Djahid Kennouche, Clément Foschia, Callum G Brownstein, Julien Gondin, Thomas Lapole, Diana Rimaud, Nicolas Royer, Guillaume Thiery, Vincent Gauthier, Pascal Giraux, Lydia Oujamaa, Marine Sorg, Samuel Vergès, Stéphane Doutreleau, Mathieu Marillier, Mélanie Prudent, Laurent Bitker, Léonard Féasson, Laurent Gergelé, Emeric Stauffer, Céline Guichon, Jérôme Morel, Guillaume Y Millet
{"title":"Covid-19 ICU患者疲劳、心肺健康和神经肌肉功能恢复：6个月随访研究","authors":"Djahid Kennouche, Clément Foschia, Callum G Brownstein, Julien Gondin, Thomas Lapole, Diana Rimaud, Nicolas Royer, Guillaume Thiery, Vincent Gauthier, Pascal Giraux, Lydia Oujamaa, Marine Sorg, Samuel Vergès, Stéphane Doutreleau, Mathieu Marillier, Mélanie Prudent, Laurent Bitker, Léonard Féasson, Laurent Gergelé, Emeric Stauffer, Céline Guichon, Jérôme Morel, Guillaume Y Millet","doi":"10.1249/MSS.0000000000003789","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>Although most patients recover well from Covid-19 infection, this may not be the case of those who experienced severe dysfunction after being admitted to intensive care unit (ICU). This study aimed to assess the recovery of patients who experienced severe multiple dysfunctions after being admitted to intensive care unit (ICU) for Covid-19 infection.</p><p><strong>Methods: </strong>Forty-seven patients hospitalized and mechanically ventilated in ICU for SARS-CoV-2 infection underwent evaluations at 4-8 weeks (T1) and 6 months (T2) post ICU discharge. Evaluations included questionnaires, lung function tests, incremental cardiopulmonary exercise testing, and neuromuscular function tests.</p><p><strong>Results: </strong>From T1 to T2, the percentage of patients classified as fatigued decreased from 56% to 21% whereas forced vital capacity and the forced expiratory volume in one second increased by 13% and 8% (p < 0.05) to reach 93% and 95% of predicted values at T2, respectively. Peak work rate also increased from 97 to 135 W (+35 ± 32%, p < 0.001). Likewise, V̇O2peak increased from 18.3 to 21.6 ml/min/kg (+18 ± 27%, p < 0.001) to reach 72% of predicted values. Maximal strength and the number of contractions during the fatigability test increased between T1 and T2 by 41% and 39%, respectively (both p < 0.001).</p><p><strong>Conclusions: </strong>Six months of recovery improved patients' physical function and reduced fatigue.</p>","PeriodicalId":18426,"journal":{"name":"Medicine and Science in Sports and Exercise","volume":" ","pages":""},"PeriodicalIF":3.9000,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Recovery of Fatigue, Cardiorespiratory Fitness, and Neuromuscular Function in Covid-19 ICU Patients: A 6-Month Follow-Up Study.\",\"authors\":\"Djahid Kennouche, Clément Foschia, Callum G Brownstein, Julien Gondin, Thomas Lapole, Diana Rimaud, Nicolas Royer, Guillaume Thiery, Vincent Gauthier, Pascal Giraux, Lydia Oujamaa, Marine Sorg, Samuel Vergès, Stéphane Doutreleau, Mathieu Marillier, Mélanie Prudent, Laurent Bitker, Léonard Féasson, Laurent Gergelé, Emeric Stauffer, Céline Guichon, Jérôme Morel, Guillaume Y Millet\",\"doi\":\"10.1249/MSS.0000000000003789\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>Although most patients recover well from Covid-19 infection, this may not be the case of those who experienced severe dysfunction after being admitted to intensive care unit (ICU). This study aimed to assess the recovery of patients who experienced severe multiple dysfunctions after being admitted to intensive care unit (ICU) for Covid-19 infection.</p><p><strong>Methods: </strong>Forty-seven patients hospitalized and mechanically ventilated in ICU for SARS-CoV-2 infection underwent evaluations at 4-8 weeks (T1) and 6 months (T2) post ICU discharge. Evaluations included questionnaires, lung function tests, incremental cardiopulmonary exercise testing, and neuromuscular function tests.</p><p><strong>Results: </strong>From T1 to T2, the percentage of patients classified as fatigued decreased from 56% to 21% whereas forced vital capacity and the forced expiratory volume in one second increased by 13% and 8% (p < 0.05) to reach 93% and 95% of predicted values at T2, respectively. Peak work rate also increased from 97 to 135 W (+35 ± 32%, p < 0.001). Likewise, V̇O2peak increased from 18.3 to 21.6 ml/min/kg (+18 ± 27%, p < 0.001) to reach 72% of predicted values. Maximal strength and the number of contractions during the fatigability test increased between T1 and T2 by 41% and 39%, respectively (both p < 0.001).</p><p><strong>Conclusions: </strong>Six months of recovery improved patients' physical function and reduced fatigue.</p>\",\"PeriodicalId\":18426,\"journal\":{\"name\":\"Medicine and Science in Sports and Exercise\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":3.9000,\"publicationDate\":\"2025-06-13\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Medicine and Science in Sports and Exercise\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1249/MSS.0000000000003789\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"SPORT SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Medicine and Science in Sports and Exercise","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1249/MSS.0000000000003789","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"SPORT SCIENCES","Score":null,"Total":0}
Recovery of Fatigue, Cardiorespiratory Fitness, and Neuromuscular Function in Covid-19 ICU Patients: A 6-Month Follow-Up Study.
Purpose: Although most patients recover well from Covid-19 infection, this may not be the case of those who experienced severe dysfunction after being admitted to intensive care unit (ICU). This study aimed to assess the recovery of patients who experienced severe multiple dysfunctions after being admitted to intensive care unit (ICU) for Covid-19 infection.
Methods: Forty-seven patients hospitalized and mechanically ventilated in ICU for SARS-CoV-2 infection underwent evaluations at 4-8 weeks (T1) and 6 months (T2) post ICU discharge. Evaluations included questionnaires, lung function tests, incremental cardiopulmonary exercise testing, and neuromuscular function tests.
Results: From T1 to T2, the percentage of patients classified as fatigued decreased from 56% to 21% whereas forced vital capacity and the forced expiratory volume in one second increased by 13% and 8% (p < 0.05) to reach 93% and 95% of predicted values at T2, respectively. Peak work rate also increased from 97 to 135 W (+35 ± 32%, p < 0.001). Likewise, V̇O2peak increased from 18.3 to 21.6 ml/min/kg (+18 ± 27%, p < 0.001) to reach 72% of predicted values. Maximal strength and the number of contractions during the fatigability test increased between T1 and T2 by 41% and 39%, respectively (both p < 0.001).
Conclusions: Six months of recovery improved patients' physical function and reduced fatigue.
期刊介绍：
Medicine & Science in Sports & Exercise® features original investigations, clinical studies, and comprehensive reviews on current topics in sports medicine and exercise science. With this leading multidisciplinary journal, exercise physiologists, physiatrists, physical therapists, team physicians, and athletic trainers get a vital exchange of information from basic and applied science, medicine, education, and allied health fields.
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