Longitudinal changes in circulating cyclic guanosine monophosphate in women over the menopause transition compared to men: the Coronary Artery Risk Development in Young Adults (CARDIA) study.

IF 2.8 3区医学 Q1 OBSTETRICS & GYNECOLOGY

Menopause: The Journal of The North American Menopause Society Pub Date : 2025-03-25 DOI:10.1097/GME.0000000000002526

Giuliana N Lee, Wendy Ying, Bharath Ambale-Venkatesh, Chike C Nwabuo, Henrique Doria de Vasconcellos, Erin D Michos, Pamela Ouyang, Chiadi Ndumele, Pamela J Schreiner, Jared P Reis, Donald M Lloyd-Jones, Cora E Lewis, Stephen Sidney, Colin O Wu, Ron Hoogeveen, Joao A C Lima, Wendy S Post, Dhananjay Vaidya

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引用次数: 0

Abstract

Objective: The menopause transition is a period of accelerated cardiovascular disease (CVD) development in women, and sex differences in CVD incidence are reduced after menopause. Higher plasma cyclic guanosine monophosphate (cGMP) levels are also associated with greater CVD risk. Thus, we examined the changes in cGMP levels associated with the menopause transition.

Methods: We measured plasma cGMP levels in 511 women and 283 men in the Coronary Artery Risk Development in Young Adults (CARDIA) study.

Results: Over a 20-year follow-up period, women who completed the menopause transition had smaller reductions in cGMP relative to women who remained premenopausal (P < 0.05) but had similar changes compared to men (P = 0.3) after adjusting for demographic variables.

Conclusions: Plasma cGMP changes through the menopause transition may reflect the underlying mechanisms associated with greater cardiovascular disease risk.

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与男性相比，女性绝经过渡期循环单磷酸环鸟苷的纵向变化：年轻成人冠状动脉风险发展（CARDIA）研究

目的：绝经过渡期是女性心血管疾病（CVD）加速发展的时期，绝经后CVD发病率的性别差异减小。较高的血浆环鸟苷单磷酸（cGMP）水平也与更高的心血管疾病风险相关。因此，我们研究了与更年期过渡相关的cGMP水平的变化。方法：在青年人冠状动脉危险发展（CARDIA）研究中，我们测量了511名女性和283名男性的血浆cGMP水平。结果：在20年的随访期间，完成更年期过渡的女性相对于绝经前女性的cGMP降低幅度较小（P < 0.05），但在调整人口统计学变量后，与男性相比有相似的变化（P = 0.3）。结论：绝经过渡期血浆cGMP变化可能反映了与心血管疾病风险增加相关的潜在机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Menopause: The Journal of The North American Menopause Society 医学-妇产科学

CiteScore

5.40

自引率

7.40%

发文量

330

审稿时长

3-8 weeks

期刊介绍： Menopause, published monthly, provides a forum for new research, applied basic science, and clinical guidelines on all aspects of menopause. The scope and usefulness of the journal extend beyond gynecology, encompassing many varied biomedical areas, including internal medicine, family practice, medical subspecialties such as cardiology and geriatrics, epidemiology, pathology, sociology, psychology, anthropology, and pharmacology. This forum is essential to help integrate these areas, highlight needs for future research, and enhance health care.