Medicine and Science in Sports and Exercise最新文献

{"title":"Associations Between Walking Pace, APOE-ε4 Genotype, and Brain Health in Middle-Aged to Older Adults.","authors":"Daniel H Aslan, M Katherine Sayre, Pradyumna K Bharadwaj, Madeline Ally, Silvio Maltagliati, Mark H C Lai, Rand R Wilcox, Yann C Klimentidis, Gene E Alexander, David A Raichlen","doi":"10.1249/MSS.0000000000003646","DOIUrl":"10.1249/MSS.0000000000003646","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to investigate whether self-reported walking pace (a marker of physical function) and the presence of APOE-ε4 allele interact to modify brain health outcomes.</p><p><strong>Methods: </strong>We used data from a prospective cohort study of middle-aged to older adults from the UK Biobank who self-reported walking pace (slow or steady-to-brisk) and who were initially free of dementia ( n = 415,110). Incident all-cause dementia was obtained from hospital and death registry records, and structural brain volumes (right and left hippocampus volumes, total gray matter volume, and volume of white matter hyperintensities) were measured from a subset of participants ( n = 33,113). Cox proportional hazard models and generalized linear models were used to assess associations between exposures and outcomes.</p><p><strong>Results: </strong>Slow walking pace and the presence of APOE-ε4 allele were associated with increased dementia risk (HR = 1.79 [95% CI = 1.66-1.93], P < 0.001; HR = 3.06 [2.90-3.23], P < 0.001, respectively), and there was an interaction between these associations, indicating that the association of walking pace with dementia risk is modified by APOE-ε4 status (reference group: HR Steady-Brisk/APOE-ε4- = 1; HR Slow/APOE-ε4- = 2.03 [1.84-2.25], P < 0.001; HR Steady-Brisk/APOE-ε4+ = 3.21 [3.02-3.41], P < 0.001; HR Slow/APOE-ε4+ = 4.99 [4.48-5.58], P < 0.001). Slow self-reported walking pace was associated with worse brain volume outcomes, and these associations were not modified by APOE-ε4 genotype.</p><p><strong>Conclusions: </strong>These results suggest walking pace and APOE-ε4 status independently influence brain volume outcomes, but both factors independently and jointly contribute to increased dementia risk. Individuals with both risk factors (slow walking pace and APOE-ε4 allele) show the strongest associations with dementia risk.</p>","PeriodicalId":18426,"journal":{"name":"Medicine and Science in Sports and Exercise","volume":" ","pages":"1212-1220"},"PeriodicalIF":4.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142950944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physical Activity Patterns and Variability, Cognitive Performance, and Dementia in the National Health and Aging Trends Study.","authors":"Anis Davoudi, Patrick T Donahue, Michelle C Carlson, Ryan J Dougherty, Amal A Wanigatunga, Vicki A Freedman, Jennifer A Schrack","doi":"10.1249/MSS.0000000000003656","DOIUrl":"10.1249/MSS.0000000000003656","url":null,"abstract":"<p><strong>Introduction: </strong>Physical activity is a modifiable risk factor for dementia. However, the potential reverse effect of adverse cognitive change on physical activity remains underexplored.</p><p><strong>Methods: </strong>Cross-sectional analysis of a subset of National Health and Aging Trends Study (NHATS; N = 706) U.S. Medicare beneficiaries. Dementia status (dementia vs. no dementia) was classified per NHATS protocol. Cognitive performance was assessed in executive function, orientation, and memory domains. Daily physical activity was assessed using wrist-worn accelerometers (Actigraph Insight).</p><p><strong>Results: </strong>Compared with participants living without dementia, participants living with dementia had lower daily activity counts (×1000) (-319.3; 95% confidence interval (CI), -471.0 - -167.5), lower activity intensity (-1129.2 maximum counts per day; 95% CI, -1518.4 - -740.0 counts per day), less time spent active (64.3 min/day; 95% CI, 28.1-100.4 min/day), and more fragmented patterns of activity (6.1%; 95% CI, 3.0%-9.2%). One-unit higher cognitive performance in executive function was associated with higher daily activity counts (×1000) (67.9; 95% CI, 19.7-116.0), higher activity intensity (375.4; 95% CI, 232.0-518.7), more time spent active (12.4 min; 95% CI, 2.1-22.7 min), and lower fragmentation (-1.4%; 95% CI, -2.2% - -0.5%). One-unit higher orientation score was associated with higher daily activity counts (×1000) (61.0; 95% CI, 31.9-90.0), higher activity intensity (266.6; 95% CI, 197.9-335.2), more time spent active (11.6 min; 95% CI, 5.2-18.0 more active minutes), greater stability of daily activities (1.1; 95% CI, 0.3-1.9), and lower fragmentation (-1.2%; 95% CI, -1.7% - -0.7%). One-unit higher memory score was associated with higher daily activity counts (×1000) (28.1; 95% CI, 15.0-41.2), higher activity intensity (113.5; 95% CI, 77.0-150.1), and more time spent active (5.2 min; 95% CI, 2.4-8.0 min), as well as lower fragmentation (-0.5%; 95% CI, -0.7% - -0.3%).</p><p><strong>Conclusions: </strong>In a nationally representative sample of older US adults, dementia and lower cognitive performance were associated with lower volume and intensity of daily physical activity, as well as more fragmented and less consistent patterns of physical activity. These associations emphasize the need for considering the impact of cognition on individuals' ability to engage in and maintain regular physical activity and suggest shifts in daily quantities and patterns of activity consistent with cognitive decline and dementia.</p>","PeriodicalId":18426,"journal":{"name":"Medicine and Science in Sports and Exercise","volume":" ","pages":"1221-1228"},"PeriodicalIF":4.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143492718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute Effects of a Single Bout of Strength and Endurance Exercise on Vitamin D Metabolites in Young Adults.","authors":"Mats Peder Mosti, Norun Aagård, Astrid Kamilla Stunes, Cathrine Langlie Brobakken, Martin Siksjø Brevig, Miriam K Gustafsson, Per Medbøe Thorsby, Eivind Wang, Unni Syversen","doi":"10.1249/MSS.0000000000003658","DOIUrl":"10.1249/MSS.0000000000003658","url":null,"abstract":"<p><strong>Purpose: </strong>The effect of exercise on serum concentration of vitamin D metabolites remains inconclusive, with studies reporting deviating results. This study evaluated the acute effect of a single session of two specific exercise forms; strength training (ST) and high-intensity interval training (HIIT), on circulating 25-hydroxyvitamin D (25(OH)D), free 25(OH)D and 1,25-dihydroxyvitamin D (1,25(OH) 2 D), and skeletal muscle vitamin D receptor (VDR) gene expression, in healthy adults.</p><p><strong>Methods: </strong>Thirty-nine participants (19 women and 20 men, aged 21-30 yr) completed a single bout of ST and HIIT exercise, separated by 2 weeks. Serum concentration of total 25(OH)D, free 25(OH)D and 1,25(OH) 2 D were assessed before exercise, immediately after, and 3 and 24 h after each session. Muscle biopsies were obtained at rest (first visit), and at 3 and 24 h post ST and HIIT, and analyzed for VDR gene expression. Repeated-measures ANOVA was used to assess serum concentration across time, whereas a one-way ANOVA was used for muscle VDR gene expression analyses.</p><p><strong>Results: </strong>Serum concentration of 25(OH)D or free 25(OH)D did not change after either exercise mode when correcting for plasma volume alterations. 1,25(OH) 2 D was reduced by 13.1 ± 18.3 pmol·L -1 and 7.1 ± 9.6 pmol·L -1 immediately after ST and HIIT, respectively ( P < 0.001). Muscle VDR mRNA expression increased after ST by 3.1 ± 1.8 (3 h) and 2.2 ± 1.7 (24 h) fold change ( P < 0.05).</p><p><strong>Conclusions: </strong>One single session of ST or HIIT did not alter serum concentration of 25(OH)D and free 25(OH)D when correcting for plasma volume changes. Both exercise modes caused a transient reduction in 1,25(OH) 2 D suggesting utilization of 1,25(OH) 2 D by muscle cells after exercise. Elevated VDR gene expression after ST suggests a functional role of VDR in fast-twitch muscle fibers.</p>","PeriodicalId":18426,"journal":{"name":"Medicine and Science in Sports and Exercise","volume":" ","pages":"1189-1201"},"PeriodicalIF":4.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143033431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validity of A-Mode Ultrasound for Estimating Body Fat Percentage of Young Adult Athletes: A Multicomponent Model Study.","authors":"Dale R Wagner, Elizabeth A Cafferty, Sara A Harper, Michael N Vakula","doi":"10.1249/MSS.0000000000003651","DOIUrl":"10.1249/MSS.0000000000003651","url":null,"abstract":"<p><strong>Purpose: </strong>This study compared %BF US with %BF 4C in young adult athletes.</p><p><strong>Methods: </strong>University club sport athletes (86 women, 138 men) from a variety of teams participated. ADP, DXA, and bioimpedance spectroscopy were used to measure body volume, bone mineral content, and total body water, respectively, for the 4C model. Ultrasound measurements were taken at three sites to estimate %BF US . Comparisons between %BF US and %BF 4C were evaluated with Pearson correlation, paired t -test, linear regression, equivalence testing, and plots of individual errors.</p><p><strong>Results: </strong>For the combined sample of men and women ( N = 224), the two methods were highly correlated ( r = 0.93) with a constant error (CE) of 0.8% BF ( P < 0.001) and standard error of estimate (SEE) of 3.0% BF. The 90% confidence intervals of the mean difference (0.47 to 1.17) were well within the ±2% BF limits for equivalence testing, and no bias was evident from the error plot. However, equivalence testing failed to remain inside the ±2% BF range for women, and the prediction errors for women (CE = 1.9% BF, P < 0.001, SEE = 3.2% BF) were larger than for men (CE = 0.1% BF, P = 0.597, SEE = 2.8% BF).</p><p><strong>Conclusions: </strong>Overall, the %BF US errors were low, suggesting that A-mode ultrasound is a valid field measure of %BF for young adult athletes. Accuracy is better for men than women.</p>","PeriodicalId":18426,"journal":{"name":"Medicine and Science in Sports and Exercise","volume":" ","pages":"1239-1245"},"PeriodicalIF":4.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142984067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genome-Wide Association Study on Muscle Stiffness Identified Novel Locus for Predisposition to Muscle Strain Injury.","authors":"Eri Miyamoto-Mikami, Hirofumi Zempo, Hiroshi Kumagai, Kosuke Hirata, Mizuki Takaragawa, Toshinori Yoshihara, Mizuho Fuku, Naoki Kikuchi, Nobuhiro Kamiya, Naokazu Miyamoto, Noriyuki Fuku","doi":"10.1249/MSS.0000000000003661","DOIUrl":"10.1249/MSS.0000000000003661","url":null,"abstract":"<p><strong>Purpose: </strong>We aimed to screen the entire genome for genetic variants associated with passive muscle stiffness, which has been suggested as a risk factor for muscle strain injury.</p><p><strong>Methods: </strong>This genome-wide association study (GWAS) on passive muscle stiffness included 350 physically active young Japanese individuals. Three hamstring constituents were measured using ultrasound shear wave elastography. Skeletal muscle transcriptomes were compared across the genotypes of GWAS-identified variants in 48 healthy Japanese individuals. Association between GWAS-identified variants and history of muscle strain injury was examined in 1428 Japanese athletes.</p><p><strong>Results: </strong>Two loci on chromosome 11 demonstrated a genome-wide significant association with passive muscle stiffness of the biceps femoris long head (rs12807854 T/C: P = 5.19 × 10 -10 , rs78405694 T/C: P = 2.09 × 10 -8 ; linear regression analysis adjusted for sex, age, and stretching exercise habits). Skeletal muscle RNA sequencing revealed significantly elevated expression of extracellular matrix-related genes in muscles carrying stiffness-increasing alleles of these variants. Among athletes, rs12807854 T/C was significantly associated with a history of muscle strain injury ( P = 0.0254; logistic regression analysis adjusted for age, sex, competitive level, and main sport). Carriers of the C allele, associated with increased muscle stiffness, exhibited a heightened risk of muscle strain injury (odds ratio = 1.62; 95% confidence interval = 1.06-2.47 per C allele increase). By contrast, rs78405694 did not show a significant association with muscle strain injury in this population.</p><p><strong>Conclusions: </strong>A novel locus associated with passive muscle stiffness and muscle strain injury was identified. Elucidating the detailed mechanisms linking the identified locus to passive muscle stiffness may lead to the development of new strategies to prevent muscle strain injuries.</p>","PeriodicalId":18426,"journal":{"name":"Medicine and Science in Sports and Exercise","volume":" ","pages":"1202-1211"},"PeriodicalIF":4.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143188880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Toward the Limits of Human Aging Physiology: Characteristics of the 50-, 60-, and 70-yr+ Male Indoor Rowing World Champions.","authors":"Lorcan S Daly","doi":"10.1249/MSS.0000000000003657","DOIUrl":"10.1249/MSS.0000000000003657","url":null,"abstract":"<p><strong>Purpose: </strong>To examine the physiological, power-duration, nutritional intake and training characteristics of the recent lightweight (- 75 kg) 50+-, 60+-, and 70-yr+ world champion indoor rowers.</p><p><strong>Methods: </strong>Laboratory assessments, undertaken over two visits, examined body composition, pulmonary function, blood lactate/ventilatory landmarks, efficiency, fat/carbohydrate oxidation, primary component time-constant to steady state (τ pc ), and peak oxygen consumption (V̇O 2peak ). Training, performance, and nutritional intake were also reported.</p><p><strong>Results: </strong>The athletes' world championship 2000 m times were 06:34.8, 06:44.0, and 07:15.2, respectively. Their training distribution could be considered pyramidal, with ≈65% in the moderate domain, ≈30% in heavy/severe domains, and ≈5% in the extreme domain (rowing ≈67 km·wk -1 ). The athletes demonstrated highly developed attributes such as fat-free mass (63.4-68.1 kg), forced vital capacity (4.9-5.5 L), τ PC (13.8-17.4 s), peak power output (550-797 W), V̇O 2peak (56.2-44.7 mL·kg·min -1 ), and critical power (217-288 W). Comparisons with young Olympic champion rowers suggest that age-related 2000-m performance mean power declines of -21.6% to -41.4% in world champions ≈25, 35, and 45 yr older may be predominantly driven by \"central\" factors (e.g., V̇O 2peak , critical power; -18.1% to -43.8%). In contrast, \"peripheral\" factors (e.g., gross efficiency, τPC ; +6.1% to -25.1%) seem to display notable preservation despite aging, aligning closely with values seen in young Olympic champions.</p><p><strong>Conclusions: </strong>These results challenge conventional perspectives of age-related physiological capacities and decline trajectories. They also suggest that, commensurate with adequate training and nutritional provision, various physiologic systems can exhibit remarkable adaptability and sustain exceptionally high function during aging. Finally, large differences among the athletes' power-duration and physiological characteristics imply that achieving world-class rowing performance can be predicated by diverse cardiovascular, metabolic, and neuromuscular attributes.</p>","PeriodicalId":18426,"journal":{"name":"Medicine and Science in Sports and Exercise","volume":" ","pages":"1266-1274"},"PeriodicalIF":4.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143029161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Leisure Physical Activity, Sedentary Behavior, and Cardiovascular Health 2-7 yr after Pregnancy in the nuMoM2b Heart Health Study Cohort.","authors":"Bethany Barone Gibbs, Sarah Modlin, Noel Bairey Merz, David M Haas, Sadiya S Khan, Abbi Lane, Rebecca B McNeil, Jasmina Varagic, Kimberly Huber, Ligia Vasquez-Huot, Janet M Catov","doi":"10.1249/MSS.0000000000003660","DOIUrl":"10.1249/MSS.0000000000003660","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to evaluate whether higher moderate- to vigorous-intensity physical activity (MVPA) and lower sedentary behavior (SB) are related to better cardiovascular health (CVH) after pregnancy.</p><p><strong>Methods: </strong>In the nuMoM2b Heart Health Study cohort, Life's Essential 8 health factors (body mass index [BMI], blood pressure, glucose, and lipids) were assessed in the first trimester of pregnancy and 2-7 yr later ( n = 3985). The four health factors were scored with Life's Essential 8 criteria (0 = poorest; 100 = ideal) and averaged to calculate a CVH health factor score (CVH hf) . Self-reported leisure MVPA and SB were assessed at follow-up. Linear regression evaluated associations of MVPA levels and SB quartiles with follow-up CVH hf after adjustment for first trimester CVH hf and covariates. Analyses were repeated after stratification by history of hypertensive disorders of pregnancy (HDP) or gestational diabetes (GDM).</p><p><strong>Results: </strong>Over follow-up (mean 3.2 yr after delivery), CVH hf declined from 85.6 to 81.6 points (-4.0 points, P < 0.001). The decline was greatest in lipid (-8.4 points, P < 0.001) and BMI scores (-5.6 points, P < 0.001). Healthier activity profiles (higher MVPA level and lower SB quartile) were each associated with higher CVH hf at follow-up: 0.7 points higher per level of MVPA, P < 0.001; 0.5 points lower per quartile of SB, P = 0.0042. Higher MVPA level associated with healthier BMI, glucose, and lipid scores; lower SB quartile associated with healthier BMI and blood pressure scores ( P < 0.05). Although HDP/GDM history was associated with lower CVH hf , patterns of CVH hf across healthier leisure MVPA levels and SB quartiles were similar in those with and without HDP or GDM.</p><p><strong>Conclusions: </strong>Higher MVPA and lower SB during leisure could help to maintain CVH health factors in the years after pregnancy, including among those who experienced HDP or GDM.</p>","PeriodicalId":18426,"journal":{"name":"Medicine and Science in Sports and Exercise","volume":" ","pages":"1229-1238"},"PeriodicalIF":4.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12081195/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143080615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Linear Modeling of the V̇O 2 /PO Relationship during Constant Work Rate Exercise.","authors":"Lena Stuer, Jan Boone, Patrick Mucci, Alessandro L Colosio, Jan G Bourgois, Kevin Caen","doi":"10.1249/MSS.0000000000003647","DOIUrl":"10.1249/MSS.0000000000003647","url":null,"abstract":"<p><strong>Introduction: </strong>The linear and continuous increase in power output (PO) during ramp incremental (RI) exercise causes a distinct V̇O 2 /PO relationship compared with constant work rate (CWR) exercise. Current methods enabling a translation of ramp-derived PO to CWR PO assume a linear development of the CWR V̇O 2 /PO relationship in the heavy-intensity domain. This study aimed to model the RI versus CWR V̇O 2 /PO relationship to investigate whether the loss of mechanical efficiency above GET develops linearly. A second aim was to assess the reliability of ramp-derived parameters incorporated in translation strategies.</p><p><strong>Methods: </strong>Fourteen healthy young participants (7 males; 7 females) performed an RI test and several CWR tests across the heavy- and severe-intensity domains in order to model the RI and CWR V̇O 2 /PO relationships. The CWR relationship was fitted using linear, polynomial, and exponential models. Root mean square error (RMSE) and Akaike information criterion (AIC C ) were determined to evaluate the model's goodness of fit. For reliability purposes, target PO of CWR tests were achieved using a preceding RI portion, similar to the initial RI test.</p><p><strong>Results: </strong>The linear fit of the CWR V̇O 2 /PO relationship was associated with the lowest RMSE and AIC C . The associated R2 for the heavy-intensity domain was 0.94. Reliability measures were excellent for baseline V̇O 2 and acceptable to good for s1-ramp and s2-ramp . For MRT, a high variability was observed.</p><p><strong>Conclusions: </strong>This study confirmed that the CWR V̇O 2 /PO relationship in the heavy-intensity domain is linear. Therefore, these results validate the use of correction strategies that are based on a linear V̇O 2 /PO relationship for translating ramp-derived PO into their CWR equivalents.</p>","PeriodicalId":18426,"journal":{"name":"Medicine and Science in Sports and Exercise","volume":" ","pages":"1275-1283"},"PeriodicalIF":4.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142971614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validity and Reliability of the Tampa Scale for Kinesiophobia for Adolescents with Heart Disease.","authors":"David A White, William R Black, Emily Cramer, Lindsey Malloy-Walton, Mollie Walton, Laura Martis, Brandy Enneking, Kelli M Teson, Jessica S Watson, Jami Gross-Toalson","doi":"10.1249/MSS.0000000000003642","DOIUrl":"10.1249/MSS.0000000000003642","url":null,"abstract":"<p><strong>Purpose: </strong>To assess the validity and reliability of a newly adapted Tampa Scale for KP for adolescents with HD (TSK-Heart-A).</p><p><strong>Methods: </strong>The TSK-Heart-A survey consists of 17 Likert scale items, producing a summary score (SS) ranging from 17 (low KP) to 68 (high KP). Following content and face validity, adolescents (age 12-18 yr) with arrhythmia disorders or Fontan palliation were recruited. The PROMIS pediatric anxiety and depression short forms, Pediatric Quality of Life Inventory (PedsQL) generic core and cardiac module, and a PA questionnaire for adolescents (PAQ-A) were used for criterion validity. The TSK-Heart-A was completed twice (20.4 ± 6.3 days apart) for assessment of internal and test-retest reliability. Pearson correlations and Cronbach's alpha determined validity and reliability, respectively.</p><p><strong>Results: </strong>Adolescents ( n = 63) were 15.5 ± 1.8 yrs old, 50.8% were female, and 69.8% had arrhythmia disorder. Mean TSK-Heart-A SS was 33.8 ± 7.8 (range, 20 to 56). The TSK-Heart-A SS correlated significantly with PROMIS T-scores (anxiety: 49.7 ± 12.2, r = 0.48; depression: 46.9 ± 12.7, r = 0.41), PedsQL score (generic QoL: 75.2 ± 18.9, r = -0.61; cardiac QoL: 74.7 ± 17.5, r = -0.56), and PAQ-A (score: 2.0 ± 0.7, r = -0.35). Test-retest and internal reliability had a total score of r = 0.77 ( P = 0.89).</p><p><strong>Conclusions: </strong>The new TSK-Heart-A survey is valid and reliable and suggests that KP is present in some adolescents with HD.</p>","PeriodicalId":18426,"journal":{"name":"Medicine and Science in Sports and Exercise","volume":" ","pages":"1246-1256"},"PeriodicalIF":4.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142950953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Wearable-Assessed Biomechanical and Physiological Demands during Load Carriage and Tactical Mobility Tasks among Male and Female Military Personnel.","authors":"Evan D Feigel, Ayden McCarthy, Mita Lovalekar, Kristen J Koltun, Matthew B Bird, Brian J Martin, Jennifer N Forse, Elizabeth J Steele, AuraLea C Fain, Jodie A Wills, Tim L A Doyle, Bradley C Nindl","doi":"10.1249/MSS.0000000000003770","DOIUrl":"https://doi.org/10.1249/MSS.0000000000003770","url":null,"abstract":"<p><strong>Purpose: </strong>Load carriage and tactical mobility are military tasks that pose significant risks for musculoskeletal injuries (MSKIs) in military personnel. This investigation compared biomechanical and physiological demands of a load carriage and tactical mobility task and examined their differences between sexes using reliable and validated wearables among United States Marine officer candidates.</p><p><strong>Methods: </strong>Forty-one candidates (16 women) performed a 15.8 km loaded ruck march and a 4.0 km endurance course that assessed load carriage and tactical mobility performance, respectively. Inertial measurement units on the distal tibia and wrist-worn watches collected biomechanical (total step count, impact load, bone stimulus, average intensity, low/medium/high g-step count) and physiological (heart rate (HRmean, HRmin, HRmax), physical activity energy expenditure (PAEE), metabolic equivalent (METmean)) data. Paired sample t-tests compared metrics between events. Principal component (PC) analyses interpreted event demands. Independent samples t-tests analyzed sex differences between PCs (α = 0.05).</p><p><strong>Results: </strong>Impact load (+1259.70 g·min-1, p < 0.001), average intensity (+7.20 g, p < 0.001), bone stimulus (+126.73 A.U., p < 0.001), high-g steps (+559.34 g, p < 0.001), HRmin (+13.15 bpm, p < 0.001), HRmean (+28.79 bpm, p < 0.001), HRmax (+16.95 bpm, p < 0.001), and METmean (-1.93 kcal·kg-1·h-1, p < 0.001) were higher during the endurance course than ruck; step count (-14934, p < 0.001) and PAEE (-713 kcal, p < 0.001) were lower. Three PCs explained 84.3% and 81.5% of variance for the ruck and endurance course. PC1 represented biomechanical variables, PC2 physiological variables, and PC3 g-step count. Sex differences were found in PC2 (p = 0.039) and PC3 (p = 0.002) for ruck, and PC3 (p < 0.01) for endurance course revealing greater demands in women.</p><p><strong>Conclusions: </strong>Tactical mobility requires greater biomechanical and physiological demands than load carriage and places greater demands on women. Task and sex-specific training strategies may improve performance and mitigate MSKI risk.</p>","PeriodicalId":18426,"journal":{"name":"Medicine and Science in Sports and Exercise","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144180880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}