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Thoracic outlet syndrome secondary to a cavernous hemangioma of the first rib.
IF 0.6 4区 医学
Medicina-buenos Aires Pub Date : 2025-01-01
Agustín Buero, Soledad Olivera Lopez, Constanza Pereyra, Michel David, Leonardo G Pankl, Mayra Samudio, Julián Méndez, Gustavo A Lyons, Domingo J Chimondeguy
{"title":"Thoracic outlet syndrome secondary to a cavernous hemangioma of the first rib.","authors":"Agustín Buero, Soledad Olivera Lopez, Constanza Pereyra, Michel David, Leonardo G Pankl, Mayra Samudio, Julián Méndez, Gustavo A Lyons, Domingo J Chimondeguy","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Bone hemangiomas are slow-growing benign tumors, with rib involvement being exceptionally rare. Thoracic outlet syndrome caused by a bone neoplasm of the first rib is even more uncommon, with only a few cases documented in the literature. We present the case of a patient with a clinical diagnosis of neurogenic thoracic outlet syndrome secondary to a bone tumor of the first rib, treated using a combined approach of video-assisted thoracoscopy and posterior access for resection. To our knowledge, this is the second reported case in the literature of a young man with thoracic outlet syndrome secondary to a cavernous hemangioma of the first rib.</p>","PeriodicalId":18419,"journal":{"name":"Medicina-buenos Aires","volume":"85 1","pages":"244-247"},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143123002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Surgical outcomes post neoadjuvant immunotherapy in lung cancer: CheckMate 816 in Argentine subpopulation].
IF 0.6 4区 医学
Medicina-buenos Aires Pub Date : 2025-01-01
Alejandro Damonte, Joaquín García Morato, Soledad Courreges, Agustín Omati Porte, Aldo Perfetti, Patricio Levit, José A Rodriguez Zamboni
{"title":"[Surgical outcomes post neoadjuvant immunotherapy in lung cancer: CheckMate 816 in Argentine subpopulation].","authors":"Alejandro Damonte, Joaquín García Morato, Soledad Courreges, Agustín Omati Porte, Aldo Perfetti, Patricio Levit, José A Rodriguez Zamboni","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>The CheckMate 816 study, a global phase III randomized trial, demonstrated that neoadjuvant treatment with nivolumab plus chemotherapy significantly improves event-free survival in patients with resectable non-small cell lung cancer (NSCLC). Additionally, the treatment significantly increases the rate of complete pathological response. We present the results of CheckMate 816 in an Argentine subpopulation to evaluate the efficacy and safety of the neoadjuvant treatment.</p><p><strong>Materials and methods: </strong>A retrospective observational and descriptive study was conducted at a high-volume single center in Argentina from January 2023 to March 2024. Patients received 360 mg of nivolumab plus chemotherapy and a platinum doublet every three weeks for three cycles before undergoing definitive surgery. The results were compared with the international trial and the Japanese population subgroup.</p><p><strong>Results: </strong>Nine patients received neoadjuvant therapy, of whom eight underwent definitive surgery. All patients achieved complete (R0) resection, and in three cases, a complete pathological response was observed. Currently, all are alive and disease-free.</p><p><strong>Discussion: </strong>The results obtained in the Argentine subpopulation were consistent with those observed in the global population and the Japanese subgroup. A high proportion of patients achieved a complete pathological response, an early indicator of therapeutic efficacy. Neoadjuvant therapy with nivolumab plus chemotherapy could be considered an effective treatment option for Argentine patients with resectable NSCLC.</p>","PeriodicalId":18419,"journal":{"name":"Medicina-buenos Aires","volume":"85 1","pages":"47-55"},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143122735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The role of pre-test probability in calculating predictive values in diagnostic studies].
IF 0.6 4区 医学
Medicina-buenos Aires Pub Date : 2025-01-01
Gabriela V Carro, Alberto Velazquez
{"title":"[The role of pre-test probability in calculating predictive values in diagnostic studies].","authors":"Gabriela V Carro, Alberto Velazquez","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The clinical reasoning process for decision-making in medicine is complex and involves multiple factors, including diagnostic probabilities, study characteristics, costs, and patient preferences. This article highlights the role of pre-test probability in calculating the positive predictive value (PPV) and negative predictive value (NPV) of diagnostic tests and also likelihood ratios. It also discusses concepts such as sensitivity, specificity, and predictive values, and their relationship with pre-test and post-test probabilities in various clinical contexts. The notion of treatment and diagnostic thresholds is introduced, emphasizing their impact on medical decision-making. Finally, it underscores that diagnostic tests should only be requested if their results can change clinical management, promoting a rational and cost-effective approach to medical practice.</p>","PeriodicalId":18419,"journal":{"name":"Medicina-buenos Aires","volume":"85 1","pages":"205-212"},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143122849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Uncommon or unusual encephalopathies].
IF 0.6 4区 医学
Medicina-buenos Aires Pub Date : 2025-01-01
Sebastián Villate, Natalia Lucero, Natalia Conci, Cecilia Cabanellas, Carla Buonanotte, Federico Buonanotte
{"title":"[Uncommon or unusual encephalopathies].","authors":"Sebastián Villate, Natalia Lucero, Natalia Conci, Cecilia Cabanellas, Carla Buonanotte, Federico Buonanotte","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Rare encephalopathies are here described in order to summarize practical tools that should be considered in the anamnesis, as well as in the physical examination. The way in which the clinical picture was established was the primary point for structuring the review; subsequently, the encephalopathies were subclassified etiologically. Focal symptoms, headaches, abdominal pain, fever or extrapyramidalism, added to the findings in the magnetic resonance imaging, especially if damage to the gray or white matter is observed, and if the lesions are bilateral or not, can be helpful when hypothesizing the etiology of the encephalopathy.</p>","PeriodicalId":18419,"journal":{"name":"Medicina-buenos Aires","volume":"85 1","pages":"152-164"},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143122856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[An electronic synapse].
IF 0.6 4区 医学
Medicina-buenos Aires Pub Date : 2025-01-01
Basilio A Kotsias
{"title":"[An electronic synapse].","authors":"Basilio A Kotsias","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":18419,"journal":{"name":"Medicina-buenos Aires","volume":"85 2","pages":"483-484"},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143803650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Bronchial infestation due to myiasis].
IF 0.6 4区 医学
Medicina-buenos Aires Pub Date : 2025-01-01
Agustina Carrabs, Marisol Zinni, Emanuel J Saad, Manuel España, Mario E F Bustos
{"title":"[Bronchial infestation due to myiasis].","authors":"Agustina Carrabs, Marisol Zinni, Emanuel J Saad, Manuel España, Mario E F Bustos","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":18419,"journal":{"name":"Medicina-buenos Aires","volume":"85 2","pages":"468"},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143803654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Perspectives on the efficacy and effectiveness of the recombinant herpes zoster vaccine.
IF 0.6 4区 医学
Medicina-buenos Aires Pub Date : 2025-01-01
Sebastián Garcia-Zamora, Laura Pulido, Álvaro Sosa-Liprandi
{"title":"Perspectives on the efficacy and effectiveness of the recombinant herpes zoster vaccine.","authors":"Sebastián Garcia-Zamora, Laura Pulido, Álvaro Sosa-Liprandi","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":18419,"journal":{"name":"Medicina-buenos Aires","volume":"85 2","pages":"473-475"},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143803735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Definition of high-priced and very high-priced drugs for Argentina].
IF 0.6 4区 医学
Medicina-buenos Aires Pub Date : 2025-01-01
Manuel Donato, Fernando Tortosa, Guadalupe Montero, Daniel E Manoukian, Agustín Iglesias, María Julia Meschini, Gustavo H Marin
{"title":"[Definition of high-priced and very high-priced drugs for Argentina].","authors":"Manuel Donato, Fernando Tortosa, Guadalupe Montero, Daniel E Manoukian, Agustín Iglesias, María Julia Meschini, Gustavo H Marin","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>New drugs contribute to improving people's quality of life with more precise and effective treatments; however, their high acquisition prices continually put the sustainability of the health system and equitable access at risk throughout the world. A starting point for its approach should be to delimit the concept of \"high-price\" and \"very high-price\" drugs, but there is no global consensus and it is not defined for Argentina. The objective was to establish the definition of high-price and very high-price drugs for Argentina through a panel with modified Delphi technique with representatives of the health system.</p><p><strong>Materials and methods: </strong>A descriptive study was conducted with a qualitative-quantitative approach in three phases that include a Phase 1 systematic review of the literature, a Phase 2 analysis of the profile of selected drugs, and a Phase 3 panel.</p><p><strong>Results: </strong>For the systematic review, 1895 publications were identified, of which 23 were included with some type of definition of high-cost or high-price drugs. A clinical and economic analysis was performed for ten reference drugs that provided examples to the panel. The modified Delphi panel consisted of a first round of 14 and a second round of consensus of 27 representatives, which resulted in the agreed definition.</p><p><strong>Discussion: </strong>This work collect the experience and vision of representatives of important institutions in our country and provides a key definition for addressing these technologies.</p>","PeriodicalId":18419,"journal":{"name":"Medicina-buenos Aires","volume":"85 2","pages":"261-280"},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143803702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Prevalence, phenotype distribution and cardiometabolic risk of polycystic ovarian syndrome in transgender population].
IF 0.6 4区 医学
Medicina-buenos Aires Pub Date : 2025-01-01
Cecilia E Calvar, Milagros Di Noto, Mayra Lema Villacis, Natalia Blanco Hirota, María Isabel Anticona Sayán
{"title":"[Prevalence, phenotype distribution and cardiometabolic risk of polycystic ovarian syndrome in transgender population].","authors":"Cecilia E Calvar, Milagros Di Noto, Mayra Lema Villacis, Natalia Blanco Hirota, María Isabel Anticona Sayán","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>The prevalence of polycystic ovary syndrome (PCOS) in transgender and non-binary genders assigned female at birth (TMNBG) men is controversial. Our objectives were to investigate the prevalence, phenotypic characteristics of PCOS, and cardiometabolic risk of TMNBG with and without PCOS prior to hormone therapy.</p><p><strong>Materials and methods: </strong>This was a retrospective study of 346 TMNBG adults presenting to our service for gender-affirming hormone therapy. PCOS was diagnosed according to the evidence-based international guideline for the evaluation and treatment of PCOS 2018 and the Rotterdam consensus of 2003.</p><p><strong>Results: </strong>The described transgender population had a prevalence of PCOS of 23.8%. Phenotype B was the most common one (39.1%), followed by phenotype A (33.7%). Transgender people with PCOS had statistically higher body mass index (BMI), systolic and diastolic blood pressure, plasma insulin levels, HOMA-IR, and HOMA-B than those who did not meet PCOS criteria. However, blood pressure and markers of insulin resistance were similar for both groups after controlling for BMI.</p><p><strong>Discussion: </strong>PCOS appears to be prevalent among TMNBG. Transgender people with PCOS may exhibit an unfavorable cardiometabolic risk profile compared to those without PCOS, especially due to a higher BMI. It is necessary to evaluate the specific components of PCOS before starting hormonal therapy due to the long-term implications it could have.</p>","PeriodicalId":18419,"journal":{"name":"Medicina-buenos Aires","volume":"85 1","pages":"31-38"},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143123145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pseudomembranous Aspergillus fumigatus tracheobronchitis.
IF 0.6 4区 医学
Medicina-buenos Aires Pub Date : 2025-01-01
M Florencia Courtois, Indalecio Carboni Bisso, Ignacio Fernández Ceballos, Marcos Las Heras
{"title":"Pseudomembranous Aspergillus fumigatus tracheobronchitis.","authors":"M Florencia Courtois, Indalecio Carboni Bisso, Ignacio Fernández Ceballos, Marcos Las Heras","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":18419,"journal":{"name":"Medicina-buenos Aires","volume":"85 1","pages":"251"},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143122989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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