Physical exercises can alleviate harmine toxicity in the case of oncological treatments

IF 2.1 4区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Medical hypotheses Pub Date : 2025-02-01 DOI:10.1016/j.mehy.2025.111579

Bogdan-Alexandru Hagiu

引用次数: 0

Abstract

Research conducted on experimental animals has shown remarkable antitumor effects of harmine. However, the doses at which therapeutic effects are observed show toxic effects on hepatic and neuronal mitochondria. A possible way to mitigate these adverse effects is to practice physical exercises that stimulate the functionality, regeneration, and even biogenesis of mitochondria in the liver and nervous system. Drugs that stimulate mitochondrial biogenesis are also being researched, but they are either not effective enough, have long-term effects that can worsen cancer, or interfere pharmacologically with harmine.

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来源期刊

Medical hypotheses 医学-医学：研究与实验

CiteScore

10.60

自引率

2.10%

发文量

167

审稿时长

60 days

期刊介绍： Medical Hypotheses is a forum for ideas in medicine and related biomedical sciences. It will publish interesting and important theoretical papers that foster the diversity and debate upon which the scientific process thrives. The Aims and Scope of Medical Hypotheses are no different now from what was proposed by the founder of the journal, the late Dr David Horrobin. In his introduction to the first issue of the Journal, he asks ''what sorts of papers will be published in Medical Hypotheses? and goes on to answer ''Medical Hypotheses will publish papers which describe theories, ideas which have a great deal of observational support and some hypotheses where experimental support is yet fragmentary''. (Horrobin DF, 1975 Ideas in Biomedical Science: Reasons for the foundation of Medical Hypotheses. Medical Hypotheses Volume 1, Issue 1, January-February 1975, Pages 1-2.). Medical Hypotheses was therefore launched, and still exists today, to give novel, radical new ideas and speculations in medicine open-minded consideration, opening the field to radical hypotheses which would be rejected by most conventional journals. Papers in Medical Hypotheses take a standard scientific form in terms of style, structure and referencing. The journal therefore constitutes a bridge between cutting-edge theory and the mainstream of medical and scientific communication, which ideas must eventually enter if they are to be critiqued and tested against observations.