{"title":"Toward the Limits of Human Aging Physiology: Characteristics of the 50-, 60-, and 70-yr+ Male Indoor Rowing World Champions.","authors":"Lorcan S Daly","doi":"10.1249/MSS.0000000000003657","DOIUrl":"10.1249/MSS.0000000000003657","url":null,"abstract":"<p><strong>Purpose: </strong>To examine the physiological, power-duration, nutritional intake and training characteristics of the recent lightweight (- 75 kg) 50+-, 60+-, and 70-yr+ world champion indoor rowers.</p><p><strong>Methods: </strong>Laboratory assessments, undertaken over two visits, examined body composition, pulmonary function, blood lactate/ventilatory landmarks, efficiency, fat/carbohydrate oxidation, primary component time-constant to steady state (τ pc ), and peak oxygen consumption (V̇O 2peak ). Training, performance, and nutritional intake were also reported.</p><p><strong>Results: </strong>The athletes' world championship 2000 m times were 06:34.8, 06:44.0, and 07:15.2, respectively. Their training distribution could be considered pyramidal, with ≈65% in the moderate domain, ≈30% in heavy/severe domains, and ≈5% in the extreme domain (rowing ≈67 km·wk -1 ). The athletes demonstrated highly developed attributes such as fat-free mass (63.4-68.1 kg), forced vital capacity (4.9-5.5 L), τ PC (13.8-17.4 s), peak power output (550-797 W), V̇O 2peak (56.2-44.7 mL·kg·min -1 ), and critical power (217-288 W). Comparisons with young Olympic champion rowers suggest that age-related 2000-m performance mean power declines of -21.6% to -41.4% in world champions ≈25, 35, and 45 yr older may be predominantly driven by \"central\" factors (e.g., V̇O 2peak , critical power; -18.1% to -43.8%). In contrast, \"peripheral\" factors (e.g., gross efficiency, τPC ; +6.1% to -25.1%) seem to display notable preservation despite aging, aligning closely with values seen in young Olympic champions.</p><p><strong>Conclusions: </strong>These results challenge conventional perspectives of age-related physiological capacities and decline trajectories. They also suggest that, commensurate with adequate training and nutritional provision, various physiologic systems can exhibit remarkable adaptability and sustain exceptionally high function during aging. Finally, large differences among the athletes' power-duration and physiological characteristics imply that achieving world-class rowing performance can be predicated by diverse cardiovascular, metabolic, and neuromuscular attributes.</p>","PeriodicalId":18426,"journal":{"name":"Medicine and Science in Sports and Exercise","volume":" ","pages":"1266-1274"},"PeriodicalIF":4.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143029161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bethany Barone Gibbs, Sarah Modlin, Noel Bairey Merz, David M Haas, Sadiya S Khan, Abbi Lane, Rebecca B McNeil, Jasmina Varagic, Kimberly Huber, Ligia Vasquez-Huot, Janet M Catov
{"title":"Leisure Physical Activity, Sedentary Behavior, and Cardiovascular Health 2-7 yr after Pregnancy in the nuMoM2b Heart Health Study Cohort.","authors":"Bethany Barone Gibbs, Sarah Modlin, Noel Bairey Merz, David M Haas, Sadiya S Khan, Abbi Lane, Rebecca B McNeil, Jasmina Varagic, Kimberly Huber, Ligia Vasquez-Huot, Janet M Catov","doi":"10.1249/MSS.0000000000003660","DOIUrl":"10.1249/MSS.0000000000003660","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to evaluate whether higher moderate- to vigorous-intensity physical activity (MVPA) and lower sedentary behavior (SB) are related to better cardiovascular health (CVH) after pregnancy.</p><p><strong>Methods: </strong>In the nuMoM2b Heart Health Study cohort, Life's Essential 8 health factors (body mass index [BMI], blood pressure, glucose, and lipids) were assessed in the first trimester of pregnancy and 2-7 yr later ( n = 3985). The four health factors were scored with Life's Essential 8 criteria (0 = poorest; 100 = ideal) and averaged to calculate a CVH health factor score (CVH hf) . Self-reported leisure MVPA and SB were assessed at follow-up. Linear regression evaluated associations of MVPA levels and SB quartiles with follow-up CVH hf after adjustment for first trimester CVH hf and covariates. Analyses were repeated after stratification by history of hypertensive disorders of pregnancy (HDP) or gestational diabetes (GDM).</p><p><strong>Results: </strong>Over follow-up (mean 3.2 yr after delivery), CVH hf declined from 85.6 to 81.6 points (-4.0 points, P < 0.001). The decline was greatest in lipid (-8.4 points, P < 0.001) and BMI scores (-5.6 points, P < 0.001). Healthier activity profiles (higher MVPA level and lower SB quartile) were each associated with higher CVH hf at follow-up: 0.7 points higher per level of MVPA, P < 0.001; 0.5 points lower per quartile of SB, P = 0.0042. Higher MVPA level associated with healthier BMI, glucose, and lipid scores; lower SB quartile associated with healthier BMI and blood pressure scores ( P < 0.05). Although HDP/GDM history was associated with lower CVH hf , patterns of CVH hf across healthier leisure MVPA levels and SB quartiles were similar in those with and without HDP or GDM.</p><p><strong>Conclusions: </strong>Higher MVPA and lower SB during leisure could help to maintain CVH health factors in the years after pregnancy, including among those who experienced HDP or GDM.</p>","PeriodicalId":18426,"journal":{"name":"Medicine and Science in Sports and Exercise","volume":" ","pages":"1229-1238"},"PeriodicalIF":4.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12081195/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143080615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
David A White, William R Black, Emily Cramer, Lindsey Malloy-Walton, Mollie Walton, Laura Martis, Brandy Enneking, Kelli M Teson, Jessica S Watson, Jami Gross-Toalson
{"title":"Validity and Reliability of the Tampa Scale for Kinesiophobia for Adolescents with Heart Disease.","authors":"David A White, William R Black, Emily Cramer, Lindsey Malloy-Walton, Mollie Walton, Laura Martis, Brandy Enneking, Kelli M Teson, Jessica S Watson, Jami Gross-Toalson","doi":"10.1249/MSS.0000000000003642","DOIUrl":"10.1249/MSS.0000000000003642","url":null,"abstract":"<p><strong>Purpose: </strong>To assess the validity and reliability of a newly adapted Tampa Scale for KP for adolescents with HD (TSK-Heart-A).</p><p><strong>Methods: </strong>The TSK-Heart-A survey consists of 17 Likert scale items, producing a summary score (SS) ranging from 17 (low KP) to 68 (high KP). Following content and face validity, adolescents (age 12-18 yr) with arrhythmia disorders or Fontan palliation were recruited. The PROMIS pediatric anxiety and depression short forms, Pediatric Quality of Life Inventory (PedsQL) generic core and cardiac module, and a PA questionnaire for adolescents (PAQ-A) were used for criterion validity. The TSK-Heart-A was completed twice (20.4 ± 6.3 days apart) for assessment of internal and test-retest reliability. Pearson correlations and Cronbach's alpha determined validity and reliability, respectively.</p><p><strong>Results: </strong>Adolescents ( n = 63) were 15.5 ± 1.8 yrs old, 50.8% were female, and 69.8% had arrhythmia disorder. Mean TSK-Heart-A SS was 33.8 ± 7.8 (range, 20 to 56). The TSK-Heart-A SS correlated significantly with PROMIS T-scores (anxiety: 49.7 ± 12.2, r = 0.48; depression: 46.9 ± 12.7, r = 0.41), PedsQL score (generic QoL: 75.2 ± 18.9, r = -0.61; cardiac QoL: 74.7 ± 17.5, r = -0.56), and PAQ-A (score: 2.0 ± 0.7, r = -0.35). Test-retest and internal reliability had a total score of r = 0.77 ( P = 0.89).</p><p><strong>Conclusions: </strong>The new TSK-Heart-A survey is valid and reliable and suggests that KP is present in some adolescents with HD.</p>","PeriodicalId":18426,"journal":{"name":"Medicine and Science in Sports and Exercise","volume":" ","pages":"1246-1256"},"PeriodicalIF":4.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142950953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lena Stuer, Jan Boone, Patrick Mucci, Alessandro L Colosio, Jan G Bourgois, Kevin Caen
{"title":"Linear Modeling of the V̇O 2 /PO Relationship during Constant Work Rate Exercise.","authors":"Lena Stuer, Jan Boone, Patrick Mucci, Alessandro L Colosio, Jan G Bourgois, Kevin Caen","doi":"10.1249/MSS.0000000000003647","DOIUrl":"10.1249/MSS.0000000000003647","url":null,"abstract":"<p><strong>Introduction: </strong>The linear and continuous increase in power output (PO) during ramp incremental (RI) exercise causes a distinct V̇O 2 /PO relationship compared with constant work rate (CWR) exercise. Current methods enabling a translation of ramp-derived PO to CWR PO assume a linear development of the CWR V̇O 2 /PO relationship in the heavy-intensity domain. This study aimed to model the RI versus CWR V̇O 2 /PO relationship to investigate whether the loss of mechanical efficiency above GET develops linearly. A second aim was to assess the reliability of ramp-derived parameters incorporated in translation strategies.</p><p><strong>Methods: </strong>Fourteen healthy young participants (7 males; 7 females) performed an RI test and several CWR tests across the heavy- and severe-intensity domains in order to model the RI and CWR V̇O 2 /PO relationships. The CWR relationship was fitted using linear, polynomial, and exponential models. Root mean square error (RMSE) and Akaike information criterion (AIC C ) were determined to evaluate the model's goodness of fit. For reliability purposes, target PO of CWR tests were achieved using a preceding RI portion, similar to the initial RI test.</p><p><strong>Results: </strong>The linear fit of the CWR V̇O 2 /PO relationship was associated with the lowest RMSE and AIC C . The associated R2 for the heavy-intensity domain was 0.94. Reliability measures were excellent for baseline V̇O 2 and acceptable to good for s1-ramp and s2-ramp . For MRT, a high variability was observed.</p><p><strong>Conclusions: </strong>This study confirmed that the CWR V̇O 2 /PO relationship in the heavy-intensity domain is linear. Therefore, these results validate the use of correction strategies that are based on a linear V̇O 2 /PO relationship for translating ramp-derived PO into their CWR equivalents.</p>","PeriodicalId":18426,"journal":{"name":"Medicine and Science in Sports and Exercise","volume":" ","pages":"1275-1283"},"PeriodicalIF":4.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142971614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The American College of Sports Medicine's 2024 Annual Meeting Abstract Supplement.","authors":"","doi":"10.1249/MSS.0000000000003768","DOIUrl":"https://doi.org/10.1249/MSS.0000000000003768","url":null,"abstract":"","PeriodicalId":18426,"journal":{"name":"Medicine and Science in Sports and Exercise","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144160262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Caleb D Johnson, Torstein E Dæhlin, Lauren K Sara, Katelyn I Guerriere, Leila A Walker, Stephen A Foulis, Julie M Hughes, Irene S Davis
{"title":"A Re-Examination of the Relationship Between Foot Strike Angle and Early Stance Loading Variables during Running.","authors":"Caleb D Johnson, Torstein E Dæhlin, Lauren K Sara, Katelyn I Guerriere, Leila A Walker, Stephen A Foulis, Julie M Hughes, Irene S Davis","doi":"10.1249/MSS.0000000000003764","DOIUrl":"https://doi.org/10.1249/MSS.0000000000003764","url":null,"abstract":"<p><strong>Purpose: </strong>To compare nonlinear and piecewise linear models for FSA with VLR/VTA during running, controlling for competitive running experience.</p><p><strong>Methods: </strong>475 U.S. Army trainees completed surveys on their participation in sports and a running gait assessment on an instrumented treadmill while VLRs, VTAs, and FSAs were measured (via force plates, tibial-mounted accelerometers, and high-speed cameras, respectively). A 3-minute warm-up was given and then participants ran for one minute at 2.68-2.91 m/s, followed by 14 strides of data collection. Multiple regression was used to assess the prediction of VLR and VTA by FSA, including nonlinear/piecewise terms and controlling for competitive running experience.</p><p><strong>Results: </strong>A nonlinear, quadratic relationship was found for FSA x VLR (R2= 0.25, p<0.001) and VTA (R2= 0.14, p<0.001), and with a significant effect of running experience (p<0.02). Models showed similar shapes but better fit for those with (VLR: R2=0.38, VTA: R2=0.16) versus without (VLR: R2=0.21, VTA: R2=0.11) competitive running experience. Finally, VLRs peaked at similar FSAs as in previous work (≈10-12° current vs 5-10° previous). Piecewise linear regression produced similar results to quadratic models (R2 Difference< 0.02).</p><p><strong>Conclusions: </strong>Our results show that nonlinear or piecewise linear models can be used to represent the relationship between VALR/VTA and FSA. While VLRs/VTAs were lowest with the lowest FSAs (i.e, most forefoot), participants with the highest FSAs (i.e., most rearfoot) showed reduced values compared to FSAs typical of a more moderate/flatter rearfoot strike pattern.</p>","PeriodicalId":18426,"journal":{"name":"Medicine and Science in Sports and Exercise","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144160132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Xiao'ao Xue, Shanshan Zheng, Zikun Wang, Yushi Chen, Lin Chang, Ziyuan Wang, Chang Liu, Ziyu Lu, Rong Lu, Yang Sun, He Wang, Yinghui Hua
{"title":"Sensory Reweighting Revealed by Superior Parietal Cortex-Based Functional Connectivity in Chronic Ankle Instability: A Resting-State fMRI Study.","authors":"Xiao'ao Xue, Shanshan Zheng, Zikun Wang, Yushi Chen, Lin Chang, Ziyuan Wang, Chang Liu, Ziyu Lu, Rong Lu, Yang Sun, He Wang, Yinghui Hua","doi":"10.1249/MSS.0000000000003762","DOIUrl":"https://doi.org/10.1249/MSS.0000000000003762","url":null,"abstract":"<p><strong>Purpose: </strong>Individuals with chronic ankle instability (CAI) are believed to rely more heavily on visual input during postural control due to impaired somatosensory function; however, the neural mechanisms underlying sensory reweighting in CAI are not well understood. This study explored the neural and behavioral correlates of increased visual reliance in CAI through functional connectivity (FC) analysis.</p><p><strong>Methods: </strong>This cross-sectional study enrolled 37 patients with CAI and 36 healthy individuals. Participants underwent postural stability assessments using the single-leg stance test, both with their eyes open and closed. Traditional and modified Romberg ratios were calculated. Resting-state functional magnetic resonance imaging was used to estimate FC between the superior parietal cortex (SPC) and visual, sensorimotor, and cerebellar regions, as well as the coefficient of variation of these FCs.</p><p><strong>Results: </strong>Compared with healthy individuals, patients with CAI displayed significantly higher visual reliance, as indicated by the traditional and modified Romberg ratios of sway length (Cohen's d = 0.47-0.57). Patients with CAI also exhibited stronger FC between the SPC and higher-level visual cortices (Cohen's d = 0.56-0.62) and more unstable coefficient of variation for FC between the SPC and the cerebellar anterior lobe (Cohen's d = 0.64). Subregion analysis revealed that variability in FC between subregions I-IV of the cerebellar anterior lobe and anterior lateral area 7 of the SPC was negatively correlated with the modified Romberg ratio in the anterior-posterior direction (r = -0.35) among the patients.</p><p><strong>Conclusions: </strong>The study revealed high visual reliance, strong yet variable SPC-based connections with visual cortices and variable SPC-based connections with the cerebellum among patients with CAI, suggesting that neural changes associated with sensory reweighting mechanisms underlie increased visual reliance during postural stability.</p>","PeriodicalId":18426,"journal":{"name":"Medicine and Science in Sports and Exercise","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144160259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Glenn Trane, Stine Pedersen, Håkon André Mehus, Jan Helgerud, Runar Jakobsen Unhjem
{"title":"Velocity specific adaptations to three widely used strength training methods.","authors":"Glenn Trane, Stine Pedersen, Håkon André Mehus, Jan Helgerud, Runar Jakobsen Unhjem","doi":"10.1249/MSS.0000000000003630","DOIUrl":"10.1249/MSS.0000000000003630","url":null,"abstract":"<p><strong>Aim: </strong>We examined bench press adaptations to three widely used strength training methods; maximal strength training (MST), hypertrophy training (HT) and explosive strength training (EST). To reflect how these methods are typically applied by practitioners, MST and EST were volume matched, whereas HT were performed at higher volume.</p><p><strong>Methods: </strong>Sixty-three moderately trained subjects (32 males; 31 females) were assigned into 8 weeks of MST, HT, EST or control (CON), 3 sessions/week. MST performed 4 x 4 repetitions bench press at ≥85% of 1RM. HT performed 3 x 8-12 repetitions at ∼70-80% of 1RM. EST performed 4 x 6-7 repetitions bench press throws at 40% of 1RM. Maximal-, explosive- and endurance strength characteristics were assessed, as well as muscle hypertrophy.</p><p><strong>Results: </strong>1RM increased more after MST (+21.5%) and HT (+17.9%) compared to EST (+5.9%) and CON (all p ≤ 0.001). Rate of force development (RFD) at 50% of 1RM increased more after MST (+58.4%) and HT (+38.9%) compared to CON ( p ≤ 0.001 and p ≤ 0.05, respectively). Mean propulsive velocity (MPV) increased more after MST and HT compared to CON across all loads (20-80% of 1RM), and more than EST at 80% and 60% (all p ≤ 0.05-0.001). MST increased MPV more than EST at 40% of 1RM ( p ≤ 0.05). Δ1RM correlated with ΔMPV at all loads of the L-v profile ( r = 0.40-0.56, p ≤ 0.001).</p><p><strong>Conclusion: </strong>MST and HT were more effective than EST for improving maximal strength and concentric velocity against moderate and high loads. At low loads, EST was not more effective than MST and HT, despite high degree of velocity specificity. Changes in muscle strength appear to be more important than velocity specificity to increase performance across the L-v profile.</p>","PeriodicalId":18426,"journal":{"name":"Medicine and Science in Sports and Exercise","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142829314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lucy M Rogers, Jonathan I Quinlan, Karen Lau, Archie E Belfield, Marie Korzepa, Sarkis J Hannaian, Ari Gritsas, Tyler A Churchward-Venne, Gareth A Wallis, Leigh Breen
{"title":"Postprandial Bioavailability and Efficacy of Recombinant Bovine β-lactoglobulin for Resistance Training-Induced Skeletal Muscle Adaptation in Young Adults.","authors":"Lucy M Rogers, Jonathan I Quinlan, Karen Lau, Archie E Belfield, Marie Korzepa, Sarkis J Hannaian, Ari Gritsas, Tyler A Churchward-Venne, Gareth A Wallis, Leigh Breen","doi":"10.1249/MSS.0000000000003756","DOIUrl":"https://doi.org/10.1249/MSS.0000000000003756","url":null,"abstract":"<p><strong>Introduction: </strong>Increasing concerns surrounding the environmental impact of animal- and plant-derived proteins warrants further investigations of alternative protein sources and their efficacy for supporting skeletal muscle anabolism. Herein, the postprandial amino acid bioavailability of a novel protein derived from recombinant bovine β-lactoglobulin (rBLG) was determined, alongside the muscle adaptive response to resistance exercise (RE) with rBLG, compared with dairy-derived whey (WHEY).</p><p><strong>Methods: </strong>Healthy adults (n = 8; age: 24 ± 4 yrs; BMI: 23.5 ± 2.1 kg·m2) completed a randomised crossover study and ingested 0.3 g·kg body mass-1 of rBLG or WHEY with arterialised blood sampled in the fasted state and 240 min postprandially for measurement of plasma amino acid concentrations via UPLC-MS. In a separate double-blind randomised parallel group design, 24 healthy adults completed thrice-weekly lower-body RE for 8 weeks, with twice daily supplementation of 0.3 g·kg body mass-1 rBLG (n = 12; age: 23 ± 6 yrs; BMI: 25.6 ± 3.4 kg·m2) or WHEY (n = 12; age: 25 ± 6 yrs; BMI 25.1 ± 3.1 kg·m2). Training-induced changes in muscle strength and DEXA-derived leg lean body mass (LBM) were assessed.</p><p><strong>Results: </strong>Plasma essential amino acid concentrations increased following protein ingestion (P < 0.001), but did not differ between trials (P = 0.554). Mean plasma leucine incremental area under curve was greater following rBLG compared to WHEY (mean diff(95%CI) 10727 (7738 to 13716) μmol·240 min·L-1P < 0.001). LBM and leg press 1RM increased following training (mean diff±SD: 0.65 ± 0.70 kg and 81.46 ± 42.81 kg, respectively; P < 0.05), with no differences between groups (P > 0.05). Training volume and daily protein intake did not differ between groups (P > 0.05 for all).</p><p><strong>Conclusions: </strong>These data highlight rBLG, a sustainable, precision-engineered mimetic of dairy-derived whey as a novel protein source with the capacity to support skeletal muscle anabolism and exercise-induced remodelling similarly to dairy-derived whey.</p>","PeriodicalId":18426,"journal":{"name":"Medicine and Science in Sports and Exercise","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144160142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Response.","authors":"Christopher R Harnish, Gregory P Swinand","doi":"10.1249/MSS.0000000000003709","DOIUrl":"https://doi.org/10.1249/MSS.0000000000003709","url":null,"abstract":"","PeriodicalId":18426,"journal":{"name":"Medicine and Science in Sports and Exercise","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143971449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}