Medical hypotheses最新文献_第7页

Stress and periodontal disease: Is the relationship bidirectional? If yes, is MMP- 8 one of the connecting links? 压力与牙周病：这种关系是双向的吗？如果是，那么 MMP- 8 是其中的一个连接环节吗？

IF 2.1 4区医学

Medical hypotheses Pub Date : 2024-10-28 DOI: 10.1016/j.mehy.2024.111508

Shipra Gupta , Shubham Sareen , Ismo T. Räisänen , Timo Sorsa , Prabhleen Kaur Brar

{"title":"Stress and periodontal disease: Is the relationship bidirectional? If yes, is MMP- 8 one of the connecting links?","authors":"Shipra Gupta , Shubham Sareen , Ismo T. Räisänen , Timo Sorsa , Prabhleen Kaur Brar","doi":"10.1016/j.mehy.2024.111508","DOIUrl":"10.1016/j.mehy.2024.111508","url":null,"abstract":"<div><div>There is sufficient evidence to indicate that a unidirectional link exists between chronic stress and periodontal disease, with stress leading to a greater degree of periodontal tissue destruction in patients susceptible to it. Modification in behaviour related to life style such as oral hygiene, smoking and diet in patients under stress eventually adds on to the risk for periodontal disease onset and progression. Recently, a link between the alteration in social behaviour, stress and increased levels of matrix metalloproteinase-8 (MMP-8) has been established. As periodontal diseases are also characterized with disruption of cytokine response, resulting increase in the levels of MMP-8 could hence be considered as directly or indirectly augmenting this relationship even further. Hence the relationship between stress and periodontal disease might be bidirectional with each worsening the other, with MMP-8 acting as one of the connecting links. Correlation nowhere suggests causation, however the proposed hypothesis could definitely be considered a matter of future research.</div></div>","PeriodicalId":18425,"journal":{"name":"Medical hypotheses","volume":"193 ","pages":"Article 111508"},"PeriodicalIF":2.1,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142552661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeting disease self-healing to designing new drugs and new treatment technologies for human diseases 以疾病自愈为目标，设计人类疾病的新药物和新治疗技术

IF 2.1 4区医学

Medical hypotheses Pub Date : 2024-10-28 DOI: 10.1016/j.mehy.2024.111509

Maosheng Yang

引用次数: 0

Dynamic tissue distraction may enhance therapeutic efficacy for Critical limb ischemia 动态组织牵引可提高临界肢体缺血的疗效

IF 2.1 4区医学

Medical hypotheses Pub Date : 2024-10-21 DOI: 10.1016/j.mehy.2024.111507

Zhishan Du, Liqiong Li, Xing Zhang, Lingwei Deng, Fuguo Wang, Bo Zhu, Jiachen Li

{"title":"Dynamic tissue distraction may enhance therapeutic efficacy for Critical limb ischemia","authors":"Zhishan Du, Liqiong Li, Xing Zhang, Lingwei Deng, Fuguo Wang, Bo Zhu, Jiachen Li","doi":"10.1016/j.mehy.2024.111507","DOIUrl":"10.1016/j.mehy.2024.111507","url":null,"abstract":"<div><div>Critical limb ischemia (CLI) is the most serious stage of lower limb arterial disease, often presenting as severe ischemic resting pain, ulcer or tissue gangrene. The treatments for CLI pose a medical challenge. Despite the various treatments available for CLI, there is still no treatment that is entirely effective and acceptable to all patients. Patients with CLI are often elderly and have complex medical conditions, multiple comorbidities, and limited surgical tolerance. Among CLIs, patients with Transatlantic Inter-Society Consensus (TASC) grade D typically exhibit long-segmental and diffuse vascular lesions in their lower extremity arteries, often accompanied by microvascular lesions. It is obviously difficult to reopen multiple extensive segmental vessels with open bypass surgery or endovascular treatment within the limited surgical time, and such methods are ineffective in improving microcirculation. As emerging techniques for lower limb microcirculation reconstruction, tibial cortex transverse distraction and periosteal distraction are both forms of distraction histogenesis (DH) technology, their efficacy in treating CLI is verified, yet their associated treatment parameters still have potential for optimization. Existing biomechanical researches suggest that dynamic stretching may yield superior biological outcomes compared to static stretching, we hypothesize that employing dynamic stretching in tissue distraction techniques may yield a better therapeutic effect, thereby enhancing the efficacy of DH techniques for CLI and reducing the associated complications.</div></div>","PeriodicalId":18425,"journal":{"name":"Medical hypotheses","volume":"193 ","pages":"Article 111507"},"PeriodicalIF":2.1,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142536285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Is brachiation a prelude to the evolution of the hominin throwing shoulder? 肱骨化是类人投掷肩进化的前奏吗？

IF 2.1 4区医学

Medical hypotheses Pub Date : 2024-10-20 DOI: 10.1016/j.mehy.2024.111506

S. Akshatha

引用次数: 0

Hypothesizing the interplay of thrombus formation, wall enhancement, and perifocal edema as predictive factors for rupture in brain AVMs 推测血栓形成、壁强化和灶周水肿的相互作用是脑动静脉畸形破裂的预测因素

IF 2.1 4区医学

Medical hypotheses Pub Date : 2024-10-15 DOI: 10.1016/j.mehy.2024.111496

Riccardo Ludovichetti , Tze Phei Kee , Taryn Rohringer , Karel G. Terbrugge , Timo Krings

{"title":"Hypothesizing the interplay of thrombus formation, wall enhancement, and perifocal edema as predictive factors for rupture in brain AVMs","authors":"Riccardo Ludovichetti , Tze Phei Kee , Taryn Rohringer , Karel G. Terbrugge , Timo Krings","doi":"10.1016/j.mehy.2024.111496","DOIUrl":"10.1016/j.mehy.2024.111496","url":null,"abstract":"<div><div>The presence of shear stress within intracranial AVMs (arteriovenous malformations) due to high flow, perinidal angiogenesis, intranidal aneurysms, and biological factors are presumed risk factors for rupture. However, emerging imaging and histological evidence suggests that risk factors for AVM rupture may extend beyond the classical understanding. The presence of perifocal edema at the time of rupture, luminal thrombosis, and vessel wall enhancement on vessel wall MRI elucidate the possibility of an underlying inflammatory process within AVMs, which may predispose them to instability and eventual rupture. We hypothesize that for some AVM ruptures, the occurrence of thrombosis within vascular outpouchings of the AVM initiates a cascade of events, including local hypoxia, inflammation, breakdown of the blood–brain barrier and wall matrix degradation, which is evident from the presence of perifocal edema and vessel wall enhancement observed on imaging. These changes might ultimately raise the risk of AVM rupture and subsequent hemorrhage. Understanding this inflammatory component offers promising insights into AVM pathogenesis and may facilitate the development of preventive strategies to mitigate rupture risk.</div></div>","PeriodicalId":18425,"journal":{"name":"Medical hypotheses","volume":"193 ","pages":"Article 111496"},"PeriodicalIF":2.1,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142445417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the feasibility of pharmacologic management in non-traumatic osteonecrosis: An etiology-based hypothesis 探索非创伤性骨坏死药物治疗的可行性：基于病因学的假设

IF 2.1 4区医学

Medical hypotheses Pub Date : 2024-10-09 DOI: 10.1016/j.mehy.2024.111497

Edward Y. Cheng, Alireza Mirzaei

{"title":"Exploring the feasibility of pharmacologic management in non-traumatic osteonecrosis: An etiology-based hypothesis","authors":"Edward Y. Cheng, Alireza Mirzaei","doi":"10.1016/j.mehy.2024.111497","DOIUrl":"10.1016/j.mehy.2024.111497","url":null,"abstract":"<div><div>Non-traumatic osteonecrosis is a debilitating condition with a major health burden for the patients. Nevertheless, effective pharmacologic interventions for non-traumatic osteonecrosis are lacking. Increasing evidence suggests a complex interplay between a lipid metabolic disorder and chronic inflammation in the development of osteonecrosis. However, there is no consensus on which of these aberrations initially occurs in the pathogenic sequence of non-traumatic osteonecrosis, as both can mutually and synergistically induce the initiation of each other, perpetuating a recurring process spiraling into the disease state. Furthermore, other pathogenic mechanisms, such as coagulopathy and endothelial dysfunction, have been introduced for non-traumatic osteonecrosis. Understanding the root pathogenic cause of non-traumatic osteonecrosis is important, as therapeutic options should focus on the root cause of the disorder to provide the highest therapeutic impact. Identifying the root pathogenic cause, when feasible, provides a basis for developing pharmacologic strategies tailored to the etiology of osteonecrosis. If the pathogenic sequence originates from a lipid metabolic disorder, pharmacologic interventions should prioritize optimizing lipid metabolism. Conversely, if the primary pathogenic cause is chronic inflammation, anti-inflammatory medications better serve patients. Depending on the underlying mechanisms, additional medications like anti-coagulants could also be considered. In this article, we first provide some clues to determine the root pathogenic cause of non-traumatic osteonecrosis and then suggest an etiology-based pharmacologic intervention based on the potential root pathogenesis.</div></div>","PeriodicalId":18425,"journal":{"name":"Medical hypotheses","volume":"193 ","pages":"Article 111497"},"PeriodicalIF":2.1,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142428779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Leptin, acne and JAK-inhibitors: A possible correlation? 瘦素、痤疮和 JAK 抑制剂：可能的相关性？

IF 2.1 4区医学

Medical hypotheses Pub Date : 2024-10-09 DOI: 10.1016/j.mehy.2024.111498

Luca Potestio , Maddalena Napolitano , Cataldo Patruno

引用次数: 0

How might acne and prostate cancer be connected? 痤疮和前列腺癌有什么联系？

IF 2.1 4区医学

Medical hypotheses Pub Date : 2024-09-27 DOI: 10.1016/j.mehy.2024.111495

Mark R. Goldstein , Luca Mascitelli

引用次数: 0

Abulia is mediated by the neural pathways responsible for passivity symptoms with initiated actions remaining subject to conscious veto 阿布利娅由负责被动症状的神经通路介导，启动的行动仍然受到意识的否决