María Angeles Idiazabal Alecha, Montserrat Palau Baduell
{"title":"[Cerebral neuromodulation in neurodevelopmental disorders].","authors":"María Angeles Idiazabal Alecha, Montserrat Palau Baduell","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Neurodevelopmental disorders comprise a heterogeneous group of conditions characterized by earlyonset impairments in cognitive, behavioral, emotional, and social functioning, that persist across the lifespan. Growing evidence on the neurobiological underpinnings of attention-deficit/hyperactivity disorder and autisms spectrum disorder has promoted the use of non-invasive brain stimulation as a complementary therapeutic approach. Repetitive transcranial magnetic stimulation and transcranial direct current stimulation can safely modulate cortical excitability and synaptic plasticity, targeting dysfunctional neural networks involved in executive control, attention, and socio-emotional processing. Findings from pediatric populations indicate that prefrontal stimulation, particularly of the dorsolateral prefrontal cortex, may improve executive functions and reduce core clinical symptoms. Both techniques show favorable safety and tolerability profiles in children and adolescents. However, variability in stimulation protocols and outcome measures highlights the need for large-scale, standardized clinical trials to establish optimal parameters and long-term efficacy.</p>","PeriodicalId":18419,"journal":{"name":"Medicina-buenos Aires","volume":"86 Suppl 1 ","pages":"8-13"},"PeriodicalIF":0.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146202092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Marta Martinez-Morga, Daniel Garrigos, Salvador Martinez-Morga, Salvador Martinez
{"title":"[Consequences of congenital COVID-19 on the cognitive development of affected children].","authors":"Marta Martinez-Morga, Daniel Garrigos, Salvador Martinez-Morga, Salvador Martinez","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Congenital COVID-19 refers to infection with the SARS-CoV-2 virus acquired in utero as a result of maternal infection during pregnancy. Although vertical transmission of the virus from mother to fetus appears to be relatively infrequent, growing clinical and epidemiological evidence indicates that prenatal exposure to SARSCoV-2, as well as to the maternal immune response it elicits, may have significant implications for early neurological development. Therefore, understanding the potential cognitive consequences of congenital COVID-19 is essential for the long-term monitoring of child health in affected individuals and for the implementation of early intervention strategies. This post-pandemic perspective on the consequences for neural development has been supported by observations showing that neonates exposed to congenital COVID-19 infection have a tenfold higher incidence of developmental delay compared with those not exposed to the virus. In this review, we examine the pathogenic mechanisms that may explain the increased incidence of neurodevelopmental alterations.</p>","PeriodicalId":18419,"journal":{"name":"Medicina-buenos Aires","volume":"86 Suppl 1 ","pages":"2-7"},"PeriodicalIF":0.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146202068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[\"All I know is that I know nothing\": a pedagogical foundation in medical and health sciences].","authors":"Sebastián A Correa","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":18419,"journal":{"name":"Medicina-buenos Aires","volume":"86 1","pages":"273"},"PeriodicalIF":0.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146125585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Stephen Hales and the origins of hemodynamic monitoring].","authors":"Eduardo Herrera-Aliaga, Manuel E Cortés","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":18419,"journal":{"name":"Medicina-buenos Aires","volume":"86 1","pages":"279-280"},"PeriodicalIF":0.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146125754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Argentine National Immunization Commission: some reflections on recent changes].","authors":"Daniel Stecher","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":18419,"journal":{"name":"Medicina-buenos Aires","volume":"86 2","pages":"564-565"},"PeriodicalIF":0.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147654419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jorge A Lax, Agustín Morales Pieruzzini, Carlos D Labadet, Darío Di Toro, Mariano Napoli, Eugenia Doppler, Tomás F Cianciulli, María C Saccheri, Gerardo Marambio, Martín Beck, Juan A Gagliardi
{"title":"[Hypertrophic cardiomyopathy and implantable cardiodefibrillator: 25 years of follow up].","authors":"Jorge A Lax, Agustín Morales Pieruzzini, Carlos D Labadet, Darío Di Toro, Mariano Napoli, Eugenia Doppler, Tomás F Cianciulli, María C Saccheri, Gerardo Marambio, Martín Beck, Juan A Gagliardi","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>The implantable cardiodefibrillator (ICD) is the best available treatment for patients with hypertrophic cardiomyopathy (HCM), survivors or at high risk of sudden cardiac death (SCD). The incidence of SCD in HCM has decreased significantly since the advent of ICD. We report our 25-year experience with its use in a public hospital.</p><p><strong>Materials and methods: </strong>A retrospective analysis of 630 patients with HCM from 1999 to 2024 was made, including 26 patients with ICD implantation. Risk factors, ICD indication, functional class, discharges, echocardiographic measurements, and ICD-related and noninterventional complications were analyzed.</p><p><strong>Results: </strong>The mean age was 42.5 ± 15.5 years, with 11 patients being women (42.3%). A total 25 patients (96.1%) were in primary prevention and 1 in secondary prevention. The maximum left ventricular wall thickness was 26 ± 5.9 mm. The risk factors for SCD that motivated implantation were family history of SCD (42.3%), nonsustained ventricular tachycardia (61.5%) and massive left ventricular hypertrophy (LVH) (50%). Fourteen ICD therapies were recorded, 8 being appropriate (1.18%/year) and 6 inappropriate (0.85%/year). The complication rate was 15.4% (0.57%/year), and no deaths were reported.</p><p><strong>Conclusion: </strong>There is very little information on the evolution of treatment of HCM with ICD in our country. We present here the results of a 25-year follow-up with a median of 10 years, in which the ICD, implanted in most cases in primary prevention, allowed excellent long-term survival with a low rate of complications.</p>","PeriodicalId":18419,"journal":{"name":"Medicina-buenos Aires","volume":"86 3","pages":"672-679"},"PeriodicalIF":0.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148302400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chen Chen, Li Menglin, Liu Jianyong, Ma Xingkai, Wu Geping
{"title":"Environmental allergen exposure in patients with allergic rhinitis in Zhangjiagang: findings from a skin prick test study.","authors":"Chen Chen, Li Menglin, Liu Jianyong, Ma Xingkai, Wu Geping","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>This study aimed to identify the main allergens causing allergic rhinitis (AR) in Zhangjiagang and analyze their epidemiological features.</p><p><strong>Materials and methods: </strong>From July 2018 to June 2019, 1684 patients with suspected allergic rhinitis in the outpatient department of the First People's Hospital of Zhangjiagang City were tested with an allergen skin prick test (SPT) and statistically analyzed.</p><p><strong>Results: </strong>The overall SPT positive rate was 65.3%. House dust mites (56.2%) and dust mites (56.0%) were the predominant inhalant allergens. Inhalant allergen positivity (59.4%) significantly exceeded ingested allergens (3.4%). The positive rate of inhalation allergens was significantly higher than that of ingestion allergens (χ2=1224.83, p<0.05). There was no significant difference in SPT positive rate between males and females (χ2=1.342, p>0.05). Positivity rates declined with age. Seasonally, autumn showed the highest positivity (74.0%), followed by winter (69.3%), summer (64.6%), and spring (54.7%). Specific allergens like birch, willow, rapeseed, Chinese parasol, and ragweed peaked in autumn, while Alternaria alternata peaked in summer, and cockroach was higher in autumn/winter.</p><p><strong>Conslusion: </strong>House dust mites (56.2%) and dust mites (56.0%) are the predominant allergens triggering allergic rhinitis in Zhangjiagang's humid subtropical climate, with inhalant allergens (59.4%) significantly exceeding ingested allergens (3.4%). The distinct age-related decline in allergen positivity, higher cockroach sensitization in males compared to females, and seasonal variation with peak positivity in autumn (74.0%) collectively inform tailored prevention strategies and region-specific immunotherapy protocols for allergic rhinitis management in this region.</p>","PeriodicalId":18419,"journal":{"name":"Medicina-buenos Aires","volume":"86 1","pages":"73-83"},"PeriodicalIF":0.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146125707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}