Medicina-buenos Aires最新文献_第8页

[Difficulties in accessing colorectal cancer treatment in older adults]. [老年人获得结直肠癌治疗的困难]。

IF 0.6 4区医学

Medicina-buenos Aires Pub Date : 2026-01-01

Lilian E Pietracci, Silvana Meek Torres, Matías Daher, María Pía Izaguirre Germain, Diego Caruso

{"title":"[Difficulties in accessing colorectal cancer treatment in older adults].","authors":"Lilian E Pietracci, Silvana Meek Torres, Matías Daher, María Pía Izaguirre Germain, Diego Caruso","doi":"","DOIUrl":"","url":null,"abstract":"Introduction: Colorectal cancer (CRC) is a leading cause of cancer-related mortality among older adults. Delays in diagnosis and treatment negatively impact survival outcomes. In Argentina, access barriers in this population have not been adequately characterized.Materials and methods: We conducted an ambispective cohort study including older adults diagnosed with CRC within the past five years. Telephone interviews were carried out to collect data on time intervals and perceived barriers across five stages of the diagnostictherapeutic process (from symptom onset or screening to treatment initiation). Multivariable linear and logistic regression models were used to assess associations between sociodemographic factors, perceived barriers, and both total time to treatment and stage-specific delays.Results: A total of 225 participants were included. The median time to treatment initiation was 6 months. Perception of barriers was significantly associated with a higher likelihood of delay in all stages analyzed. The most frequently reported barrier was accessibility -mainly difficulties in obtaining medical appointments- present throughout the care continuum. In later stages, resource shortages were also reported. Female sex was associated with longer time to treatment.Conclusion: Our findings highlight the need for structural health system interventions aimed at reducing treatment delays in older adults with CRC. Identifying and addressing perceived barriers could enhance equity and efficiency in access to oncological care. Time to treatment exceeded internationally recommended standards. Perceived barriers were present in all stages and were significantly associated with delays in care delivery.","PeriodicalId":18419,"journal":{"name":"Medicina-buenos Aires","volume":"86 1","pages":"99-112"},"PeriodicalIF":0.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146125410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Overall and cause based mortality in General Villegas District, Buenos Aires, Argentina (2015-2020). A population-based analysis within the framework of the Population-Based Epidemiological Study on Stroke (EstEPA)]. [2015-2020年阿根廷布宜诺斯艾利斯维勒加斯将军区总体死亡率和基于原因的死亡率]。基于人群的卒中流行病学研究（EstEPA）框架内的基于人群的分析。

IF 0.6 4区医学

Medicina-buenos Aires Pub Date : 2026-01-01

Matías J Alet, Mario O Melcon, Sebastián F Ameriso

{"title":"[Overall and cause based mortality in General Villegas District, Buenos Aires, Argentina (2015-2020). A population-based analysis within the framework of the Population-Based Epidemiological Study on Stroke (EstEPA)].","authors":"Matías J Alet, Mario O Melcon, Sebastián F Ameriso","doi":"","DOIUrl":"","url":null,"abstract":"Introduction: There are few recent population-based studies on mortality in Argentina outside the context of the COVID-19 pandemic. Our objective was to describe overall and cause-based mortality in the General Villegas District (Buenos Aires) between 2015 and 2020, and to compare it with provincial and national rates.Materials and methods: We conducted a population-based observational cohort study that included all deaths among individuals aged ≥18 years occurring between June 2015 and May 2020 in General Villegas (total population: 35 251 inhabitants). Data were obtained from death certificates, medical records, interviews, and verbal autopsies. Causes of death were classified according to the International Statistical Classification of Diseases and Related Health Problems, 10th Revision: ICD-10. Crude and age--and sex-adjusted mortality rates were calculated using the Argentine standard population, the WHO standard population, and the modified Segi standard for Latin America.Results: A total of 1031 deaths were recorded (56.5% men), yielding a crude mortality rate of 9.7‰, higher than the provincial (8.2‰) and national (7.9‰) rates. The rate was higher in men (11.0‰) than in women (8.4‰). Adjusted mortality rates were 5.2‰ (Argentina), 6.8‰ (modified Segi), and 5.8‰ (WHO). Cardiovascular diseases (170/100 000; 25.4%) and neoplasms (140/100 000; 21.5%) were the leading causes of death. In individuals aged 18-39 years, external causes predominated (36%).Discussion: General Villegas shows a mortality profile comparable to the national average. Data obtained from this stable and representative setting may contribute to the design of regional public health strategies targeting chronic diseases and preventable external causes.","PeriodicalId":18419,"journal":{"name":"Medicina-buenos Aires","volume":"86 1","pages":"12-25"},"PeriodicalIF":0.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146125661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The potential risk of type 2 diabetes mellitus and coagulopathies associated with consumption of energy drinks. 2型糖尿病和凝血疾病的潜在风险与能量饮料的消费有关。

IF 0.6 4区医学

Medicina-buenos Aires Pub Date : 2026-01-01

Mamdouh Allahyani

{"title":"The potential risk of type 2 diabetes mellitus and coagulopathies associated with consumption of energy drinks.","authors":"Mamdouh Allahyani","doi":"","DOIUrl":"","url":null,"abstract":"Introduction: The consumption of energy drinks (EDs) has risen in recent years and is associated with numerous health concerns. This study aims to evaluate the effects of EDs consumption on blood glucose, HbA1c, hematological, coagulation parameters, and liver markers in mice.Materials and methods: Twenty mice were equally divided into two groups; one group served as a control and the other was given EDs. After four months, blood glucose, HbA1c, hematological, coagulation profile, and liver markers were analyzed using an unpaired t-test.Results: Results showed that mice fed EDs had higher blood glucose and HbA1c. In addition, platelet count was lower, whereas levels of prothrombin time, activated partial thromboplastin time, international normalized ratio and D-dimer were higher in ED-treated group, with reduced levels of fibrinogen. Results showed that levels of alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase were significantly higher in ED-treated mice, while total protein and albumin were reduced.Conclusion: These data suggest that the intake of EDs potentially increases the risk of type 2 diabetes mellitus and coagulation abnormalities.","PeriodicalId":18419,"journal":{"name":"Medicina-buenos Aires","volume":"86 4","pages":"906-914"},"PeriodicalIF":0.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148765268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Outcomes after surgical treatment of chest wall sarcomas. 胸壁肉瘤手术治疗后的结果。

IF 0.6 4区医学

Medicina-buenos Aires Pub Date : 2026-01-01

Walter S Nardi, Francisco Thibaud, Agustín Buero, Leonardo Pankl, Gustavo Lyons, Sergio D Quildrian

{"title":"Outcomes after surgical treatment of chest wall sarcomas.","authors":"Walter S Nardi, Francisco Thibaud, Agustín Buero, Leonardo Pankl, Gustavo Lyons, Sergio D Quildrian","doi":"","DOIUrl":"","url":null,"abstract":"Introduction: Chest wall sarcomas are very rare even within an already rare disease and can arise from soft tissue, cartilaginous, or osseous components of the thoracic wall. Various locations can be affected needing different types of oncologic and reconstructive surgeries. Hence, treatment is challenging and requires a multidisciplinary specialized team.Materials and methods: All patients with diagnosis of localized chest wall sarcomas between January 2014 and June 2025 primarily operated at our center or referred after treatment elsewhere were included. Demographic data and tumor characteristics were evaluated (type of sarcoma, size, FNCLCC grade, neo/adjuvant treatment) as well as surgical outcomes (R classification). Overall survival (OS), local recurrence- (LRFS) and distant metastasis free survival (DMFS) were analyzed only for the chest wall soft tissue sarcoma (CWSTS) subgroup.Results: A total of 17 patients with chest wall sarcomas underwent surgical resection, out of which 14 were primarily resected and 3 had previous resections elsewhere. Twelve patients (70%) had soft-tissue sarcomas (STS) and 5 (30%) bony sarcomas. All patients had macroscopic complete en bloc resections (94% R0 and 6% planned R1 margins). Four (24%) patients had superficial tumors and 13 (76%) had deep-seated sarcomas requiring 10 of them full-thickness resections. Median number of resected ribs per surgery was 3 (range, 1 - 3). For CWSTS subgroup, 5-years OS and LRFS were 81%.Conclusion: In localized chest wall sarcomas, multidisciplinary en bloc surgical resection with clear margins by a specialized team is key and led to good rates of local control.","PeriodicalId":18419,"journal":{"name":"Medicina-buenos Aires","volume":"86 4","pages":"963-969"},"PeriodicalIF":0.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148765198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[The hidden infection: nocardiosis with multiple extra pulmonary foci]. 【隐性感染：诺卡菌病伴多肺外灶】。

IF 0.6 4区医学

Medicina-buenos Aires Pub Date : 2026-01-01

María Trinidad Pennini Guelfi, Camilo Martínez, Ana De Lajonquiere, Mariana Boccia, Agustín Mucci, Facundo Camperi, Regina Blanco, Betsika Quirpa, Catalina Podestá, Juana García Gieser

{"title":"[The hidden infection: nocardiosis with multiple extra pulmonary foci].","authors":"María Trinidad Pennini Guelfi, Camilo Martínez, Ana De Lajonquiere, Mariana Boccia, Agustín Mucci, Facundo Camperi, Regina Blanco, Betsika Quirpa, Catalina Podestá, Juana García Gieser","doi":"","DOIUrl":"","url":null,"abstract":"Nocardiosis is a rare infection caused by Gram-positive aerobic bacteria of the genus Nocardia, mainly affecting immunocompromised patients. Its clinical presentation is variable and can mimic other infectious or neoplastic diseases, making it difficult to diagnose. We report the case of a 48-year-old patient recently diagnosed with HIV and a CD4 lymphocyte count of less than 50 cells/ uL, who consulted for prolonged fever without apparent focus. Despite initial empirical antibiotic treatment, fever persisted. Computed tomography showed multiple extrapulmonary abscesses in unusual sites: iliac muscle, prescapular region, adrenal gland and cerebellar hemisphere. The definitive diagnosis was established by culture of the material obtained by percutaneous drainage, identifying Nocardia spp. The patient received targeted treatment with imipenem, ceftriaxone and trimethoprimsulfamethoxazole, achieving a favorable clinical course. This case highlights the importance of considering nocardiosis in the differential diagnosis of prolonged fever with multiple deep lesions in immunocompromised patients.","PeriodicalId":18419,"journal":{"name":"Medicina-buenos Aires","volume":"86 4","pages":"1037-1039"},"PeriodicalIF":0.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148758740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Treatment of severe recurrent laryngotracheal papillomatosis with tracheobronchial stent]. 气管支气管支架治疗重度复发性喉气管乳头状瘤病

IF 0.6 4区医学

Medicina-buenos Aires Pub Date : 2026-01-01

Marisol A Zinni, Manuel I España, Agustina Carrabs, Mario E F Bustos

引用次数: 0

[Differential diagnosis of hyperferritinemia]. [高铁素血症的鉴别诊断]。

IF 0.6 4区医学

Medicina-buenos Aires Pub Date : 2026-01-01

María Margarita Anders, Juan Antonio Sorda

引用次数: 0

[Multiple venous compression syndromes in sequential evolution: a case report with intravascular ultrasound guided endovascular treatment]. 【多静脉压迫综合征的顺序演变：血管内超声引导血管内治疗一例报道】。

IF 0.6 4区医学

Medicina-buenos Aires Pub Date : 2026-01-01

Juan Ignacio Damonte, Juan Manuel Telayna, Juan Manuel Telayna, Fátima Lezcano Sticchi, Sergio Sierre, Ricardo Costantini

{"title":"[Multiple venous compression syndromes in sequential evolution: a case report with intravascular ultrasound guided endovascular treatment].","authors":"Juan Ignacio Damonte, Juan Manuel Telayna, Juan Manuel Telayna, Fátima Lezcano Sticchi, Sergio Sierre, Ricardo Costantini","doi":"","DOIUrl":"","url":null,"abstract":"Venous compression syndromes, such as nutcracker syndrome (NCS) and May-Thurner syndrome (MTS), are rare entities with a complex diagnosis due to their nonspecific symptoms. The coexistence of multiple compression syndromes is exceptional. We present the case of a 38-year-old woman with a history of chronic abdominal and pelvic pain, initially diagnosed with symptomatic NCS associated with pelvic congestion syndrome, successfully treated with venous angioplasty and stent placement guided by intravascular ultrasound (IVUS) with improvement of the symptoms after the treatment. Four years later, the patient developed symptomatic MTS, which worsened the pelvic congestion and required a new endovascular intervention with placement of a dedicated venous stent, also optimized with IVUS. This case highlights the rarity of sequential progression from NCS to MTS and underscores the importance of maintaining a high index of suspicion in young women with chronic pelvic pain. We here in report a case of pelvic congestion syndrome caused by sequential NCS and MTS, resolved with IVUS-optimized endovascular treatment at both stages.","PeriodicalId":18419,"journal":{"name":"Medicina-buenos Aires","volume":"86 2","pages":"521-525"},"PeriodicalIF":0.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147654443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Evaluation of reproductive and developmental toxicity: its importance in the preclinical phase of new vaccines]. [生殖和发育毒性评价：在新疫苗临床前阶段的重要性]。

IF 0.6 4区医学

Medicina-buenos Aires Pub Date : 2026-01-01

María Florencia Beltramino, Fátima B Gasser, Antonela F Stassi, Hugo H Ortega, María Eugenia Baravalle

{"title":"[Evaluation of reproductive and developmental toxicity: its importance in the preclinical phase of new vaccines].","authors":"María Florencia Beltramino, Fátima B Gasser, Antonela F Stassi, Hugo H Ortega, María Eugenia Baravalle","doi":"","DOIUrl":"","url":null,"abstract":"Preclinical trials in laboratory animals, particularly those aimed at evaluating potential effects on reproduction and offspring development, have gained importance in recent years due to the development of new drugs and vaccines intended for both children and individuals of reproductive age. The current challenge lies in the need for reliable and rapidly obtainable data to enable the transition of new compounds to clinical phases and eventual approval. Since pregnant and breastfeeding women are often excluded from clinical vaccine trials, including those assessing toxicity, there is limited knowledge about this vulnerable population and their offspring. In this context, preclinical studies designed to assess the effects of vaccine and therapeutic candidates on reproduction and development must rely on in vivo models that accurately replicate key aspects of the pathogenesis observed in human disease. When evaluating the reproductive toxicity of vaccines, it is essential not only to assess potential effects on fertility, embryogenesis, development, and reproduction, but also to consider the interactions of the vaccine with the immune system of both the mother and her offspring. This review updates and describes preclinical studies in laboratory animals for new vaccines, particularly those developed against COVID-19, highlighting published studies on reproductive and developmental toxicity, as well as the current regulatory framework governing such studies.","PeriodicalId":18419,"journal":{"name":"Medicina-buenos Aires","volume":"86 1","pages":"166-178"},"PeriodicalIF":0.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146125505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Detection of VIM-3 in oral squamous cell carcinomas: methodological limitations. 口腔鳞状细胞癌中VIM-3的检测：方法学上的局限性。

IF 0.6 4区医学

Medicina-buenos Aires Pub Date : 2026-01-01

Gizem Teoman, Zeynep Sagnak Yilmaz, Zeynep Türkmen Usta, Safak Ersöz, Ümit Çobanoglu, Hatice Bengü Yaldiz Çobanoglu

引用次数: 0