{"title":"[原位心脏移植术后随访中三尖瓣功能不全的机制]。","authors":"Pilar Domenech, Estefanía Mestrallet, Ricardo Posatini, César Belziti, Rodolfo Pizarro","doi":"","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>Tricuspid regurgitation (TR) is the most frequent valvulopathy after cardiac transplantation, with an incidence ranging from 19% to 84%. Severity increases with follow-up. The objectives were to describe the mechanisms involved in the development of post-transplantation TR.</p><p><strong>Materials and methods: </strong>Single-center, retrospective cohort study including patients who received orthotopic heart transplantation between 2012 and 2022. Echocardiograms were performed at 6, 12 and 18 months' post-transplantation. The mechanisms of tricuspid regurgitation described were atrial dilatation or bi-atrial technique, multiple endomyocardial biopsies, right ventricular dilatation and dysfunction, previous pulmonary hypertension and mismatch of the recipient cavity with the transplanted organ.</p><p><strong>Results: </strong>A total of 234 patients were included. The incidence of significant tricuspid regurgitation from 6 months post-transplantation was 12.8%. Right ventricular dilatation and dysfunction was the most prevalent mechanism in 67%, mismatch 17%, organic valve lesion and previous pulmonary hypertension 7% and atrial dilatation 3%. The 40% of patients who had right ventricular dysfunction also presented left ventricular dysfunction.</p><p><strong>Discussion: </strong>The incidence of tricuspid regurgitation in heart transplant patients was 12.8% during the follow-up. The main mechanism observed was the right ventricular dilatation and dysfunction.</p>","PeriodicalId":18419,"journal":{"name":"Medicina-buenos Aires","volume":"85 2","pages":"331-336"},"PeriodicalIF":0.6000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"[Mechanisms of tricuspid insufficiency in the follow-up of patients post orthotopic heart transplantation].\",\"authors\":\"Pilar Domenech, Estefanía Mestrallet, Ricardo Posatini, César Belziti, Rodolfo Pizarro\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>Tricuspid regurgitation (TR) is the most frequent valvulopathy after cardiac transplantation, with an incidence ranging from 19% to 84%. Severity increases with follow-up. The objectives were to describe the mechanisms involved in the development of post-transplantation TR.</p><p><strong>Materials and methods: </strong>Single-center, retrospective cohort study including patients who received orthotopic heart transplantation between 2012 and 2022. Echocardiograms were performed at 6, 12 and 18 months' post-transplantation. The mechanisms of tricuspid regurgitation described were atrial dilatation or bi-atrial technique, multiple endomyocardial biopsies, right ventricular dilatation and dysfunction, previous pulmonary hypertension and mismatch of the recipient cavity with the transplanted organ.</p><p><strong>Results: </strong>A total of 234 patients were included. The incidence of significant tricuspid regurgitation from 6 months post-transplantation was 12.8%. Right ventricular dilatation and dysfunction was the most prevalent mechanism in 67%, mismatch 17%, organic valve lesion and previous pulmonary hypertension 7% and atrial dilatation 3%. The 40% of patients who had right ventricular dysfunction also presented left ventricular dysfunction.</p><p><strong>Discussion: </strong>The incidence of tricuspid regurgitation in heart transplant patients was 12.8% during the follow-up. The main mechanism observed was the right ventricular dilatation and dysfunction.</p>\",\"PeriodicalId\":18419,\"journal\":{\"name\":\"Medicina-buenos Aires\",\"volume\":\"85 2\",\"pages\":\"331-336\"},\"PeriodicalIF\":0.6000,\"publicationDate\":\"2025-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Medicina-buenos Aires\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"MEDICINE, GENERAL & INTERNAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Medicina-buenos Aires","FirstCategoryId":"3","ListUrlMain":"","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
[Mechanisms of tricuspid insufficiency in the follow-up of patients post orthotopic heart transplantation].
Introduction: Tricuspid regurgitation (TR) is the most frequent valvulopathy after cardiac transplantation, with an incidence ranging from 19% to 84%. Severity increases with follow-up. The objectives were to describe the mechanisms involved in the development of post-transplantation TR.
Materials and methods: Single-center, retrospective cohort study including patients who received orthotopic heart transplantation between 2012 and 2022. Echocardiograms were performed at 6, 12 and 18 months' post-transplantation. The mechanisms of tricuspid regurgitation described were atrial dilatation or bi-atrial technique, multiple endomyocardial biopsies, right ventricular dilatation and dysfunction, previous pulmonary hypertension and mismatch of the recipient cavity with the transplanted organ.
Results: A total of 234 patients were included. The incidence of significant tricuspid regurgitation from 6 months post-transplantation was 12.8%. Right ventricular dilatation and dysfunction was the most prevalent mechanism in 67%, mismatch 17%, organic valve lesion and previous pulmonary hypertension 7% and atrial dilatation 3%. The 40% of patients who had right ventricular dysfunction also presented left ventricular dysfunction.
Discussion: The incidence of tricuspid regurgitation in heart transplant patients was 12.8% during the follow-up. The main mechanism observed was the right ventricular dilatation and dysfunction.