Menopause: The Journal of The North American Menopause Society最新文献

{"title":"The effect of emotional freedom techniques on menopausal symptoms, quality of life, and depression level: a randomized sham-controlled trial.","authors":"Esra Karataş Okyay, Sinem Güven Santur, Zeliha Özşahin, Çiğdem Karakayali Ay","doi":"10.1097/GME.0000000000002713","DOIUrl":"10.1097/GME.0000000000002713","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to evaluate the effect of Emotional Freedom Techniques (EFT) on menopausal symptoms, quality of life, and depression.</p><p><strong>Methods: </strong>The study was designed as a three-arm randomized controlled trial with a pretest-posttest design, conducted among women in menopause. The sample included 35 participants in the EFT group, 35 in the sham group, and 35 in the control group, totaling 105 participants. The intervention was administered to the EFT and sham groups once weekly for four weeks. Data were collected using the Personal Information Form, Menopause Symptoms Rating Scale (MSRS), Menopause-Specific Quality of Life Scale (MSQLS), and Perimenopausal Depression Scale (Meno-D). Data analysis was performed using χ 2 tests, paired-samples t -tests, one-way ANOVA, and two-way mixed ANOVA for repeated measures.</p><p><strong>Results: </strong>After the intervention, statistically significant differences were observed in the mean posttest scores of the MSRS (EFT: 10.14±5.96; sham: 16.80±7.21; control: 17.74±5.79), MSQOL (EFT: 50.31±24.69; sham: 57.91±24.43; control: 75.51±24.87), and Meno-D (EFT: 7.69±5.02; sham: 13.31±7.60; control: 15.40±6.17) among the EFT, sham, and control groups ( P <0.05). The EFT group had the lowest MSRS and Meno-D scores, with significant differences observed between the EFT group and both the sham and control groups ( P <0.05). The EFT group also had the lowest MSQOL score, with significant differences identified between the control group and both the sham and EFT groups ( P <0.05). Repeated measures analyses revealed that the time-dependent changes between groups were statistically significant ( P <0.05).</p><p><strong>Conclusion: </strong>EFT can be considered an effective complementary intervention for reducing menopausal symptoms, alleviating depression, and improving quality of life in women. Incorporating low-cost and feasible techniques such as EFT into women's health services is recommended.</p>","PeriodicalId":18435,"journal":{"name":"Menopause: The Journal of The North American Menopause Society","volume":" ","pages":"559-575"},"PeriodicalIF":3.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146113617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between anxiety, depression, and menopausal symptoms in postmenopausal women.","authors":"Fatma Keskin Töre, Gülçin Nacar, Cansu Ağrali","doi":"10.1097/GME.0000000000002708","DOIUrl":"10.1097/GME.0000000000002708","url":null,"abstract":"<p><strong>Objectives: </strong>This study examined the relationship of anxiety and depression with menopausal symptoms in postmenopausal women.</p><p><strong>Methods: </strong>This descriptive, cross-sectional study was conducted with 236 postmenopausal women aged 45-65 years. Data were collected using the Personal Information Form, the Beck Anxiety Inventory, the Beck Depression Inventory, and the Menopause Symptom Assessment Scale. Descriptive statistics, Pearson correlation analysis, and multivariable-adjusted linear analysis were employed for the statistical evaluation of the data. The models were adjusted for the following covariates: age, educational status, income status, marital status, number of living children, presence of chronic disease, body mass index, duration of menopause, and perception of the menopausal period.</p><p><strong>Results: </strong>A statistically significant positive correlation was found between anxiety and menopausal symptoms ( r =0.623, P <0.001). Multivariable-adjusted linear regression analysis indicated that a one-unit increase in anxiety was associated with a 0.424-unit increase in menopausal symptom scores ( B =0.424, P <0.001). Similarly, a statistically significant positive correlation was observed between depression and menopausal symptoms ( r =0.442, P <0.001). A one-unit increase in depression was associated with a 0.416-unit increase in menopausal symptom scores ( B =0.416, P <0.001).</p><p><strong>Conclusions: </strong>In conclusion, a significant relationship was found between anxiety and depression and menopausal symptoms. This finding highlights the importance of not overlooking psychological factors such as anxiety and depression when evaluating menopausal symptoms in postmenopausal women.</p>","PeriodicalId":18435,"journal":{"name":"Menopause: The Journal of The North American Menopause Society","volume":" ","pages":"536-543"},"PeriodicalIF":3.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145708599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychological treatments for sexual concerns in perimenopausal and postmenopausal women: a systematic review and meta-analysis.","authors":"Sheryl M Green, Melissa Furtado, Julia Peak, Zoryana Babiy","doi":"10.1097/GME.0000000000002698","DOIUrl":"10.1097/GME.0000000000002698","url":null,"abstract":"<p><strong>Importance: </strong>Sexual concerns are commonly reported by perimenopausal and postmenopausal women. Nonpharmacological treatments, including psychological-based treatments, may serve as an alternative and/or complementary option for those who cannot, or choose not, to take medication or who continue to experience symptoms despite their use.</p><p><strong>Objective: </strong>This systematic review and meta-analysis examined psychological interventions that directly targeted and/or assessed sexual functioning in perimenopausal and postmenopausal women using standardized measures.</p><p><strong>Evidence review: </strong>Web of Science, MEDLINE, and PubMed were searched for studies that evaluated the effects of psychological interventions for sexual concerns during perimenopause and postmenopause. Risk of bias assessments were done using the Cochrane Risk-of-Bias Tool and the Newcastle-Ottawa Scale. Data were pooled in a primary meta-analysis using the Female Sexual Function Index (FSFI), as well as subgroup analyses based on psychological intervention type, with effects reported separately for each subgroup.</p><p><strong>Findings: </strong>Sixteen articles (n=1,445) met the eligibility criteria and were included in the systematic review and meta-analysis. Overall, nine randomized controlled trials (n=738) containing FSFI data were pooled in a meta-analysis showing psychological interventions were associated with significant improvements in sexual concerns (standardized mean difference [SMD]=1.37, 95% CI=1.17-1.58, P <0.00001; n=475). Subgroup analysis based on type of psychological intervention revealed that cognitive-behavioral therapy (SMD =-0.00, 95% CI=-0.26 to 0.25; n=233; I2 =0%) and mindfulness-based interventions (SMD =0.02, 95% CI=-0.40 to 0.45; n=86; I2 =0%) had no to small effect on the sexual function in perimenopausal and postmenopausal women, while education programs (SMD=2.53, 95% CI=-2.19 to 2.86; P <0.00001; n=268; I2 =94%) and counseling (SMD=2.43, 95% CI=1.92-2.94; P <0.00001; n=106; I2 =0%) had a large effect. Only one motivational interviewing study (effect size of 0.72) was included, but it revealed a large effect on sexual functioning. Overall risk of bias ranged from low to some concerns, with one study scoring high.</p><p><strong>Conclusions and relevance: </strong>This systematic review and meta-analysis suggests that psychological interventions are an effective nonpharmacological treatment option for addressing sexual concerns in perimenopausal and postmenopausal women. Although cognitive-behavioral therapy and mindfulness-based approaches showed small to no effects on sexual concerns, these findings should be interpreted with caution, as the included studies did not directly target sexual concerns but instead assessed them as secondary outcomes. Psychological interventions should be considered when discussing treatment options for sexual concerns in perimenopausal and postmenopausal women.</p>","PeriodicalId":18435,"journal":{"name":"Menopause: The Journal of The North American Menopause Society","volume":" ","pages":"614-623"},"PeriodicalIF":3.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145768694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between decreased bone mineral density and dynapenia in postmenopausal women: a case-control study.","authors":"Violeta Rios-Escalante, Juan Carlos Perez-Barba, Maria Claudia Espinel-Bermudez, Trujillo Xochitl, Ana Bertha Zavalza-Gomez, Pablo Hernandez-Ascencio, Sergio Sanchez-Garcia","doi":"10.1097/GME.0000000000002711","DOIUrl":"10.1097/GME.0000000000002711","url":null,"abstract":"<p><strong>Objective: </strong>To analyze the association between decreased bone mineral density (BMD) and dynapenia in postmenopausal women.</p><p><strong>Methods: </strong>An age-matched case-control study was conducted in postmenopausal women with and without dynapenia. Assessments were carried out by measuring dominant handgrip strength with a Jamar dynamometer; BMI-adjusted cut-off points were applied. BMD was evaluated according to the World Health Organization criteria ( T -score ≤-1 SD), using dual-energy x-ray absorptiometry (Hologic Horizon). The study included sociodemographic, anthropometric, body composition, biochemical, and lifestyle variables. Descriptive and inferential statistical analyses were performed, and unconditional logistic regression was used to estimate odds ratios (OR) with 95% confidence intervals (CIs); statistical significance was set at P ≤0.05. The study adhered to national and international ethical standards.</p><p><strong>Results: </strong>A total of 201 women were included in the study: 67 with dynapenia (cases) and 134 without (controls). Median ages were 68 years for cases and 66 years for controls. Dynapenia was significantly associated with decreased BMD (OR=3.89, 95% CI=1.31-11.56), high-very high visceral fat levels (OR=3.12, 95% CI=1.26-7.72), and polypharmacy (OR=2.16, 95% CI=1.05-4.63).</p><p><strong>Conclusions: </strong>Decreased BMD is associated with dynapenia in postmenopausal women, as well as with high-very high visceral fat levels and polypharmacy. These findings highlight the importance of a comprehensive assessment of musculoskeletal and metabolic risk factors in this population.</p>","PeriodicalId":18435,"journal":{"name":"Menopause: The Journal of The North American Menopause Society","volume":" ","pages":"583-592"},"PeriodicalIF":3.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145966489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The long and winding road to menopause: a true milestone or an illusion for women with endometriosis?","authors":"Francesca Marrocco, Daniela Alberico, Paola Pifarotti, Anna Nasini, Martina Anna Buffa, Sonia Cipriani, Giussy Barbara","doi":"10.1097/GME.0000000000002709","DOIUrl":"10.1097/GME.0000000000002709","url":null,"abstract":"<p><strong>Objective: </strong>The primary objective of this study was to determine whether women with and without a history of endometriosis experience menopause differently, in terms of their satisfaction with quality of life.</p><p><strong>Methods: </strong>This study was conducted at Fondazione IRCCS Ca' Granda Policlinico Hospital, Milan, from October 2022 to April 2024. The total sample included 394 postmenopausal women aged 48-55 years: 197 with a clinical history of endometriosis (group 1) and 197 without (group 2). All participants were required to complete a series of validated questionnaires assessing quality of life (Short-Form Health Survey 12, SF-12), sexual function (Female Sexual Function Index [FSFI]), anxiety and depression (Hospital Anxiety and Depression Scale [HADS]), climacteric symptoms (Menopause-Specific Quality of Life Questionnaire [MENQOL]), and satisfaction with their clinical condition using a 5-point Likert scale.</p><p><strong>Results: </strong>The SF-12 scores were significantly higher in group 2 than in group 1 (physical score: P =0.01; mental score: P <0.001). Group 1 reported lower satisfaction levels than group 2; however, this difference was not statistically significant (OR = 0.78, 95% CI: 0.5-1.2, P =0.26). The FSFI, HADS, and MENQOL scores were not significantly different between the two groups (FSFI score, P = 0.20; HADS anxiety score, P =0.11; HADS depression score, P =0.48; MENQOL score, P = 0.91).</p><p><strong>Conclusion: </strong>Postmenopausal women with a history of endometriosis appear to have a similar quality of life compared with those without such a history. While the overall quality of life scores were higher in women without endometriosis, both groups reported comparable climacteric symptoms, sexual functioning, and anxiety and depression levels.</p>","PeriodicalId":18435,"journal":{"name":"Menopause: The Journal of The North American Menopause Society","volume":" ","pages":"576-582"},"PeriodicalIF":3.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145768419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Content validity, face validity and acceptability of three hot flash diaries for vasomotor symptoms: a cognitive interview study.","authors":"Claudia Rutherford, Martha Hickey, Angela Ju, Natalie D'Abrew, Louise Acret, Sarah Lensen","doi":"10.1097/GME.0000000000002696","DOIUrl":"10.1097/GME.0000000000002696","url":null,"abstract":"<p><strong>Objective: </strong>Around 70% of women experience vasomotor symptoms (VMS) over the menopause transition. These are a leading patient priority for treatment. To robustly evaluate treatment effectiveness, validated tools are needed. VMS diaries are widely used in clinical trials, but their content validity and acceptability for symptomatic women is not established. The objective of this study is to evaluate acceptability, content validity and face validity of available hot flash diaries.</p><p><strong>Methods: </strong>We conducted semi-structured interviews to explore acceptability, content, interpretation and experience of completion of three widely used hot flash diaries: Sloan, Guttuso, Menopause Strategies: Finding Lasting Answers for Symptoms and Health (MsFLASH) with English speaking symptomatic peri/postmenopausal women in Australia, recruited through social media (Facebook groups), a registry of previous trial participants, and through Menopause clinics. Content analysis was used to analyze findings.</p><p><strong>Results: </strong>Of 33 women who completed screening questions, 25 provided contact details and consented to being interviewed. Women were aged 40-69 years, most reported menopause between 50 and 59 years, and 18 experienced moderate-severe VMS. Participants considered daily reporting of VMS acceptable, preferred diaries reporting VMS in real-time or twice daily (rather than once daily) and found descriptions for severity categories helpful in assigning severity of their VMS.</p><p><strong>Conclusion: </strong>Two diaries (Guttuso and MsFLASH) were found to be acceptable and valid measures of VMS severity and frequency. However, adding descriptions for severity categories to the MsFLASH diary and distinguishing between day and night-time VMS in the Guttuso diary were recommended improvements. Real-time data collection may be preferable.</p>","PeriodicalId":18435,"journal":{"name":"Menopause: The Journal of The North American Menopause Society","volume":" ","pages":"521-528"},"PeriodicalIF":3.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145768716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the accuracy and readability of large language model responses on menopause and hormone therapy.","authors":"Jana Karam, Chrisandra Shufelt, Nancy Safwan, Ekta Kapoor, Monica M Christmas, Stephanie S Faubion","doi":"10.1097/GME.0000000000002695","DOIUrl":"10.1097/GME.0000000000002695","url":null,"abstract":"<p><strong>Objective: </strong>Generative artificial intelligence is rapidly evolving and is now being explored in health care to support patient and clinician education. This study evaluated the accuracy, completeness, and readability of four large language models (LLMs): ChatGPT 3.5, Gemini, ChatGPT 4.0, and OpenEvidence in answering questions about menopause and hormone therapy.</p><p><strong>Methods: </strong>A total of 35 questions (20 patient-level, 15 clinician-level) were entered into each LLM. OpenEvidence was only used for clinician-level questions. Four blinded expert reviewers rated responses as accurate and complete, accurate but incomplete, or inaccurate. Readability of patient-level responses was assessed using the Flesch Reading Ease Score (FRES) and word count. Analysis used ANOVA for readability, odds ratios for accuracy comparisons.</p><p><strong>Results: </strong>For patient-level questions, ChatGPT 3.5 achieved the highest accuracy (70%), followed by ChatGPT 4.0 (60%) and Gemini (30%); Gemini had significantly lower odds of accuracy compared with ChatGPT 3.5 (OR=0.18, 95% CI=0.05-0.71; P =0.014). FRES scores differed significantly ( P <0.001): Gemini scored 38.9±7.3 (\"difficult\"), ChatGPT 3.5 scored 31.0±11.2, and ChatGPT 4.0 scored 26.5±8.6 (both \"very difficult\"). For clinician-level questions, ChatGPT 4.0 achieved the highest accuracy (67%), followed by ChatGPT 3.5 and OpenEvidence (60% each) and Gemini (47%); no significant differences were observed among models (all P >0.05).</p><p><strong>Conclusion: </strong>LLMs demonstrated limited accuracy and frequent incorrect or incomplete responses to menopause-related queries, highlighting the need to improve model performance to ensure accurate and reliable information for both patients and clinicians.</p>","PeriodicalId":18435,"journal":{"name":"Menopause: The Journal of The North American Menopause Society","volume":" ","pages":"515-520"},"PeriodicalIF":3.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145661304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deciphering the predictors of endometrial nonbenign lesions in asymptomatic postmenopausal women via explainable machine learning.","authors":"Linlin Yang, Chen Xu, Rongjia Su, Xiaoyan Gao, Baoying Ye, Yuan Liu, Jing Wang, Yidan Chen, Qiong Fan, Jiangjing Yuan, Xiaojing Lu, Dongjian Yang, Yuhong Li, Yudong Wang","doi":"10.1097/GME.0000000000002699","DOIUrl":"10.1097/GME.0000000000002699","url":null,"abstract":"<p><strong>Objectives: </strong>Timely identification of endometrial nonbenign lesions led to improved outcomes, but there was a lack of effective predictive models for asymptomatic endometrial thickening. The aim of this study was to develop a strong machine learning (ML) model for assessing the risk of endometrial malignancy in asymptomatic patients after menopause.</p><p><strong>Methods: </strong>This retrospective study was designed to collect data from 971 postmenopausal asymptomatic women with endometrial thickening. The bootstrap resampling method was used for model training, internal validation, and external validation. With 41 easily accessible characteristics, multifactor regression and least absolute shrinkage and selection operator regression were performed for feature selection. Nine ML algorithms were applied to build a model. To explain the final model and rank feature importance, the SHapley Additive exPlanation (SHAP) method was utilized. Meanwhile, a nomogram was developed to facilitate model interpretation.</p><p><strong>Results: </strong>The comprehensive methodologies identified parity, Doppler flow signals, endometrial thickness, cancer antigen 125, and D-dimer as significant predictors. The logistic regression (LR) model demonstrated superior performance compared with other ML algorithms, achieving an accuracy of 88%, a sensitivity of 78%, a specificity of 98%, and an area under the receiver operating characteristic curve of 0.81. Furthermore, individualized predictions of endometrial malignancy were visualized through a force plot generated by SHAP analysis. A nomogram based on the LR model was subsequently constructed, showing area under the receiver operating characteristic curve values of 0.82, 0.82, and 0.81 for the training, internal validation, and external validation cohorts, respectively. The calibration curve demonstrated excellent consistency.</p><p><strong>Conclusions: </strong>We developed an LR-based nomogram model and interpreted using the SHAP method, which provided visual insights for detecting endometrial nonbenign lesions in asymptomatic postmenopausal women. This approach would aid clinicians in providing individualized treatment and help avoid unnecessary invasive surgeries.</p>","PeriodicalId":18435,"journal":{"name":"Menopause: The Journal of The North American Menopause Society","volume":" ","pages":"593-607"},"PeriodicalIF":3.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13105743/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146052902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Menopause and large language models: not quite ready for mid-life.","authors":"Lisa N Kransdorf","doi":"10.1097/GME.0000000000002789","DOIUrl":"10.1097/GME.0000000000002789","url":null,"abstract":"","PeriodicalId":18435,"journal":{"name":"Menopause: The Journal of The North American Menopause Society","volume":" ","pages":"511-512"},"PeriodicalIF":3.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147513452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond the medicine cabinet: psychological approaches to midlife sexual concerns.","authors":"Jan Shifren","doi":"10.1097/GME.0000000000002798","DOIUrl":"10.1097/GME.0000000000002798","url":null,"abstract":"","PeriodicalId":18435,"journal":{"name":"Menopause: The Journal of The North American Menopause Society","volume":" ","pages":"513-514"},"PeriodicalIF":3.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147627814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}