痤疮和前列腺癌有什么联系？

IF 2.1 4区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Medical hypotheses Pub Date : 2024-09-27 DOI:10.1016/j.mehy.2024.111495

Mark R. Goldstein , Luca Mascitelli

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引用次数: 0

摘要

痤疮和前列腺癌在一定程度上因饮食特点而间接相关，饮食特点会导致细胞生长信号的过度刺激。此外，与痤疮相关的痤疮丙酸杆菌的一种促炎系统型也将它们直接联系在一起，这种细菌会从痤疮患者的皮肤扩散到前列腺组织，并长期存在于其分泌的生物膜中，从而形成局部炎症和免疫抑制微环境，最终导致前列腺癌的发生和发展。饮食-痤疮-前列腺癌之间的关系有待进一步探讨，它对饮食、抗生素和疫苗在预防和治疗前列腺癌方面的作用也有影响。

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How might acne and prostate cancer be connected?

Acne and prostate cancer are in part indirectly connected by dietary characteristics that lead to overstimulation of cellular growth signaling. Further, they are directly connected by a proinflammatory phylotype of the acne related bacterium, Cutibacterium acnes, which spreads from acne affected skin to prostate tissue and exists there chronically within a biofilm it secretes, resulting in a local inflammatory and immunosuppressive microenvironment, eventually culminating in prostate cancer initiation and progression. The diet-acne-prostate cancer nexus needs to be explored further and has implications regarding diet, antibiotics, and vaccinations in the prevention and treatment of prostate cancer.

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来源期刊

Medical hypotheses 医学-医学：研究与实验

CiteScore

10.60

自引率

2.10%

发文量

167

审稿时长

60 days

期刊介绍： Medical Hypotheses is a forum for ideas in medicine and related biomedical sciences. It will publish interesting and important theoretical papers that foster the diversity and debate upon which the scientific process thrives. The Aims and Scope of Medical Hypotheses are no different now from what was proposed by the founder of the journal, the late Dr David Horrobin. In his introduction to the first issue of the Journal, he asks ''what sorts of papers will be published in Medical Hypotheses? and goes on to answer ''Medical Hypotheses will publish papers which describe theories, ideas which have a great deal of observational support and some hypotheses where experimental support is yet fragmentary''. (Horrobin DF, 1975 Ideas in Biomedical Science: Reasons for the foundation of Medical Hypotheses. Medical Hypotheses Volume 1, Issue 1, January-February 1975, Pages 1-2.). Medical Hypotheses was therefore launched, and still exists today, to give novel, radical new ideas and speculations in medicine open-minded consideration, opening the field to radical hypotheses which would be rejected by most conventional journals. Papers in Medical Hypotheses take a standard scientific form in terms of style, structure and referencing. The journal therefore constitutes a bridge between cutting-edge theory and the mainstream of medical and scientific communication, which ideas must eventually enter if they are to be critiqued and tested against observations.