在激素治疗方案中使用含黄体酮的宫内系统：数据是什么？

IF 3 3区医学 Q1 OBSTETRICS & GYNECOLOGY

Menopause: The Journal of The North American Menopause Society Pub Date : 2025-09-16 DOI:10.1097/GME.0000000000002672

Amy J Voedisch

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引用次数: 0

摘要

左炔诺孕酮宫内系统（IUS）常用于围绝经期避孕和止血，在围绝经期和绝经期均用于子宫内膜保护，同时使用雌激素治疗来控制令人烦恼的更年期症状。作为激素治疗的一部分，使用IUS来保护子宫内膜在美国是禁用的，但在100多个国家被批准使用长达5年。一些iu已被批准用于8年的避孕，但如果与雌激素治疗联合使用超过5年，它们是否能提供足够的子宫内膜保护仍是一个问题。

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Use of progestin-containing intrauterine systems in hormone therapy regimens: what are the data?

The levonorgestrel intrauterine system (IUS) is frequently used in perimenopause for contraception and bleeding control and in both perimenopause and menopause for endometrial protection while using estrogen therapy to control bothersome menopause symptoms. The use of an IUS for endometrial protection as part of hormone therapy is off label in the United States but is approved for use in more than 100 countries for up to 5 years. Some IUSs have been approved for contraceptive use for 8 years, and questions remain whether they provide adequate endometrial protection when combined with estrogen therapy beyond 5 years of use.

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来源期刊

Menopause: The Journal of The North American Menopause Society 医学-妇产科学

CiteScore

5.40

自引率

7.40%

发文量

330

审稿时长

3-8 weeks

期刊介绍： Menopause, published monthly, provides a forum for new research, applied basic science, and clinical guidelines on all aspects of menopause. The scope and usefulness of the journal extend beyond gynecology, encompassing many varied biomedical areas, including internal medicine, family practice, medical subspecialties such as cardiology and geriatrics, epidemiology, pathology, sociology, psychology, anthropology, and pharmacology. This forum is essential to help integrate these areas, highlight needs for future research, and enhance health care.