Medicine and Science in Sports and Exercise最新文献

{"title":"Association of Daily Steps with Incident Nonalcoholic Fatty Liver Disease: Evidence from the UK Biobank Cohort.","authors":"Evelynne S Fulda, Laura Portas, Charlie Harper, David Preiss, Derrick Bennett, Aiden Doherty","doi":"10.1249/MSS.0000000000003738","DOIUrl":"10.1249/MSS.0000000000003738","url":null,"abstract":"<p><strong>Purpose: </strong>Low physical activity has been shown to be associated with a higher risk of nonalcoholic fatty liver disease (NAFLD). However, the strength and shape of this association are currently uncertain due to a reliance on self-reported physical activity measures. This report aims to investigate the relationship of median daily step count with NAFLD using accelerometer-derived step count from a large prospective cohort study.</p><p><strong>Methods: </strong>The wrist-worn accelerometer substudy of the UK Biobank ( N = ~100,000) was used to characterize median daily step count over a 7-d period. NAFLD cases were ascertained via record linkage with hospital inpatient data and death registers or by using a measure of liver fat from imaging. Cox proportional hazards models were employed to assess the association between step count and NAFLD, adjusting for age, sociodemographic, and lifestyle factors. Mediation analyses were conducted.</p><p><strong>Results: </strong>Among 91,031 participants (709,440 person-years of follow-up), there were 762 incident NAFLD cases. Higher step count was log-linearly and inversely associated with risk of NAFLD. A 1000-step increase (representing 10 min of walking) was associated with a 12% (95% confidence interval, 10%-14%) lower hazard of NAFLD. When using imaging to identify NAFLD, a 1000-step increase was associated with a 6% (95% confidence interval, 6%-7%) lower risk. There was evidence for mediation by adiposity, accounting for 39% of the observed association.</p><p><strong>Conclusions: </strong>Daily step count, a modifiable risk factor, is log-linearly and inversely associated with NAFLD. This association was only partially explained by adiposity. These findings from a large cohort study may have important implications for strategies to lower NAFLD risk.</p>","PeriodicalId":18426,"journal":{"name":"Medicine and Science in Sports and Exercise","volume":" ","pages":"1905-1913"},"PeriodicalIF":3.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7617666/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144034519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does Delivery of a Nutrition and Exercise Intervention Simultaneously or Sequentially Prevent Excessive Gestational Weight Gain? The NELIP Trial.","authors":"Roberta Bgeginski, Taniya S Nagpal, Karishma Hosein, Mollie Manley, Stephanie Paplinskie, Harry Prapavessis, Christina G Campbell, Barbra DE Vrijer, Michelle F Mottola","doi":"10.1249/MSS.0000000000003729","DOIUrl":"10.1249/MSS.0000000000003729","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the effectiveness of sequential versus simultaneous introduction of nutrition and exercise behavior intervention strategies at preventing early or late excessive gestational weight gain (EGWG).</p><p><strong>Methods: </strong>Parallel-group randomized trial at a single center (London, Canada) included 84 healthy pregnant individuals (mean age: 32.4 ± 3.4 yr; prepregnancy body mass index: 26.0 ± 5.1 kg·m -2 ) randomly allocated at 12-18 wk gestational age (GA; baseline) to either NE (nutrition and exercise delivered simultaneously; n = 25), N + E (nutrition first and exercise added at 25 wk GA; n = 29) or E + N (exercise first and nutrition added at 25 wk GA; n = 30). Early weight gain was analyzed weekly from baseline up to 25 wk GA (midpoint) and later from midpoint to 36 wk GA.</p><p><strong>Results: </strong>From baseline to 25 wk, no differences were found for the amount of EGWG (NE: 1.6 ± 1.4 kg, N + E: 1.9 ± 1.7 kg, E + N: 1.3 ± 1.3 kg; P = 0.62) or for the number of those who gained excessively ( P = 0.38). However, from midpoint to final assessment, N + E gained more excessive weight (2.9 ± 2.3 kg; NE 2.5 ± 1.7 kg; E + N 1.6 ± 1.3 kg; P = 0.002, respectively) with more participants ( n = 21; P = 0.03) gaining excessively than NE ( n = 11) and E + N ( n = 12).</p><p><strong>Conclusions: </strong>Delivering the components of a nutrition and exercise intervention sequentially or simultaneously equally influences early EGWG. However, after 25 wk GA, introducing nutrition sequentially into an exercise program (E + N) or the continuation of combined nutrition and exercise (NE), mitigated EGWG compared with introducing exercise sequentially to a nutrition program (N + E). Sequencing of components may be an important factor to consider for intervention success, specifically by introducing an exercise component first followed by nutrition led to superior overall program adherence, with the least amount of EGWG.</p>","PeriodicalId":18426,"journal":{"name":"Medicine and Science in Sports and Exercise","volume":" ","pages":"2032-2039"},"PeriodicalIF":3.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143803689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combined Cold Exposure and Exercise Improves NAFLD: Mechanistic Insights.","authors":"Xue Geng, Zhijian Rao, Jianhong Zhang, Peng Huang, Chaoyi Qu, Dongzhe Wu, Qiangman Wei, Shijie Liu, Xiaokan Zhuang, Jiexiu Zhao","doi":"10.1249/MSS.0000000000003719","DOIUrl":"10.1249/MSS.0000000000003719","url":null,"abstract":"<p><strong>Introduction: </strong>Nonalcoholic fatty liver disease (NAFLD) affects a quarter of the global population and poses a remarkably serious threat to human health.</p><p><strong>Objectives: </strong>The effect and potential molecular mechanisms of combined cold exposure and exercise intervention on NAFLD remain unclear.</p><p><strong>Materials and methods: </strong>A high-fat diet-induced NAFLD mouse model was used. Twenty-four NAFLD mice were divided into three groups and subjected to cold exposure (5°C), regular-temperature exercise (22°C), or combined cold exposure and exercise (5°C) for 8 wk, 5 d·wk -1 , once daily for 1 h each session. Intervention effects were evaluated through bodyweight, liver mass, liver/bodyweight ratio, blood lipid profile, circulating fibroblast growth factor 21 (FGF21) levels, and liver histopathology. Immunoblotting and quantitative PCR were used to assess the protein and gene expression of liver FGF21, β-klotho, and FGFR1 to preliminarily elucidate the molecular mechanisms underlying NAFLD improvement by combined cold exposure and exercise.</p><p><strong>Results: </strong>Compared with cold exposure or regular-temperature exercise alone, combined cold exposure and exercise significantly reduced the bodyweight, liver weight, and liver/bodyweight ratio in the NAFLD mice. The levels of blood lipids, circulating FGF21, and liver glycogen also significantly decreased. Furthermore, the combined intervention significantly reduced liver fat deposition and fibrosis and significantly increased the expression of FGFR1 and β-klotho proteins, suggesting the activation of the FGF21-β-klotho/FGFR1 signaling pathway.</p><p><strong>Conclusions: </strong>This preclinical study demonstrates that combined cold exposure and exercise synergistically alleviates NAFLD progression in animal models, primarily by activating the FGF21-β-klotho/FGFR1 pathway to enhance lipid metabolism and reduce liver injury. These findings highlight the translational potential of dual environmental and behavioral interventions, providing a mechanistic foundation for developing nonpharmacological therapies targeting metabolic pathways in humans, particularly for NAFLD patients resistant to conventional lifestyle modifications or pharmacotherapy.</p>","PeriodicalId":18426,"journal":{"name":"Medicine and Science in Sports and Exercise","volume":" ","pages":"1988-2000"},"PeriodicalIF":3.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143803740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Leveraging Accelerometry and Heart Rate Data from Consumer Wearables to Predict Physical Activity in Children: A Device Agnostic Approach.","authors":"Rahul Ghosal, James W White, Olivia Finnegan, Srihari Nelakuditi, Trey Brown, Russ Pate, Greg Welk, Massimiliano DE Zambotti, Yuan Wang, Sarah Burkart, Elizabeth L Adams, Bridget Armstrong, Michael W Beets, R Glenn Weaver","doi":"10.1249/MSS.0000000000003721","DOIUrl":"10.1249/MSS.0000000000003721","url":null,"abstract":"<p><strong>Introduction: </strong>This study examined the potential of a device agnostic approach for predicting physical activity energy expenditure (PAEE) from research-grade and consumer wearable accelerometry and heart rate (HR) raw data compared with indirect calorimetry in children.</p><p><strong>Methods: </strong>Two hundred thirty-one 5- to 12-yr-olds (52.4% male) of diverse skin tone and body weights participated in a 60-min protocol with multiple activities at varying intensities. Children wore two of three consumer wearables (Apple Watch Series 7, Garmin Vivoactive 4S, Fitbit Sense) and a research-grade accelerometer (ActiGraph GT9X) on their nondominant wrist, and a chest-placed, research-grade HR monitor (Actiheart 5, ECG), concurrently. Children also wore a K5 criterion measure of PAEE (i.e., COSMED K5). Cross-sectional time series (CSTS), generalized additive mixed effects model (GAMM), and random forest (RF) were used to estimate minute-by-minute PAEE from features extracted from raw accelerometry and HR data. Variance explained ( R2 ), in addition to other metrics, evaluated agreement between estimated and criterion measurements.</p><p><strong>Results: </strong>For the research-grade devices (i.e., ActiGraph accelerometry and Actiheart HR), R2 values were 0.74, 0.74, and 0.76 for CSTS, GAMM, and RF, respectively. For Apple, R2 values were 0.77, 0.76, and 0.78; Garmin's values were 0.73, 0.73, and 0.75; and Fitbit's values were 0.63, 0.65, and 0.67 for CSTS, GAMM, and RF, respectively. Across all other evaluation metrics, a similar pattern was observed with Fitbit performing the worst but with little variability between the modeling approaches or the other devices.</p><p><strong>Conclusions: </strong>Except for Fitbit, accelerometry and HR data from consumer wearables predicted PAEE comparably to research-grade devices, and there was little variability across modeling approach. These outcomes support deploying a consumer wearable device-agnostic approach for PAEE estimation in children.</p>","PeriodicalId":18426,"journal":{"name":"Medicine and Science in Sports and Exercise","volume":" ","pages":"2083-2092"},"PeriodicalIF":3.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143803656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frequency Matters: The Influence of Stimulation Frequency on Force Loss for Human Females and Males.","authors":"Alexander D Paish, Neil D Eves, Chris J McNeil","doi":"10.1249/MSS.0000000000003724","DOIUrl":"10.1249/MSS.0000000000003724","url":null,"abstract":"<p><strong>Purpose: </strong>Most studies applying repeated neuromuscular electrical stimulation (NMES) to assess intrinsic contractile properties employ frequencies considerably greater than the mean motor unit discharge rate (MUDR) for a given force level. It is hypothesized that force loss increases with stimulation frequency, but this has not been evaluated in the same pool of participants when other parameters are unchanged. Furthermore, there is a paucity of research investigating possible sex-based differences for force loss during an NMES protocol, with the presence or absence of a group difference seemingly dependent on stimulation frequency. To address these limitations, we compared force loss of electrically evoked contractions at (10 Hz), slightly above (15 Hz), and well above (30 Hz) the expected mean MUDR of the quadriceps at 25% maximal voluntary force.</p><p><strong>Methods: </strong>On three separate occasions, 24 participants (12 females) received 3 min of intermittent NMES (10, 15, or 30 Hz) over the quadriceps of the dominant leg.</p><p><strong>Results: </strong>Force impairment increased with NMES frequency (19.8 ± 14.5, 42.6 ± 8.1, and 52.9 ± 4.7 for 10, 15, and 30 Hz, respectively), with no significant differences between sexes. Relative to the start of each task, the rates of force development (RFD) and relaxation (RFR) slowed markedly during the 10-, 15-, and 30-Hz fatiguing protocols (RFD: 42.1 ± 13.5, 61.6 ± 13.2, and 75.9 ± 9.8; RFR: 38.0 ± 13.9, 64.2 ± 9.1, and 80.4 ± 5.0, respectively). RFD impairment was less at 10 compared with 15 and 30 Hz, whereas the slowing of RFR increased with NMES frequency. Post-hoc analysis revealed no sex-based differences at any time point for RFD or RFR.</p><p><strong>Conclusions: </strong>These findings underscore the impact of stimulus frequency on muscle fatigability and highlight a lack of sex-based differences for electrically evoked force loss, emphasizing the need for appropriate frequency selection in NMES protocols.</p>","PeriodicalId":18426,"journal":{"name":"Medicine and Science in Sports and Exercise","volume":" ","pages":"2009-2020"},"PeriodicalIF":3.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143780448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of a Ketogenic Diet on Submaximal Exercise Capacity and Efficiency in Runners-Erratum.","authors":"David M Shaw, Fabrice Merien, Andrea Braakhuis, E Maunder, Deborah K Dulson","doi":"10.1249/MSS.0000000000003251","DOIUrl":"10.1249/MSS.0000000000003251","url":null,"abstract":"","PeriodicalId":18426,"journal":{"name":"Medicine and Science in Sports and Exercise","volume":" ","pages":"2098"},"PeriodicalIF":3.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142391678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Vegan Diets on Resistance Exercise-Mediated Myofibrillar Protein Synthesis in Healthy Young Males and Females: A Randomized Controlled Trial.","authors":"Andrew T Askow, Takeshi M Barnes, Zan Zupancic, Max T Deutz, Kevin J M Paulussen, Colleen F McKenna, Amadeo F Salvador, Alexander V Ulanov, Scott A Paluska, Jared W Willard, Steven J Petruzzello, Nicholas A Burd","doi":"10.1249/MSS.0000000000003725","DOIUrl":"10.1249/MSS.0000000000003725","url":null,"abstract":"<p><strong>Background: </strong>Protein ingestion stimulates muscle protein synthesis (MPS) rates to support the turnover of skeletal muscle protein mass. However, dietary patterns consist of a variety of protein foods with different amino acid compositions consumed at multiple meal times throughout the day. Omnivorous (OMN) and vegan (VGN) dietary patterns may differentially stimulate MPS. Moreover, the distribution and frequency of protein intake may also play an important anabolic regulatory role.</p><p><strong>Objective: </strong>We aimed to determine the effect of OMN and VGN dietary patterns and protein distribution (balanced (B) and unbalanced (UB)) in regulating changes in daily myofibrillar protein synthesis rates during a 9-d resistance training intervention.</p><p><strong>Design: </strong>Forty healthy, physically active males and females (28 males, 12 females; 25 ± 4 yr; body mass index, 24.1 ± 2.1 kg·m -2 ) consumed a weight-maintenance diet providing 1.1-1.2 g·kg -1 ·d -1 of dietary protein from an OMN or VGN dietary pattern with UB (10%, 30%, and 60% of daily protein at meals 1, 2, and 3, respectively) or B (20% of daily protein at five eating occasions) distribution. Participants completed whole-body resistance exercise three times during the controlled feeding trial while consuming deuterated water (D 2 O) for the measurement of daily myofibrillar protein synthesis rates.</p><p><strong>Results: </strong>The percent kilocalories from carbohydrate was higher ( P = 0.045) in the OMN compared with VGN groups, but no other differences in dietary intakes were observed. Myofibrillar protein synthesis rates did not differ between the OMN-UB (3.04% ± 1.85%·d -1 ), OMN-B (2.43% ± 1.21%·d -1 ), VGN-UB (2.52% ± 1.77%·d -1 ), and VGN-B (2.49% ± 1.56%·d -1 ) groups (all P > 0.05).</p><p><strong>Conclusions: </strong>Our results demonstrated that the anabolic action of animal versus vegan dietary patterns is similar. Moreover, there is no regulatory influence of distribution between the two dietary patterns on the stimulation of myofibrillar protein synthesis rates in young adults.This trial was registered with ClinicalTrials.gov (NCT04232254).</p>","PeriodicalId":18426,"journal":{"name":"Medicine and Science in Sports and Exercise","volume":" ","pages":"1923-1934"},"PeriodicalIF":3.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143803695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-Intensity Interval Training Combined with Glycine Supplementation Drives Ferroptosis Resistance to Counteract Skeletal Muscle Atrophy in Aging Mice.","authors":"Pin-Shi Ni, Meng-Meng Jia, Jia-Han He, Zhi Yu, Fang-Hui Li","doi":"10.1249/MSS.0000000000003722","DOIUrl":"10.1249/MSS.0000000000003722","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to investigate the molecular mechanisms underlying the improvement of aged skeletal muscle atrophy by high-intensity interval training (HIIT) combined with glycine supplementation.</p><p><strong>Methods: </strong>Male C57BL/6J mice aged 19 months ( n = 16) were randomly assigned to old sedentary (OSED), HIIT, OSED + glycine, and HIIT + glycine (H-Gly) groups for an 8-wk intervention. Maximum grip strength and running speed were assessed. Myocyte apoptosis was detected by TUNEL staining; myofiber cross-sectional area was measured by laminin staining; reactive oxygen species in myocytes were detected by dihydroethidium staining. Western blot and RT-qPCR were used to measure protein and gene expression levels related to senescence, apoptosis, and ferroptosis in myocytes. Chemical methods were employed to detect changes in malondialdehyde, lipid peroxide, glutathione, glutathione-oxidized, and total glutathione contents. RNA-seq technology was utilized to screen for key differentially expressed genes. AutoDockTools software was used for molecular docking predictions between glycine and key differential proteins.</p><p><strong>Results: </strong>H-Gly group mice showed an improved maximum grip strength and muscle fiber cross-sectional area, with a significant reduction in TUNEL-positive cells. RNA-seq analysis revealed a high correlation between ferroptosis pathway genes and Slc25a25 ion transport-related genes, which was further validated by the detection of ferroptosis-related markers. Molecular docking indicated that glycine has binding sites with Slc25a25, with the highest binding energy of -3.7 kcal·mol -1 .</p><p><strong>Conclusions: </strong>Glycine supplementation has a significant synergistic effect with HIIT in increasing muscle mass and grip strength in aged muscle. The mechanism might be associated with the decrease of Slc25a25-mediated ferroptosis.</p>","PeriodicalId":18426,"journal":{"name":"Medicine and Science in Sports and Exercise","volume":" ","pages":"1852-1865"},"PeriodicalIF":3.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143803693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Running Distance and Biomechanical Risk Factors for Plantar Fasciitis: A 1-yr Prospective 4HAIE Cohort Study - Corrigendum.","authors":"Jan Plesek, Joseph Hamill, Michal Burda, Steriani Elavsky, Jiri Skypala, Jan Urbaczka, Julia Freedman-Silvernail, David Zahradnik, Jaroslav Uchyti, Daniel Jandacka","doi":"10.1249/MSS.0000000000003711","DOIUrl":"10.1249/MSS.0000000000003711","url":null,"abstract":"","PeriodicalId":18426,"journal":{"name":"Medicine and Science in Sports and Exercise","volume":" ","pages":"2100"},"PeriodicalIF":3.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144024951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regular Long Runs and Higher Training Volumes are Associated with Better Running Economy Durability in Performance Matched Well-Trained Male Runners.","authors":"Michele Zanini, Jonathan P Folland, Richard C Blagrove","doi":"10.1249/MSS.0000000000003840","DOIUrl":"https://doi.org/10.1249/MSS.0000000000003840","url":null,"abstract":"<p><strong>Introduction: </strong>Running economy (RE) deteriorates during prolonged running (i.e. RE durability), although it is unknown if runners' training characteristics influence RE durability. Furthermore, the extent of the decrement in neuromuscular capabilities after running could also contribute to differences in RE durability. Therefore, this study aimed to compare RE durability during a 90 min run and the decrements in neuromuscular capabilities, between athletes that did, or did not, practice regular long runs, whilst pair-matched for performance status.</p><p><strong>Methods: </strong>Two groups of 13 male runners were recruited as long (LDT; regular long runs ≥90 min) or short distance training runners (SDT; all runs <70 min) and matched for 10 km performance (39:10 vs 39:00 min:s; maximal oxygen uptake (V̇O2max) 56.6 vs 58.9 ml·kg-1·min-1). Participants completed preliminary assessments to determine lactate threshold (LT) and V̇O2max, then on a separate occasion, a 90 min run at LT. Respiratory gases were collected every 15 min, and isometric squat peak force and countermovement jump (CMJ) were assessed before and after the run.</p><p><strong>Results: </strong>Changes in RE occurred earlier and were larger for SDT than LDT, reaching +6.0% vs +3.1% at 90 min, respectively (p < 0.001). Isometric squat force (-19.4 vs -12.2%; p = 0.002) and CMJ mean power (-6.6 vs +2.2%; p = 0.011) decreased more in SDT than LDT runners, however these changes were not correlated with RE durability, whilst correlations were found between RE durability and the weekly longest run (r = -0.67; p < 0.001) and training volume (r = -0.48; p = 0.0038).</p><p><strong>Conclusions: </strong>This study is the first to demonstrate that the presence of long runs and higher training volumes positively affects RE durability and decrements in neuromuscular capability in performance-matched runners. These results provide important insights into how training characteristics may help explain differences in durability, although intervention studies are needed to confirm these cross-sectional findings.</p>","PeriodicalId":18426,"journal":{"name":"Medicine and Science in Sports and Exercise","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144960356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}