Medicine and Science in Sports and Exercise最新文献

{"title":"Response.","authors":"Stephen Burns, Man Tong Chua, Alexiaa Sim, Abdul Rashid Aziz, Ted Polglaze","doi":"10.1249/MSS.0000000000004001","DOIUrl":"https://doi.org/10.1249/MSS.0000000000004001","url":null,"abstract":"","PeriodicalId":18426,"journal":{"name":"Medicine and Science in Sports and Exercise","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147616275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is the \"Rest\" Truly Rest? Cardiovascular Considerations of Blood Flow Restriction Applied During Recovery Periods in HIIT.","authors":"Akin Torun","doi":"10.1249/MSS.0000000000004000","DOIUrl":"https://doi.org/10.1249/MSS.0000000000004000","url":null,"abstract":"","PeriodicalId":18426,"journal":{"name":"Medicine and Science in Sports and Exercise","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147616328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"American College of Sports Medicine Position Stand. Resistance Training Prescription for Muscle Function, Hypertrophy, and Physical Performance in Healthy Adults: An Overview of Reviews.","authors":"Brad S Currier, Alysha C D'Souza, Maria A Fiatarone Singh, Caroline V Lowisz, Eric S Rawson, Brad J Schoenfeld, Abbie E Smith-Ryan, Jeremy P Steen, Gwendolyn A Thomas, N Travis Triplett, Tyrone A Washington, Timothy J Werner, Stuart M Phillips","doi":"10.1249/MSS.0000000000003897","DOIUrl":"10.1249/MSS.0000000000003897","url":null,"abstract":"<p><strong>Purpose: </strong>The aim of this overview of reviews was to determine the impact of resistance training (RT) prescription on muscle function and hypertrophy, utilizing evidence synthesis methods. It updates the American College of Sports Medicine 2009 Position Stand, \"Progression models in resistance training for healthy adults.\"</p><p><strong>Data sources: </strong>Ovid MEDLINE(R) ALL, Ovid Emcare, Ovid Embase, Cochrane Database of Systematic Reviews, EBSCOhost SPORTDiscus, and Web of Science Core Collection current to October 2024.</p><p><strong>Eligibility criteria: </strong>Eligible systematic reviews synthesized randomized trials of healthy adults (≥18 yr) who completed RT (≥6 wk; range: 6-52 wk), compared with a group that completed no exercise or an alternative RT program, and reported the change in muscle function, size, or physical performance.</p><p><strong>Results: </strong>We synthesized data from 137 systematic reviews (>30,000 participants). Compared with no exercise (control), RT significantly improved muscle strength, size (hypertrophy), power, endurance, contraction velocity, gait speed, balance, and multiple physical function outcomes. Few RT prescription (RTx) variables affected primary adaptations. However, voluntary strength was enhanced by lifting heavier loads (≥80% one-repetition maximum), through a complete range of motion, for 2-3 sets, at the beginning of training sessions, and ≥2 sessions/wk. Muscle hypertrophy was enhanced by higher volumes (≥10 sets/wk) and eccentric overload. Power was enhanced by moderate loads (30%-70% one-repetition maximum), low-to-moderate volume (≤24 repetitions⋅sets), Olympic-style weightlifting, and power RT (fast concentric phase). Power RT enhanced physical function. Training to momentary muscle fatigue, equipment type, exercise complexity, set structure, time under tension, blood flow restriction, and periodization did not consistently impact training outcomes.</p><p><strong>Conclusions: </strong>Healthy adults should perform progressive RT, with variable prescription consistent with our findings, to improve muscle function, size, and physical performance. Muscle strength, hypertrophy, power, and certain components of physical function can be enhanced by manipulating the RT variables highlighted.</p>","PeriodicalId":18426,"journal":{"name":"Medicine and Science in Sports and Exercise","volume":"58 4","pages":"851-872"},"PeriodicalIF":3.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12965823/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147474373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proteomic Signatures Related to Physical Activity Are Associated with Risks of Future Disease.","authors":"Shaoni Huang, Guangfeng Long, Guoxi Li, Sijia Dai, Guoze Li, Zhuhang He, Yingxin Chen, Q I Lu, Haobing Huang, Aihua Zhang, Cheng Xu","doi":"10.1249/MSS.0000000000003909","DOIUrl":"https://doi.org/10.1249/MSS.0000000000003909","url":null,"abstract":"<p><strong>Purpose: </strong>Physical activity (PA) can lower the risk of developing chronic diseases. However, few studies have examined the proteomic signatures linked to PA, and the role of these signatures in the connection between PA levels and future disease risk remains unclear. This study aimed to investigate whether proteomic signatures indicative of PA are associated with the risk of developing common chronic diseases and to explore their role as statistical links in the relationship between PA levels and disease development.</p><p><strong>Methods: </strong>We used data from a subcohort of UK Biobank participants. PA intensity data were collected from accelerometers worn by each participant. Plasma proteomics results were obtained through Olink analysis. The risks of developing each primary chronic disease were evaluated for types of PA and their associated proteomic signatures, adjusting for age, sex, ethnicity, socioeconomic status, lifestyle factors, and key measurement time-lag covariates.</p><p><strong>Results: </strong>Based on the UK Biobank, we identified significant differences among the proteomic signatures of accelerometer-measured light PA, moderate-to-vigorous PA, and total PA. The main enriched pathways of these proteomic signatures included cell adhesion, cell migration, and immune response. Higher levels of accelerometer-measured PA and their associated proteomic signatures correlated with a lower risk of developing cardiometabolic disorders, cancers, psychological or neurological disorders, and respiratory diseases.</p><p><strong>Conclusions: </strong>Our findings show that PA and PA-related proteomic signatures are statistically associated with lower risks of chronic diseases. Further analyses identified proteins that were correlated with both PA and disease risk. These results need to be confirmed through longitudinal studies involving diverse populations.</p>","PeriodicalId":18426,"journal":{"name":"Medicine and Science in Sports and Exercise","volume":"58 4","pages":"786-797"},"PeriodicalIF":3.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147474533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Short-Term Moderately High-Fat Diet Has No Effect on Physical Performance.","authors":"Michael Alan Dawson, Claire C Whitney, Tshinanne V Ndou, James Philip Karl, Lee M Margolis, Tracey J Smith, Graham Finlayson, Erin Gaffney-Stomberg, Julianna M Jayne","doi":"10.1249/MSS.0000000000003908","DOIUrl":"https://doi.org/10.1249/MSS.0000000000003908","url":null,"abstract":"<p><strong>Purpose: </strong>Military personnel and first responders engage in physically demanding activities resulting in high daily energy expenditures, often coupled with inadequate energy intake. Increasing dietary fat for short durations (<6 d) is one strategy to increase energy intake. However, some studies suggest that short-term high-fat diets may impair endurance performance, while other research indicates that longer-term high-fat diets appear to have no effect on performance.</p><p><strong>Methods: </strong>This randomized crossover study aimed to determine the impact of a short-term moderately high-fat diet (MHF; 40% of total kcal) compared with a standard fat diet (SF; 30% of total kcal) on multiple dimensions of physical performance. Twenty healthy adults (22 ± 5 y, body mass: 80.3 ± 12.2 kg, : 47.9 ± 9.0 mL·kg·min-1] consumed controlled, weight-maintaining, isocaloric, protein-matched MHF and SF diets for 5 d, separated by ≥7 d. To assess physical performance, participants completed vertical jump, 4-mile time trial, and time to exhaustion (85% ) tests and the six-event Army Combat Fitness Test before and immediately after each intervention.</p><p><strong>Results: </strong>Consistent with the experimental design, the MHF diet resulted in a higher proportional energy intake from fat (41 ± 1% vs 30 ± 3%; P < 0.001) and less from carbohydrate (40 ± 1% vs 52 ± 4%; P < 0.001) versus the SF diet, without differences in energy intake (MHF: 2474 ± 297 vs SF: 2493 ± 303 kcal·d-1; P = 0.25). No between-group differences in any performance measure were observed (P ≥ 0.05).</p><p><strong>Conclusions: </strong>Short-term consumption of a higher-fat diet neither impaired nor meaningfully improved measures of physical performance.</p>","PeriodicalId":18426,"journal":{"name":"Medicine and Science in Sports and Exercise","volume":"58 4","pages":"840-850"},"PeriodicalIF":3.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147473384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cold-Water Immersion Impairs Power Earlier than Strength Through Time-Dependent Reductions in Intramuscular Temperature in Human Dorsiflexor Muscles.","authors":"Rohin Malekzadeh, Andrew J Richards, Alireza Vaziri, Robert Laham, Michael T Paris, Arthur J Cheng","doi":"10.1249/MSS.0000000000003904","DOIUrl":"https://doi.org/10.1249/MSS.0000000000003904","url":null,"abstract":"<p><strong>Introduction: </strong>We aimed to investigate the time- and intramuscular temperature-dependent changes in neuromuscular function throughout 1 h of cold-water immersion (CWI) at 10°C. It was hypothesized that acute CWI (<30 min) would not affect neuromuscular function due to limited reductions in intramuscular temperature, whereas prolonged CWI (>30 min) would impair muscle contractility by drastically reducing intramuscular temperature.</p><p><strong>Methods: </strong>Twelve healthy participants (nine males and three females) partook in a randomized crossover design study involving 1-h CWI at 10°C of their lower leg, with three experimental visits consisting of 1) 1-h CWI at 10°C (CWI-only), 2) nonfatiguing exercise followed by 1-h CWI at 10°C to mimic the use of postexercise CWI (Ex + CWI), and 3) passive muscle preheating followed by 1-h CWI at 10°C (Heat + CWI). Skin temperature, intramuscular temperature, and neuromuscular function were periodically assessed in the dorsiflexors throughout the 1 h of CWI.</p><p><strong>Results: </strong>Decreased peak power was observed after 10 min of CWI, CWI-only (50.3 ± 16.0%, P < 0.05), Ex + CWI (55.0 ± 18.3%, P < 0.05), and Heat + CWI (62.0 ± 16.8%, P < 0.05), whereas maximal isometric torque decreased after ≥30 min of CWI, CWI-only (81.1 ± 9.1%, P < 0.05), Ex + CWI (86.6 ± 14.3%, P < 0.05), and Heat + CWI (88.7 ± 10.0%, P < 0.05). Decreases in M-wave peak-to-peak amplitude, 50-Hz torque, and postactivation potentiation were only evident following prolonged CWI (P < 0.05).</p><p><strong>Conclusions: </strong>These results highlight that peak power is more sensitive to reductions in intramuscular temperature than maximal isometric strength, reflecting a time- and temperature-dependent effect on skeletal muscle function.</p>","PeriodicalId":18426,"journal":{"name":"Medicine and Science in Sports and Exercise","volume":"58 4","pages":"733-744"},"PeriodicalIF":3.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147474553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of Accelerometer-Determined Sedentary and Physical Activity Behaviors with Heart Failure Biomarkers during Midlife: CARDIA Study.","authors":"Kelley Pettee Gabriel, Bjoern Hornikel, Erin E Dooley, Baojiang Chen, Sylvia E Badon, Ankeet S Bhatt, Mercedes R Carnethon, David R Jacobs, Sadiya S Khan, Joao A C Lima, Jared P Reis, Pamela J Schreiner, James M Shikany, Stephen Sidney, Kara M Whitaker, Barbara Sternfeld, Cora E Lewis","doi":"10.1249/MSS.0000000000003895","DOIUrl":"10.1249/MSS.0000000000003895","url":null,"abstract":"<p><strong>Background: </strong>Few studies have examined the longitudinal associations of accelerometer-based measures of sedentary and physical activity behaviors with subclinical heart failure (HF) in midlife. This is a key gap, given that an improved understanding of modifiable factors associated with HF risk may better inform prevention strategies. We hypothesize that more time in light intensity physical activity and/or moderate or vigorous intensity physical activity (MVPA) and less sedentary time will be related to lower levels of HF biomarkers (N-terminal pro B-type natriuretic peptide and high-sensitivity cardiac troponin T [hscTnT]) across midlife.</p><p><strong>Methods: </strong>Data are from 2494 Coronary Artery Risk Development in Young Adults (CARDIA) participants without clinical HF (58.9% women, 45.7% Black persons, mean [±standard deviation] aged 51.1 ± 7.2 yr at the baseline contributing exam) with at least one occurrence of concurrent valid accelerometer (ActiGraph 7164/GT3X; Ametris; Pensacola, FL) wear and HF biomarkers at the CARDIA year 20, 30 and/or year 35 follow-up examinations. Adjusted linear mixed effects models were used to estimate the associations. Heterogeneity in the associations by the four race-sex groups represented in CARDIA was also examined.</p><p><strong>Results: </strong>In the fully adjusted models, every 5-min higher MVPA was associated with -0.05 (95% confidence interval: -0.09 to -0.01, P = 0.022) lower hscTnT. The associations of sedentary and light intensity physical activity with hscTnT and associations of any accelerometer estimate with N-terminal pro B-type natriuretic peptide were not statistically supported (all P > 0.05). Findings were similar when clinically relevant categories of HF biomarker outcomes were used in the analysis.</p><p><strong>Conclusions: </strong>Findings address research gaps in the literature and demonstrate the importance of MVPA during the midlife transition for HF prevention before the onset of overt signs or symptoms.</p>","PeriodicalId":18426,"journal":{"name":"Medicine and Science in Sports and Exercise","volume":" ","pages":"776-785"},"PeriodicalIF":3.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12629602/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145540957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Human Performance Across the Extreme- and Severe-Intensity Domains: Insights from Decremental and Priming Exercise Protocols.","authors":"Gabriele Marinari, Juan M Murias, Danilo Iannetta","doi":"10.1249/MSS.0000000000003906","DOIUrl":"https://doi.org/10.1249/MSS.0000000000003906","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate whether W' in the extreme-intensity domain is smaller, yet linked to the W' predicted by the severe-intensity time series.</p><p><strong>Methods: </strong>Twelve recreationally active participants (four females) completed 1) three extreme-intensity and three severe-intensity constant-power output (PO) trials to establish the PO duration series and to obtain W' within their respective domains (W'EXT and W'SVR, respectively); 2) two decremental protocols from extreme-to-severe (EXT1→SVR3) and from severe-to-severe POs (SVR2→SVR3); 3) one extreme- and one severe-intensity constant-PO trial preceded by priming exercise (EXT1P and SVR2P, respectively); and 4) control extreme- and severe-intensity constant-PO trials. Peak values for oxygen uptake (V̇O2peak), blood lactate concentration ([La-]b-peak), and minute ventilation (V̇Epeak) were also analyzed.</p><p><strong>Results: </strong>W'EXT was significantly smaller than W'SVR (P < 0.001). There was no difference in W' between the composite EXT1→SVR3 and SVR2→SVR3 and SVR3 alone (all P > 0.05). Priming-induced increase in W'EXT and W'SVR was not different (P = 0.401). V̇O2peak, V̇Epeak, and [La-]b-peak were all greater in EXT1P compared with EXT1 (all P < 0.05).</p><p><strong>Conclusions: </strong>We showed that W'EXT is smaller than W'SVR during cycling. Following task failure during EXT1, more work could be performed at SVR3 until complete depletion of W'SVR. Additionally, heavy-intensity priming exercise increased W'EXT and W'SVR by a similar magnitude. Collectively, these findings suggest that performance within the extreme-intensity domain is limited by mechanisms, at least in part, different from those that limit performance within the severe-intensity domain.</p>","PeriodicalId":18426,"journal":{"name":"Medicine and Science in Sports and Exercise","volume":"58 4","pages":"756-765"},"PeriodicalIF":3.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147474467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effects of Vitamin K2 on Recovery from Muscle-Damaging Resistance Exercise in Young and Older Adults: The TAKEOVER Randomized Controlled Trial.","authors":"Hannah Lithgow, Lynsey Johnston, Frederick Ho, Emma Dunning, Shinya Nakada, Carlos Celis-Morales, Angus M Hunter, Jennifer S Lees, Patrick B Mark, Terry J Quinn, Stuart R Gray","doi":"10.1249/MSS.0000000000003901","DOIUrl":"10.1249/MSS.0000000000003901","url":null,"abstract":"<p><strong>Purpose: </strong>Vitamin K2 supplementation has emerged as a strategy to enhance recovery and modulate postexercise physiological responses. This study aimed to assess the effects of vitamin K2 on recovery from muscle-damaging exercise in young and older adults.</p><p><strong>Methods: </strong>Healthy young (18-40 yr) and older (65+ yr) adults were randomly assigned to either vitamin K2 (menaquinone-7, MK-7, 240 μg/d) or placebo (cellulose) for 12 wk in this double-blind randomized controlled trial. Before and after supplementation, knee extensor maximal torque, functional ability, muscle soreness, and systemic blood markers of muscle damage and inflammation were measured before (0 h) and 3, 24, 48, and 72-h postexercise. Data were analyzed using regression and mixed models.</p><p><strong>Results: </strong>Seventy-one participants (35 young and 36 older) completed the study, with 12 wk of vitamin K2 supplementation increasing circulating MK-7 levels (P-value <0.001). There were no supplement × time effects for any variables. Significant supplement × time × older age interaction effects were noted for electromechanical delay (EMD) (P-value = 0.03), electromyography root mean square (RMS) (P-value = 0.01), interleukin-6 (IL-6) concentrations (P-value <0.001), and creatine kinase (CK) levels (P-value = 0.02). In older adults, after 12 wk, EMD appeared lower at all time points and RMS higher postexercise in the vitamin K2 group. No clear pattern in IL-6 or CK was observed, but at 72-h postexercise CK was lower in older adults in the vitamin K2 group.</p><p><strong>Conclusions: </strong>Vitamin K2 supplementation had no effect on muscle strength, physical function, muscle soreness, or inflammatory responses in the recovery period after a bout of resistance exercise. Effects of supplementation were observed on EMD, RMS, IL-6, and CK by age and warrant further investigation.</p>","PeriodicalId":18426,"journal":{"name":"Medicine and Science in Sports and Exercise","volume":"58 4","pages":"683-694"},"PeriodicalIF":3.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7618900/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147473885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Context-specific Sitting time with Healthcare Costs at Midlife: The Northern Finland Birth Cohort 1966 Study.","authors":"Sanaz Akhavan Rad, Anna-Maiju Leinonen, Raija Korpelainen, Mikko Vaaramo, Frank Kiwanuka, Katja Ryynänen, Kristiina Patja, Paulus Torkki","doi":"10.1249/MSS.0000000000003995","DOIUrl":"10.1249/MSS.0000000000003995","url":null,"abstract":"<p><strong>Purpose: </strong>Prolonged sitting is linked to poor health outcomes; however, its context, particularly work versus leisure, and its economic impact are less understood. This study examined the extent and context of daily sitting time and its association with annual healthcare costs at midlife in a large Finnish cohort.</p><p><strong>Methods: </strong>A sample (n=7147) of Finnish adults at the 46-year (46-yr) follow-up point of the Northern Finland Birth Cohort 1966 study was used. Data were collected between 2012 and 2014, including self-reported sitting time (work and leisure) and healthcare costs estimated from self-reported visits to public, private, and occupational primary healthcare services using unit costs based on the Finnish Institute for Health and Welfare. Finally, a generalized linear model (gamma distribution with log link), was used to examine the associations between sitting time and annual healthcare costs.</p><p><strong>Results: </strong>Total sitting time was 7.3 ± 3.3 hours per day (h·d⁻¹), including 4.0 ± 2.2 h·d⁻¹ during leisure and 3.4 ± 2.6 h·d⁻¹ at work. In adjusted GLM analyses, participants in the second quartile of work-related sitting (1.01-3.00 h·d⁻¹) had approximately 20% higher annual primary healthcare costs compared with those in the lowest quartile (p = 0.025). Leisure-time sitting showed no independent association.</p><p><strong>Conclusions: </strong>In this population-based cohort, work-related sitting, but not leisure-time sitting, was associated with higher annual primary healthcare costs. These findings highlight the potential economic impact of occupational sedentary behavior and suggest that work-related sitting should be considered in future strategies and studies addressing sedentary behavior in workplace settings.</p>","PeriodicalId":18426,"journal":{"name":"Medicine and Science in Sports and Exercise","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147513432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}