Medicina-buenos Aires最新文献_第2页

[Pulmonary cryptococcosis in a non-HIV patient]. [非hiv患者的肺隐球菌病]。

IF 0.6 4区医学

Medicina-buenos Aires Pub Date : 2026-01-01

Alejandro Avilés-Salas, Manuel A Gonzalez-Adame, Irene González-Nava, Carolina Pérez-Jiménez, Oscar Arrieta

{"title":"[Pulmonary cryptococcosis in a non-HIV patient].","authors":"Alejandro Avilés-Salas, Manuel A Gonzalez-Adame, Irene González-Nava, Carolina Pérez-Jiménez, Oscar Arrieta","doi":"","DOIUrl":"","url":null,"abstract":"Cryptococcosis is an opportunistic and conditional disease. The lungs and central nervous system are common organs invaded by Cryptococcus. Most patients with pulmonary cryptococcosis are immunocompromised, such as acquired immune deficiency síndrome, subjects with immunosupressive drugs and hematological malignancies. We present an immunocompetent 46-year-old man with diabetes mellitus, who had cough, chest pain and weight loss. Computed tomography of thorax demonstrated a pulmonary nodule in the right upper lobe, measuring 8.5 cm. To confirm the diagnosis, the patient underwent CT-guided biopsy of the nodule. Pathology revealed round structures with asymmetric budding on Periodic acid-Schiff-diastase, Grocott methenamine silver and mucicarmine stains, morphologically compatible with Cryptococcus sp. Serum cryptococcal antigen was positive. Once the diagnosis of isolated pulmonary cryptococcosis was confirmed, the patient was treated with oral fluconazole 400 mg daily for 6 months. The treatment response was categorized as partial resolution, and the patient underwent a right upper lobectomy. Pulmonary cryptococcosis in non-HIV patients is a relatively common, and in some of them is difficult to differentiate from lung cancer.","PeriodicalId":18419,"journal":{"name":"Medicina-buenos Aires","volume":"86 2","pages":"529-533"},"PeriodicalIF":0.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147654417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Post-hysterectomy chyloascites: A rare complication]. 子宫切除术后乳糜腹水：一种罕见的并发症。

IF 0.6 4区医学

Medicina-buenos Aires Pub Date : 2026-01-01

Sofia Montiel, Cristina Pasaca, Melina Lopepe, Fernando Gorosito, Agustina Rubiño, Pedro Wainer

引用次数: 0

[Difficulties in accessing colorectal cancer treatment in older adults]. [老年人获得结直肠癌治疗的困难]。

IF 0.6 4区医学

Medicina-buenos Aires Pub Date : 2026-01-01

Lilian E Pietracci, Silvana Meek Torres, Matías Daher, María Pía Izaguirre Germain, Diego Caruso

{"title":"[Difficulties in accessing colorectal cancer treatment in older adults].","authors":"Lilian E Pietracci, Silvana Meek Torres, Matías Daher, María Pía Izaguirre Germain, Diego Caruso","doi":"","DOIUrl":"","url":null,"abstract":"Introduction: Colorectal cancer (CRC) is a leading cause of cancer-related mortality among older adults. Delays in diagnosis and treatment negatively impact survival outcomes. In Argentina, access barriers in this population have not been adequately characterized.Materials and methods: We conducted an ambispective cohort study including older adults diagnosed with CRC within the past five years. Telephone interviews were carried out to collect data on time intervals and perceived barriers across five stages of the diagnostictherapeutic process (from symptom onset or screening to treatment initiation). Multivariable linear and logistic regression models were used to assess associations between sociodemographic factors, perceived barriers, and both total time to treatment and stage-specific delays.Results: A total of 225 participants were included. The median time to treatment initiation was 6 months. Perception of barriers was significantly associated with a higher likelihood of delay in all stages analyzed. The most frequently reported barrier was accessibility -mainly difficulties in obtaining medical appointments- present throughout the care continuum. In later stages, resource shortages were also reported. Female sex was associated with longer time to treatment.Conclusion: Our findings highlight the need for structural health system interventions aimed at reducing treatment delays in older adults with CRC. Identifying and addressing perceived barriers could enhance equity and efficiency in access to oncological care. Time to treatment exceeded internationally recommended standards. Perceived barriers were present in all stages and were significantly associated with delays in care delivery.","PeriodicalId":18419,"journal":{"name":"Medicina-buenos Aires","volume":"86 1","pages":"99-112"},"PeriodicalIF":0.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146125410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Evaluation of reproductive and developmental toxicity: its importance in the preclinical phase of new vaccines]. [生殖和发育毒性评价：在新疫苗临床前阶段的重要性]。

IF 0.6 4区医学

Medicina-buenos Aires Pub Date : 2026-01-01

María Florencia Beltramino, Fátima B Gasser, Antonela F Stassi, Hugo H Ortega, María Eugenia Baravalle

{"title":"[Evaluation of reproductive and developmental toxicity: its importance in the preclinical phase of new vaccines].","authors":"María Florencia Beltramino, Fátima B Gasser, Antonela F Stassi, Hugo H Ortega, María Eugenia Baravalle","doi":"","DOIUrl":"","url":null,"abstract":"Preclinical trials in laboratory animals, particularly those aimed at evaluating potential effects on reproduction and offspring development, have gained importance in recent years due to the development of new drugs and vaccines intended for both children and individuals of reproductive age. The current challenge lies in the need for reliable and rapidly obtainable data to enable the transition of new compounds to clinical phases and eventual approval. Since pregnant and breastfeeding women are often excluded from clinical vaccine trials, including those assessing toxicity, there is limited knowledge about this vulnerable population and their offspring. In this context, preclinical studies designed to assess the effects of vaccine and therapeutic candidates on reproduction and development must rely on in vivo models that accurately replicate key aspects of the pathogenesis observed in human disease. When evaluating the reproductive toxicity of vaccines, it is essential not only to assess potential effects on fertility, embryogenesis, development, and reproduction, but also to consider the interactions of the vaccine with the immune system of both the mother and her offspring. This review updates and describes preclinical studies in laboratory animals for new vaccines, particularly those developed against COVID-19, highlighting published studies on reproductive and developmental toxicity, as well as the current regulatory framework governing such studies.","PeriodicalId":18419,"journal":{"name":"Medicina-buenos Aires","volume":"86 1","pages":"166-178"},"PeriodicalIF":0.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146125505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Overall and cause based mortality in General Villegas District, Buenos Aires, Argentina (2015-2020). A population-based analysis within the framework of the Population-Based Epidemiological Study on Stroke (EstEPA)]. [2015-2020年阿根廷布宜诺斯艾利斯维勒加斯将军区总体死亡率和基于原因的死亡率]。基于人群的卒中流行病学研究（EstEPA）框架内的基于人群的分析。

IF 0.6 4区医学

Medicina-buenos Aires Pub Date : 2026-01-01

Matías J Alet, Mario O Melcon, Sebastián F Ameriso

{"title":"[Overall and cause based mortality in General Villegas District, Buenos Aires, Argentina (2015-2020). A population-based analysis within the framework of the Population-Based Epidemiological Study on Stroke (EstEPA)].","authors":"Matías J Alet, Mario O Melcon, Sebastián F Ameriso","doi":"","DOIUrl":"","url":null,"abstract":"Introduction: There are few recent population-based studies on mortality in Argentina outside the context of the COVID-19 pandemic. Our objective was to describe overall and cause-based mortality in the General Villegas District (Buenos Aires) between 2015 and 2020, and to compare it with provincial and national rates.Materials and methods: We conducted a population-based observational cohort study that included all deaths among individuals aged ≥18 years occurring between June 2015 and May 2020 in General Villegas (total population: 35 251 inhabitants). Data were obtained from death certificates, medical records, interviews, and verbal autopsies. Causes of death were classified according to the International Statistical Classification of Diseases and Related Health Problems, 10th Revision: ICD-10. Crude and age--and sex-adjusted mortality rates were calculated using the Argentine standard population, the WHO standard population, and the modified Segi standard for Latin America.Results: A total of 1031 deaths were recorded (56.5% men), yielding a crude mortality rate of 9.7‰, higher than the provincial (8.2‰) and national (7.9‰) rates. The rate was higher in men (11.0‰) than in women (8.4‰). Adjusted mortality rates were 5.2‰ (Argentina), 6.8‰ (modified Segi), and 5.8‰ (WHO). Cardiovascular diseases (170/100 000; 25.4%) and neoplasms (140/100 000; 21.5%) were the leading causes of death. In individuals aged 18-39 years, external causes predominated (36%).Discussion: General Villegas shows a mortality profile comparable to the national average. Data obtained from this stable and representative setting may contribute to the design of regional public health strategies targeting chronic diseases and preventable external causes.","PeriodicalId":18419,"journal":{"name":"Medicina-buenos Aires","volume":"86 1","pages":"12-25"},"PeriodicalIF":0.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146125661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Multiple venous compression syndromes in sequential evolution: a case report with intravascular ultrasound guided endovascular treatment]. 【多静脉压迫综合征的顺序演变：血管内超声引导血管内治疗一例报道】。

IF 0.6 4区医学

Medicina-buenos Aires Pub Date : 2026-01-01

Juan Ignacio Damonte, Juan Manuel Telayna, Juan Manuel Telayna, Fátima Lezcano Sticchi, Sergio Sierre, Ricardo Costantini

{"title":"[Multiple venous compression syndromes in sequential evolution: a case report with intravascular ultrasound guided endovascular treatment].","authors":"Juan Ignacio Damonte, Juan Manuel Telayna, Juan Manuel Telayna, Fátima Lezcano Sticchi, Sergio Sierre, Ricardo Costantini","doi":"","DOIUrl":"","url":null,"abstract":"Venous compression syndromes, such as nutcracker syndrome (NCS) and May-Thurner syndrome (MTS), are rare entities with a complex diagnosis due to their nonspecific symptoms. The coexistence of multiple compression syndromes is exceptional. We present the case of a 38-year-old woman with a history of chronic abdominal and pelvic pain, initially diagnosed with symptomatic NCS associated with pelvic congestion syndrome, successfully treated with venous angioplasty and stent placement guided by intravascular ultrasound (IVUS) with improvement of the symptoms after the treatment. Four years later, the patient developed symptomatic MTS, which worsened the pelvic congestion and required a new endovascular intervention with placement of a dedicated venous stent, also optimized with IVUS. This case highlights the rarity of sequential progression from NCS to MTS and underscores the importance of maintaining a high index of suspicion in young women with chronic pelvic pain. We here in report a case of pelvic congestion syndrome caused by sequential NCS and MTS, resolved with IVUS-optimized endovascular treatment at both stages.","PeriodicalId":18419,"journal":{"name":"Medicina-buenos Aires","volume":"86 2","pages":"521-525"},"PeriodicalIF":0.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147654443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Differential diagnosis of hyperferritinemia]. [高铁素血症的鉴别诊断]。

IF 0.6 4区医学

Medicina-buenos Aires Pub Date : 2026-01-01

María Margarita Anders, Juan Antonio Sorda

引用次数: 0

[Dolichoectasia of the basilar artery]. [基底动脉扩张]。

IF 0.6 4区医学

Medicina-buenos Aires Pub Date : 2026-01-01

Dalila León, David Bejarano, Nebil Larrañaga

引用次数: 0

[Ventilator-associated polymicrobial pneumonia: importance and clinical considerations]. [呼吸机相关的多微生物肺炎：重要性和临床考虑]。