Menopause: The Journal of The North American Menopause Society最新文献

{"title":"\"I did not recognize myself\": a mixed methods study to better understand the experiences of menopause in a US workplace.","authors":"Sharon Mallen, Jennifer Coppola, Nicole Shaffer, Mary Jane Minkin, Alexis Ward, Sally Snow","doi":"10.1097/GME.0000000000002575","DOIUrl":"10.1097/GME.0000000000002575","url":null,"abstract":"<p><strong>Objective: </strong>This mixed-methods study aimed to describe the prevalence and impact of menopausal symptoms on midlife women in a US workplace.</p><p><strong>Methods: </strong>An online survey was disseminated to all US-based employees of a US-headquartered pharmaceutical company. Eligible respondents were aged 40-65 years and self-identified as having (or expecting to have) personal experience of menopause. Descriptive statistics were generated. Survey respondents were sampled for in-depth interviews, on which thematic analysis was performed.</p><p><strong>Results: </strong>Eligible survey responses were received from 1,642 employees, of which 18 participated in in-depth interviews. The mean respondent age was 51 years, and a range of job roles were represented. The majority of respondents (83%) reported that they had current or prior experience of menopause. Menopause symptoms most commonly impacting workplace performance included changes to sleep patterns, changes to memory, hot flashes and anxiety, although interviews highlighted a diversity of symptom presentations. Menopause symptoms were reported to affect stress levels, confidence in abilities, patience with others, and ability to concentrate at work; 7% of menopausal respondents took time off work due to menopause symptoms. Although half of the respondents disclosed that they would feel extremely or somewhat comfortable discussing menopause with colleagues, only 9% of those with current symptoms reported that they had received support with their menopause symptoms at work.</p><p><strong>Conclusions: </strong>This study found that menopause impacts women's perceptions of their own performance at work, and that many are unsure how to approach conversations about menopause in the workplace. A substantial gap in knowledge about menopause was identified, highlighting the need for further education and support.</p>","PeriodicalId":18435,"journal":{"name":"Menopause: The Journal of The North American Menopause Society","volume":" ","pages":"920-929"},"PeriodicalIF":3.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144540768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"To the editor.","authors":"Sok-Ja Janket, Jukka H Meurman, Eleftherios P Diamandis","doi":"10.1097/GME.0000000000002664","DOIUrl":"10.1097/GME.0000000000002664","url":null,"abstract":"","PeriodicalId":18435,"journal":{"name":"Menopause: The Journal of The North American Menopause Society","volume":"32 10","pages":"985-986"},"PeriodicalIF":3.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145199771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anger, aging, and reproductive aging: observations from the Seattle Midlife Women's Health Study.","authors":"Nancy Fugate Woods, Ken Pike, Ellen Sullivan Mitchell","doi":"10.1097/GME.0000000000002587","DOIUrl":"10.1097/GME.0000000000002587","url":null,"abstract":"<p><strong>Objectives: </strong>Although investigators have devoted significant effort to understanding women's experiences of depressed mood and clinical depression during the menopausal transition and early postmenopause, they have focused less on women's perimenopausal experiences of emotional arousal, including anger. The purpose of these analyses was to examine the influence of aging and reproductive aging stages on women's reports of anger.</p><p><strong>Methods: </strong>Participants aged 35-55 years from the Seattle Midlife Women's Health Study population-based cohort (N=501 at baseline) completed an annual health report. Participants completed the State-Trait Anger Inventory (STAXI) (State Anger, Trait Anger, Anger Temperament, Anger Reaction, Anger-in, and Anger Control subscales) and the SCL90 Hostility scale on up to five occasions during the course of the study. Reproductive aging stages were assessed using menstrual calendars and questionnaire data. Menstrual calendars were used to identify menopausal transition stages using the Mitchell (2000) criteria for stages of reproductive aging: late reproductive stages (LRS1 and LRS2), early menopausal transition stage (EMT), late menopausal transition stage (LMT), and postmenopause (PM). Multilevel modeling with Mixed Models Analysis of Linear Models (SPSS 28) was used to examine the effects of age and reproductive aging stages on the repeated measures of anger and hostility using the STAXI Scales and SCL-90 Hostility Subscale.</p><p><strong>Results: </strong>Age was significantly related to most anger measures, with State and Trait Anger and Anger Control increasing with age. Anger Temperament, Anger Reaction, Anger Expressed Aggressively, and Hostility each decreased significantly with age. Only Anger Suppressed was not related to age. When accounting for age effects, Reproductive Aging Stages significantly affected State and Trait Anger and Anger Temperament: each decreased after the late reproductive stages with women's progression through further reproductive aging stages.</p><p><strong>Conclusions: </strong>Aging was significantly related to anger, with anger expression indicators decreasing with age, suggesting emotion regulation may occur during midlife. When aging was taken into account, reproductive aging was associated with decreasing levels of State and Trait Anger and Anger Temperament Scale scores. Both chronological aging and reproductive aging had important effects on dimensions of anger, warranting further attention during midlife and the menopausal transition and early postmenopause.</p>","PeriodicalId":18435,"journal":{"name":"Menopause: The Journal of The North American Menopause Society","volume":" ","pages":"930-939"},"PeriodicalIF":3.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144540769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In reply.","authors":"Sarah Glynne","doi":"10.1097/GME.0000000000002665","DOIUrl":"10.1097/GME.0000000000002665","url":null,"abstract":"","PeriodicalId":18435,"journal":{"name":"Menopause: The Journal of The North American Menopause Society","volume":"32 10","pages":"986-987"},"PeriodicalIF":3.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145199779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heightened menopausal symptoms mediate the associations between stress and depressive symptoms among midlife women.","authors":"Nicole E Logan, Janis Gaudreau, Bridget Owens, Brietta M Oaks, Christie L Ward-Ritacco, Natalie J Sabik","doi":"10.1097/GME.0000000000002596","DOIUrl":"10.1097/GME.0000000000002596","url":null,"abstract":"<p><strong>Objectives: </strong>Investigate associations between stress, cortisol, menopause symptoms, and depression in a sample of midlife women. Because stress has been associated with greater menopause symptoms, we examined this as a mediator for the association between stress and depressive symptoms.</p><p><strong>Methods: </strong>Data from a cross-sectional study of 118 women (40-64 y old) were analyzed. Participants completed in-person visits and self-reported questionnaires, including the Menopause-Specific Quality of Life questionnaire, the Perceived Stress Scale, and the Center for Epidemiological Studies Depression Scale. Saliva samples were collected at 4 intervals upon waking (wake, 30 min, 45 min, and 60 min after waking), and one sample before bed, as a measure of cortisol. Both the diurnal cortisol slope and the cortisol area under the curve with respect to ground (AUCg) were used to characterize cortisol secretion and exposure. A multivariate analysis of variance determined differences in menopause symptoms and depression outcomes. Mediation models examined the indirect effects of menopause symptoms on associations between perceived stress and depressive symptoms.</p><p><strong>Results: </strong>Women with moderate stress had significantly lower cortisol awakening responses ( P = 0.047), poorer psychosocial ( P < 0.001), physical ( P < 0.001), and sexual ( P <0.001) menopause symptoms, and depression symptoms ( P < 0.001) compared to women with low stress. Mediation analyses (95% CI) between stress and depression demonstrated significant positive indirect effects of psychological (B = 0.247; 0.117, 0.355), physical (B = 0.120; 0.049, 0.210), and sexual menopause symptoms (B = 0.042; 0.006, 0.106).</p><p><strong>Conclusions: </strong>Cross-sectional data revealed that greater stress was associated with poorer outcomes of menopause symptoms, depressive symptoms, and a lower cortisol awakening response. The association between stress and depression was mediated by the psychosocial, physical, and sexual menopause symptoms, and future longitudinal studies should seek to confirm these findings.</p>","PeriodicalId":18435,"journal":{"name":"Menopause: The Journal of The North American Menopause Society","volume":" ","pages":"956-965"},"PeriodicalIF":3.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144642925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In reply.","authors":"Sarah Glynne","doi":"10.1097/GME.0000000000002670","DOIUrl":"10.1097/GME.0000000000002670","url":null,"abstract":"","PeriodicalId":18435,"journal":{"name":"Menopause: The Journal of The North American Menopause Society","volume":"32 10","pages":"984-985"},"PeriodicalIF":3.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145199857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prolonging youth or prolonging perimenopause? Beware the Monkey's Paw.","authors":"Nanette F Santoro, Sean D Lawley, Mary D Sammel, Joshua Johnson","doi":"10.1097/GME.0000000000002590","DOIUrl":"10.1097/GME.0000000000002590","url":null,"abstract":"<p><strong>Objective: </strong>To discuss the potential for adverse consequences that could arise from the quest to prolong the functional life span of the human ovary.</p><p><strong>Methods: </strong>A series of arguments are presented that: (a) question the dogma that monthly ovulatory menstrual cycles are critical for women's health; (b) review adverse consequences of decades of menstrual cyclicity; (c) review the evidence for a longevity benefit of ovarian steroid hormone treatment after the age at natural menopause has been achieved; and (d) utilize a mathematical model of ovarian follicle loss over time to raise the possibility that current strategies directed at delaying menopause might well backfire and in fact cause a woman to have a prolonged menopause transition.</p><p><strong>Results: </strong>Regular, monthly menstrual cycles have not been the reality for women for most of history. Rather, when not pregnant, lactational amenorrhea and nutritionally based hypothalamic amenorrhea were the norm for reproductive-aged women. Moreover, monthly menstrual cycles cause substantial morbidity for women during their reproductive years. Providing steroid hormones after menopause has failed to demonstrate an increase in the female life span. Restoring ovarian follicles either surgically or medically has a high probability of causing women to spend more years of life in the menopause transition.</p><p><strong>Conclusions: </strong>Strategies to prevent or delay menopause would benefit from careful consideration of unintended consequences as they are implemented. Directing treatment trials to those with the greatest chance for benefit should be undertaken before adopting this type of treatment for a broader population.</p>","PeriodicalId":18435,"journal":{"name":"Menopause: The Journal of The North American Menopause Society","volume":" ","pages":"978-982"},"PeriodicalIF":3.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144216307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Parity and low hand grip strength in postmenopausal women: data from KNHANES (2014-2019).","authors":"Thi Minh Chau Tran, Yun Soo Chung, Jin Kyung Baek, Hae-Rim Kim, Bo Hyon Yun, Heeyon Kim, Seok Kyo Seo","doi":"10.1097/GME.0000000000002576","DOIUrl":"10.1097/GME.0000000000002576","url":null,"abstract":"<p><strong>Objective: </strong>Low hand grip strength, with or without reduced physical performance, has been defined previously as possible sarcopenia. Identifying credential parameters of sarcopenia is crucial given its high prevalence among postmenopausal women. Since hand grip strength is a key parameter in diagnosis of sarcopenia and parity affects estrogen exposure, this study aims to examine the association between parity and hand grip strength (HGS).</p><p><strong>Methods: </strong>Data from the Korean National Health and Nutrition Examination Survey (KNHANES), from 2014 to 2019, were analyzed and included 4,102 postmenopausal women aged 45-65 years. Participants were categorized into two groups: hand grip strength <18 kg and hand grip strength ≥18 kg. Parity was determined through the collection of standardized questionnaires regarding information on the total number of pregnancies carried to a viable gestational age and subsequently, categorized into four groups: parity 0, parity 1, parity 2, and parity greater than three. The association between parity and hand grip strength was assessed utilizing logistic regression analysis.</p><p><strong>Results: </strong>Among participants, 17.8% had HGS <18 kg, indicating possible sarcopenia. Mean HGS was 20.33 kg for nulliparous women, 21.65 kg for primiparous women, and 21.76 kg for those whose parity was  two, and 21.88 kg for those whose parity was three or more ( P <0.01). Compared with nulliparity, the odds of low HGS decreased by 49% in multiparity after adjusting for height, weight, age, menopause age, high alcohol intake, dyslipidemia, and diabetes mellitus (OR: 0.51, P <0.01).</p><p><strong>Conclusions: </strong>The results of this study found that higher parity is significantly associated with increased hand grip strength, which may reduce the likelihood of possible sarcopenia.</p>","PeriodicalId":18435,"journal":{"name":"Menopause: The Journal of The North American Menopause Society","volume":" ","pages":"940-946"},"PeriodicalIF":3.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144317333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The change isn't the end: self-love and menopause.","authors":"Erika L Kelley","doi":"10.1097/GME.0000000000002671","DOIUrl":"10.1097/GME.0000000000002671","url":null,"abstract":"","PeriodicalId":18435,"journal":{"name":"Menopause: The Journal of The North American Menopause Society","volume":" ","pages":"899-900"},"PeriodicalIF":3.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144960348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The use of vaginal estriol and its effects on sexual intercourse and serum estriol levels in postmenopausal women.","authors":"Stany Rodrigues Campos de Paula, Maria Celia Mendes, Sergio Henrique Pires Okano, Rui Alberto Ferriani, Rosana Maria Reis, Lucia Alves da Silva Lara","doi":"10.1097/GME.0000000000002589","DOIUrl":"10.1097/GME.0000000000002589","url":null,"abstract":"<p><strong>Objectives: </strong>Vaginal estrogenization plays a crucial role in alleviating pain during sexual activity while low-dose vaginal estrogen therapy provides benefit often with no increase in systemic estrogen levels after use. This study aimed to compare the effects of estriol applied to the distal or proximal thirds of the vagina on dyspareunia in postmenopausal women, evaluate serum estriol levels, and assess sexual function.</p><p><strong>Methods: </strong>This prospective, randomized clinical trial included a total of 116 sexually active postmenopausal women with dyspareunia who were randomized to receive vaginal estriol (1.0 mg/application, every other day) for 12 weeks in the proximal estriol group (PEG) or distal estriol group (DEG), or a vaginal lubricant gel (VLG) before intercourse. Plasma estriol levels, coital pain (McGill Pain Questionnaire), sexual function (FSFI), and emotional status (HADS) were assessed at baseline and after 12 weeks. Statistical analyses included the Shapiro-Wilk test for normality, one-way ANOVA with Tukey's post-hoc test, χ 2 test, and Pearson correlation as appropriate.</p><p><strong>Results: </strong>No significant changes in serum estriol levels were observed in any group after the intervention. PEG and DEG showed significant increases in FSFI total scores and all domains. The VLG group showed improvements in FSFI total scores and the domains of desire, arousal, lubrication, satisfaction, and pain. Intergroup analysis revealed that the PEG group showed significantly greater improvement in the lubrication domain compared with DEG (mean difference=0.70; 95% CI: 0.05-1.37; P =0.04) and VLG (mean difference=1.22; 95% CI: 0.58-1.86; P <0.01). All other domains showed no statistically significant differences between groups.</p><p><strong>Conclusions: </strong>Vaginal estriol, applied distally or proximally, improved dyspareunia and sexual function without increasing systemic estriol levels. Lubricant use also enhanced sexual function (except orgasm) and reduced pain comparably to estriol.</p>","PeriodicalId":18435,"journal":{"name":"Menopause: The Journal of The North American Menopause Society","volume":" ","pages":"947-955"},"PeriodicalIF":3.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144540771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}