Physical exercises can alleviate harmine toxicity in the case of oncological treatments

Research conducted on experimental animals has shown remarkable antitumor effects of harmine. However, the doses at which therapeutic effects are observed show toxic effects on hepatic and neuronal mitochondria. A possible way to mitigate these adverse effects is to practice physical exercises that stimulate the functionality, regeneration, and even biogenesis of mitochondria in the liver and nervous system. Drugs that stimulate mitochondrial biogenesis are also being researched, but they are either not effective enough, have long-term effects that can worsen cancer, or interfere pharmacologically with harmine.