Medicina-buenos Aires最新文献_第3页

[Utility of LUI-Spanish for evaluating pragmatics in children with autism spectrum disorder]. [lui -西班牙语在评估自闭症谱系障碍儿童语用学中的应用]。

IF 0.6 4区医学

Medicina-buenos Aires Pub Date : 2025-03-01

Nerea Gascón, Inmaculada Baixauli, Carmen Moret-Tatay, Nuria Senent

引用次数: 0

[Future of intelligence: natural brain, artificial brain]. [智能的未来：自然大脑，人工大脑]。

IF 0.6 4区医学

Medicina-buenos Aires Pub Date : 2025-03-01

Marta Martinez-Morga, Salvador J Martinez, Daniel Garrigos, Salvador Martínez

引用次数: 0

[Inflexibility in autism spectrum disorder]. [自闭症谱系障碍的不灵活性]。

IF 0.6 4区医学

Medicina-buenos Aires Pub Date : 2025-03-01

Juan Martos Pérez, María Llorente Comí

引用次数: 0

[Early diagnosis of ASD using biomarkers: a narrative review]. [使用生物标记物早期诊断ASD：一个叙述性回顾]。

IF 0.6 4区医学

Medicina-buenos Aires Pub Date : 2025-03-01

Luna Maddalon, Maria Eleonora Minissi, Mariano Alcañiz

{"title":"[Early diagnosis of ASD using biomarkers: a narrative review].","authors":"Luna Maddalon, Maria Eleonora Minissi, Mariano Alcañiz","doi":"","DOIUrl":"","url":null,"abstract":"Autism Spectrum Disorder (ASD) encompasses a range of neurodevelopmental conditions characterized by social challenges, repetitive behaviors, and communication difficulties. While diagnosis traditionally relies on behavioral observations, new biomedical approaches, such as the Research Domain Criteria (RDoC), aim to identify biomarkers that integrate genetic, neural, and behavioral factors. Notable biomarkers include genetic variants, molecular alterations such as abnormal neurotransmitter levels, and markers associated with immune dysfunction. Brain organoids have also enabled the investigation of specific neural mechanisms. In neuroimaging, techniques such as functional magnetic resonance imaging (fMRI) and functional near-infrared spectroscopy (fNIRS) have identified atypical connectivity patterns in infants at high risk for ASD. Similarly, measures like electroencephalography (EEG) and eye tracking have revealed differences in visual attention and brain activity, while physiological indicators such as electrodermal activity (EDA) and heart rate variability (HRV) reflect sensory and autonomic dysfunctions. The use of digital biomarkers is rapidly growing, with devices like tablets and virtual reality capturing data on children's interactions. Analyzed using artificial intelligence, these data show promise for improving early ASD detection, though further validation is needed. Integrating traditional and digital approaches is essential for advancing diagnosis and intervention strategies.","PeriodicalId":18419,"journal":{"name":"Medicina-buenos Aires","volume":"85 Suppl 1 ","pages":"3-8"},"PeriodicalIF":0.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143527889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Treatment adherence for Attention Deficit Hyperactivity Disorder (ADHD) in the ChAMP UT-Health Houston Program]. [ChAMP UT-Health Houston项目中注意缺陷多动障碍（ADHD）的治疗依从性]。

IF 0.6 4区医学

Medicina-buenos Aires Pub Date : 2025-03-01

Rachitha P Jadala, Hali Temkin, Kerri L Daniel, Cesar A Soutullo

{"title":"[Treatment adherence for Attention Deficit Hyperactivity Disorder (ADHD) in the ChAMP UT-Health Houston Program].","authors":"Rachitha P Jadala, Hali Temkin, Kerri L Daniel, Cesar A Soutullo","doi":"","DOIUrl":"","url":null,"abstract":"Introduction: ADHD has a safe and effective treatment, but treatment adherence is often low. Several factors contribute to this low adherence, some of which are modifiable.Methods: We conducted a literature review of recent studies on medication adherence in children and adolescents with ADHD. We gathered data on ADHD treatment adherence from our clinic in the ADHD Program and the Child and Adolescent Mood Disorders Program (ChAMP) at the University of Texas Health-Houston Program. We analyzed factors related to medication adherence, such as patient age, sex, prescription type, release formula, and their association with adherence in 117 patients with ADHD who were prescribed stimulant or nonstimulant medications.Results: We found publications identifying factors influencing medication adherence, including disorder characteristics, the patient, the healthcare system, socioeconomic factors, the medication itself, and the environment. Factors that can improve adherence include: knowledge about ADHD, the medication, its benefits, and potential side effects; simple, once-daily extendedrelease medication regimens; patients younger than 12 years old; female sex; reduced barriers to accessing healthcare; and a positive, proactive attitude of parents toward ADHD and medication use.Discussion: Optimizing adherence and long-term prognosis of ADHD is achieved by reinforcing factors that increase adherence and reducing biases and lack of knowledge about ADHD.","PeriodicalId":18419,"journal":{"name":"Medicina-buenos Aires","volume":"85 Suppl 1 ","pages":"82-89"},"PeriodicalIF":0.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143527915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Autism Spectrum Disorders (ASD) and Obsessive Compulsive Disorder (OCD): a new approach from the DSM-5-TR and its management]. [自闭症谱系障碍（ASD）和强迫症（OCD）：来自DSM-5-TR及其管理的新方法]。

IF 0.6 4区医学

Medicina-buenos Aires Pub Date : 2025-03-01

Amaia Hervás

引用次数: 0

[Autism and burnout]. [自闭症和倦怠]。

IF 0.6 4区医学

Medicina-buenos Aires Pub Date : 2025-03-01

Víctor Ruggieri

引用次数: 0

[Heritability in neurodevelopmental disorders]. [神经发育障碍的遗传性]。

IF 0.6 4区医学

Medicina-buenos Aires Pub Date : 2025-03-01

Jesús Eirís-Puñal, E Monteagudo-Saavedra

{"title":"[Heritability in neurodevelopmental disorders].","authors":"Jesús Eirís-Puñal, E Monteagudo-Saavedra","doi":"","DOIUrl":"","url":null,"abstract":"Neurodevelopmental disorders (NDD) share two main characteristics: their high comorbidity between them and other processes - psychiatric disorders and epilepsy - and their high heritability, with a gap between that extracted through family studies (familial heritability, 0.66) and that obtained through genetic studies (genetic heritability, 0.19). There is a strong genetic correlation between NDD and different behavioral disorders, with a familial genetic correlation coefficient estimated at 0.62, suggesting a shared genetic load that encompasses these processes as well as others such as bipolar disorder, schizophrenia or depression. Missing heritability, mutational load and genetic vulnerability are important concepts for understanding the complex interactions between different NDD and their comorbidities, as well as for illustrating the discrepancy between genetic and familial heritability figures. Genetic vulnerability determines which genes are more likely to cause diseases when mutated; Mutational load accumulates the genetic effects that influence the phenotypic expression of a disorder, and the interaction between different variants (epistasis) and their accumulation, including common variants, can amplify the probability of developing a disorder. Missing heritability illustrates the proportion of heritability not explained by identified genetic variants. Although genome-wide association studies (GWAS) identify common variants associated with diseases, these usually explain only a small part of the total genetic risk. This gap can be related to different factors, including rare variants present in non-coding regions, epigenetic factors that regulate vulnerable genes, and complex interactions between genes.","PeriodicalId":18419,"journal":{"name":"Medicina-buenos Aires","volume":"85 Suppl 1 ","pages":"22-29"},"PeriodicalIF":0.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143527892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[The most serious comorbidities of ADHD: a worrying review]. [ADHD最严重的合并症：令人担忧的回顾]。

IF 0.6 4区医学

Medicina-buenos Aires Pub Date : 2025-03-01

Germán Casas, Carolina García S, Damaris Cote Martínez

{"title":"[The most serious comorbidities of ADHD: a worrying review].","authors":"Germán Casas, Carolina García S, Damaris Cote Martínez","doi":"","DOIUrl":"","url":null,"abstract":"Attention-deficit hyperactivity disorder (ADHD) is the most prevalent neurodevelopmental disorder in children and adolescents, and it is frequently associated with a range of comorbidities. However, an analysis of critical factors -such as mortality, legal issues, access to care, and academic or occupational impairment- reveals that the most serious comorbidities of ADHD are primarily psychiatric in nature. These include depression, suicidal behaviors, substance use disorders, legal problems, and personality disorders, particularly borderline and antisocial personalities. These comorbid conditions share core features, including difficulties with self-regulation, impulsivity and repetitive behaviors. They also exhibit overlapping neurological and genetic substrates, as well as common environmental risk factors. A review of the current literature underscores the significant morbidity and adverse outcomes associated with ADHD when these comorbidities are present. Given the complexity and severity of these conditions, it is crucial for clinicians working with children and adolescents, to be vigilant about monitoring their appearance. Early recognition and intervention may help mitigate the risk of developing these associated psychiatric disorders and their long-term consequences. Furthermore, evidence suggests that timely and appropriate treatment of ADHD can play a protective role in preventing the onset of these comorbid conditions.","PeriodicalId":18419,"journal":{"name":"Medicina-buenos Aires","volume":"85 Suppl 1 ","pages":"16-21"},"PeriodicalIF":0.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143527912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Neurophysiological approach to Attention Deficit Hyperactivity Disorder]. [注意缺陷多动障碍的神经生理学方法]。

IF 0.6 4区医学

Medicina-buenos Aires Pub Date : 2025-03-01

María Ángeles Idiazábal Alecha, Montserrat Palau Baduell

{"title":"[Neurophysiological approach to Attention Deficit Hyperactivity Disorder].","authors":"María Ángeles Idiazábal Alecha, Montserrat Palau Baduell","doi":"","DOIUrl":"","url":null,"abstract":"Attention Deficit Hyperactivity Disorder (ADHD) is the most common neurodevelopmental disorder in childhood. Its diagnosis and treatment are complex due to its clinical heterogeneity and comorbid pathologies, such as epilepsy and sleep disorders, which affect its evolution and management. Studies such as electroencephalogram (EEG), quantified EEG and event related potentials (ERP) provide key neurophysiological information to better understand this disorder. EEG allows the identification of abnormal patterns such as increased frontal theta activity and increased the theta/beta ratio, which are associated with problems with attention and inhibitory control. Comorbidity between epilepsy and ADHD is high. Patients with ADHD are more likely to present subclinical interictal discharges. EEG allows us to differentiate between ADHD and epilepsy symptoms, such as typical absences, which can be confused with inattention, as well as detect the presence of interictal epileptiform discharges, improving diagnosis and treatment. ERP, such as P300, evaluate cognitive functions such as attention, working memory and inhibitory control, providing information for the diagnosis, developmental monitoring and treatment of ADHD. In parallel, sleep studies using polysomnography reveal a high prevalence of sleep disorders such as respiratory disorders and decreased REM sleep, exacerbating ADHD symptoms. Neurophysiological studies allow a more precise approach to ADHD, integrating objective diagnoses and personalized treatments that improve clinical results and long-term prognosis.","PeriodicalId":18419,"journal":{"name":"Medicina-buenos Aires","volume":"85 Suppl 1 ","pages":"42-47"},"PeriodicalIF":0.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143527895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0