Menopause: The Journal of The North American Menopause Society最新文献

{"title":"Handgrip strength and diabetes in postmenopausal women: insights from the Korean National Health and Nutrition Examination Survey 2014-2019.","authors":"Yun Soo Chung, Jin Kyung Baek, Thi Minh Chau Tran, Hae-Rim Kim, Hye In Jung, Jae Kyung Lee, Eun A Choi, Hee Yon Kim, Bo Hyon Yun, Seok Kyo Seo","doi":"10.1097/GME.0000000000002453","DOIUrl":"10.1097/GME.0000000000002453","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to investigate the association between handgrip strength (HGS) and diabetes mellitus (DM) in postmenopausal women in Korea relative to the menopausal duration.</p><p><strong>Methods: </strong>Data from the Korean National Health and Nutrition Examination Survey conducted between 2014 and 2019 were analyzed. A total of 4,098 postmenopausal women aged 45 to 65 years were included in the study. Handgrip strength was measured using a digital hand dynamometer. Participants were categorized into quartiles based on HGS with Q1 representing the weakest strength and Q4 the greatest strength. The association between DM and HGS was assessed using logistic regression analysis while adjusting for relevant covariates.</p><p><strong>Results: </strong>Postmenopausal women aged 45 to 65 years with stronger HGS were less likely to have DM ( P < 0.001). This association persisted even after adjusting for age, body mass index, and comorbidities ( P < 0.001). The inverse relationship between HGS and DM prevalence was more pronounced in women who had been postmenopausal for >10 years than in those who had been postmenopausal for a shorter duration (P-interaction <0.001). In addition, compared to their nondiabetic counterparts, women with DM were less likely to be categorized into the Q4 group ( P < 0.001).</p><p><strong>Conclusions: </strong>The findings suggest that weaker HGS was associated with likelihood of having DM among postmenopausal women in Korea. Owing to the inherent limitation to the cross-sectional study design, further research is warranted to elucidate the underlying mechanisms of the association between DM and HGS in postmenopausal women.</p>","PeriodicalId":18435,"journal":{"name":"Menopause: The Journal of The North American Menopause Society","volume":" ","pages":"31-37"},"PeriodicalIF":2.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142770506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Menopausal age, adipokines, and heart failure incidence in postmenopausal women of the Multi-Ethnic Study of Atherosclerosis.","authors":"Imo A Ebong, Machelle Wilson, Erin D Michos, Duke Appiah, Pamela J Schreiner, Susan B Racette, Matthew Allison, Karol Watson, Alain Bertoni","doi":"10.1097/GME.0000000000002456","DOIUrl":"10.1097/GME.0000000000002456","url":null,"abstract":"<p><strong>Objective: </strong>The mechanisms through which menopausal age influences heart failure (HF) development are controversial. Adiposity increases after menopause and could affect HF risk by influencing serum adipokine secretion. We investigated the associations of early menopause, and serum adipokines with incident HF in postmenopausal women.</p><p><strong>Methods: </strong>We included 746 postmenopausal women from the Multi-Ethnic Study of Atherosclerosis who reported their menopausal age and had data on adipokines and incident HF at the end of follow-up. Multivariable Cox proportional hazards models were used for analysis.</p><p><strong>Results: </strong>The mean age was 65.1 years. Over a median follow-up period of 17.8 years, 45 HF events occurred. After adjusting for waist circumference, other cardiovascular disease risk factors and myocardial infarction, the hazard ratios (95% confidence intervals) of incident HF attributable to early menopause were 4.50 (1.41-14.3), 4.64 (1.46-14.7), and 5.16 (1.59-16.7) in models that additionally included adiponectin, leptin, and resistin, respectively. In adjusted analyses, adiponectin was independently associated with incident HF 2.20 (1.35-3.57), while leptin and resistin were not. The interaction terms of early menopause with adiponectin, leptin, and resistin for incident HF were not significant ( Pint = 0.08-0.82).</p><p><strong>Conclusions: </strong>Early menopause was significantly associated with incident HF. This association did not differ by serum adipokine levels. Only adiponectin was independently associated with incident HF in postmenopausal women when waist circumference, body mass index, and waist-hip ratio were used as the adiposity metric.</p>","PeriodicalId":18435,"journal":{"name":"Menopause: The Journal of The North American Menopause Society","volume":" ","pages":"72-80"},"PeriodicalIF":2.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142770510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The prospective association of cellular markers of biological aging with menopause in the Coronary Artery Risk Development in Young Adults Study.","authors":"Duke Appiah, Melissa F Wellons, Pamela J Schreiner, Eli Puterman, Lifang Hou, Catherine Kim","doi":"10.1097/GME.0000000000002457","DOIUrl":"10.1097/GME.0000000000002457","url":null,"abstract":"<p><strong>Objective: </strong>Evidence from cross-sectional studies mainly among postmenopausal women suggests that biological aging is associated with reproductive senescence. We evaluated the prospective association of cellular markers of biological aging measured during the premenopausal period, and changes in these markers, with age at menopause.</p><p><strong>Methods: </strong>We studied 583 premenopausal women (39% Black) from the Coronary Artery Risk Development in Young Adults Study who had data on biological aging markers in 2000-2001 and reached menopause by 2020-2021. Linear regression models were used to evaluate the association of telomere length, mitochondrial DNA copy number, intrinsic or extrinsic epigenetic age acceleration, and PhenoAge or GrimAge acceleration with age at menopause.</p><p><strong>Results: </strong>The mean age at baseline was 41.2 ± 3.3 years, with the mean age at menopause being 49.1 (median, 50) years. About one in five women had surgical menopause. In chronological age-adjusted models, only baseline GrimAge acceleration was associated with age at menopause; women whose epigenetic age was older than their chronological age reached menopause at 0.12 years (~6 weeks) earlier compared with women with equal epigenetic and chronological age ( β = -0.123; 95% CI, -0.224 to -0.022; P = 0.018). However, this association was not statistically significant after adjustment for sociodemographic, behavior/lifestyle, and metabolic factors. Similar results were observed when changes in these biological aging markers were evaluated. The same associations were observed in analyses limited to women who reached natural menopause.</p><p><strong>Conclusions: </strong>Sociodemographic, behavior/lifestyle, and metabolic factors remain comparable, if not more robust predictors of the age at menopause compared with cellular measures of biological age.</p>","PeriodicalId":18435,"journal":{"name":"Menopause: The Journal of The North American Menopause Society","volume":" ","pages":"91-94"},"PeriodicalIF":2.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142769987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The menopausal transition and multiple physiologic measures of early brain health in the Coronary Artery Risk Development in Young Adults study.","authors":"Muna J Tahir, Yang Xie, Ilya M Nasrallah, Martine Elbejjani, Melissa F Wellons, R Nick Bryan, Sudipto Dolui, Guray Erus, Lenore J Launer, Pamela J Schreiner","doi":"10.1097/GME.0000000000002450","DOIUrl":"10.1097/GME.0000000000002450","url":null,"abstract":"<p><strong>Objective: </strong>This study proposed to investigate the cross-sectional and longitudinal associations of menopausal status with physiologic brain magnetic resonance imaging measures.</p><p><strong>Methods: </strong>The sample included women from the Coronary Artery Risk Development in Young Adults study who self-reported their reproductive histories and participated in the brain magnetic resonance imaging substudies at the year 25 (n = 292) and year 30 (n = 258) follow-up examinations. Menopausal status was classified based on natural menstrual cycle regularity/cessation at both time points. Gray matter cerebrovascular reactivity (CVR) was calculated as mean percent change in blood oxygen level-dependent signals in activated voxels following a breath-hold challenge. Gray matter cerebral blood flow (CBF) was assessed using pseudo-continuous arterial spin labeling. Linear regression models were used to examine cross-sectional and longitudinal associations of menopausal status with gray matter CVR and CBF after adjustment for potential age-related covariates.</p><p><strong>Results: </strong>Women were mean age 50 years at year 25; 37% were Black; and 46% were postmenopausal. Relative to premenopause or perimenopause, postmenopause was associated with lower gray matter CVR at year 30 cross-sectionally (1.86% vs 1.69%, P = 0.03, respectively) and longitudinally for women who were postmenopausal at both time points (-0.32% [95% CI, -0.63% to -0.02%]) after covariate adjustment. Mean CVR values were also lower for these women when compared with women who remained premenopausal or perimenopausal (1.71% compared with 2.04%, respectively). Menopausal status was unrelated to either concurrent or longitudinal gray matter CBF.</p><p><strong>Conclusions: </strong>These findings suggest that the ability of vessels to adapt in response to hypercapnia may be impaired during menopause, even within a relatively short time window.</p>","PeriodicalId":18435,"journal":{"name":"Menopause: The Journal of The North American Menopause Society","volume":" ","pages":"45-53"},"PeriodicalIF":2.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142770518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Jazz dancing for improving cardiorespiratory fitness, body composition, muscle strength, and sleep quality in postmenopausal women: a randomized clinical trial with 6- and 12-month follow-ups.","authors":"Julia Beatriz Bocchi Martins, Danielly Yani Fausto, Anelise Sonza, Adriana Coutinho de Azevedo Guimarães","doi":"10.1097/GME.0000000000002455","DOIUrl":"10.1097/GME.0000000000002455","url":null,"abstract":"<p><strong>Objective: </strong>The aim of the study was to analyze the effects of 16 weeks of Jazz Dance training compared to a control group in postmenopausal women, postintervention, and at the 6- and 12-month follow-ups, on cardiorespiratory fitness, body composition, muscle strength, and sleep quality.</p><p><strong>Methods: </strong>Two-arm randomized clinical trial with a total of 47 women (jazz dance intervention group [JDIG] [n = 23] and control group (CG) [n = 24]) with a mean age of 53.41 ± 2.8 y. Data collection was carried out at four times, baseline, postintervention, and 6- and 12-month follow-ups using the 6-minute walk test (cardiorespiratory fitness); bioimpedance (body composition); isokinetic dynamometry (muscle strength); and the Pittsburgh Sleep Quality Index (sleep quality).</p><p><strong>Results: </strong>In the intention-to-treat analysis, the results showed positive differences for the JDIG in cardiorespiratory fitness at all time points (P = 0.034) and in the group x time interaction (P = <0.001). Lower limb muscle strength showed differences from baseline to postintervention and from baseline to the 12-month follow-up for the concentric force ratio (P = 0.021; P = 0.009). However, for peak extension and flexion, the results were not positive for the JDIG. There was a short-term improvement in sleep duration for the JDIG (P = 0.001) and significant intergroup differences in subjective sleep quality, where the JDIG showed better results compared to the CG (P = 0.041).</p><p><strong>Conclusions: </strong>Jazz Dance is effective for improving cardiorespiratory fitness (in the short, medium, and long term) and sleep quality (in the short and medium term); however, it does not seem to have presented sufficient intensity and duration for facilitating changes in body composition or increasing lower limb muscle strength in postmenopausal women.</p>","PeriodicalId":18435,"journal":{"name":"Menopause: The Journal of The North American Menopause Society","volume":"32 1","pages":"54-63"},"PeriodicalIF":2.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142895655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"N-Acetylcysteine enhances low-dose estrogen efficacy against ischemia-reperfusion injury in estrogen-deprived obese insulin-resistant rats.","authors":"Sivaporn Sivasinprasasn, Kenneth Chattipakorn, Wasana Pratchayasakul, Siriporn C Chattipakorn, Nipon Chattipakorn","doi":"10.1097/GME.0000000000002452","DOIUrl":"10.1097/GME.0000000000002452","url":null,"abstract":"<p><strong>Objectives: </strong>Postmenopausal women are at higher risk of metabolic syndrome and cardiovascular disease, which are aggravated by obesity. Although estrogen provides cardiometabolic protection, chronic high-dose treatment could be harmful. This study investigated the efficacy of combined N-acetylcysteine (NAC) and low-dose estrogen treatment against cardiometabolic dysfunction in female estrogen-deprived obese rats with cardiac ischemia-reperfusion (I/R) injury.</p><p><strong>Methods: </strong>Bilateral ovariectomized (O) female Wistar rats were fed a high-fat diet (H) for 12 weeks. Then, rats were treated for 4 weeks with one of the following: vehicle (OH; sesame oil), regular-dose estrogen (E; 50 μg/kg/d), low-dose estrogen (e; 25 μg/kg/d), NAC (N; 100 mg/kg/d), or combined low-dose estradiol with NAC (eN). All rats then underwent cardiac I/R injury, and the left ventricle (LV) function and mitochondrial function were investigated (n = 6/group). Statistical analysis was performed by one-way ANOVA followed by Fisher's least significant difference post hoc test.</p><p><strong>Results: </strong>Body weight, visceral fat, plasma glucose, and plasma cholesterol were significantly increased with impaired LV function and heart rate variability in OH rats. OH-E rats had decreased plasma insulin and Homeostatic Model Assessment for Insulin Resistance index. Both OH-E and OH-eN rats had similarly improved heart rate variability and LV function. During cardiac I/R, OH-E and OH-eN rats had preserved left ventricular ejection fraction, stroke volume, and attenuated arrhythmias. Impaired cardiac mitochondrial function and infarct size were similarly reduced in OH-E and OH-eN rats.</p><p><strong>Conclusions: </strong>Combined NAC and low-dose estrogen treatment shares similar efficacy as regular-dose estrogen in attenuating cardiac dysfunction, cardiac mitochondrial dysfunction, and protecting the heart against I/R injury in estrogen-deprived obese insulin-resistant rats.</p>","PeriodicalId":18435,"journal":{"name":"Menopause: The Journal of The North American Menopause Society","volume":" ","pages":"81-90"},"PeriodicalIF":2.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142770513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sexual orientation and sexual functioning in midlife women veterans.","authors":"Laura A Muratore, Anna E Blanken, Alison J Huang, Carolyn J Gibson","doi":"10.1097/GME.0000000000002449","DOIUrl":"10.1097/GME.0000000000002449","url":null,"abstract":"<p><strong>Objective: </strong>Midlife women experience menopause- and aging-related health changes that may impact sexual functioning. Research has historically relied on heteronormative constructs of sexuality, and little is known about the experiences of sexual minority women (SMW) during menopause. We therefore examined whether indices of sexual function differed between SMW and heterosexual midlife women Veterans.</p><p><strong>Methods: </strong>Data were drawn from a cross-sectional survey designed to examine midlife women Veterans' experiences of menopause and aging. Participants self-reported sexual orientation, sociodemographic characteristics, vaginal symptoms, past-month engagement in sexual activity, and pain with sexual activity with structured-item responses. Sexual function was assessed with validated questionnaires. Logistic and linear regression models examined group differences adjusted for age, education, race, menopause status, and body mass index.</p><p><strong>Results: </strong>In this sample (n = 232, mean age = 56.0, SD = 5.14), 25% self-identified as SMW. Relative to heterosexual women, SMW were more likely to endorse recent sexual activity (odds ratio [OR], 2.20; 95% confidence interval [CI], 11.13-4.30), less likely to report pain during sex (OR, 0.07; 95% CI, 0.16-0.32), less likely to report past-month vaginal symptoms (OR, 0.33; 95% CI, 0.17-0.66), and endorsed lower impact of vaginal symptoms on sexual function (β = -0.24; 95% CI, -0.97 to -0.26). Both groups reported high levels of distress related to sexual dysfunction (sample mean = 19.9, SD = 8.0).</p><p><strong>Conclusions: </strong>Midlife SMW Veterans reported better sexual functioning and less impact of vaginal symptoms compared with heterosexual peers. Despite this, both groups reported high levels of distress related to sexual function.</p>","PeriodicalId":18435,"journal":{"name":"Menopause: The Journal of The North American Menopause Society","volume":" ","pages":"5-11"},"PeriodicalIF":2.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142846973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression of concern: Effect of laser acupuncture on pain and density of bone in osteoporotic postmenopausal women: a randomized controlled trial.","authors":"","doi":"10.1097/GME.0000000000002509","DOIUrl":"10.1097/GME.0000000000002509","url":null,"abstract":"","PeriodicalId":18435,"journal":{"name":"Menopause: The Journal of The North American Menopause Society","volume":"32 1","pages":"100"},"PeriodicalIF":2.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142895707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Menopause symptom burden and management across rural, suburban, and urban settings in a US population.","authors":"Erin R Dwyer, Pauline M Maki, Ronit Katz, Monica P Mallampalli, Susan D Reed","doi":"10.1097/GME.0000000000002454","DOIUrl":"10.1097/GME.0000000000002454","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study was to compare menopause experience in rural, suburban, and urban-residing women.</p><p><strong>Methods: </strong>A 2019 online survey of US females queried respondents on menopause symptoms, resources, and treatments. Those ≥45 years of age and in late menopause transition or postmenopause were included in the analysis. Late menopause transition and postmenopause subgroups were stratified by rural, suburban, and urban residence, and age-weighted proportions for menopause symptoms and treatments were calculated and compared using chi-square tests.</p><p><strong>Results: </strong>A total of 1,531 respondents, 45% (n = 686) late menopause transition, mean age of 50.7 (SD 3.9) and 55% (n = 845) postmenopause, and mean age of 65.1 (SD 8.5) were included. More prevalent symptoms in late menopause transition rural residents were as follows: muscle aches and pains (urban: 49%, suburban: 49%, rural: 65%, P = 0.003), and panic attacks (urban: 18%, suburban: 24%, rural: 30%, P = 0.04). More prevalent symptoms in postmenopause rural residents were as follows: mood swings (urban: 18%, suburban: 14%, rural: 23%, P = 0.02), urinary incontinence (urban: 19%, suburban: 14%, rural: 23%, P = 0.02), and vaginal dryness (urban: 22%, suburban: 29%, rural: 37%, P = 0.004). Vasomotor symptom prevalence was high (71% late menopause transition, 20% postmeopause), but current menopause hormone therapy use was low (11% late menopause transition, 11% postmenopause) and did not differ by residence, despite differences in menopausal resources used.</p><p><strong>Conclusions: </strong>Rural women may experience greater burden of psychological and somatic menopause symptoms but not vasomotor symptoms. Overall low rates of menopause hormone therapy use suggest a need for education regarding hormone therapy, tailored to residential groups who rely on different resources on healthy aging.</p>","PeriodicalId":18435,"journal":{"name":"Menopause: The Journal of The North American Menopause Society","volume":" ","pages":"23-30"},"PeriodicalIF":2.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142846971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A new orientation on our understanding of midlife sexuality.","authors":"Jan Shifren","doi":"10.1097/GME.0000000000002482","DOIUrl":"10.1097/GME.0000000000002482","url":null,"abstract":"","PeriodicalId":18435,"journal":{"name":"Menopause: The Journal of The North American Menopause Society","volume":" ","pages":"1-2"},"PeriodicalIF":2.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142846965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}