Depressive symptoms in women with premature ovarian insufficiency (POI): a cross-sectional observational study.

IF 2.8 3区医学 Q1 OBSTETRICS & GYNECOLOGY

Menopause: The Journal of The North American Menopause Society Pub Date : 2025-07-15 DOI:10.1097/GME.0000000000002614

Charissa van Zwol-Janssens, Yvonne V Louwers, Joop S E Laven, Jits Schipper, Geranne Jiskoot

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引用次数: 0

Abstract

Objective: To explore associations between clinical and patient-reported variables and depressive symptoms in women with premature ovarian insufficiency (POI).

Methods: An exploratory cross-sectional observational study was conducted using data from the center of expertise for women with POI, Erasmus MC, the Netherlands. To identify variables associated with depressive symptoms, as assessed by patient and clinician-reported outcome measures, we used logistic regression models.

Results: Between April 2020 and December 2023, 345 women with POI were included. In this cohort, the prevalence of depressive symptoms was 29.9%. No significant difference was found in depressive symptoms between women using estrogen plus progestogen therapy (EPT) (41.7%) and those not using EPT (42.6%, P=0.89). Younger age at diagnosis (P=0.01), POI due to a genetic cause (P=0.04), severe menopausal symptoms (P<0.001), and lack of emotional support (P<0.001) were independently associated with depressive symptoms. The use of EPT or levels of estradiol were not associated with depressive symptoms.

Conclusions: The high prevalence of depressive symptoms among women with POI underscores a need for targeted mental health support. Our findings highlight that younger age at diagnosis, severe menopausal symptoms, and fertility-related grief are associated with depression in this population. Given that estradiol levels did not correlate with depressive symptoms, this suggests that psychosocial factors are crucial. Psychological interventions should focus on these factors to address the unique needs of this population.

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卵巢功能不全（POI）女性的抑郁症状：一项横断面观察研究

目的：探讨临床和患者报告的变量与卵巢功能不全（POI）女性抑郁症状之间的关系。方法：一项探索性横断面观察性研究使用来自荷兰Erasmus MC的POI女性专家中心的数据。为了确定与抑郁症状相关的变量，通过患者和临床报告的结果测量进行评估，我们使用了逻辑回归模型。结果：在2020年4月至2023年12月期间，纳入了345名患有POI的女性。在这个队列中，抑郁症状的患病率为29.9%。使用雌激素加孕激素治疗（EPT）与未使用EPT治疗（42.6%，P=0.89）的女性在抑郁症状方面无显著差异（41.7%）。诊断时年龄较低（P=0.01），遗传原因导致的POI (P=0.04)，严重的绝经期症状(P)结论：POI妇女抑郁症状的高患病率强调了有针对性的心理健康支持的必要性。我们的研究结果强调，在这一人群中，较年轻的诊断年龄、严重的更年期症状和与生育有关的悲伤与抑郁症有关。鉴于雌二醇水平与抑郁症状无关，这表明心理社会因素至关重要。心理干预应侧重于这些因素，以解决这一人群的独特需求。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Menopause: The Journal of The North American Menopause Society 医学-妇产科学

CiteScore

5.40

自引率

7.40%

发文量

330

审稿时长

3-8 weeks

期刊介绍： Menopause, published monthly, provides a forum for new research, applied basic science, and clinical guidelines on all aspects of menopause. The scope and usefulness of the journal extend beyond gynecology, encompassing many varied biomedical areas, including internal medicine, family practice, medical subspecialties such as cardiology and geriatrics, epidemiology, pathology, sociology, psychology, anthropology, and pharmacology. This forum is essential to help integrate these areas, highlight needs for future research, and enhance health care.