{"title":"[Malaria. Paludism. Two names for the same disease].","authors":"José Luis Leone","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":18419,"journal":{"name":"Medicina-buenos Aires","volume":"85 2","pages":"481"},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143803333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Novel mutations in the calcium-sensing receptor encoding genes as a cause of familial hypocalciuric hypercalcemia].","authors":"Marcelo Sarli, Elbio Genovesi, Luciana Levi, Damián Robbiani","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Hypercalcemia is a rare reason for consultation in clinical practice and is often an incidental finding in a routine biochemical evaluation. Its most frequent cause is primary hyperparathyroidism. Rarely, hypercalcemia is due to mutations in the calcium-sensing receptor (CaSR) signaling pathway that give rise to the different forms of familial hypocalciuric hypercalcemia (FHH). Two aspects are essential to suspect a probable FHH, the first is the existence of other cases in the family of elevated calcium and PTH associated with low urinary calcium excretion. In this context, a calcium clearance to creatinine clearance ratio (Ca urine 24 h. x serum Cr) / (Cr urine 24 h x serum Ca) ≤ 0.01 is highly suggestive of the diagnosis of FHH, which should subsequently be confirmed by sequencing of the genes involved in the different forms of FHH. Two families with FHH with mutations not described in the literature are presented.</p>","PeriodicalId":18419,"journal":{"name":"Medicina-buenos Aires","volume":"85 2","pages":"429-433"},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143803393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Juan S Alvarado Giménez, Beder G Farez, Gustavo G Vega
{"title":"[Can changes in diastolic function be predicted according to risk factors?]","authors":"Juan S Alvarado Giménez, Beder G Farez, Gustavo G Vega","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Diastolic function has a dynamic behavior according to modifying factors. We describe the variables used in its assessment by echocardiography in different population groups of men and women to determine whether changes can be predicted according to their risk factors.</p><p><strong>Materials and methods: </strong>Observational and descriptive cross-sectional registry. A systematic collection of anthropometric characteristics, risk factors and specific echocardiographic variables of diastolic function was performed in an outpatient echocardiography laboratory. Quantitative variables were expressed as mean and standard deviation for Gaussian distribution variables. Discrete variables were analyzed using contingency tables, qualitative variables are expressed as percentages. Means were compared using the Student t test.</p><p><strong>Results: </strong>A total of 107 patients were admitted. Those with sedentary lifestyle had a mean left atrial volume of 29 ml/m2, a deceleration time of 218 ms, a transmittal flow ratio E/A (EA) of 1.5, tissue Doppler ratio Ee´ (Ee) of 6 and e´a´ (ea) of 1.4; those who performed physical activity 3 times a week were characterized by having a left atrial volume of 35 ml/m2, a deceleration time of 210 ms, EA of 1.8, Ee of 5 and ea of 1.8. Patients with obesity had a left atrial volume of 35 ml/m2, deceleration time of 226 ms, E/A 1.1, Ee of 9 and ea of 1.2. Those with arterial hypertension had a left atrial volume of 33 ml/m2, deceleration time of 224 ms and E/A ratio of 1, Ee of 8 and ea of 1.</p><p><strong>Discussion: </strong>The inclusion of certain risk factors in the history prior to echocardiographic evaluation can predict subgroups with different diastolic function.</p>","PeriodicalId":18419,"journal":{"name":"Medicina-buenos Aires","volume":"85 1","pages":"23-30"},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143123209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Malena Chiaborelli, Camila Volij, Karin S Kopitowski, Sergio A Terrasa
{"title":"[Excessive use of vitamin D testing in the private health system].","authors":"Malena Chiaborelli, Camila Volij, Karin S Kopitowski, Sergio A Terrasa","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Given the importance of reducing lowvalue care practices and acknowledging that vitamin D testing in the general population is rising despite the absence of evidence to support such conduct, we decided to investigate its overuse.</p><p><strong>Materials and methods: </strong>Design: cross-sectional study.</p><p><strong>Data source: </strong>electronic medical records.</p><p><strong>Population: </strong>patients aged between 18 and 64 on the Hospital Italiano de Buenos Aires Health Maintenance Organization membership list, to whom at least one test of vitamin D had been performed between July 1st and December 31st 2022. A sample of electronic medical records was manually analyzed. In the presence/suspicion of a clinical condition that counts with recommendation for Vitamin D testing, its indication was considered appropriate; however, in its absence, it was considered inappropriate.</p><p><strong>Results: </strong>A total of 10 095 vitamin D tests were performed on 9623 patients (mean age 47, 78.1% female). These patients were 10% of the 97 584 HMO members aged between 18 and 64 in 2022. A hundred and sixty of the 242 patients whose electronic medical records were analyzed (66%, CI 95% 60 - 72), did not have a clinical condition that justified vitamin D testing. The most frequent clinical conditions found for testing were osteopenia in 37/242 patients (15%); osteoporosis, 13/242 (5%) and chronic kidney disease 11/242 (5%).</p><p><strong>Discussion: </strong>Two-thirds of the vitamin D tests performed did not have a clinical condition that justified the practice. These findings represent an opportunity to design strategies to institutionally reduce this low-value care practice.</p>","PeriodicalId":18419,"journal":{"name":"Medicina-buenos Aires","volume":"85 1","pages":"56-63"},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143123219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nerina García Rosolen, Silvana P Fili, Mario A Aranda, Diego Fernández, Vanesa Ávalos Gómez, Estefania Rossetti, Carolina Pepe, Silvia Eandi Eberle, Carolina Zuanich
{"title":"[From persistent \"hypoxemia\" to the diagnosis of an hemoglobinopathy].","authors":"Nerina García Rosolen, Silvana P Fili, Mario A Aranda, Diego Fernández, Vanesa Ávalos Gómez, Estefania Rossetti, Carolina Pepe, Silvia Eandi Eberle, Carolina Zuanich","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Low oxygen (O2) affinity hemoglobin (Hb) variants are a group of structural hemoglobinopathies, caused in most cases by point mutations in beta or alpha globin genes. The clinical presentation is widely variable, from asymptomatic patients to those presenting cyanosis and/or low O 2 saturation without signs of chronic hypoxia. Accurate identification of these patients is essential to avoid invasive cardiorespiratory procedures that could be unnecessary. We present the case of a girl in an acute viral illness context, with repeated low peripheral O2 saturation (SpO2) readings without clinical picture of hypoxemia. The differential diagnosis included a low O 2 affinity Hb, suspected by an increased partial pressure of O2 at 50% (p50) and confirmed by molecular biology. We highlight the usefulness of arterial blood gas analysis and the p50 determination in the initial phase of evaluation of an unexplained \"hypoxemia\".</p>","PeriodicalId":18419,"journal":{"name":"Medicina-buenos Aires","volume":"85 1","pages":"221-224"},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143123221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Camila Alves, María Belén López, Anahí Ossio, Paula Zamorano, Ruben Solari, Julian García, Andrés Benchetrit
{"title":"[Klebsiella pneumoniae liver abscess syndrome: an emerging global disease].","authors":"Camila Alves, María Belén López, Anahí Ossio, Paula Zamorano, Ruben Solari, Julian García, Andrés Benchetrit","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Klebsiella pneumoniae liver abscess syndrome due to hypermucoviscous strains is defined by the presence of monomicrobial liver abscess, without biliary tree or colorectal disease. These strains may be easily identified in the laboratory by performing a string test. It has the potential to spread to other organs, leading to a high morbimortality. We report two cases of liver abscess due to naturally susceptible Klebsiella pneumoniae, one of them with endogenous endophthalmitis as metastatic involvement that required evisceration.</p>","PeriodicalId":18419,"journal":{"name":"Medicina-buenos Aires","volume":"85 1","pages":"213-216"},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143123226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cristian L Rodríguez, Martín Milanesio, Ana R Montivero, María B Castro, Ana L Basquiera
{"title":"[Myositis secondary to all-transretinoic acid during induction in acute promyelocytic leukemia].","authors":"Cristian L Rodríguez, Martín Milanesio, Ana R Montivero, María B Castro, Ana L Basquiera","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Acute promyelocytic leukemia (APL) is a specific subtype of acute myeloid leukemia (AML) characterized by the presence of the 15;17 translocation, that generates the PML/RARalpha fusion gene. First-line induction treatment includes the combination of all-transretinoic acid (ATRA) and arsenic trioxide, with which complete response rates greater than 90% are achieved. Although the combination is very effective, there are adverse reactions associated with the treatment, which include cellular differentiation syndrome, headache, fatigue, elevated triglycerides, and myositis. The latter is rare and is manifested by intense muscle pain a few days after starting ATRA. Creatine phosphokinase (CPK) values are not always elevated and this can make diagnosis difficult with delayed treatment and increased risk of complications. We report the case of a woman with APL who, during the induction phase of treatment, presented myositis of the pelvic muscles and lower extremities secondary to the administration of ATRA. The condition resolved after the administration of corticosteroids and temporary suspension of ATRA, with no recurrence after its restart.</p>","PeriodicalId":18419,"journal":{"name":"Medicina-buenos Aires","volume":"85 2","pages":"449-453"},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143803441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[To leave the WHO: a decision that puts Argentine Public Health at risk].","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":18419,"journal":{"name":"Medicina-buenos Aires","volume":"85 2","pages":"464-466"},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143803495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jorge L Olivares, María Del Carmen Silva Croome, María Julia Gutierrez, Fany Arrese, Marina Villarreal, Luis A Ramírez Stieben
{"title":"Assessment of iodine intake in rural schoolchildren from La Pampa, Argentina: a comparative analysis between 2002 and 2023.","authors":"Jorge L Olivares, María Del Carmen Silva Croome, María Julia Gutierrez, Fany Arrese, Marina Villarreal, Luis A Ramírez Stieben","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Iodine is an essential micronutrient for the synthesis of thyroid hormones, crucial for neurological development. In 2002, a mild iodine deficiency was identified in schoolchildren from La Pampa, Argentina. This study aims to reassess iodine intake in the same rural school population in 2023 by analyzing urinary iodine concentration (UIC), goiter prevalence, and salt iodization.</p><p><strong>Materials and methods: </strong>A cross-sectional study was conducted in 6- to 12-year-old schoolchildren from School No. 45 in Ataliva Roca, La Pampa. Parents provided informed consent. UIC, weight, height, blood pressure, and goiter were assessed. UIC was measured using the modified Sandell-Kolthoff method, and salt iodization was analyzed using sodium thiosulfate titration. The results were compared with those from 2002.</p><p><strong>Results: </strong>A total of 74 schoolchildren were evaluated in 2023. The median UIC was 145.45 υg/L, with 28.8% of students showing levels below 50 υg/L. Goiter prevalence was 21.6%, compared to 17.9% in 2002. In 85.5% of the salt samples, iodine levels were adequate. There were no statistically significant differences between the 2002 and 2023 cohorts in the prevalence of goiter or iodine fortification of salt.</p><p><strong>Discussion: </strong>Despite improvements in iodine intake since 2002, a considerable percentage of schoolchildren still show moderate iodine deficiency.</p>","PeriodicalId":18419,"journal":{"name":"Medicina-buenos Aires","volume":"85 2","pages":"314-321"},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143803725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}