Menopause: The Journal of The North American Menopause Society最新文献

{"title":"Exploring Mirena use in association with symptoms at midlife.","authors":"Ava Warner, Sofiya Shreyer, Daniel E Brown, Lynnette L Sievert","doi":"10.1097/GME.0000000000002578","DOIUrl":"https://doi.org/10.1097/GME.0000000000002578","url":null,"abstract":"<p><strong>Objective: </strong>The Mirena IUD is prescribed for the treatment of heavy menstrual bleeding and contraception. The purpose of this study was to examine the use of Mirena in relation to vasomotor, psychological, musculoskeletal, and sexual symptoms and to see whether the use of a Mirena IUD increased the likelihood of experiencing symptoms during the menopause transition.</p><p><strong>Methods: </strong>Data were drawn from a study of brown adipose tissue and hot flashes (n=274). Participants were aged 45-55, living in western Massachusetts. Twenty-three (8%) were using Mirena at the time of the interview. Nine symptoms were examined individually and after grouping into clusters by factor analysis. Following bivariate analyses, logistic regressions were used to examine the use of Mirena in relation to hot flashes, night sweats, leg cramps, aches/stiffness, backaches, and depressed mood, while adjusting for age and BMI. We did not adjust for menopausal status because the use of Mirena influenced menstruation, which inhibited accurate estimation of menopausal status.</p><p><strong>Results: </strong>There were no significant relationships between the use of Mirena and symptoms at midlife. Higher BMI increased the likelihood of hot flashes, night sweats, and leg cramps.</p><p><strong>Conclusions: </strong>These findings suggest that the use of the Mirena IUD, whether for treatment of heavy blood loss, contraceptive control, or for the management of other menstrual symptoms, is unlikely to have adverse effects on symptom experience in midlife.</p>","PeriodicalId":18435,"journal":{"name":"Menopause: The Journal of The North American Menopause Society","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144317330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sexual minority women and symptoms at midlife.","authors":"Lynnette L Sievert, Krystal Kittle, Nicole VanKim, Raeann Leblanc, Sofiya Shreyer, Daniel E Brown, Aline Gubrium","doi":"10.1097/GME.0000000000002580","DOIUrl":"https://doi.org/10.1097/GME.0000000000002580","url":null,"abstract":"<p><strong>Objective: </strong>The purpose of this study was to examine vasomotor, somatic, emotional, and sexual symptoms in relation to sexual orientation.</p><p><strong>Methods: </strong>Women aged 45 to 55 (n=274) from western Massachusetts participated in face-to-face interviews and anthropometric measures. Participants were asked, \"Do you think of yourself as lesbian or gay; straight, that is not lesbian or gay; bisexual; something else; or don't know?\" Bivariate analyses assessed sexual orientation in relation to each of 11 symptoms. Logistic regressions were carried out for aches/stiffness in joints, irritability, vaginal dryness, and loss of sexual desire in relation to sexual orientation, adjusting for menopausal status, partnership status, and body mass index (BMI).</p><p><strong>Results: </strong>Participants described themselves as \"straight\" (81%), \"lesbian or gay\" (7%), \"bisexual\" (7%), or other (5%). Partnership status, economic comfort, perceived stress, BMI, smoking habits, and parity did not differ by sexual orientation, but heterosexual women were more likely to drink alcohol. Compared with heterosexual women, sexual minority women had lower odds of reporting a loss of sexual desire (OR: 0.46, 95% CI: 0.24-0.89), and unpartnered women had a lower likelihood of reporting a loss of sexual desire (OR: 0.42, 95% CI: 0.24-0.73) compared with women with partners. Sexual minority women had higher odds of aches/stiffness in joints (OR: 3.78, 95% CI: 1.35-10.59).</p><p><strong>Conclusions: </strong>Sexual minority women had lower odds of reporting a loss of sexual desire but were more likely to report aches/stiffness in joints. More research is needed to better understand factors contributing to the menopause experiences of sexual minority populations.</p>","PeriodicalId":18435,"journal":{"name":"Menopause: The Journal of The North American Menopause Society","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144317335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychological quality of life in BRCA1/2- carriers following risk-reducing salpingo-oophorectomy: a preliminary report.","authors":"Åsa Ehlin von Kartaschew, Angelica Lindén Hirschberg, Kristina Gemzell-Danielsson, Angelique Flöter Rådestad","doi":"10.1097/GME.0000000000002571","DOIUrl":"https://doi.org/10.1097/GME.0000000000002571","url":null,"abstract":"<p><strong>Objective: </strong>The psychological consequences following risk-reducing salpingo-oophorectomy (RRSO) have not been clarified. Our objective was to investigate general well-being and symptoms of anxiety and depression before and 1 year after RRSO in BRCA1/2- pathogenic variant carriers, versus comparators and to study if testosterone levels after RRSO correlate with psychological well-being and vitality.</p><p><strong>Methods: </strong>In this observational follow-up study, 43 BRCA1/2-carriers planned for RRSO and 73 age-matched comparators were evaluated using the Hospital Anxiety and Depression Scale (HADS) and Psychological General Well-being Index (PGWBI) before and one year after surgery or at inclusion (comparators). Blood samples for analysis of testosterone by tandem mass spectrometry were also collected, and free androgen index (FAI) was calculated.</p><p><strong>Results: </strong>In the RRSO group, 53.5% reported elevated anxiety levels at baseline that decreased to 32.6% at follow-up (P=0.029). However, at 1 year, the RRSO group still reported higher anxiety levels versus the comparator group (16.4%, P=0.038). The RRSO group reported low and stable levels on the depression scale, and no change was found in well-being, but significantly worse scores of the PGWBI dimensions depressed mood and general health at follow-up as opposed to comparators (80.0 vs. 86.7, P=0.04; 80.0 vs. 86.7, P=0.028). FAI was significantly lower in the RRSO group versus comparators at 1-year follow-up (0.6 vs. 0.9, P=0.041). Testosterone levels were not correlated with either well-being or vitality.</p><p><strong>Conclusions: </strong>Our data identified no negative effect on psychological quality of life 1 year following RRSO. Larger studies are needed to confirm these preliminary findings.</p>","PeriodicalId":18435,"journal":{"name":"Menopause: The Journal of The North American Menopause Society","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144317334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing the management of menopause at the workplace: a scoping review of workplace non-hormone interventions and impact on women with menopause.","authors":"Angeliki Taniskidi, Eirini Mitsinga, Dani Binnington, Vikram Talaulikar, Bassel H Al Wattar","doi":"10.1097/GME.0000000000002569","DOIUrl":"https://doi.org/10.1097/GME.0000000000002569","url":null,"abstract":"<p><strong>Importance: </strong>There is a need for interventions that employers and employees can adopt to optimize the health, safety, and productivity of women with menopause at the workplace.</p><p><strong>Objective: </strong>We conducted a structured scoping review to summarize the literature and identify effective interventions that could help women manage menopausal symptoms at the workplace.</p><p><strong>Evidence review: </strong>We searched electronic databases (MEDLINE and EMBASE) until July 2024 for all studies that evaluated any non-hormone interventions used among women with menopause at the workplace and reported as per PRISMA-ScR. We used a standardized data extraction tool to capture relevant data and conducted a thematic analysis to identify the prominent themes.</p><p><strong>Findings: </strong>Out of 4,284 potentially relevant citations, we included seven studies, including four randomized trials and three observational studies. Four studies evaluated cognitive behavioral interventions showing improvement in hot flushes, workability, presenteeism, and quality of life, though results varied between studies. One randomized study examined the impact of a structured aerobic exercise program on menopausal symptoms and work-related outcomes showing slight improvement in workability and mental strain. Raja Yoga meditation combined with sleep hygiene education was evaluated in one randomized study showing improvements in insomnia, sleep quality, and menopausal symptoms. Offering regular consultations at an outpatient menopause clinic for managing symptoms through lifestyle modifications improved menopausal symptoms and workability at 3 months after adjusting for potential confounders.</p><p><strong>Conclusions and relevance: </strong>Several behavioral and lifestyle interventions can help to optimize the health, productivity, and quality of life of women with menopause at the workplace. However, there is limited high-quality evidence on the best available intervention with wide variation in reported outcomes and measurement tools.</p>","PeriodicalId":18435,"journal":{"name":"Menopause: The Journal of The North American Menopause Society","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144317332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Parity and low hand grip strength in postmenopausal women: data from KNHANES (2014-2019).","authors":"Thi Minh Chau Tran, Yun Soo Chung, Jin Kyung Baek, Hae-Rim Kim, Bo Hyon Yun, Heeyon Kim, Seok Kyo Seo","doi":"10.1097/GME.0000000000002576","DOIUrl":"https://doi.org/10.1097/GME.0000000000002576","url":null,"abstract":"<p><strong>Objective: </strong>Low hand grip strength, with or without reduced physical performance, has been defined previously as possible sarcopenia. Identifying credential parameters of sarcopenia is crucial given its high prevalence among postmenopausal women. Since hand grip strength is a key parameter in diagnosis of sarcopenia and parity affects estrogen exposure, this study aims to examine the association between parity and hand grip strength (HGS).</p><p><strong>Methods: </strong>Data from the Korean National Health and Nutrition Examination Survey (KNHANES), from 2014 to 2019, were analyzed and included 4,102 postmenopausal women aged 45-65 years. Participants were categorized into two groups: hand grip strength <18 kg and hand grip strength ≥18 kg. Parity was determined through the collection of standardized questionnaires regarding information on the total number of pregnancies carried to a viable gestational age and subsequently, categorized into four groups: parity 0, parity 1, parity 2, and parity greater than three. The association between parity and hand grip strength was assessed utilizing logistic regression analysis.</p><p><strong>Results: </strong>Among participants, 17.8% had HGS <18 kg, indicating possible sarcopenia. Mean HGS was 20.33 kg for nulliparous women, 21.65 kg for primiparous women, and 21.76 kg for those whose parity was two, and 21.88 kg for those whose parity was three or more (P<0.01). Compared with nulliparity, the odds of low HGS decreased by 49% in multiparity after adjusting for height, weight, age, menopause age, high alcohol intake, dyslipidemia, and diabetes mellitus (OR: 0.51, P<0.01).</p><p><strong>Conclusions: </strong>The results of this study found that higher parity is significantly associated with increased hand grip strength, which may reduce the likelihood of possible sarcopenia.</p>","PeriodicalId":18435,"journal":{"name":"Menopause: The Journal of The North American Menopause Society","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144317333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A survey of menopausal symptoms in chinese community women based on the STRAW+10 staging system.","authors":"Jie Wang, Yehuan Yang, Yilin Yang, Zhiqi Sun, Ying Chen, Ruimin Zheng","doi":"10.1097/GME.0000000000002561","DOIUrl":"https://doi.org/10.1097/GME.0000000000002561","url":null,"abstract":"<p><strong>Objective: </strong>To assess the prevalence and factors influencing menopausal symptom severity among perimenopausal women in the Chinese community.</p><p><strong>Methods: </strong>Participants aged 35-60 from 26 districts in 12 Chinese provinces were recruited through the Epidemiological Investigation of Menopause Status among Chinese Women (EIM-CW). Exclusion criteria included congenital absence of the uterus and premenopausal hysterectomy. Data collected included demographics, lifestyle, Kupperman index, physical examination, and menstrual history.</p><p><strong>Results: </strong>Of 55,056 women screened, 51,118 met the inclusion criteria. A total of 27,953 participants were classified in stage -3, 1,983 in stage -2, 2,319 in stage -1, 880 in stage +1a, 3,027 in stage +1b, 6,580 in stage +1c, and 8,376 in stage +2. The prevalence of symptoms after menopause (18,863 individuals including stage +1a and subsequent stages) included insomnia (50.60%), sexual complaints (45.70%), fatigue (44.70%), nervousness (42.40%), arthralgia/myalgia (41.40%), and hot flushes (27.30%). Higher education, better family satisfaction, and lower physical labor were associated with more mild symptoms (P<0.05). Symptoms prevalence varied by STRAW+10 stages: nervousness peaked at stage -3 (51.82%), fatigue at stage -2 (50.13%), and insomnia during stages -1 to +2 (50.23%-55.15%). In stage -2, the most severe symptoms include headaches (1.11%), paresthesia (0.50%), palpitations (0.35%), and formication (0.25%). Hot flushes are most severe in stage -1, with a prevalence of 1.08%. The greatest severity of symptoms is observed in stage +1a, particularly for insomnia (1.59%), nervousness (1.14%), fatigue (1.14%), vertigo (0.68%), and melancholia (0.45%). Stage +2 shows the highest severity for sexual complaints (8.15%), urinary symptoms (0.88%), and musculoskeletal pain (0.69%).</p><p><strong>Conclusions: </strong>Insomnia is the most common symptom among perimenopausal women (during STRAW+10 stages -1 to +2) in Chinese communities. Insomnia, nervousness, fatigue, vertigo, and melancholia symptoms are most severe in stage +1a; headaches, paresthesia, palpitations, and formication are most severe in stage -2; sexual discomfort, urinary tract infection, and musculoskeletal pain are most severe in stage +2; hot flashes are most severe in stage -1. Menopausal symptom severity is associated with multiple factors such as education, family satisfaction, and physical labor.</p>","PeriodicalId":18435,"journal":{"name":"Menopause: The Journal of The North American Menopause Society","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144317329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genitourinary syndrome of menopause-it has only just begun!","authors":"Marcie K Richardson","doi":"10.1097/GME.0000000000002601","DOIUrl":"https://doi.org/10.1097/GME.0000000000002601","url":null,"abstract":"","PeriodicalId":18435,"journal":{"name":"Menopause: The Journal of The North American Menopause Society","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144317331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Construction of a nomogram prediction model for deep vein thrombosis in epithelial ovarian cancer.","authors":"Chenxiang Pan, Shihao Xu, Aidi Lin, Lijiao Li","doi":"10.1097/GME.0000000000002603","DOIUrl":"10.1097/GME.0000000000002603","url":null,"abstract":"<p><strong>Objective: </strong>To develop and validate a nomogram prediction model for deep vein thrombosis (DVT) in epithelial ovarian cancer (EOC).</p><p><strong>Methods: </strong>Between May 2021 and May 2024, 429 EOC patients admitted to our hospital were retrospectively identified. The patients were randomly divided into a modeling group and a validation group. Based on whether DVT occurred, the modeling group was classified into a DVT group and a non-DVT group. The influencing factors associated with DVT in EOC were analyzed using multivariable logistic regression. R software was used to construct the nomogram model. The receiver operating characteristic (ROC) curve was used to evaluate the discrimination of the nomogram. Moreover, the decision curve analysis (DCA) was used to evaluate the clinical utility of the model.</p><p><strong>Results: </strong>Of 429 patients, 116 developed DVT, with an incidence rate of 27.04%. In the modeling group of 300 patients, 81 developed DVT, with an incidence rate of 27.00%. Multivariate logistic regression showed that age, BMI, hypertriglyceridemia, tumor staging, tumor grade, CA125 level, platelet count (PLT), and fibrinogen level (FIB) were independent risk factors for developing DVT in EOC ( P <0.05). The area under the ROC curve (AUC) for the modeling group was 0.893, and the AUC of the validation group was 0.973. The Hosmer-Lemeshow (H-L) test of the modeling group showed χ 2 =7.324 ( P= 0.722), and the H-L test of the validation group showed χ 2 =7.043 ( P= 0.711), suggesting good calibration. DCA curve showed that the threshold probability was between 0.08 and 0.97, the clinical value of the DVT nomogram model provided a net clinical benefit.</p><p><strong>Conclusion: </strong>Age, BMI, hypertriglyceridemia, tumor stage, tumor grade, CA125 level, platelet count (PLT), and fibrinogen level (FIB) are significant independent risk factors for EOC patients developing DVT. The nomogram constructed with these factors demonstrates good predictive performance and clinical utility in predicting the risk of DVT in EOC patients.</p>","PeriodicalId":18435,"journal":{"name":"Menopause: The Journal of The North American Menopause Society","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144285408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genitourinary syndrome of menopause and sexual function, partner knowledge, and the impact on coupled sexual relationships.","authors":"Lúcia Costa-Paiva, Maria Paula Perini, Karla Simonia de Padua, Ana Lucia Ribeiro Valadares","doi":"10.1097/GME.0000000000002553","DOIUrl":"https://doi.org/10.1097/GME.0000000000002553","url":null,"abstract":"<p><strong>Objectives: </strong>To assess the prevalence of genitourinary syndrome of menopause (GSM) and its association with female sexual dysfunction, the partner's knowledge, and repercussions on the couple's sexual life.</p><p><strong>Methods: </strong>A cross-sectional study was conducted on 266 couples (532 individuals) aged 50-70 years. Women and their partners were selected utilizing the \"snowball\" technique, formed from the \"ego\" couples who answered the interview regarding general health, genitourinary symptoms, sexual function, and partner knowledge information via telephone by trained interviewers.</p><p><strong>Results: </strong>The prevalence rate of GSM was 74.44%. Low sexual function was significantly more frequent in women (46.15%) than in their partners (15.77%) (P<0.001). Vaginal dryness present in 44.15% and dyspareunia (58.67%) were associated with female sexual dysfunction (P<0.01), decreased satisfaction with sex, and avoidance of sex for fear of pain or lack of desire. Urinary incontinence, nocturia, and urgency were reported by 17.29%, 35.34%, and 24.81% of women, respectively. and were not associated with sexual dysfunction. Approximately 49% of partners knew about their partner's GSM symptoms. Vaginal discomfort led to the loss of men's desire, and women avoided intercourse because they were concerned about pain.</p><p><strong>Conclusions: </strong>The prevalence of GSM is high and related to low female sexual function. Half of the partners knew about problems with GSM, and the women's symptoms interfered with the couple's sexual desire and satisfaction, which could impact the affective and sexual aspects of the couple's relationship.</p>","PeriodicalId":18435,"journal":{"name":"Menopause: The Journal of The North American Menopause Society","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144216305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of body composition with the symptoms of pelvic floor disorders in middle-aged women: a longitudinal study.","authors":"Mari A Kuutti, Enni-Maria Hietavala, Hanna-Kaarina Juppi, Sarianna Sipilä, Pauliina Aukee, Eija K Laakkonen","doi":"10.1097/GME.0000000000002572","DOIUrl":"https://doi.org/10.1097/GME.0000000000002572","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the association of body composition with symptoms of pelvic floor disorders ie, stress urinary incontinence, urgency urinary incontinence, fecal incontinence, and feeling of pelvic organ prolapse among middle-aged women.</p><p><strong>Methods: </strong>A longitudinal study with two measurement points 4 years apart was performed using a population sample of 376 Finnish women aged 47 to 55 years at the baseline. Total and regional body composition was assessed with dual x-ray absorptiometry (DXA) and multifrequency bioelectrical impedance analyzer (BIA). Body height, weight, and waist circumference were measured, and body mass index (BMI) was calculated. The symptoms of pelvic floor disorders were assessed using self-report questionnaire. Generalized estimating equations models were used to investigate associations. Models were adjusted with demographical, gynecologic, and physical activity variables.</p><p><strong>Results: </strong>The change in body composition was not associated with the change in the symptoms of pelvic floor disorders after 4-year follow-up. In cross-sectional analysis, the symptoms of stress urinary incontinence were found to be associated with total fat mass (OR 1.03, 95% CI: 1.01-1.06, P=0.017), trunk fat mass (OR 1.06, 95% CI: 1.02-1.11, P=0.009), android fat mass (OR 1.33, 95% CI: 1.05-1.70, P=0.020), visceral fat area (OR 1.01, 95% CI: 1.00-1.02, P=0.019), BMI (OR 1.07, 95% CI: 1.01-1.13, P=0.027), and waist circumference (OR 1.03, 95% CI: 1.01-1.05, P=0.008). No significant associations were found for other symptoms of pelvic floor disorders.</p><p><strong>Conclusions: </strong>Having a higher total or regional body fat mass, higher BMI, or larger waist circumference may increase the risk of stress urinary incontinence in middle-aged women.</p>","PeriodicalId":18435,"journal":{"name":"Menopause: The Journal of The North American Menopause Society","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144216302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}