vasomotor symptoms and diabetes.</p><p><strong>Conclusion: </strong>The pilot study findings revealed some important hypothesis-generating differences that are worthy of further investigation in a larger study.</p>","PeriodicalId":18435,"journal":{"name":"Menopause: The Journal of The North American Menopause Society","volume":" ","pages":"571-582"},"PeriodicalIF":2.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between reproductive health factors and sociodemographic characteristics and the severity of moderate to severe postmenopausal depression: a secondary analysis of randomized controlled trial data.","authors":"Xiao Wang, Qinge Zhang, Gang Wang, Jingjing Zhou","doi":"10.1097/GME.0000000000002543","DOIUrl":"10.1097/GME.0000000000002543","url":null,"abstract":"<p><strong>Objectives: </strong>The cessation of the menstrual cycle is associated with numerous physiological changes and symptoms, with depression being common during perimenopause and postmenopause, causing significant impacts on one's life. The objective of this study was to explore the relationship between the severity of moderate to severe postmenopausal depression and reproductive health factors, as well as sociodemographic characteristics.</p><p><strong>Methods: </strong>This secondary analysis is based on data from a randomized controlled trial conducted at both a psychiatric hospital (Beijing Anding Hospital) and a general hospital (Beijing Chaoyang Hospital) between April 2013 and September 2017. The original randomized controlled trial employed a multicenter, randomized design over an 8-week period to evaluate depression and associated clinical characteristics. Of the 189 women screened, 5 did not meet the inclusion criteria, leaving 184 eligible for this secondary analysis. The study group consisted of 184 postmenopausal women. Depression was the primary outcome, measured by a 24-item Hamilton Depression Rating Scale observer-rated scale. Quick Inventory of Depressive Symptomatology-Self-Report was used for sensitivity analysis and was considered a secondary outcome. The visual analog scale (VAS) primarily assesses physical pain symptoms. The patient's basic sociodemographic characteristics and reproductive-related information are considered secondary indicators.</p><p><strong>Results: </strong>Linear regression analysis revealed that a lower age at menopause (β = -0.380; P < 0.001), married/partnered (β = -3.028; P = 0.001), higher body mass index (BMI) (β = 0.744; P < 0.001), higher VAS (β = 0.126; P < 0.001), and have chronic physical diseases (β = 2.335; P = 0.015) are significantly associated with more severe depressive symptoms in moderate to severe postmenopausal depression. Logistic regression analysis revealed that BMI [odds ratio (OR) = 1.156; 95% CI: 1.012-1.32], VAS (OR = 1.04; 95% CI: 1.017-1.063), and being single (OR = 3.658; 95% CI: 1.618-8.27) were significantly associated with an increased risk of severe depressive symptoms in postmenopausal participants, while age at menopause (OR = 0.857; 95% CI: 0.765-0.96) emerged as a protective factor.</p><p><strong>Conclusions: </strong>Our findings indicate that an earlier age at menopause, being single, the presence of concomitant physical illnesses, a higher BMI, and more severe pain symptoms are associated with increased severity of moderate to severe postmenopausal depression. These results contribute to raising awareness of moderate to severe depression among postmenopausal women and underscore the importance of early diagnosis through targeted screening efforts.</p>","PeriodicalId":18435,"journal":{"name":"Menopause: The Journal of The North American Menopause Society","volume":" ","pages":"621-629"},"PeriodicalIF":2.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12188832/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144216303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychoeducation in the management of menopause symptoms for women living with a serious mental illness: a scoping review.","authors":"Tania Perich, Kelly Kakakios","doi":"10.1097/GME.0000000000002540","DOIUrl":"10.1097/GME.0000000000002540","url":null,"abstract":"<p><strong>Importance and objective: </strong>People living with a serious mental illness (SMI) may require additional management during the menopause transition and may have specific education needs regarding menopause. The aim of this scoping review was to assess the literature on psychoeducation programs that have been developed to address the menopause knowledge needs of people living with a mental illness.</p><p><strong>Methods: </strong>A scoping review of the literature was conducted in November 2024, focussing on psychoeducation programs for menopause developed for women living with a SMI using PsycINFO, Medline, Embase, and Google Scholar using the \"Population, Concept, and Context\" framework. The population considered was individuals with SMI, mental illness, bipolar disorder, schizophrenia, schizoaffective disorder, personality disorder, post-traumatic stress disorder, depression, anxiety disorders, obsessive-compulsive disorder, alcohol use, substance use, and eating disorders. Five studies were found that utilized psychoeducation in the context of cognitive behavior therapy delivered as a treatment of either depression or menopause symptoms. Participants in these studies included women living with depression or bipolar disorder. No studies were identified that delivered any psychoeducation intervention for the majority of conditions assessed. Population groups with no research included schizophrenia or schizoaffective disorder, personality disorder, post-traumatic stress disorder, anxiety disorders, obsessive-compulsive disorder, alcohol use, substance use, and eating disorders.</p><p><strong>Discussion and conclusion: </strong>More research is needed to further explore how people living with a mental illness may be best prepared for the menopause transition considering both menopause symptoms and psychiatric symptoms. The development and assessment of psychoeducation programs and materials addressing individual needs should be further considered for those living with a mental illness.</p>","PeriodicalId":18435,"journal":{"name":"Menopause: The Journal of The North American Menopause Society","volume":" ","pages":"658-664"},"PeriodicalIF":2.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144006915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letters to the Editor.","authors":"Frank Z Stanczyk, Sharon A Winer, Donna Shoupe","doi":"10.1097/GME.0000000000002583","DOIUrl":"10.1097/GME.0000000000002583","url":null,"abstract":"","PeriodicalId":18435,"journal":{"name":"Menopause: The Journal of The North American Menopause Society","volume":" ","pages":"669-671"},"PeriodicalIF":2.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144151141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letters to the Editor.","authors":"Sarah Glynne","doi":"10.1097/GME.0000000000002584","DOIUrl":"10.1097/GME.0000000000002584","url":null,"abstract":"","PeriodicalId":18435,"journal":{"name":"Menopause: The Journal of The North American Menopause Society","volume":" ","pages":"671-674"},"PeriodicalIF":2.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144151145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mood and menopause.","authors":"Pauline M Maki","doi":"10.1097/GME.0000000000002566","DOIUrl":"10.1097/GME.0000000000002566","url":null,"abstract":"","PeriodicalId":18435,"journal":{"name":"Menopause: The Journal of The North American Menopause Society","volume":"32 7","pages":"652-654"},"PeriodicalIF":2.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144528683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}