Medicina-buenos Aires最新文献_第3页

[Lepromatous leprosy with respiratory failure in the City of Buenos Aires]. [布宜诺斯艾利斯市伴有呼吸衰竭的麻风病人]。

IF 0.6 4区医学

Medicina-buenos Aires Pub Date : 2024-01-01

Roberto A Villa

引用次数: 0

[What is being investigated and who conducts clinical research related to medicines in Argentina?] [阿根廷正在调查什么，谁在进行与药品有关的临床研究？］

IF 0.6 4区医学

Medicina-buenos Aires Pub Date : 2024-01-01

Gustavo H Marin, Silvia Boni, Valeria Garay, Manuel Limeres

{"title":"[What is being investigated and who conducts clinical research related to medicines in Argentina?]","authors":"Gustavo H Marin, Silvia Boni, Valeria Garay, Manuel Limeres","doi":"","DOIUrl":"","url":null,"abstract":"Introduction: Clinical trials that involve medicines are performed in order to determine their effectiveness and safety. In Argentina, these studies are presented either to National Administration of Drugs, Food and Medical Technology (ANMAT) to obtain drug registration, or to the National Ministry of Health (MSAL) (to obtain the official recognition). This work was carried out to increase the knowledge about the clinical trials performed in Argentina.Materials and methods: The MSAL/ANMAT databases were explored. The variables were: dates of request, institution, phase of the study, enrollment modality, product investigated, therapeutic group, comparator, pathology involved, and location of laboratory performance.Results: A total of 201 protocols were detected in the period of study, all of them performed with registration purposes. Twenty pharmaceutical companies carried out 60% of the studies (17 with foreign capital). Seventy percent were phase III (90% multicenter protocols). Three out of 4 trials corresponded to the oncology / immunosuppressant therapeutical group. In 65% the comparator used was placebo. A 71% of the studies were carried out in health institutions of Buenos Aires City. Ninety-eight per cent of laboratory controls were carried out abroad.Discussion: Foreign pharmaceutical companies are the only ones that carry out clinical trials on medicines in Argentina, all of them for registration purposes. The use of placebo as a comparator is inappropriate, since each drug is expected to be validated against another of recognized efficacy already available in the market. Oncological/immunological pathologies are the ones that arouse greater interest among local researchers due to their prevalence and their greater profitability in the pharmaceutical market.","PeriodicalId":18419,"journal":{"name":"Medicina-buenos Aires","volume":"84 5","pages":"929-936"},"PeriodicalIF":0.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142469569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of Greek and Latin terminology by medical students. 医学生对希腊语和拉丁语术语的评估。

IF 0.8 4区医学

Medicina-buenos Aires Pub Date : 2024-01-01

Manuel E Cortés, Eduardo Herrera-Aliaga, Luis Vicencio-Villaseca

引用次数: 0

Pulmonary strain and end-expiratory lung volume during apnea test: a comparative analysis using electrical impedance tomography. 呼吸暂停测试时的肺应变和呼气末肺活量：使用电阻抗断层扫描进行比较分析。

IF 0.8 4区医学

Medicina-buenos Aires Pub Date : 2024-01-01

Ignacio Fernández Ceballos, Joaquín Ems, Emilio Steinberg, Juan M Nuñez Silveira, Micaela B Hornos, Melany Berdiñas Anfuso, Carlos Videla, Nicolás M Ciarrocchi, Indalecio Carboni Bisso, Marcos Las Heras

{"title":"Pulmonary strain and end-expiratory lung volume during apnea test: a comparative analysis using electrical impedance tomography.","authors":"Ignacio Fernández Ceballos, Joaquín Ems, Emilio Steinberg, Juan M Nuñez Silveira, Micaela B Hornos, Melany Berdiñas Anfuso, Carlos Videla, Nicolás M Ciarrocchi, Indalecio Carboni Bisso, Marcos Las Heras","doi":"","DOIUrl":"","url":null,"abstract":"The apnea test, employed for brain death assessment, aims to demonstrate the absence of respiratory drive due to hypercapnia. The tracheal oxygen insufflation apnea test mode (I-AT) involves disconnecting the patient from invasive mechanical ventilation (iMV) for approximately 8 minutes while maintaining oxygenation. This test supports the diagnosis of brain death based on a specified increase in PaCO2. Common complications include hypoxemia and hemodynamic instability, and lung collapse-induced reduction in end-expiratory lung volume (EELV). In our case series utilizing electrical impedance tomography (EIT), we observed that continuous positive airway pressure during the apnea test (CPAP-AT) effectively mitigated lung collapse. This resulted in improved pulmonary strain compared to the disconnection of iMV. These findings suggest the potential benefits of routine CPAP-AT, particularly for potential lung donors, emphasizing the relevance of our study in providing quantitative insights into EELV loss and its association with pulmonary strain and potential lung injury.","PeriodicalId":18419,"journal":{"name":"Medicina-buenos Aires","volume":"84 2","pages":"359-363"},"PeriodicalIF":0.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140855448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Ischemic stroke due to paradoxical embolism through pulmonary arteriovenous malformation in a young patient]. [年轻患者肺动静脉畸形引起的矛盾性栓塞导致缺血性中风]。

IF 0.8 4区医学

Medicina-buenos Aires Pub Date : 2024-01-01

Matías J Alet, Hernán Bertoni, Sebastián F Ameriso

引用次数: 0

[Primary hepatic sarcomatoid carcinoma, an unusual case]. [原发性肝肉瘤样癌，一个不寻常的病例]。

IF 0.6 4区医学

Medicina-buenos Aires Pub Date : 2024-01-01

Darío A Rueda, Florencia Antinucci, Marcelo F Amante, Carlos A Bas

引用次数: 0

[Abscessed tuberculomas in immunocompetent patient]. [免疫功能正常患者的脓毒性结核瘤]。

IF 0.6 4区医学

Medicina-buenos Aires Pub Date : 2024-01-01

María Victoria Perez Allub, Cinthya Reznik, Ignacio Saguier Padilla, Alberto R Aguirre, Silvia S Folgar, Flavio C B Mercado

引用次数: 0

[Brush migration in a tracheostomized patient]. [气管插管病人的刷子移位]。

IF 0.6 4区医学

Medicina-buenos Aires Pub Date : 2024-01-01

Hugo Paez Pastor, Juan Rouquaud, Artemio Garcia, Julieta Franzoy, Pablo Young

引用次数: 0

[Intestinal pneumatosis and pneumoperitonum: not always a surgical indication]. [肠积气和腹腔积气：不一定是手术指征]。

IF 0.6 4区医学

Medicina-buenos Aires Pub Date : 2024-01-01

Julio César Rotondaro, Manuel Maya, Magalí Gutierrez, Gonzalo L Echavarria, Gustavo H Badariotti

{"title":"[Intestinal pneumatosis and pneumoperitonum: not always a surgical indication].","authors":"Julio César Rotondaro, Manuel Maya, Magalí Gutierrez, Gonzalo L Echavarria, Gustavo H Badariotti","doi":"","DOIUrl":"","url":null,"abstract":"Pneumatosis intestinalis and pneumoperitoneum are not pathological entities in themselves, they are radiological signs that result from some underlying condition. In general, these are associated with serious intra-abdominal processes that result in emergency surgeries with bowel resections. Below, we present the case of an 80-year-old woman, diagnosed with stage IV breast cancer under treatment with fulvestrant and ribociclib, who was admitted to our center due to abdominal pain and vomiting. She was diagnosed with intestinal pneumatosis and pneumoperitoneum, so she underwent exploratory laparotomy for suspected intestinal ischemia. There was no evidence of intestinal necrosis or perforation, so resection was not performed. She progressed satisfactorily during hospitalization and in the tomographic control one month after discharge there was complete resolution of the condition. Although this condition has been described in relation to episodes of increased intra-abdominal pressure, such as emesis, it has also been described in patients with neoplasms, mainly of the digestive tract, either due to local damage or toxicity associated with chemotherapy. We found no reports in the literature of pneumatosis intestinalis linked to this antineoplastic medication in humans. Probably in our case the etiology was multifactorial. It is possible that ribociclib played a role, either through an indirect mechanism associated with vomiting and immunosuppression or directly on the enterocyte due to its non-specific cellular mechanism of action.","PeriodicalId":18419,"journal":{"name":"Medicina-buenos Aires","volume":"84 3","pages":"574-578"},"PeriodicalIF":0.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141440607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Molecular diagnosis of bacteriaemia: benefits of using the FilmArray® BCID2 sepsis panel in a third level hospital]. [细菌血症的分子诊断：在一家三级医院使用 FilmArray® BCID2 败血症面板的益处]。

IF 0.6 4区医学

Medicina-buenos Aires Pub Date : 2024-01-01

Natalia A Díaz, Javier Farina, Liucó Zubeldía Brenner, Glenda Guzman, Sofía Lucini, Candela Serra, María Laura Negro, María Florencia Gil

{"title":"[Molecular diagnosis of bacteriaemia: benefits of using the FilmArray® BCID2 sepsis panel in a third level hospital].","authors":"Natalia A Díaz, Javier Farina, Liucó Zubeldía Brenner, Glenda Guzman, Sofía Lucini, Candela Serra, María Laura Negro, María Florencia Gil","doi":"","DOIUrl":"","url":null,"abstract":"Introduction: Delay in initiating appropriate antimicrobial therapy prolongs hospitalization, increases in-hospital mortality, and raises economic costs. Currently, the identification and susceptibility testing of bacteria in positive blood cultures require a considerable amount of time. The objective of this study was to assess the impact of the BCID2 FilmArray® (FA) panel on the timing of appropriate antimicrobial therapy and potential antimicrobial costs.Methods: This is a retrospective observational study focused on positive blood cultures in hospitalized patients. FA processing was conducted concurrently with routine sample processing. Changes in antibiotic treatments based on FA results were evaluated, and the reduction in antimicrobial therapy duration and associated cost savings were calculated.Results: Eighty-seven bacteremia episodes were analysed. In 42 (48%) of them antimicrobial therapy was de-escalated to narrower spectrum agents, while in 7 (8%) therapy was escalated to broader spectrum antimicrobials. Additionally, in 8 (9%) antimicrobials were switched without changing spectrum and in 30 (34%) no changes were made based on FA results. Antimicrobial changes were made 2.3 days faster than with routine sample processing resulting in calculated potential savings of US$ 7408.Conclusion: The implementation of FA facilitated a faster administration of appropriate antimicrobial therapy, leading to a reduction in the duration of broadspectrum empirical antimicrobial therapy and subsequent economic savings.","PeriodicalId":18419,"journal":{"name":"Medicina-buenos Aires","volume":"84 4","pages":"649-655"},"PeriodicalIF":0.6,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142036317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0