Medical hypotheses最新文献_第10页

Tubular visual field defect relies on hyperbolic geometry spatial representations 管状视野缺陷依赖于双曲几何空间表征

IF 2.1 4区医学

Medical hypotheses Pub Date : 2024-08-22 DOI: 10.1016/j.mehy.2024.111465

Lana Frankle

引用次数: 0

Comment on: Toxic advanced glycation end-products (TAGE) are major structures of cytotoxic AGEs derived from glyceraldehyde 评论：毒性高级糖化终产物（TAGE）是由甘油醛衍生的细胞毒性 AGEs 的主要结构

IF 2.1 4区医学

Medical hypotheses Pub Date : 2024-08-22 DOI: 10.1016/j.mehy.2024.111466

Gokul Sudhakaran

引用次数: 0

Functional seizure therapy via transauricular vagus nerve stimulation 通过经耳迷走神经刺激进行功能性癫痫治疗

IF 2.1 4区医学

Medical hypotheses Pub Date : 2024-08-21 DOI: 10.1016/j.mehy.2024.111462

Abhijit Das , Anirban Dutta

{"title":"Functional seizure therapy via transauricular vagus nerve stimulation","authors":"Abhijit Das , Anirban Dutta","doi":"10.1016/j.mehy.2024.111462","DOIUrl":"10.1016/j.mehy.2024.111462","url":null,"abstract":"<div><p>This article explores the potential of transauricular Vagus nerve stimulation (taVNS) in treating Functional Seizures (FS), a condition that significantly burdens healthcare systems. Traditional seizure treatments are ineffective for FS due to its unique pathophysiology, highlighting the urgent need for alternative therapeutic strategies. While invasive VNS has shown promise in improving autonomic balance, its invasive nature poses limitations in FS treatment. taVNS, a non-invasive alternative, enhances parasympathetic tone and reduces sympathetic activity. Additionally, it is hypothesized to modulate interoceptive processing by influencing Heart Rate Evoked Potential and normalizing interoceptive signals. This hypothesis article examines taVNS from a closed-loop perspective, focusing on the controllability and observability of its effects using wearable physiological sensors. It postulates regulating desired therapeutic states through physiological sensor feedback, suggesting the potential for customized, adaptive stimulation in FS treatment. However, rigorous testing of its controller and observer functions will be necessary for optimal clinical translation of adaptive taVNS.</p></div>","PeriodicalId":18425,"journal":{"name":"Medical hypotheses","volume":"191 ","pages":"Article 111462"},"PeriodicalIF":2.1,"publicationDate":"2024-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0306987724002056/pdfft?md5=c86eb29eb533207c19258a99cd037a8f&pid=1-s2.0-S0306987724002056-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142083945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuromodulation using transcranial focused ultrasonography in neonates with perinatal hypoxic-ischemic encephalopathy 利用经颅聚焦超声对围产期缺氧缺血性脑病新生儿进行神经调控

IF 2.1 4区医学

Medical hypotheses Pub Date : 2024-08-19 DOI: 10.1016/j.mehy.2024.111463

Mehmet N. Cizmeci , Can Sarica , Brian T. Kalish , Andres M. Lozano , Robert Chen

{"title":"Neuromodulation using transcranial focused ultrasonography in neonates with perinatal hypoxic-ischemic encephalopathy","authors":"Mehmet N. Cizmeci , Can Sarica , Brian T. Kalish , Andres M. Lozano , Robert Chen","doi":"10.1016/j.mehy.2024.111463","DOIUrl":"10.1016/j.mehy.2024.111463","url":null,"abstract":"<div><p>Perinatal hypoxic-ischemic encephalopathy (HIE) is the most common cause of neonatal encephalopathy, accounting for over half of all cases and the consequences of HIE can be devastating, making it one of the most severe perinatal complications. Therapeutic hypothermia has been shown to offer neuroprotection by reducing metabolic demand and slowing the cascade of injury processes. However, despite its benefits, therapeutic hypothermia has only modestly improved neurodevelopmental outcomes, indicating a major need for additional therapeutic approaches. Low-intensity transcranial ultrasound stimulation (TUS) is an emerging non-invasive brain stimulation technique for focally modulating specific brain regions that has recently drawn attention for its potential to modulate brain activity and promote neuroplasticity. The capacity of TUS to induce neuroplasticity through specific sonication parameters has been demonstrated in adult patients. Leveraging TUS to enhance functional connectivity and inhibit GABAergic systems within the injured thalami holds promise for inducing neuroplasticity in neonates with HIE. We hypothesize that enhancing thalamocortical functional connectivity and reducing local GABA levels through the use of TUS could potentially improve neurodevelopmental outcomes in neonates with HIE who have sustained thalamic injury and aim to test this hypothesis. Testing of the hypothesis will be conducted with a comprehensive assessment of safety and feasibility in neonates through a Phase I study, followed by further clinical studies to evaluate efficacy.</p></div>","PeriodicalId":18425,"journal":{"name":"Medical hypotheses","volume":"191 ","pages":"Article 111463"},"PeriodicalIF":2.1,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0306987724002068/pdfft?md5=f2257345d4eee4cd492bfcbe9c2dffde&pid=1-s2.0-S0306987724002068-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142007107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Can hydrogen prevent stress fractures in athletes? 氢气能预防运动员应力性骨折吗？

IF 2.1 4区医学

Medical hypotheses Pub Date : 2024-08-11 DOI: 10.1016/j.mehy.2024.111461

Bogdan-Alexandru Hagiu

引用次数: 0

Möbius strip and cancer 莫比乌斯带与癌症

IF 2.1 4区医学

Medical hypotheses Pub Date : 2024-08-05 DOI: 10.1016/j.mehy.2024.111448

Li Yanchu , Pu Rong

引用次数: 0

The strengthening case that simuliids play a role in Amazon region Hepatitis-B transmission 加强模拟人在亚马逊地区乙型肝炎传播中的作用

IF 2.1 4区医学

Medical hypotheses Pub Date : 2024-08-05 DOI: 10.1016/j.mehy.2024.111460

Cláudia Patrícia Mendes de Araújo , Antônio Alcirley da Silva Balieiro , James Lee Crainey

{"title":"The strengthening case that simuliids play a role in Amazon region Hepatitis-B transmission","authors":"Cláudia Patrícia Mendes de Araújo , Antônio Alcirley da Silva Balieiro , James Lee Crainey","doi":"10.1016/j.mehy.2024.111460","DOIUrl":"10.1016/j.mehy.2024.111460","url":null,"abstract":"<div><p>Hepatitis B virus (HBV) outbreaks are typically associated with injection drug use and high-risk sexual behavior; however, some cannot be easily explained in these terms. The messy blood-feeding methods of simuliids, provoked Chanteau et al. to investigate the simuliid-facilitated Hepatitis-B transmission (SFHBVT) hypothesis in French Polynesia in the early 1990s. Souto et al. later proposed the hypothesis could explain a HBV outbreak in the Brazilian Amazon which they suggested was driven by the biting of the <em>M. ozzardi</em> vector <em>Simulium oyapockense</em>. A recent Amazon region blood bank survey has provided important further support for the SFHBVT hypothesis playing a role in Amazon region transmission, but the results of this study have hitherto not been discussed in a SFHBVT context. <em>Mansonella ozzardi</em> positive donations were significantly more likely to test positive in anti-HBc and anti-HBc plus HBsAg tests than were <em>M. ozzardi</em> negative donations, suggesting both exposure to the HBV and HBV infections are significantly more common in individuals infected with <em>M. ozzardi</em>. It is argued here that these Amazon region blood bank observations substantially increase the viability of the SFHBVT hypothesis and thus that the hypothesis should be considered more carefully when HBV disease control measures are formulated for the Brazilian Amazon region and indeed beyond.</p></div>","PeriodicalId":18425,"journal":{"name":"Medical hypotheses","volume":"191 ","pages":"Article 111460"},"PeriodicalIF":2.1,"publicationDate":"2024-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141939412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Materialization of Information (MI) in Biology; 3-D Printing Inside the Cell: A productive analogy 生物学中的信息物质化 (MI)；细胞内的 3-D 打印：一个富有成效的比喻

IF 2.1 4区医学

Medical hypotheses Pub Date : 2024-08-05 DOI: 10.1016/j.mehy.2024.111459

Nuri Faruk Aykan

引用次数: 0

Epiisopiloturine possibly controls inflammation and accelerates wound healing 表异丙基嘌呤可能能控制炎症并加速伤口愈合

IF 2.1 4区医学

Medical hypotheses Pub Date : 2024-07-31 DOI: 10.1016/j.mehy.2024.111447

Ayane Araújo Rodrigues , Paulo Sérgio de Araújo Sousa , Francisco Douglas Oliveira Matias , Tereza Cristina de Carvalho Souza Garcês , André dos Santos Carvalho , Leiz Maria Costa Véras , Jefferson Almeida Rocha , Daniel Fernando Pereira Vasconcelos

{"title":"Epiisopiloturine possibly controls inflammation and accelerates wound healing","authors":"Ayane Araújo Rodrigues , Paulo Sérgio de Araújo Sousa , Francisco Douglas Oliveira Matias , Tereza Cristina de Carvalho Souza Garcês , André dos Santos Carvalho , Leiz Maria Costa Véras , Jefferson Almeida Rocha , Daniel Fernando Pereira Vasconcelos","doi":"10.1016/j.mehy.2024.111447","DOIUrl":"10.1016/j.mehy.2024.111447","url":null,"abstract":"<div><p>Wound healing is a dynamic process that encompasses cellular, immunological, physiological and biochemical events, involving the recovery of tissue anatomy and restoration of homeostasis. Although we see advances in treatments that aim to help this process, there is still a constant need for more effective and accessible treatments. In this context, studies carried out with the alkaloid epiisopiloturine (EPI) have proven its anti-inflammatory potential, or which presents itself as a promising alternative. It is hypothesized that EPI has important anti-inflammatory properties, which can be effective in wound healing, bringing inflammatory hallmarks, such as the selective inhibitory activity of COX-2 and the production of pro-inflammatory cytokines. Furthermore, EPI reduces levels of oxidative stress in the tissue, presenting antioxidant characteristics, which can help protect against damage caused to the wound. EPI is believed to have promising treatment against inflammation and accelerating wound healing.</p></div>","PeriodicalId":18425,"journal":{"name":"Medical hypotheses","volume":"191 ","pages":"Article 111447"},"PeriodicalIF":2.1,"publicationDate":"2024-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141939414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comments on “3-Hydroxybutyrate could serve as a principal energy substrate for human microbiota” 关于 "3-羟丁酸可作为人类微生物群的主要能量底物 "的评论

IF 2.1 4区医学

Medical hypotheses Pub Date : 2024-07-31 DOI: 10.1016/j.mehy.2024.111449

Xuejuan Zhang , Ying Huang , Zhengwei Huang

引用次数: 0