Menopause: The Journal of The North American Menopause Society最新文献

{"title":"Associations of reproductive hormones and stress-related factors with menopausal symptoms.","authors":"Ieva Brimienė, Monika Šiaudinytė, Erik Ilkevič, Eglė Mazgelytė, Dovilė Karčiauskaitė, Jurgita Songailienė, Andrius Kaminskas, Tomas Petrėnas, Algirdas Utkus, Aurelijus Burokas, Ramunė Grikšienė","doi":"10.1097/GME.0000000000002463","DOIUrl":"https://doi.org/10.1097/GME.0000000000002463","url":null,"abstract":"<p><strong>Objective: </strong>The main aim was to evaluate the relationships between menopausal symptoms, endogenous hormones, and stress-related factors.</p><p><strong>Methods: </strong>Participants were recruited through online advertisements at Vilnius University and social networks. Sixty-three White Lithuanian women aged 50.2 ± 2.9 years without any known diseases or conditions that could affect menopausal symptoms, hormone levels, or mental health were selected to participate in the cross-sectional study. The Menopause-Specific Quality of Life Questionnaire was used to assess the intensity of menopausal symptoms in four domains (vasomotor, psychosocial, physical, and sexual). The levels of reproductive hormones were measured in blood serum. To evaluate the level of chronic stress, we used the Perceived Stress Scale 10 (PSS-10) and the assessment of hair glucocorticoids (cortisol, cortisone). Multiple linear regression analysis was performed to estimate the associations between menopausal symptoms severity, endogenous hormones, and stress-related factors.</p><p><strong>Results: </strong>Age (the unstandardized β [B] = 0.12), follicle-stimulating hormone concentration (B = 0.9), and PSS-10 score (B = 0.08) were associated with the total Menopause-Specific Quality of Life Questionnaire score (all P < 0.05). The vasomotor domain was related to age (B = 0.19), follicle-stimulating hormone (B = 1.24), and dehydroepiandrosterone sulfate concentration (B = -2.8) (all P < 0.05). The psychosocial domain was associated with the PSS-10 score (B = 0.13, P < 0.001). The physical domain was associated with the number of sleep hours (B = -0.35, P = 0.02). The sexual domain was negatively related to testosterone concentration (B = -3.5, P = 0.01).</p><p><strong>Conclusions: </strong>The results of the present study show that not only hormonal changes but also other factors, such as age, hours of sleep, and experienced stress, are associated with the intensity of menopausal symptoms.</p>","PeriodicalId":18435,"journal":{"name":"Menopause: The Journal of The North American Menopause Society","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142846968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor.","authors":"Shagun Kapoor, Priyanka Sah, Nilanchali Singh","doi":"10.1097/GME.0000000000002489","DOIUrl":"https://doi.org/10.1097/GME.0000000000002489","url":null,"abstract":"","PeriodicalId":18435,"journal":{"name":"Menopause: The Journal of The North American Menopause Society","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142801497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The need for biopsychosocial menopause care: a narrative review.","authors":"Subhadra Evans, Leesa Van Niekerk, Liliana Orellana, Melissa O'Shea, Marilla I Druitt, Sara Jones, Sarah Corrigan, Campbell Heggen, Zuleika Arashiro, Rodney Baber, Lata Satyen, Dave Skvarc, Antonina Mikocka-Walus","doi":"10.1097/GME.0000000000002441","DOIUrl":"10.1097/GME.0000000000002441","url":null,"abstract":"<p><strong>Importance and objective: </strong>Menopause is a reproductive transition affecting half the world's population. Stigma and limited availability of evidence-based treatments that support biopsychosocial well-being mean that this life stage is often associated with challenging symptoms and reduced quality of life (QoL). The aim of this review was to examine the extent literature on psychological and mind-body interventions to manage perimenopausal and postmenopausal symptoms, and apply an interdisciplinary clinical, research, and cultural knowledge framework to guide recommendations for improving QoL and healthy aging in this population. We also aimed to understand the ideal delivery mode for such interventions.</p><p><strong>Methods: </strong>Using Scopus, Medline, and PubMed, a review of systematic reviews, guidelines, and randomized controlled trials was undertaken to examine the use of psychological and mind-body interventions to improve menopause-related QoL and symptoms, including hot flushes, depression, anxiety, fatigue, pain, and sleep; conclusions were based on an analysis of this available evidence and linked to clinical and cultural considerations.</p><p><strong>Discussion and conclusion: </strong>Empirical support exists for a number of psychological and mind-body approaches to support QoL and symptoms during the menopause transition. The literature also identifies the need for menopause care that is culturally responsive.An online multimodal model of menopause care is thus recommended, incorporating evidence-based treatments (eg, cognitive behavioral therapy, yoga, hypnosis) and treatment techniques (eg, mindfulness, and education including nutrition support), as well as First Nations wisdom. We also recommend financial well-being approaches to support people undergoing menopause. Integrated, multimodal approaches should be available online to remove time, location, and healthcare access barriers, and be designed with diverse consumers to ensure equity for those underserved due to region, LGBTIQ+ assigned female at birth status, and for multicultural and First Nations people.</p>","PeriodicalId":18435,"journal":{"name":"Menopause: The Journal of The North American Menopause Society","volume":" ","pages":"1090-1096"},"PeriodicalIF":2.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142522291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Addressing menopause symptoms in the primary care setting: opportunity to bridge care delivery gaps.","authors":"Mackenzie L Bevry, Emily R Stogdill, Catherine M Lea, Kathryn R Taylor, Anna M Lovaas, Kaitlyn J Bailey, Kristin C Mara, Ross A Dierkhising, Rajeev Chaudhry, Stephanie S Faubion, Ekta Kapoor","doi":"10.1097/GME.0000000000002439","DOIUrl":"10.1097/GME.0000000000002439","url":null,"abstract":"<p><strong>Objective: </strong>Menopause symptoms affect quality of life and financial well-being but are often unaddressed in primary care clinics. Therefore, we evaluated the extent of menopause symptom documentation in electronic health records (EHRs) by primary health care professionals.</p><p><strong>Methods: </strong>We retrospectively reviewed adult women who reported moderate or higher vasomotor symptoms on a Mayo Clinic survey conducted from March 1, 2021, through June 30, 2021. We then assessed adequacy of menopause symptom documentation in the EHRs of these women who had primary care visits during the survey period. We reviewed the percentage of documented vasomotor symptoms from May 1, 2019, through May 1, 2021.</p><p><strong>Results: </strong>In the Mayo Clinic Health System-Northwest Wisconsin Region, 229 women self-reported moderate or higher vasomotor symptoms in the Mayo Clinic survey. Although only 23% of these women had vasomotor symptoms listed in the EHR clinical problem lists, 60% of these women had vasomotor symptoms documented in their clinic notes from the primary care visit. Approximately 6% of women reported hormone therapy use for management of menopause symptoms, and nearly 15% reported use of nonhormone prescription therapies for vasomotor symptoms.</p><p><strong>Conclusions: </strong>A greater proportion of women in our study had EHR documentation of bothersome menopause symptoms than those reported in other studies, but vasomotor symptoms remain generally untreated. We need better methods for identifying midlife women with bothersome menopause symptoms in primary care clinics so that appropriate treatment options, including hormone therapy, can be discussed and offered.</p>","PeriodicalId":18435,"journal":{"name":"Menopause: The Journal of The North American Menopause Society","volume":" ","pages":"1044-1048"},"PeriodicalIF":2.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142349743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between age at natural menopause and risk of asthma among postmenopausal women from the Canadian Longitudinal Study on Aging.","authors":"Durmalouk Kesibi, Michael Rotondi, Heather Edgell, Hala Tamim","doi":"10.1097/GME.0000000000002443","DOIUrl":"10.1097/GME.0000000000002443","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to investigate the association between age at natural menopause and incidence of asthma among postmenopausal Canadian women.</p><p><strong>Methods: </strong>Women between the ages of 45-85 yr were followed for a 10-yr period. Analysis was restricted to naturally postmenopausal women who are nonsmokers and did not have asthma prior to menopause. Age at natural menopause was examined using the following categories: 40-44, 45-49, 50-54 (reference), and ≥55. Survival analysis was utilized to determine time to onset of asthma. Multivariable Cox regression analysis was performed to assess the relationship between age at natural menopause and asthma after adjusting for covariates.</p><p><strong>Results: </strong>The multivariable Cox regression analysis showed a 30% decreased risk of asthma in women with age at natural menopause of 40-44 yr compared with age at natural menopause of 50-54 yr with a hazard ratio of 0.7 (95% confidence interval: 0.49-0.95).</p><p><strong>Conclusions: </strong>Women with later ages at natural menopause may be at increased risk for asthma.</p>","PeriodicalId":18435,"journal":{"name":"Menopause: The Journal of The North American Menopause Society","volume":" ","pages":"1069-1077"},"PeriodicalIF":2.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142522290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of insurance type with unmet need for menopause care in Oregon.","authors":"Maria I Rodriguez, Haley Burns, Kaitlin Schrote, Sara Cichowski, Karen Adams","doi":"10.1097/GME.0000000000002437","DOIUrl":"10.1097/GME.0000000000002437","url":null,"abstract":"<p><strong>Objective: </strong>To determine unmet need for menopause care in Oregon and evaluate if insurance type is associated with receipt of care.</p><p><strong>Methods: </strong>We conducted a cross-sectional survey of patients using an Oregon Listserv. Our primary outcome was use of medication for the treatment of moderate or severe symptoms of menopause. We used the Menopause Rating Scale to evaluate respondents' symptoms: 0-4 none or little symptoms; 5-8 mild symptoms; 9-16 moderate symptoms; and 17+ severe symptoms. We abstracted demographic and clinical information including age, rurality, race, ethnicity, primary language, and insurance type. We used a regression model to determine the association between public insurance and treatment for moderate to severe menopause symptoms. We examined reasons for nonuse of therapy.</p><p><strong>Results: </strong>Our sample included 845 perimenopausal or postmenopausal individuals who were predominantly White (93.0%), aged 45-49 (32.8%) or 50-54 years (39.1%), and privately insured (81.3%). Overall, 62.4% of individuals with moderate and severe symptoms of menopause were not receiving any therapy. After adjustment for age and rurality, public insurance was associated with an average of 47% increased odds of nontreatment for moderate or severe menopause symptoms (adjusted odds ratio: 1.47, 95% CI: 0.99-2.19). The most common reasons for nontreatment in both groups were \"therapy was not recommended by a provider\" (43%) and worries about safety or side effects (40%).</p><p><strong>Conclusions: </strong>Even in well-insured persons, the majority of people with moderate and severe symptoms of menopause are not receiving treatment. People who are publicly insured are more likely to go untreated than privately insured individuals.</p>","PeriodicalId":18435,"journal":{"name":"Menopause: The Journal of The North American Menopause Society","volume":" ","pages":"1062-1068"},"PeriodicalIF":2.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142349744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cinnamon potential in alleviating early postmenopause symptoms: a randomized clinical trial.","authors":"Mansoureh Refaei, Zahra Karami, Farideh Kazemi, Shirin Moradkhani, Seyedeh Zahra Masoumi, Ensieh Jenabi, Mobina Jafari","doi":"10.1097/GME.0000000000002444","DOIUrl":"10.1097/GME.0000000000002444","url":null,"abstract":"<p><strong>Objective: </strong>Menopause is a substantial physical, mental, and emotional transition in a woman's life. Most women suffer symptoms during menopause, impacting their quality of life for a decade or more. This study aimed to determine the effect of cinnamon on the severity of postmenopause symptoms.</p><p><strong>Methods: </strong>A randomized, triple-blind, parallel clinical trial was conducted on 60 postmenopausal women in the health centers of Hamadan, Iran. The study included women aged 45 to 60 years who were 1 to 3 years after their last menstrual period. The participants were assigned to two groups using a permuted block randomization method. The intervention group received a daily dose of one cinnamon capsule (1 g) for 2 months, whereas the control group received a placebo. The participants, researchers, and statistical analysts were all blinded. The study measured the severity of menopause symptoms using the Menopause Rating Scale before and 2 months later. Data were analyzed using Stata-13 software.</p><p><strong>Results: </strong>Data from 59 individuals were analyzed. The analyses were adjusted for baseline Menopause Rating Scale scores. After the intervention, the severity of menopause symptoms was lower in the intervention group (13.95 ± 4.16) compared to the control group (16.64 ± 4.16) (P = 0.01), with an effect size of 0.65 (95% CI, 0.12-1.17). Additionally, the intervention group had lower scores for psychological symptoms compared to the control group (P = 0.006), with an effect size of 0.74 (95% CI, 0.21-1.27).</p><p><strong>Conclusions: </strong>The consumption of cinnamon in postmenopausal women has been found to improve the severity of menopause symptoms, with a particular emphasis on the psychological domain.</p>","PeriodicalId":18435,"journal":{"name":"Menopause: The Journal of The North American Menopause Society","volume":"31 12","pages":"1078-1084"},"PeriodicalIF":2.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142695647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Natural menopause timing and menopause symptoms among lesbian, bisexual, and heterosexual women in the Nurses' Health Study II.","authors":"Nicole A VanKim, Brittany M Charlton, Isa Berzansky, Nicole D Fields, Brian W Whitcomb, Susan E Hankinson, Lynnette Leidy Sievert, Elizabeth R Bertone-Johnson","doi":"10.1097/GME.0000000000002442","DOIUrl":"10.1097/GME.0000000000002442","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to examine sexual orientation differences in natural menopause timing and symptoms between lesbian and bisexual women compared with heterosexual women.</p><p><strong>Methods: </strong>We used longitudinal questionnaire data (1989-2015) from 92,314 women (858 lesbian, 375 bisexual) in the Nurses' Health Study II cohort. Women were 24-44 yr old at baseline and biennially reported their menopause status, including reasons for cessation of menstrual periods. In 2009 and 2013, women reported on their experience of hot flashes and night sweats. Covariates included age, age at menarche, body mass index, smoking, and parity. Sexual orientation was reported in 1995 and 2009.</p><p><strong>Results: </strong>Age-adjusted Cox models and logistic regression models suggest that there were no statistically significant differences in menopause timing between lesbian or bisexual women when compared with heterosexual women. When examining menopause symptoms, lesbian women consistently had a statistically significantly (P < 0.05) higher odds of experiencing hot flashes or night sweats (odds ratio range: 1.17 to 1.72) and moderate/severe symptoms (OR range: 1.26 to 1.77) than heterosexual women, even after adjusting for covariates such as smoking and obesity. There were no statistically significant differences in menopause symptoms between bisexual and heterosexual women.</p><p><strong>Conclusions: </strong>Our findings suggest no meaningful difference in menopause timing between sexual minority and heterosexual women. Additionally, menopause symptoms were more likely among lesbian women and warrants additional study.</p>","PeriodicalId":18435,"journal":{"name":"Menopause: The Journal of The North American Menopause Society","volume":"31 12","pages":"1049-1054"},"PeriodicalIF":2.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11681838/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142695629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postmenopausal dyspareunia.","authors":"Lauren Streicher","doi":"10.1097/GME.0000000000002438","DOIUrl":"10.1097/GME.0000000000002438","url":null,"abstract":"<p><p>Dyspareunia in the postmenopausal woman is often multifactorial and requires a thorough history, a targeted physical examination, and coordination of multiple disciplines, including medical professionals, pelvic floor physical therapists, and sex therapists. Although we have come a long way since early assessments of painful sex, evaluation and treatment of dyspareunia remain an unmet need. This is particularly true in postmenopausal women in whom it is commonly assumed that pain with penetrative sex is solely a consequence of atrophy.</p>","PeriodicalId":18435,"journal":{"name":"Menopause: The Journal of The North American Menopause Society","volume":" ","pages":"1087-1089"},"PeriodicalIF":2.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142503474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vaginal microbiota, menopause, and the use of menopausal hormone therapy: a cross-sectional, pilot study in Chinese women.","authors":"Yibing Lan, Bihui Jin, Yue Zhang, Yizhou Huang, Zhou Luo, Chang Su, Jingjing Li, Linjuan Ma, Jianhong Zhou","doi":"10.1097/GME.0000000000002432","DOIUrl":"10.1097/GME.0000000000002432","url":null,"abstract":"<p><strong>Objective: </strong>To compare the vaginal microbiota of premenopausal and postmenopausal women and postmenopausal women undergoing menopausal hormone therapy (MHT) and examine the association between vaginal microbiota and genitourinary syndrome of menopause (GSM).</p><p><strong>Methods: </strong>This cross-sectional study classified 94 women aged 40 to 60 years into three groups: premenopausal (Pre, n = 32), postmenopausal (Post, n = 30), and postmenopausal women who received MHT orally (Post + MHT, n = 32). Neither the Pre nor the Post group received hormone therapy within the past 6 months. Postmenopausal women who received vaginal MHT were not included. Vaginal swabs were obtained, and microbial composition was characterized by 16S rRNA gene sequencing targeting the V3 to V4 region. Clinical data were collected and serum sex hormones were measured. The most bothersome symptom approach and vaginal health index were used to evaluate GSM. Mann-Whitney U or Kruskal-Wallis ANOVA followed by multiple comparison tests were performed for comparison between or across groups. The correlations between GSM symptom scores and vaginal microbiota were determined using Spearman's correlation analysis.</p><p><strong>Results: </strong>The vaginal community of postmenopausal women was characterized by a decreased abundance of Lactobacillus (Post 18% vs Pre 69%); an increased abundance of several anaerobic bacteria, including Prevotella , Escherichia-Shigella , and Bifidobacterium ; and a higher microbial diversity ( P < 0.001 for Shannon and Simpson indexes) than those of premenopausal women. The vaginal community of postmenopausal women who received MHT had an increased abundance of Lactobacillus (54%) and lower microbial diversity ( P < 0.001 for Shannon and Simpson indexes) than the postmenopausal women. The vaginal microbial community composition of the Pre group shared more similarity with that of the Post + MHT group (Adonis P = 0.051) than with that of the Post group (Adonis P < 0.001). A decreased abundance of Lactobacillus and high diversity in the vaginal community were found in women with moderate to severe GSM symptoms.</p><p><strong>Conclusions: </strong>Among Chinese postmenopausal women, those receiving MHT had higher Lactobacillus abundance but lower abundance of diverse anaerobes and diversity of the vaginal microbial community compared to non-MHT women. MHT in postmenopausal women may potentially contribute to reestablishing vaginal microbiota homeostasis. Findings in this pilot study, however, need to be examined in larger, prospective studies.</p>","PeriodicalId":18435,"journal":{"name":"Menopause: The Journal of The North American Menopause Society","volume":" ","pages":"1014-1023"},"PeriodicalIF":2.8,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142126156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}