Menopause: The Journal of The North American Menopause Society最新文献

{"title":"Letter: depressive symptoms in women with premature ovarian insufficiency (POI): a cross-sectional observational study.","authors":"Zheru Ye","doi":"10.1097/GME.0000000000002811","DOIUrl":"10.1097/GME.0000000000002811","url":null,"abstract":"","PeriodicalId":18435,"journal":{"name":"Menopause: The Journal of The North American Menopause Society","volume":"33 8","pages":"946"},"PeriodicalIF":3.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148579213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vaginal estrogen therapy utilization and associated outcomes in younger survivors of endometrial cancer.","authors":"Christine D Hsu, Xiaoying Yu, Gwyn Richardson, Yong-Fang Kuo, Fangjian Guo, Victor Adekanmbi, Thao N Hoang, Pranay Sharma, Abbey B Berenson","doi":"10.1097/GME.0000000000002747","DOIUrl":"10.1097/GME.0000000000002747","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the utilization of vaginal estrogen therapy (ET) and outcomes associated with its use among younger endometrial cancer survivors, using a propensity score-matched cohort.</p><p><strong>Methods: </strong>We conducted a cohort study using data from the TriNetX database's US Collaborative Network, which includes electronic health records and insurance claims data from 68 health care organizations. Women 18-51 years old diagnosed with endometrial cancer between November 1, 2005, and December 31, 2023, were included. We used 1:1 propensity score matching to create cohorts with and without vaginal ET in the year after their endometrial cancer diagnosis. We estimated hazard ratios (HRs) with 95% CIs for the primary outcome of endometrial cancer recurrence and assessed the risks of negative control outcomes.</p><p><strong>Results: </strong>We identified 1,412 endometrial cancer survivors with vaginal ET and 23,859 without vaginal ET. After propensity score matching, the vaginal ET and non-ET groups included 1,412 individuals each. The mean ET treatment duration was 1.88 years (SD, 0.36 y). Endometrial cancer recurrence risk was not increased among those with vaginal ET use (HR, 0.87; 95% CI, 0.60-1.27).</p><p><strong>Conclusions: </strong>Endometrial cancer survivors with short-term exposure to vaginal ET did not have an elevated risk of endometrial cancer recurrence compared with those without vaginal ET.</p>","PeriodicalId":18435,"journal":{"name":"Menopause: The Journal of The North American Menopause Society","volume":" ","pages":"865-871"},"PeriodicalIF":3.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147344609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hormone therapy use and cancer survivorship.","authors":"Monica Christmas","doi":"10.1097/GME.0000000000002869","DOIUrl":"10.1097/GME.0000000000002869","url":null,"abstract":"","PeriodicalId":18435,"journal":{"name":"Menopause: The Journal of The North American Menopause Society","volume":"33 8","pages":"932-934"},"PeriodicalIF":3.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13395264/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148579065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of GS1-144, a novel neurokinin 3 receptor antagonist, for moderate-to-severe vasomotor symptoms associated with menopause in Chinese women: a randomized, double-blind, placebo-controlled phase 2 trial.","authors":"Yaping Wang, Xuefeng Wang, Wei Wang, Jiajing Lin, Yao He, Hua Chen, Huafeng Shou, Xiaoyan Ai, Qinghua Zhang, Yiling Cai, Yinglan Wu, Ruixia Guo, Lina Hu, Haijun Chen, Wei Xiang, Chao Pan, Qi Yu","doi":"10.1097/GME.0000000000002748","DOIUrl":"10.1097/GME.0000000000002748","url":null,"abstract":"<p><strong>Objective: </strong>This multicenter, randomised, double-blind, placebo-controlled, phase 2 trial investigated the efficacy and safety of the selective neurokinin 3 receptor (NK3R) antagonist GS1-144 for moderate-to-severe vasomotor symptoms (VMS).</p><p><strong>Methods: </strong>Eligible participants aged between 40 and 64 years randomly (1:1:1:1) received GS1-144 30 mg once daily (QD), 60 mg QD, or 30 mg twice daily (BID) and placebo for 12 weeks. Co-primary endpoints were the mean change in the frequency and severity of moderate-to-severe VMS from baseline to weeks 4 and 12.</p><p><strong>Results: </strong>Among 276 randomized participants, 271 (98.2%) and 258 (93.5%) completed 4 and 12 weeks of treatment, respectively. VMS frequency was significantly reduced versus placebo for GS1-144 30 mg BID at week 4 (difference in change in least squares mean -1.31 [90% CI: -2.35 to -0.26], P =0.04) and week 12 (-1.41 [-2.28 to -0.54], P =0.008), and for GS1-144 60 mg QD at week 12 (-1.42 [-2.28 to 0.55], P =0.007). GS1-144 30 mg BID and 60 mg QD significantly reduced VMS severity versus placebo at week 4 (-0.14 [-0.26 to -0.01], P =0.07; -0.13 [-0.26 to -0.01], P =0.07) and week 12 (-0.24 [-0.43 to -0.05], P =0.04; -0.19 [-0.38 to 0.00], P =0.098). Treatment-emergent adverse events occurred in 67.6% (140/207) of participants who received GS1-144 and 62.3% (43/69) in the placebo group. No liver safety risks were observed with GS1-144.</p><p><strong>Conclusions: </strong>GS1-144 is well tolerated and significantly reduces VMS frequency and severity in postmenopausal Chinese women.</p>","PeriodicalId":18435,"journal":{"name":"Menopause: The Journal of The North American Menopause Society","volume":" ","pages":"879-889"},"PeriodicalIF":3.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13395265/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147675001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perimenopause and menopause in the military: a scoping review.","authors":"Laura M Segovia, Susan Cox, Shannel Matthews, David Garon Bailey, Angela K Phillips, Sarah Huffman","doi":"10.1097/GME.0000000000002750","DOIUrl":"10.1097/GME.0000000000002750","url":null,"abstract":"<p><strong>Importance and objective: </strong>Military service shapes the health and wellness of its members through a complex interplay of factors. These dynamics may influence the perimenopausal and menopausal experiences among military servicemembers. The objective of this scoping review is to identify and analyze literature on perimenopause/menopause in the military, explore geographical differences in menopausal experiences, and highlight knowledge gaps to guide future research studies and policy development.</p><p><strong>Methods: </strong>CINAHL, Embase, PubMed, Scopus, and Web of Science databases were searched from inception until September 2024. The results were reported using PRISMA-ScR.</p><p><strong>Discussion: </strong>Eighteen articles were included in this scoping review. Most studies were conducted in the United States (83%), among veterans (67%), and focused on a variety of outcomes. The major themes addressed in the articles included participant menopausal knowledge, menopausal hormone therapy, experience of menopause, and resources.</p><p><strong>Conclusions: </strong>This scoping review systematically synthesized the evidence to offer a comprehensive overview of perimenopausal and menopausal research in a military context. Several gaps were identified, leading to the establishment of focused priorities for future research.</p>","PeriodicalId":18435,"journal":{"name":"Menopause: The Journal of The North American Menopause Society","volume":" ","pages":"938-945"},"PeriodicalIF":3.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13395266/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147633960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Premature menopause is associated with the development of high blood pressure: a UK Biobank cohort study.","authors":"Vicente Arrarte, Vicente Bertomeu-González, Alberto Cordero, Francisco Sánchez-Ferrer, Cristina Soriano-Maldonado, Juan M Ruiz-Nodar, José M López-Ayala, Diego Cazorla, José A Quesada","doi":"10.1097/GME.0000000000002834","DOIUrl":"https://doi.org/10.1097/GME.0000000000002834","url":null,"abstract":"<p><strong>Objectives: </strong>Hormonal fluctuations during menopause may contribute to an increased risk of hypertension. Evidence of a direct association is not well defined. The objective of this study was to analyze the association between premature (<40 y of age) and early menopause (40-45 y) and the onset of hypertension in the UK Biobank database.</p><p><strong>Methods: </strong>A prospective observational cohort study was conducted in postmenopausal women in the UK Biobank database. Enrollment was between 2006 and 2010, with follow-up until the end of 2023. The outcome variable was the diagnosis of hypertension during follow-up. Lifestyle behaviors, comorbidities, and laboratory tests were collected. Survival models with Weibull distribution were fitted to the time of onset of hypertension.</p><p><strong>Results: </strong>Of a total of 107,836 women with a mean follow-up of 14.5 years, 18,508 cases of hypertension were observed (17.2%). The cumulative incidence increased with earlier menopause onset: 16.6% in normal menopause, 18.8% in early menopause, and 22.6% in premature menopause (χ2 test, P<0.001). Incidence of hypertension was higher in women with surgical menopause, but there was no association in the multivariate model. The effect of premature menopause was maintained in the multivariate model, with a 12.3% higher risk of developing hypertension.</p><p><strong>Conclusions: </strong>Premature menopause had a significant effect on the development of hypertension during follow-up. Surgical menopause did not have a significant, independent effect.</p>","PeriodicalId":18435,"journal":{"name":"Menopause: The Journal of The North American Menopause Society","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148604912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The integration of migraine and sleep disturbance in perimenopause: a narrative review.","authors":"Roberta Heale, Christie Tait","doi":"10.1097/GME.0000000000002863","DOIUrl":"https://doi.org/10.1097/GME.0000000000002863","url":null,"abstract":"<p><strong>Importance and objective: </strong>This narrative review examines the intersection of migraine and sleep disturbances during perimenopause. Although hormone fluctuations exacerbate both conditions, clinical guidelines for their coordinated management are lacking. This review explores the impact of perimenopause on these comorbidities, evaluates how treatments for one affect the other, and provides evidence-based recommendations for integrated care.</p><p><strong>Methods: </strong>A search for full-text studies and clinical guidelines written in English was undertaken. The search included PubMed, CINAHL (EBSCOhost), Google Scholar, and ProQuest Nursing and Allied Health from 2015 to 2025. Manual extraction of research articles from review articles and foundational physiology was also undertaken expanding the years from 2003.</p><p><strong>Discussion and conclusion: </strong>An integrated approach to assessment and monitoring of migraine and sleep disorders during perimenopause, and treatment considerations impacting both conditions can reduce the burden of migraine and improve sleep. Coordination of treatment across both has the potential to improve quality of life of women in perimenopause. Further research is needed to better understand coordinated approaches to this complex interplay.</p>","PeriodicalId":18435,"journal":{"name":"Menopause: The Journal of The North American Menopause Society","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148604967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modeling cardiovascular risk across the menopause transition: a synthetic cohort study.","authors":"Alexandre Vallée","doi":"10.1097/GME.0000000000002851","DOIUrl":"https://doi.org/10.1097/GME.0000000000002851","url":null,"abstract":"<p><strong>Objective: </strong>The menopause transition is associated with adverse cardiometabolic changes, but annualized modeling of menopause-related cardiovascular risk remains limited. We developed a synthetic cohort framework to simulate menopause transition, risk-factor trajectories, menopausal hormone therapy (MHT) use, and atherosclerotic cardiovascular disease (ASCVD) risk over time.</p><p><strong>Methods: </strong>I generated a synthetic cohort of 100,000 women aged 40-79 years without prior ASCVD. Age at natural menopause was assigned using a literature-informed mixture distribution, and menopausal status was defined from age and menopause timing. Systolic blood pressure, total cholesterol, high-density lipoprotein cholesterol, and body mass index were simulated jointly using correlated distributions; smoking, diabetes, antihypertensive treatment, and MHT use were assigned probabilistically. Ten-year ASCVD risk was estimated annually using the published female Pooled Cohort Equation structure. Annual updates included aging, transition to postmenopause, risk-factor changes, diabetes onset, treatment changes, and competing non-cardiovascular disease (non-CVD) mortality.</p><p><strong>Results: </strong>At baseline, the mean age was 55.0 ± 7.6 years, and 33.4% of women were premenopausal. Mean predicted 10-year ASCVD risk was 1.18% in premenopausal women and 4.35% in postmenopausal women; the proportion above the 7.5% high-risk threshold was 0.20% and 13.73%, respectively. Over 10 years, the model generated 4,891 first ASCVD events (4.89%) and 11,046 non-CVD deaths (11.05%). ASCVD incidence was 1.56% among premenopausal women at baseline and 6.56% among those postmenopausal at baseline.</p><p><strong>Conclusion: </strong>This synthetic cohort provides a transparent framework for simulating menopause-related cardiovascular risk trajectories and prevention scenarios.</p>","PeriodicalId":18435,"journal":{"name":"Menopause: The Journal of The North American Menopause Society","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148604966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Menopause education in undergraduate medical curricula: a narrative review of teaching models, content gaps, and learner preparedness.","authors":"Rhianna Bhatia, Sarah Baker, Peggy Drecker, Kanchi Chadha","doi":"10.1097/GME.0000000000002845","DOIUrl":"https://doi.org/10.1097/GME.0000000000002845","url":null,"abstract":"<p><strong>Importance and objective: </strong>Menopause accounts for approximately one-third of a woman's lifetime and requires competent counseling and longitudinal management by physicians across specialties. Although menopause education has received increasing attention in graduate medical education, the quality of menopause teaching in undergraduate medical education remains unclear. This narrative review aimed to characterize the current state of menopause education in undergraduate medical curricula and identify deficiencies in curricular structure, content, and pedagogy. Secondary aims describe learner outcomes and identify opportunities for development of standardized menopause education.</p><p><strong>Methods: </strong>A narrative literature review was conducted to evaluate menopause education for medical students in the United States and internationally. Searches were performed in PubMed/MEDLINE, Scopus, and MedEd Portal, with additional gray literature sources including The American College of Obstetricians and Gynecologists (ACOG) and The Menopause Society. Eligible studies described educational interventions or curricula for medical students or medical trainees with extractable data on medical students, with or without a defined evaluation of the intervention. Study characteristics and outcomes were extracted and synthesized narratively.</p><p><strong>Discussion and conclusions: </strong>The literature search identified 1,305 records, of which 12 studies met inclusion criteria. Menopause education was inconsistently incorporated into undergraduate medical curricula and often embedded within broader primary care teaching rather than delivered as structured content. Although students generally demonstrated accurate recognition of menopausal symptoms, many showed gaps in management and counseling skills. Menopause education in undergraduate medical curricula is inconsistently delivered and lacks standardization. Development of a structured, competency-based menopause curriculum for undergraduate medical education may improve learner preparedness to better care for menopause patients.</p>","PeriodicalId":18435,"journal":{"name":"Menopause: The Journal of The North American Menopause Society","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148604932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Translation, cross-cultural adaptation, and validation of the Thai version of the Hot Flash-related Daily Interference Scale (Thai HFRDIS).","authors":"Chanakan Youkhong, Kitti Chattrakulchai, Orawin Vallibhakara, Sakda Arj-Ong Vallibhakara, Pimpun Prasanchit, Chatchawan Silpakit, Jittima Manonai","doi":"10.1097/GME.0000000000002862","DOIUrl":"https://doi.org/10.1097/GME.0000000000002862","url":null,"abstract":"<p><strong>Objective: </strong>To translate, culturally adapt, and validate the Thai Hot Flash-related Daily Interference Scale for assessing interference from vasomotor symptoms.</p><p><strong>Methods: </strong>In this cross-sectional psychometric validation study, the Hot Flash-related Daily Interference Scale was translated using forward-backward translation, expert review, and cognitive debriefing. Women in the menopause transition or postmenopause at the menopause clinic in Bangkok completed the Thai Hot Flash-related Daily Interference Scale, the Thai Menopause Rating Scale, and the Thai Menopause-Specific Quality of Life questionnaire. Psychometric evaluation included content validity, structural validity, internal consistency, test-retest reliability using the intraclass correlation coefficient, construct validity evidence, floor and ceiling effects, and exploratory receiver operating characteristic analyses to support score interpretation.</p><p><strong>Results: </strong>Of 336 enrolled women, 330 were analyzed (164 symptomatic and 166 asymptomatic controls). Content validity was high (scale-level content validity index=0.960). Reliability was excellent (Cronbach's alpha=0.963; intraclass correlation coefficient=0.981; 95% CI: 0.971-0.987). Factor analyses supported a predominantly unidimensional structure. Construct validity evidence was supported by a strong correlation with the vasomotor domain of the Thai Menopause-Specific Quality of Life Questionnaire (Spearman's correlation coefficient=0.716; P<0.001) and by known-groups differences between symptomatic and asymptomatic women (mean, 3.67 vs. 0.43; P<0.001). In exploratory supplementary analyses, scale scores showed good discrimination between Menopause Rating Scale-defined symptom-burden groups.</p><p><strong>Conclusion: </strong>The Thai Hot Flash-related Daily Interference Scale demonstrated reliability and validity and provides a brief measure of vasomotor symptom-related interference for Thai-speaking women in clinical practice and research.</p>","PeriodicalId":18435,"journal":{"name":"Menopause: The Journal of The North American Menopause Society","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148604999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}