Menopause: The Journal of The North American Menopause Society最新文献

{"title":"Achieving Menopausal Health Equity Network (AMEN): an educational intervention to improve OB/GYN knowledge of menopause-related racial and ethnic health disparities.","authors":"Shilpa Kalluru, Celine M Akande, Margot B Bellon, Nikhita Mahendru, Dona Jalili, Amani Sampson, Steven R Goldstein, Margaret J Nachtigall, Lila E Nachtigall, Samantha M Dunham, Kameelah A Phillips, Gwendolyn P Quinn","doi":"10.1097/GME.0000000000002545","DOIUrl":"https://doi.org/10.1097/GME.0000000000002545","url":null,"abstract":"<p><strong>Objectives: </strong>To study the impact of an educational intervention on obstetrician-gynecologist clinicians' knowledge of racial and ethnic disparities in the menopause experience.</p><p><strong>Methods: </strong>Twenty-five obstetrician-gynecologist physicians (residents, fellows, and attendings) at an academic medical center in New York, NY, completed the Achieving Menopausal Health Equity Network course, a brief web-based intervention consisting of four modules delivered through narrated didactic videos and interactive tools, a 10-item pretest and posttest, and a course evaluation survey. The primary outcome was a change in knowledge scores after the completion of the educational intervention. Item analysis was also performed to assess item discrimination, item difficulty, and response frequency. Feedback on modules was obtained, and thematic analysis was performed.</p><p><strong>Results: </strong>In this study, 25 participants completed the educational intervention. There was a statistically significant increase in mean test scores after participation (pretest mean score=7.1/10 vs. posttest mean score=8.1/10, P =0.0021). The following themes emerged in thematic analysis: knowledge building with potential for practical application for clinicians and non-clinicians, clarity and relevance, and opportunities for growth for future iterations of the modules.</p><p><strong>Conclusions: </strong>This brief, online educational curriculum focused on racial and ethnic disparities in menopause significantly improved the knowledge of obstetrician-gynecologist clinicians at various levels of training and provides a useful model for introducing more formal training on menopause medicine for obstetrician-gynecologist clinicians.</p>","PeriodicalId":18435,"journal":{"name":"Menopause: The Journal of The North American Menopause Society","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144032781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Engagement with patients' sexual problems: a comparative study among general practitioners and obstetrician-gynecologists.","authors":"Anna Aromaa, Katja Kero, Sanna-Mari Manninen, Tero Vahlberg, Päivi Polo-Kantola","doi":"10.1097/GME.0000000000002551","DOIUrl":"https://doi.org/10.1097/GME.0000000000002551","url":null,"abstract":"<p><strong>Objectives: </strong>Even though good sexual health is an important part of well-being, the evaluation of patients' sexual problems is not necessarily routine for physicians. We compared engagement (attitudes, barriers to bringing up, and practice patterns) with patients' sexual problems among general practitioners (GPs) and obstetrician-gynecologists (OB/GYNs) with special regard for the sex and age of the physician.</p><p><strong>Methods: </strong>A web-based questionnaire was used for data collection from 2 samples of physicians. The completed questionnaires from 402 GPs and 299 OB/GYNs were eligible for analysis. In the statistical analysis, the GPs were compared with the OB/GYNs as entire groups with multivariable binary logistic regression adjusted for sex and age. In addition, interaction and subgroup analysis by sex and age groups were both carried out.</p><p><strong>Results: </strong>Both GPs and OB/GYNs considered treating sexual problems to be an important health care practice. However, compared with the OB/GYNs, the GPs were less likely to inquire about sexual problems during general medical history-taking [adjusted odds ratio (aOR): 0.23, 95% CI: 0.16-0.33, P < 0.0001] and more likely to consider diagnosing female sexual problems as being difficult (aOR: 2.44, 95% CI: 1.73-3.44, P < 0.0001). Compared with the OB/GYNs, the GPs were more likely to report having barriers-for example, \"shortness of the appointment time\" (aOR: 2.36, 95% CI: 1.53-3.63, P < 0.0001), \"personal attitudes and beliefs\" (aOR: 2.07, 95% CI: 1.41-3.67, P = 0.001), and \"lack of knowledge about sexual medicine\" (aOR: 2.05, 95% CI: 1.36-3.10, P = 0.001).</p><p><strong>Conclusions: </strong>Both GPs and OB/GYNs considered the treatment of sexual problems to be an important health care practice; however, the engagement with patients' sexual problems among GPs was less structured.</p>","PeriodicalId":18435,"journal":{"name":"Menopause: The Journal of The North American Menopause Society","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143971453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychological function in a randomized trial of continuous nitroglycerin for menopausal hot flashes.","authors":"Emily L Zhao, Carolyn J Gibson, Harini Raghunathan, Michael Schembri, Peter Ganz, Alison J Huang","doi":"10.1097/GME.0000000000002556","DOIUrl":"https://doi.org/10.1097/GME.0000000000002556","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate prospective changes in psychological function among menopausal women using continuous nitroglycerin for hot flashes and examine repeated associations between psychological symptoms and hot flashes.</p><p><strong>Methods: </strong>Menopausal women with ≥7 hot flashes/day were randomized to continuous transdermal nitroglycerin (0.2-0.4 mg/h) or placebo for 12 weeks. Psychological function was evaluated using the Center for Epidemiologic Studies-Depression Scale (CES-D), Generalized Anxiety Disorders-7 (GAD-7), and Menopause-Specific Quality of Life (MENQOL) Psychosocial Subscale. Linear mixed models examined treatment effects on mood symptoms from baseline to 5 and 12 weeks. Based on validated 7-day hot flash diaries, additional models examined associations between mood symptoms and hot flash frequency in both groups combined.</p><p><strong>Results: </strong>Among the 141 randomized participants (mean 10.8±3.5 hot flashes/day), nitroglycerin therapy did not improve CES-D or GAD-7 scores (prespecified secondary outcomes) from baseline to 5 and 12 weeks compared with placebo. Greater hot flash frequency was associated with worse GAD-7 scores across all timepoints (β=0.05 per 1 hot flash, P=0.005), but no associations between hot flashes and CES-D or MENQOL Psychosocial scores were observed. Improvement in hot flash frequency was associated with improvement in MENQOL Psychosocial score (β=0.04 per 1 hot flash, P=0.03), but no associations between improvements in hot flashes and improvements in GAD-7 or CES-D scores were detected.</p><p><strong>Conclusions: </strong>In a randomized trial of continuous nitroglycerin, improvements in hot flash frequency did not consistently translate into improvements in mood. Clinicians caring for women with overlapping hot flashes and mood symptoms should consider other factors influencing midlife psychological function.</p>","PeriodicalId":18435,"journal":{"name":"Menopause: The Journal of The North American Menopause Society","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144011510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The longitudinal relation of inflammation to incidence of vasomotor symptoms: Erratum.","authors":"","doi":"10.1097/GME.0000000000002577","DOIUrl":"https://doi.org/10.1097/GME.0000000000002577","url":null,"abstract":"","PeriodicalId":18435,"journal":{"name":"Menopause: The Journal of The North American Menopause Society","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144031352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between night eating syndrome, eating disorders, and menopausal symptoms in climacteric women: a pilot study.","authors":"Pelin Ayar, Haci Ömer Yilmaz","doi":"10.1097/GME.0000000000002517","DOIUrl":"10.1097/GME.0000000000002517","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study was to examine the relationship between night eating syndrome, eating disorders, and menopausal symptoms in climacteric women.</p><p><strong>Methods: </strong>In this descriptive study, 90 climacteric women who met the inclusion criteria volunteered to participated. The data for the participants were collected via a face-to-face interview method using a sociodemographic and menopause questionnaire, the Eating Disorder Examination Questionnaire, the Night Eating Questionnaire, and the Menopause Rating Scale, and their anthropometric measurements were recorded.</p><p><strong>Results: </strong>Among all participants, 51.1% had night eating syndrome. However, the night eating syndrome ( P  = 0.790) and eating disorders ( P  = 0.634) of the participants did not differ significantly according to the climacteric periods. Menopausal symptoms were found to be higher in perimenopausal and postmenopausal women than in premenopausal women ( P  = 0.001). There were significant positive correlations between eating disorders and both night eating ( r  = 0.253 and P  < 0.05) and menopausal symptoms ( r  = 0.291 and P  < 0.001). There was no relationship between menopausal symptoms and night eating habits ( r  = 0.141 and P  > 0.05).</p><p><strong>Conclusions: </strong>Eating disorders were found to be associated with night eating and menopausal symptom severity in climacteric women. There is a need for multidisciplinary studies to measure the risk of occurrence and recurrence of menopausal symptoms and the association with eating disorders experienced by women.</p>","PeriodicalId":18435,"journal":{"name":"Menopause: The Journal of The North American Menopause Society","volume":" ","pages":"461-468"},"PeriodicalIF":2.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143516112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The unmet needs of breast cancer survivors: is menopausal hormone therapy ever an option?","authors":"Amy Comander, Maryam B Lustberg, Lisa Larkin","doi":"10.1097/GME.0000000000002568","DOIUrl":"https://doi.org/10.1097/GME.0000000000002568","url":null,"abstract":"","PeriodicalId":18435,"journal":{"name":"Menopause: The Journal of The North American Menopause Society","volume":"32 5","pages":"385-387"},"PeriodicalIF":2.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144017865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative study of time-restricted eating on body composition and metabolic parameters in climacteric women with obesity: analysis of a pre-post intervention.","authors":"Nathália Cavalcanti de Morais Araújo, Júlia Acioli Paixão, Fabiane de Oliveira Freitas, Daniel Nunes de Araújo Gonçalves, Fernando Wesley Cavalcanti de Araujo, Silvia Alves da Silva, Elizabeth do Nascimento","doi":"10.1097/GME.0000000000002518","DOIUrl":"10.1097/GME.0000000000002518","url":null,"abstract":"<p><strong>Objective: </strong>The physiological changes inherent to the climacteric period can trigger or aggravate overweight/obesity, among several other health disorders. This study aimed to evaluate the effects of time-restricted eating (TRE) on body composition and cardiometabolic parameters in climacteric women with obesity submitted to caloric restriction (CR) through a hypocaloric diet.</p><p><strong>Methods: </strong>We conducted an analysis of a clinical trial in a pre-post design that included adult climacteric women with obesity. Participants were divided into two groups: hypocaloric diet control group (n = 30) - with hypocaloric diet and free meal times, and hypocaloric diet and time-restricted eating group (HTRE) (n = 27) - with hypocaloric diet and TRE (fasting from 7  pm to 7  am ), for 10 weeks. Anthropometric and biochemical parameters were evaluated before and after the intervention period. A significance level of P  < 0.05 was considered for all cases.</p><p><strong>Results: </strong>Both groups showed a reduction in all anthropometric parameters, but without significant difference ( P  = 0.34) between groups. However, some metabolic parameters were significantly highlighted in the HTRE such as cholesterol level normalization (HTRE, 181.76 ± 34.20 mg/dL) and a decrease in plasma atherogenicity ( P  = 0.02), glycated hemoglobin ( P  < 0.001), estimated mean glucose ( P  = 0.02), and alanine aminotransferase ( P  = 0.02), unlike the hypocaloric diet control group, which did not show such significance.</p><p><strong>Conclusions: </strong>In this study, from the perspective of body composition, similar changes were observed between the group subjected to CR alone and the group subjected to CR combined with a 12-hour overnight fast. However, there was an indication of superior improvement in glycemic and lipid parameters in the group subjected to the 12-hour overnight fast. These findings suggest the potential for TRE, as implemented, to have positive effects on reducing cardiovascular risk and other chronic metabolic diseases.</p>","PeriodicalId":18435,"journal":{"name":"Menopause: The Journal of The North American Menopause Society","volume":" ","pages":"453-460"},"PeriodicalIF":2.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143502282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contraception in perimenopause.","authors":"Barbara A Soltes","doi":"10.1097/GME.0000000000002554","DOIUrl":"https://doi.org/10.1097/GME.0000000000002554","url":null,"abstract":"<p><p>Perimenopause is characterized by wide hormone fluctuations and irregular menstrual cycles for 5 or more years preceding menopause and lasts until 12 months of amenorrhea have been achieved. It represents a period of reproductive transition with a decline in fertility. However, unintended pregnancies do occur, with a high risk for poor outcomes and maternal complications. All women transitioning through perimenopause should be adequately counseled. There are many hormone and nonhormone contraceptive methods that are highly effective and suited to the personal and medical needs of the perimenopausal woman. Contraception should continue until menopause is confirmed.</p>","PeriodicalId":18435,"journal":{"name":"Menopause: The Journal of The North American Menopause Society","volume":"32 5","pages":"472-474"},"PeriodicalIF":2.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144027712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Breast cancer patients' experience of menopause care in the UK: thematic analysis of free-text comments.","authors":"Sarah Glynne, Kathy Seymour, Daniel Reisel, Aini Kamal, Louise Newson","doi":"10.1097/GME.0000000000002505","DOIUrl":"10.1097/GME.0000000000002505","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study was to explore women's experience of menopause care after breast cancer in the UK.</p><p><strong>Methods: </strong>This study is a thematic analysis of free-text comments in an online survey that asked women about their experience of menopause care after breast cancer. A coding framework was used that mapped comments to eight domains of patient experience (deductive analysis). An inductive approach was used to identify subthemes within each of the eight domains.</p><p><strong>Results: </strong>A total of 1,195 women completed the survey. Two hundred twenty-six women (18.9%) left free-text comments in response to questions about shared decision making and patient experience. Most were White (96.9%), university educated (52.6%), and aged 41 to 60 years at breast cancer diagnosis (81.8%). The menopausal symptom burden was high (96.5%, 87.6%, and 75.7% reported physical, psychological, and genitourinary symptoms, respectively). Lack of involvement in shared decision making was the dominant theme (n = 120, 53%), followed by issues concerning access to menopause care (n = 65, 29%). Lack of information, communication issues, and feeling unsupported were prevalent themes/subthemes. Twenty women (9%) reported a lack of courtesy and respect in their interactions with healthcare professionals.</p><p><strong>Conclusions: </strong>In this study, women's experience of menopause-related breast cancer aftercare was poor. Larger studies are needed to qualitatively explore the experience, unmet needs, and expectations of all breast cancer survivors including women from more deprived and ethnic minority groups.</p>","PeriodicalId":18435,"journal":{"name":"Menopause: The Journal of The North American Menopause Society","volume":" ","pages":"409-419"},"PeriodicalIF":2.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12024847/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143502281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of abaloparatide on fracture incidence and bone mineral density in postmenopausal women with osteoporosis at highest risk for fracture.","authors":"Kristi Tough DeSapri, Bart L Clarke, Paul Kostenuik, Yamei Wang, Bruce H Mitlak","doi":"10.1097/GME.0000000000002516","DOIUrl":"10.1097/GME.0000000000002516","url":null,"abstract":"<p><strong>Objective: </strong>This post hoc analysis evaluated the efficacy of abaloparatide treatment in a subgroup of postmenopausal women from the Abaloparatide Comparator Trial In Vertebral Endpoints (ACTIVE; NCT01343004) study who met high fracture risk criteria (defined in several professional society guidelines).</p><p><strong>Methods: </strong>Women from ACTIVE meeting ≥1 of the following fracture risk criteria were included: fracture within the past 12 months or prevalent vertebral fracture, baseline T score of <-3.0 at any site, very high fracture risk probability by FRAX (ie, 10-yr major osteoporotic fracture >30% or hip fracture >4.5%), or multiple prior fractures at baseline since age ≥45 years.</p><p><strong>Results: </strong>A total of 2,026 participants met ≥1 fracture risk criteria defined in clinical guidelines (abaloparatide, n = 664; placebo, n = 677; teriparatide, n = 685). New vertebral fracture risk was reduced in participants receiving abaloparatide (4 [0.72%]) and teriparatide (6 [0.99%]) versus placebo (28 [4.77%]; both P  < 0.0001). Estimated Kaplan-Meier cumulative incidence of nonvertebral fracture was 3.0%, 5.3%, and 3.0% in the abaloparatide, placebo, and teriparatide groups, respectively; 4.0%, 9.0%, 4.3% for clinical fracture; 1.6%, 6.8%, 3.0% for major osteoporotic fractures; and 1.1%, 2.1%, 2.1% for wrist fracture. Abaloparatide was associated with bone mineral density gains from baseline at the lumbar spine, total hip, and femoral neck at all time points (6, 12, and 18 mo; P  < 0.0001 for all). Common adverse events reported in participants treated with abaloparatide were hypercalciuria (11.5%), dizziness (11.0%), and arthralgia (8.9%).</p><p><strong>Conclusions: </strong>Abaloparatide reduced fracture incidence and increased bone mineral density in participants at highest fracture risk, consistent with the overall ACTIVE study.</p>","PeriodicalId":18435,"journal":{"name":"Menopause: The Journal of The North American Menopause Society","volume":" ","pages":"388-395"},"PeriodicalIF":2.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12024850/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143502285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}