Stress and periodontal disease: Is the relationship bidirectional? If yes, is MMP- 8 one of the connecting links?

IF 2.1 4区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Medical hypotheses Pub Date : 2024-10-28 DOI:10.1016/j.mehy.2024.111508

Shipra Gupta , Shubham Sareen , Ismo T. Räisänen , Timo Sorsa , Prabhleen Kaur Brar

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引用次数: 0

Abstract

There is sufficient evidence to indicate that a unidirectional link exists between chronic stress and periodontal disease, with stress leading to a greater degree of periodontal tissue destruction in patients susceptible to it. Modification in behaviour related to life style such as oral hygiene, smoking and diet in patients under stress eventually adds on to the risk for periodontal disease onset and progression. Recently, a link between the alteration in social behaviour, stress and increased levels of matrix metalloproteinase-8 (MMP-8) has been established. As periodontal diseases are also characterized with disruption of cytokine response, resulting increase in the levels of MMP-8 could hence be considered as directly or indirectly augmenting this relationship even further. Hence the relationship between stress and periodontal disease might be bidirectional with each worsening the other, with MMP-8 acting as one of the connecting links. Correlation nowhere suggests causation, however the proposed hypothesis could definitely be considered a matter of future research.

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压力与牙周病：这种关系是双向的吗？如果是，那么 MMP- 8 是其中的一个连接环节吗？

有足够的证据表明，慢性压力与牙周病之间存在着单向联系，压力会导致易受其影响的患者的牙周组织受到更大程度的破坏。压力过大的患者在口腔卫生、吸烟和饮食等生活方式方面的行为改变，最终会增加牙周病发病和恶化的风险。最近，人们发现社会行为的改变、压力和基质金属蛋白酶-8（MMP-8）水平的增加之间存在联系。由于牙周病也具有细胞因子反应紊乱的特点，因此 MMP-8 水平的增加可被视为直接或间接地进一步加剧了这种关系。因此，压力与牙周病之间的关系可能是双向的，两者都会加重对方的病情，而 MMP-8 则是其中的一个连接点。相关性并不能说明因果关系，但所提出的假设绝对可以被视为未来研究的一个事项。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Medical hypotheses 医学-医学：研究与实验

CiteScore

10.60

自引率

2.10%

发文量

167

审稿时长

60 days

期刊介绍： Medical Hypotheses is a forum for ideas in medicine and related biomedical sciences. It will publish interesting and important theoretical papers that foster the diversity and debate upon which the scientific process thrives. The Aims and Scope of Medical Hypotheses are no different now from what was proposed by the founder of the journal, the late Dr David Horrobin. In his introduction to the first issue of the Journal, he asks ''what sorts of papers will be published in Medical Hypotheses? and goes on to answer ''Medical Hypotheses will publish papers which describe theories, ideas which have a great deal of observational support and some hypotheses where experimental support is yet fragmentary''. (Horrobin DF, 1975 Ideas in Biomedical Science: Reasons for the foundation of Medical Hypotheses. Medical Hypotheses Volume 1, Issue 1, January-February 1975, Pages 1-2.). Medical Hypotheses was therefore launched, and still exists today, to give novel, radical new ideas and speculations in medicine open-minded consideration, opening the field to radical hypotheses which would be rejected by most conventional journals. Papers in Medical Hypotheses take a standard scientific form in terms of style, structure and referencing. The journal therefore constitutes a bridge between cutting-edge theory and the mainstream of medical and scientific communication, which ideas must eventually enter if they are to be critiqued and tested against observations.