Menopause: The Journal of The North American Menopause Society最新文献

{"title":"Psychological quality of life in BRCA1/2- carriers following risk-reducing salpingo-oophorectomy: a preliminary report.","authors":"Åsa Ehlin von Kartaschew, Angelica Lindén Hirschberg, Kristina Gemzell-Danielsson, Angelique Flöter Rådestad","doi":"10.1097/GME.0000000000002571","DOIUrl":"https://doi.org/10.1097/GME.0000000000002571","url":null,"abstract":"<p><strong>Objective: </strong>The psychological consequences following risk-reducing salpingo-oophorectomy (RRSO) have not been clarified. Our objective was to investigate general well-being and symptoms of anxiety and depression before and 1 year after RRSO in BRCA1/2- pathogenic variant carriers, versus comparators and to study if testosterone levels after RRSO correlate with psychological well-being and vitality.</p><p><strong>Methods: </strong>In this observational follow-up study, 43 BRCA1/2-carriers planned for RRSO and 73 age-matched comparators were evaluated using the Hospital Anxiety and Depression Scale (HADS) and Psychological General Well-being Index (PGWBI) before and one year after surgery or at inclusion (comparators). Blood samples for analysis of testosterone by tandem mass spectrometry were also collected, and free androgen index (FAI) was calculated.</p><p><strong>Results: </strong>In the RRSO group, 53.5% reported elevated anxiety levels at baseline that decreased to 32.6% at follow-up (P=0.029). However, at 1 year, the RRSO group still reported higher anxiety levels versus the comparator group (16.4%, P=0.038). The RRSO group reported low and stable levels on the depression scale, and no change was found in well-being, but significantly worse scores of the PGWBI dimensions depressed mood and general health at follow-up as opposed to comparators (80.0 vs. 86.7, P=0.04; 80.0 vs. 86.7, P=0.028). FAI was significantly lower in the RRSO group versus comparators at 1-year follow-up (0.6 vs. 0.9, P=0.041). Testosterone levels were not correlated with either well-being or vitality.</p><p><strong>Conclusions: </strong>Our data identified no negative effect on psychological quality of life 1 year following RRSO. Larger studies are needed to confirm these preliminary findings.</p>","PeriodicalId":18435,"journal":{"name":"Menopause: The Journal of The North American Menopause Society","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144317334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing the management of menopause at the workplace: a scoping review of workplace non-hormone interventions and impact on women with menopause.","authors":"Angeliki Taniskidi, Eirini Mitsinga, Dani Binnington, Vikram Talaulikar, Bassel H Al Wattar","doi":"10.1097/GME.0000000000002569","DOIUrl":"https://doi.org/10.1097/GME.0000000000002569","url":null,"abstract":"<p><strong>Importance: </strong>There is a need for interventions that employers and employees can adopt to optimize the health, safety, and productivity of women with menopause at the workplace.</p><p><strong>Objective: </strong>We conducted a structured scoping review to summarize the literature and identify effective interventions that could help women manage menopausal symptoms at the workplace.</p><p><strong>Evidence review: </strong>We searched electronic databases (MEDLINE and EMBASE) until July 2024 for all studies that evaluated any non-hormone interventions used among women with menopause at the workplace and reported as per PRISMA-ScR. We used a standardized data extraction tool to capture relevant data and conducted a thematic analysis to identify the prominent themes.</p><p><strong>Findings: </strong>Out of 4,284 potentially relevant citations, we included seven studies, including four randomized trials and three observational studies. Four studies evaluated cognitive behavioral interventions showing improvement in hot flushes, workability, presenteeism, and quality of life, though results varied between studies. One randomized study examined the impact of a structured aerobic exercise program on menopausal symptoms and work-related outcomes showing slight improvement in workability and mental strain. Raja Yoga meditation combined with sleep hygiene education was evaluated in one randomized study showing improvements in insomnia, sleep quality, and menopausal symptoms. Offering regular consultations at an outpatient menopause clinic for managing symptoms through lifestyle modifications improved menopausal symptoms and workability at 3 months after adjusting for potential confounders.</p><p><strong>Conclusions and relevance: </strong>Several behavioral and lifestyle interventions can help to optimize the health, productivity, and quality of life of women with menopause at the workplace. However, there is limited high-quality evidence on the best available intervention with wide variation in reported outcomes and measurement tools.</p>","PeriodicalId":18435,"journal":{"name":"Menopause: The Journal of The North American Menopause Society","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144317332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A survey of menopausal symptoms in chinese community women based on the STRAW+10 staging system.","authors":"Jie Wang, Yehuan Yang, Yilin Yang, Zhiqi Sun, Ying Chen, Ruimin Zheng","doi":"10.1097/GME.0000000000002561","DOIUrl":"https://doi.org/10.1097/GME.0000000000002561","url":null,"abstract":"<p><strong>Objective: </strong>To assess the prevalence and factors influencing menopausal symptom severity among perimenopausal women in the Chinese community.</p><p><strong>Methods: </strong>Participants aged 35-60 from 26 districts in 12 Chinese provinces were recruited through the Epidemiological Investigation of Menopause Status among Chinese Women (EIM-CW). Exclusion criteria included congenital absence of the uterus and premenopausal hysterectomy. Data collected included demographics, lifestyle, Kupperman index, physical examination, and menstrual history.</p><p><strong>Results: </strong>Of 55,056 women screened, 51,118 met the inclusion criteria. A total of 27,953 participants were classified in stage -3, 1,983 in stage -2, 2,319 in stage -1, 880 in stage +1a, 3,027 in stage +1b, 6,580 in stage +1c, and 8,376 in stage +2. The prevalence of symptoms after menopause (18,863 individuals including stage +1a and subsequent stages) included insomnia (50.60%), sexual complaints (45.70%), fatigue (44.70%), nervousness (42.40%), arthralgia/myalgia (41.40%), and hot flushes (27.30%). Higher education, better family satisfaction, and lower physical labor were associated with more mild symptoms (P<0.05). Symptoms prevalence varied by STRAW+10 stages: nervousness peaked at stage -3 (51.82%), fatigue at stage -2 (50.13%), and insomnia during stages -1 to +2 (50.23%-55.15%). In stage -2, the most severe symptoms include headaches (1.11%), paresthesia (0.50%), palpitations (0.35%), and formication (0.25%). Hot flushes are most severe in stage -1, with a prevalence of 1.08%. The greatest severity of symptoms is observed in stage +1a, particularly for insomnia (1.59%), nervousness (1.14%), fatigue (1.14%), vertigo (0.68%), and melancholia (0.45%). Stage +2 shows the highest severity for sexual complaints (8.15%), urinary symptoms (0.88%), and musculoskeletal pain (0.69%).</p><p><strong>Conclusions: </strong>Insomnia is the most common symptom among perimenopausal women (during STRAW+10 stages -1 to +2) in Chinese communities. Insomnia, nervousness, fatigue, vertigo, and melancholia symptoms are most severe in stage +1a; headaches, paresthesia, palpitations, and formication are most severe in stage -2; sexual discomfort, urinary tract infection, and musculoskeletal pain are most severe in stage +2; hot flashes are most severe in stage -1. Menopausal symptom severity is associated with multiple factors such as education, family satisfaction, and physical labor.</p>","PeriodicalId":18435,"journal":{"name":"Menopause: The Journal of The North American Menopause Society","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144317329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Construction of a nomogram prediction model for deep vein thrombosis in epithelial ovarian cancer.","authors":"Chenxiang Pan, Shihao Xu, Aidi Lin, Lijiao Li","doi":"10.1097/GME.0000000000002603","DOIUrl":"10.1097/GME.0000000000002603","url":null,"abstract":"<p><strong>Objective: </strong>To develop and validate a nomogram prediction model for deep vein thrombosis (DVT) in epithelial ovarian cancer (EOC).</p><p><strong>Methods: </strong>Between May 2021 and May 2024, 429 EOC patients admitted to our hospital were retrospectively identified. The patients were randomly divided into a modeling group and a validation group. Based on whether DVT occurred, the modeling group was classified into a DVT group and a non-DVT group. The influencing factors associated with DVT in EOC were analyzed using multivariable logistic regression. R software was used to construct the nomogram model. The receiver operating characteristic (ROC) curve was used to evaluate the discrimination of the nomogram. Moreover, the decision curve analysis (DCA) was used to evaluate the clinical utility of the model.</p><p><strong>Results: </strong>Of 429 patients, 116 developed DVT, with an incidence rate of 27.04%. In the modeling group of 300 patients, 81 developed DVT, with an incidence rate of 27.00%. Multivariate logistic regression showed that age, BMI, hypertriglyceridemia, tumor staging, tumor grade, CA125 level, platelet count (PLT), and fibrinogen level (FIB) were independent risk factors for developing DVT in EOC ( P <0.05). The area under the ROC curve (AUC) for the modeling group was 0.893, and the AUC of the validation group was 0.973. The Hosmer-Lemeshow (H-L) test of the modeling group showed χ 2 =7.324 ( P= 0.722), and the H-L test of the validation group showed χ 2 =7.043 ( P= 0.711), suggesting good calibration. DCA curve showed that the threshold probability was between 0.08 and 0.97, the clinical value of the DVT nomogram model provided a net clinical benefit.</p><p><strong>Conclusion: </strong>Age, BMI, hypertriglyceridemia, tumor stage, tumor grade, CA125 level, platelet count (PLT), and fibrinogen level (FIB) are significant independent risk factors for EOC patients developing DVT. The nomogram constructed with these factors demonstrates good predictive performance and clinical utility in predicting the risk of DVT in EOC patients.</p>","PeriodicalId":18435,"journal":{"name":"Menopause: The Journal of The North American Menopause Society","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144285408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of body composition with the symptoms of pelvic floor disorders in middle-aged women: a longitudinal study.","authors":"Mari A Kuutti, Enni-Maria Hietavala, Hanna-Kaarina Juppi, Sarianna Sipilä, Pauliina Aukee, Eija K Laakkonen","doi":"10.1097/GME.0000000000002572","DOIUrl":"10.1097/GME.0000000000002572","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the association of body composition with symptoms of pelvic floor disorders ie, stress urinary incontinence, urgency urinary incontinence, fecal incontinence, and feeling of pelvic organ prolapse among middle-aged women.</p><p><strong>Methods: </strong>A longitudinal study with two measurement points 4 years apart was performed using a population sample of 376 Finnish women aged 47 to 55 years at the baseline. Total and regional body composition was assessed with dual x-ray absorptiometry (DXA) and multifrequency bioelectrical impedance analyzer (BIA). Body height, weight, and waist circumference were measured, and body mass index (BMI) was calculated. The symptoms of pelvic floor disorders were assessed using self-report questionnaire. Generalized estimating equations models were used to investigate associations. Models were adjusted with demographical, gynecologic, and physical activity variables.</p><p><strong>Results: </strong>The change in body composition was not associated with the change in the symptoms of pelvic floor disorders after 4-year follow-up. In cross-sectional analysis, the symptoms of stress urinary incontinence were found to be associated with total fat mass (OR 1.03, 95% CI: 1.01-1.06, P=0.017), trunk fat mass (OR 1.06, 95% CI: 1.02-1.11, P=0.009), android fat mass (OR 1.33, 95% CI: 1.05-1.70, P=0.020), visceral fat area (OR 1.01, 95% CI: 1.00-1.02, P=0.019), BMI (OR 1.07, 95% CI: 1.01-1.13, P=0.027), and waist circumference (OR 1.03, 95% CI: 1.01-1.05, P=0.008). No significant associations were found for other symptoms of pelvic floor disorders.</p><p><strong>Conclusions: </strong>Having a higher total or regional body fat mass, higher BMI, or larger waist circumference may increase the risk of stress urinary incontinence in middle-aged women.</p>","PeriodicalId":18435,"journal":{"name":"Menopause: The Journal of The North American Menopause Society","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12382721/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144216302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of menstrual cycle phases and reproductive aging stages on arousal symptoms: observations from the Seattle Midlife Women's Health Study.","authors":"Nancy Fugate Woods, Ellen Sullivan Mitchell","doi":"10.1097/GME.0000000000002570","DOIUrl":"https://doi.org/10.1097/GME.0000000000002570","url":null,"abstract":"<p><strong>Objective: </strong>Although investigators have devoted significant effort to understanding women's experiences of depressed mood and clinical depression during the menopausal transition and early postmenopause, they have focused less on women's experiences of emotional arousal, including emotions such as anxiety, irritability, and anger during these reproductive aging stages. The purpose of these analyses was to examine the influence of menstrual cycle phases and reproductive aging stages on women's reports of symptoms reflecting emotional arousal.</p><p><strong>Methods: </strong>A subset of Seattle Midlife Women's Health Study (SMWHS) participants (N=301) in late reproductive stages 1 or 2 (LRS1, LRS2) or early menopausal transition (EMT) rated the severity of symptoms daily for a complete menstrual cycle during the first year of SMWHS. They rated symptom severity daily on a 1-4 scale (least to most severe) in a health diary for anxiety symptoms (anxiety, out of control, tension, nervousness, panic, and palpitations) and anger symptoms (anger, hostility, impatience, and irritability). A two-way mixed ANOVA was used to test the cycle phase (postmenses/premenses) and reproductive aging stages on each symptom for LRS1, LRS2, and EMT and also for LRS2 versus EMT.</p><p><strong>Results: </strong>When all three groups were included in the analyses, only anger and irritability differed by menstrual cycle phase and were significantly more severe during premenses than during postmenses. There were no significant effects of reproductive aging stages and no interactions between cycle phases and stages. When analyses focused only on women in LRS2 versus EMT, anger, irritability, and feeling out of control were significantly more severe premenses than postmenses. Women in EMT versus LRS2 experienced more severe irritability, impatience, and out-of-control feelings. There were no significant interaction effects of the cycle phase and reproductive aging stages on any of the symptoms.</p><p><strong>Conclusions: </strong>Although there were no significant differences in the severity of the arousal or anxiety symptoms when comparing LRS1, LRS2, and EMT, comparison of LRS2 versus EMT ratings revealed significant stage effects on irritability, impatience, and feeling out of control and significant cycle phase effects on anger, irritability, and feeling out of control.</p>","PeriodicalId":18435,"journal":{"name":"Menopause: The Journal of The North American Menopause Society","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144151137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Equivalence of self-selected versus imposed intensity in resistance training: effects on muscle mass, strength, and performance in postmenopausal women.","authors":"Sebastião Henrique Assis Silva, Mariana L de Lima, Cláudio de Oliveira Assumpção, Markus Vinicius C Souza, Fábio L Orsatti","doi":"10.1097/GME.0000000000002535","DOIUrl":"https://doi.org/10.1097/GME.0000000000002535","url":null,"abstract":"<p><strong>Objective: </strong>The objective of this study was to investigate the equivalence between resistance training protocol with self-selected intensity (RT-SSI) and resistance training protocol with imposed intensity (RT-II) in postmenopausal women.</p><p><strong>Methods: </strong>A randomized study involving 49 women was carried out. Participants were randomly assigned to either RT-II or RT-SSI. The RT-II group performed with a training load initially imposed at 60%, increasing to the 70%-85% range of one maximum repetition (1RM), while the RT-SSI group performed with a training load self-selected by the volunteers for 12 weeks. Muscle strength (1RM), the 6-minute walk test (6MWT), and body composition were assessed before and after the intervention.</p><p><strong>Results: </strong>Both groups showed significant improvements in strength (P<0.001), muscle mass (P=0.027), and physical performance (P=0.023) after the 12-week intervention. However, there were no significant differences in the effects of the time/group interaction on muscle mass (P=0.750), strength (P=0.651), and physical performance (P=0.724). The equivalence analysis indicated Cohen d values for the effect estimate above the lower limit value for equivalence (d=-0.5). These results suggest that there is no evidence of the inferiority of RT-SSI in relation to RT-II for muscle mass, muscle strength, and physical performance. However, equivalence between interventions was not established, as the upper limits for equivalence were exceeded by the 90% CI.</p><p><strong>Conclusion: </strong>Our findings indicated that RT-SSI is comparable to RT-II in terms of muscle mass, muscle strength, and physical performance gains in postmenopausal women.</p>","PeriodicalId":18435,"journal":{"name":"Menopause: The Journal of The North American Menopause Society","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144079014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The longitudinal relation of inflammation to incidence of vasomotor symptoms: Erratum.","authors":"","doi":"10.1097/GME.0000000000002577","DOIUrl":"https://doi.org/10.1097/GME.0000000000002577","url":null,"abstract":"","PeriodicalId":18435,"journal":{"name":"Menopause: The Journal of The North American Menopause Society","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144031352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between night eating syndrome, eating disorders, and menopausal symptoms in climacteric women: a pilot study.","authors":"Pelin Ayar, Haci Ömer Yilmaz","doi":"10.1097/GME.0000000000002517","DOIUrl":"10.1097/GME.0000000000002517","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study was to examine the relationship between night eating syndrome, eating disorders, and menopausal symptoms in climacteric women.</p><p><strong>Methods: </strong>In this descriptive study, 90 climacteric women who met the inclusion criteria volunteered to participated. The data for the participants were collected via a face-to-face interview method using a sociodemographic and menopause questionnaire, the Eating Disorder Examination Questionnaire, the Night Eating Questionnaire, and the Menopause Rating Scale, and their anthropometric measurements were recorded.</p><p><strong>Results: </strong>Among all participants, 51.1% had night eating syndrome. However, the night eating syndrome ( P  = 0.790) and eating disorders ( P  = 0.634) of the participants did not differ significantly according to the climacteric periods. Menopausal symptoms were found to be higher in perimenopausal and postmenopausal women than in premenopausal women ( P  = 0.001). There were significant positive correlations between eating disorders and both night eating ( r  = 0.253 and P  < 0.05) and menopausal symptoms ( r  = 0.291 and P  < 0.001). There was no relationship between menopausal symptoms and night eating habits ( r  = 0.141 and P  > 0.05).</p><p><strong>Conclusions: </strong>Eating disorders were found to be associated with night eating and menopausal symptom severity in climacteric women. There is a need for multidisciplinary studies to measure the risk of occurrence and recurrence of menopausal symptoms and the association with eating disorders experienced by women.</p>","PeriodicalId":18435,"journal":{"name":"Menopause: The Journal of The North American Menopause Society","volume":" ","pages":"461-468"},"PeriodicalIF":2.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143516112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of obesity on women's health.","authors":"Domenica Rubino, Samantha Schon","doi":"10.1097/GME.0000000000002593","DOIUrl":"10.1097/GME.0000000000002593","url":null,"abstract":"","PeriodicalId":18435,"journal":{"name":"Menopause: The Journal of The North American Menopause Society","volume":"32 S1","pages":"S3-S9"},"PeriodicalIF":2.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144187269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}