Membranes最新文献_第4页

Investigation of the Ternary System, Water/Hydrochloric Acid/Polyamide 66, for the Production of Polymeric Membranes by Phase Inversion.

IF 3.3 4区工程技术

Membranes Pub Date : 2025-01-01 DOI: 10.3390/membranes15010007

Jocelei Duarte, Camila Suliani Raota, Camila Baldasso, Venina Dos Santos, Mara Zeni

{"title":"Investigation of the Ternary System, Water/Hydrochloric Acid/Polyamide 66, for the Production of Polymeric Membranes by Phase Inversion.","authors":"Jocelei Duarte, Camila Suliani Raota, Camila Baldasso, Venina Dos Santos, Mara Zeni","doi":"10.3390/membranes15010007","DOIUrl":"10.3390/membranes15010007","url":null,"abstract":"The starting point for the preparation of polymeric membranes by phase inversion is having a thermodynamically stable solution. Ternary diagrams for the polymer, solvent, and non-solvent can predict this stability by identifying the phase separation and describing the thermodynamic behavior of the membrane formation process. Given the lack of data for the ternary system water (H2O)/hydrochloric acid (HCℓ)/polyamide 66 (PA66), this work employed the Flory-Huggins theory for the construction of the ternary diagrams (H2O/HCℓ/PA66 and H2O/formic acid (FA)/PA66) by comparing the experimental data with theoretical predictions. Pure polymer and the membranes produced by phase inversion were characterized to provide the information required to create the ternary diagrams. PA66/FA and PA66/HCℓ solutions were also evaluated regarding their classification as true solutions, and the universal quasi-chemical functional group activity coefficient (UNIFAC) method was used for determining non-solvent/solvent interaction parameters (g12). Swelling measurements determined the polymer/non-solvent interaction parameter (χ13) for H2O/PA66 and the solvent/polymer interaction parameter (χ23) for PA66/FA and PA66/HCℓ. The theoretical cloud point curve was calculated based on \"Boom's LCP Correlation\" and compared to the curve of the experimental cloud point. The ternary Gibbs free energy of mixing and χ23 indicated FA as the best solvent for the PA66. However, for HCℓ, the lower concentration (37-38%), volatility, and fraction volume of dissolved PA66 (ϕ3) indicated that HCℓ is also adequate for PA66 solubilization based on the similar membrane morphology observed when compared to the PA66/FA membrane.","PeriodicalId":18410,"journal":{"name":"Membranes","volume":"15 1","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11767114/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143032960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dual Repurposing of End-of-Life BWRO Membranes: Ultrafiltration Membranes for Advanced Wastewater Treatment and Cation Exchange Membranes for Fungal Microbial Fuel Cells.

IF 3.3 4区工程技术

Membranes Pub Date : 2024-12-27 DOI: 10.3390/membranes15010005

Anissa Somrani, Mehri Shabani, Zaineb Mohamed, Kholoud Abohelal, Salam S Alsharari, Ahmed Hannachi, Noreddine Ghaffour, Maxime Pontié

{"title":"Dual Repurposing of End-of-Life BWRO Membranes: Ultrafiltration Membranes for Advanced Wastewater Treatment and Cation Exchange Membranes for Fungal Microbial Fuel Cells.","authors":"Anissa Somrani, Mehri Shabani, Zaineb Mohamed, Kholoud Abohelal, Salam S Alsharari, Ahmed Hannachi, Noreddine Ghaffour, Maxime Pontié","doi":"10.3390/membranes15010005","DOIUrl":"10.3390/membranes15010005","url":null,"abstract":"The objective of this study is to evaluate the degradation of end-of-life BWRO membranes sourced from a factory in France by analyzing their water permeability, roughness, and chemical composition in order to diagnose the level of degradation incurred during their first life cycle in water softening. Following this, two new applications for the end-of-life BWRO membranes were investigated: (i) as ultrafiltration membranes (UF) for domestic effluent treatment and (ii) as cation exchange membranes (CEM) for use in fungal microbial fuel cells (FMFC). The UF membrane was renovated with an acetic acid treatment and, subsequently, used for domestic effluent filtration. The cation exchange membrane was developed in two steps: (i) chlorine treatment and (ii) the deposition of an Amer Sil layer, a functional coating formed by an interpenetrating polymer network (IPN) made of sulfonated polyether sulfone (S-PES) in a cross-linked matrix of acrylic acid and divinylbenzene.","PeriodicalId":18410,"journal":{"name":"Membranes","volume":"15 1","pages":""},"PeriodicalIF":3.3,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11766833/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143033382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Systematic Study of Steroid Drugs' Ability to Cross Biomembranes-The Possible Environmental Impact and Health Risks Associated with Exposure During Pregnancy.

IF 3.3 4区工程技术

Membranes Pub Date : 2024-12-26 DOI: 10.3390/membranes15010004

Anna W Sobańska, Aleksandra Orlikowska, Karolina Famulska, Lovro Bošnjak, Domagoj Bosiljevac, Aleksandra Rasztawicka, Andrzej M Sobański

{"title":"Systematic Study of Steroid Drugs' Ability to Cross Biomembranes-The Possible Environmental Impact and Health Risks Associated with Exposure During Pregnancy.","authors":"Anna W Sobańska, Aleksandra Orlikowska, Karolina Famulska, Lovro Bošnjak, Domagoj Bosiljevac, Aleksandra Rasztawicka, Andrzej M Sobański","doi":"10.3390/membranes15010004","DOIUrl":"10.3390/membranes15010004","url":null,"abstract":"Thirty-seven steroid drugs of different types were investigated in silico for their environmental and pharmacokinetic properties (partition between soil and water, bioaccumulation in aquatic organisms, ability to be absorbed from the gastrointestinal tract and to cross biological barriers-skin, blood-brain barrier and placenta) using on-line tools and novel QSAR models. The same drugs were studied by Molecular Docking in the context of their ability to interact with two enzymes-glutathione S-transferase (GST) and human N-acetyltransferase 2 (NAT2), which are involved in the placenta's protective system against harmful xenobiotics. Steroid drugs are released to the environment from households, hospitals, manufacturing plants and farms (e.g., with natural fertilizers) and they can affect the aquatic life (reproduction and development of aquatic organisms), even at sub-ng/L concentrations. It was established that the majority of studied drugs are mobile in soil, so they may reach surface waters far from point of discharge, e.g., from farming; however, only a few of them are likely to bioaccumulate. All of them can be absorbed orally or through skin, and they are also expected to cross the placenta. Over 30% of studied compounds are likely to pass through the blood-brain barrier (although five compounds in this group are likely P-gp substrates, which may reduce their activity in the central nervous systems); they have also very high affinity for both studied enzymes.","PeriodicalId":18410,"journal":{"name":"Membranes","volume":"15 1","pages":""},"PeriodicalIF":3.3,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11766822/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143033479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Carbon Nanofiber-Reinforced Carbon Black Support for Enhancing the Durability of Catalysts Used in Proton Exchange Membrane Fuel Cells Against Carbon Corrosion.

IF 3.3 4区工程技术

Membranes Pub Date : 2024-12-26 DOI: 10.3390/membranes15010003

Minki Sung, Hyeonseok Yi, Jimin Han, Jong Beom Lee, Seong-Ho Yoon, Joo-Il Park

{"title":"Carbon Nanofiber-Reinforced Carbon Black Support for Enhancing the Durability of Catalysts Used in Proton Exchange Membrane Fuel Cells Against Carbon Corrosion.","authors":"Minki Sung, Hyeonseok Yi, Jimin Han, Jong Beom Lee, Seong-Ho Yoon, Joo-Il Park","doi":"10.3390/membranes15010003","DOIUrl":"10.3390/membranes15010003","url":null,"abstract":"This study addresses the critical challenge of carbon corrosion in proton exchange membrane fuel cells (PEMFCs) by developing hybrid supports that combine the high surface area of carbon black (CB) with the superior crystallinity and graphitic structure of carbon nanofibers (CNFs). Two commercially available CB samples were physically activated and composited with two types of CNFs synthesized via chemical vapor deposition using different carbon sources. The structure, morphology, and crystallinity of the resulting CNF-CB hybrid supports were characterized, and the performances of these hybrid supports in mitigating carbon corrosion and enhancing the PEMFC performance was evaluated through full-cell testing in collaboration with a membrane electrode assembly (MEA) manufacturer (VinaTech, Seoul, Republic, of Korea), adhering to industry-standard fabrication and evaluation procedures. Accelerated stress tests following the US Department of Energy protocols revealed that incorporating CNFs enhanced the durability of the CB-based hybrid supports without compromising their performance. The improved performance of the MEAs with the hybrid carbon support is attributed to the ability of the CNF to act as a structural backbone, facilitate water removal, and provide abundant edge plane sites for anchoring the platinum catalyst, which promoted the oxygen reduction reaction and improved catalyst utilization. The findings of this study highlight the potential of CNF-reinforced CB supports for enhancing the durability and performance of PEMFCs.","PeriodicalId":18410,"journal":{"name":"Membranes","volume":"15 1","pages":""},"PeriodicalIF":3.3,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11767076/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143033476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Simulation of a Reverse Electrodialysis-Absorption Refrigeration Integration System for the Efficient Recovery of Low-Grade Waste Heat.

IF 3.3 4区工程技术

Membranes Pub Date : 2024-12-24 DOI: 10.3390/membranes15010002

Xi Wu, Linjing Yan, Xiaojing Zhu, Mingjun Liu

{"title":"Simulation of a Reverse Electrodialysis-Absorption Refrigeration Integration System for the Efficient Recovery of Low-Grade Waste Heat.","authors":"Xi Wu, Linjing Yan, Xiaojing Zhu, Mingjun Liu","doi":"10.3390/membranes15010002","DOIUrl":"10.3390/membranes15010002","url":null,"abstract":"The absorption refrigeration system (ARS) stands as a remarkable device that is capable of efficiently harnessing low-grade thermal energy and converting it into cooling capacity. The reverse electrodialysis (RED) system harvests the salinity gradient energy embedded in two solutions of different concentrations into electricity. An innovative RED-ARS integration system is proposed that outputs cooling capacity and electric energy, driven by waste heat. In this study, a comprehensive mathematical simulation model of a RED-ARS integration system was established, and an aqueous lithium bromide solution was selected as the working solution. Based on this model, the authors simulated and analyzed the impact of various factors on system performance, including the heat source temperature (90 °C to 130 °C), concentrated solution concentration (3 mol∙L⁻1 to 9 mol∙L⁻1), dilute solution concentration (0.002 mol∙L⁻1 to 0.5 mol∙L⁻1), condensing temperature of the dilute solution (50 °C to 70 °C), solution temperature (30 °C to 60 °C) and flow rate (0.4 cm∙s⁻1 to 1.3 cm∙s⁻1) in the RED stacks, as well as the number of RED stacks. The findings revealed the maximum output power of 934 W, a coefficient of performance (COP) of 0.75, and overall energy efficiency of 33%.","PeriodicalId":18410,"journal":{"name":"Membranes","volume":"15 1","pages":""},"PeriodicalIF":3.3,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11766999/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143033478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electro-Conductive Modification of Polyvinylidene Fluoride Membrane for Electrified Wastewater Treatment: Optimization and Antifouling Performance.

IF 3.3 4区工程技术

Membranes Pub Date : 2024-12-24 DOI: 10.3390/membranes15010001

Jinzhuo Shi, Yisong Hu, Songhua Li, Wenqian Xiao, Yuan Yang, Jiayuan Ji

{"title":"Electro-Conductive Modification of Polyvinylidene Fluoride Membrane for Electrified Wastewater Treatment: Optimization and Antifouling Performance.","authors":"Jinzhuo Shi, Yisong Hu, Songhua Li, Wenqian Xiao, Yuan Yang, Jiayuan Ji","doi":"10.3390/membranes15010001","DOIUrl":"10.3390/membranes15010001","url":null,"abstract":"Electro-conductive membranes coupled with a low-voltage electric field can enhance pollutant removal and mitigate membrane fouling, demonstrating significant potential for electrified wastewater treatment. However, efficient fabrication of conductive membranes poses challenges. An in situ oxidative polymerization approach was applied to prepare PVDF-based conductive membranes (PVDF-CMs) and response surface methodology (RSM) was adopted to optimize modification conditions enhancing membrane performance. The anti-fouling property of the conductive membranes was analyzed using model pollutants. The results indicate that when the concentrations of the pyrrole, BVIMBF4, and FeCl3·6H2O are 0.9 mol/L, 4.8 mmol, and 0.8 mol/L, respectively, the electrical resistance of the PVDF-CM is 93 Ω/sq with the water contact angle of 31°, demonstrating good conductivity and hydrophilicity. Batch membrane filtration experiments coupled with negative voltage indicated that when an external voltage of 2.0 V is applied, membrane fouling rates for the conductive membrane filtering BSA and SA solutions are reduced by 17.7% and 17.2%, respectively, compared to the control (0 V). When an external voltage of 0.5 V is applied, the membrane fouling rate for the conductive membrane filtering HA solution is reduced by 72.6%. This study provides a valuable reference for the efficient preparation of conductive membranes for cost-effective wastewater treatment.","PeriodicalId":18410,"journal":{"name":"Membranes","volume":"15 1","pages":""},"PeriodicalIF":3.3,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11767159/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143033402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recycling Lithium-Ion Batteries-Technologies, Environmental, Human Health, and Economic Issues-Mini-Systematic Literature Review. 回收锂离子电池-技术，环境，人类健康和经济问题-小系统文献综述。

IF 3.3 4区工程技术

Membranes Pub Date : 2024-12-21 DOI: 10.3390/membranes14120277

Geani Teodor Man, Andreea Maria Iordache, Ramona Zgavarogea, Constantin Nechita

{"title":"Recycling Lithium-Ion Batteries-Technologies, Environmental, Human Health, and Economic Issues-Mini-Systematic Literature Review.","authors":"Geani Teodor Man, Andreea Maria Iordache, Ramona Zgavarogea, Constantin Nechita","doi":"10.3390/membranes14120277","DOIUrl":"10.3390/membranes14120277","url":null,"abstract":"Global concerns about pollution reduction, associated with the continuous technological development of electronic equipment raises challenge for the future regarding lithium-ion batteries exploitation, use, and recovery through recycling of critical metals. Several human and environmental issues are reported, including related diseases caused by lithium waste. Lithium in Li-ion batteries can be recovered through various methods to prevent environmental contamination, and Li can be reused as a recyclable resource. Classical technologies for recovering lithium from batteries are associated with various environmental issues, so lithium recovery remains challenging. However, the emergence of membrane processes has opened new research directions in lithium recovery, offering hope for more efficient and environmentally friendly solutions. These processes can be integrated into current industrial recycling flows, having a high recovery potential and paving the way for a more sustainable future. A second method, biolexivation, is eco-friendly, but this point illustrates significant drawbacks when used on an industrial scale. We discussed toxicity induced by metals associated with Li to iron-oxidizing bacteria, which needs further study since it causes low recycling efficiency. One major environmental problem is the low efficiency of the recovery of Li from the water cycle, which affects global-scale safety. Still, electromembranes can offer promising solutions in the future, but there is needed to update regulations to actual needs for both producing and recycling LIB.","PeriodicalId":18410,"journal":{"name":"Membranes","volume":"14 12","pages":""},"PeriodicalIF":3.3,"publicationDate":"2024-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11678226/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142895883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Operational Performance of an Ultrafiltration Pilot Unit for the Treatment of Ultra-Concentrated Brines. 超滤中试装置处理超浓卤水的运行性能。

IF 3.3 4区工程技术

Membranes Pub Date : 2024-12-20 DOI: 10.3390/membranes14120276

Giuseppe Scelfo, Paula Serrano-Tari, Ritamaria Raffaelli, Fabrizio Vicari, Isabel Oller, Andrea Cipollina, Alessandro Tamburini, Giorgio Micale

{"title":"The Operational Performance of an Ultrafiltration Pilot Unit for the Treatment of Ultra-Concentrated Brines.","authors":"Giuseppe Scelfo, Paula Serrano-Tari, Ritamaria Raffaelli, Fabrizio Vicari, Isabel Oller, Andrea Cipollina, Alessandro Tamburini, Giorgio Micale","doi":"10.3390/membranes14120276","DOIUrl":"10.3390/membranes14120276","url":null,"abstract":"The valorization of ultra-concentrated seawater brines, named bitterns, requires preliminary purification processes, such as membrane filtration, before they can be fully exploited. This study investigates the performance of an ultrafiltration pilot plant aimed at separating organic matter and large particles from real bitterns. An empirical model for the bittern viscosity was developed to better characterize the membrane. Distinct variations in permeability, fouling resistance and rejection coefficient were observed under operational pressures ranging from 2 to 4 bar. Working at low pressure (2 bar), the pilot plant achieves permeability and rejection coefficient values of 17 L/m2hbar and 95%, respectively. Foulant behavior was characterized by determining a \"fouling resistance\", obtaining an average value of 1013 m-1. Tests with three distinct bittern samples were conducted to assess the influence of chemical composition and organic matter content on membrane permeability and fouling characteristics. The collected data enabled a comprehensive characterization of the ultrafiltration pilot unit working with this particular saline feed solution, which has very high technical-economic potential.","PeriodicalId":18410,"journal":{"name":"Membranes","volume":"14 12","pages":""},"PeriodicalIF":3.3,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11677959/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142895996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Composite Anion Exchange Membranes Containing a Long-Side Chain Ionomer and Exfoliated Lamellar Double Hydroxides. 复合阴离子交换膜包含长侧链离聚体和剥离层状双氢氧化物。

IF 3.3 4区工程技术

Membranes Pub Date : 2024-12-20 DOI: 10.3390/membranes14120275

Riccardo Narducci, Suanto Syahputra, Maria Luisa Di Vona, Philippe Knauth, Luca Pasquini

{"title":"Composite Anion Exchange Membranes Containing a Long-Side Chain Ionomer and Exfoliated Lamellar Double Hydroxides.","authors":"Riccardo Narducci, Suanto Syahputra, Maria Luisa Di Vona, Philippe Knauth, Luca Pasquini","doi":"10.3390/membranes14120275","DOIUrl":"10.3390/membranes14120275","url":null,"abstract":"Anion Exchange Membranes (AEMs) are promising materials for electrochemical devices, such as fuel cells and electrolyzers. However, the main drawback of AEMs is their low durability in alkaline operating conditions. A possible solution is the use of composite ionomers containing inorganic fillers stable in a basic environment. In this work, composite anion exchange membranes are prepared from poly (2,6-dimethyl-1,4-phenylene oxide) with quaternary ammonium groups on long-side chains (PPO-LC) and exfoliated Mg/Al lamellar double hydroxide (LDH) as inorganic filler added in different percentages (2, 5, and 10%). The mechanical stiffness of the membranes increases significantly by the addition of exfoliated LDH up to 5%. The ionic conductivity is measured as a function of the temperature in fully humidified conditions and as a function of relative humidity (RH). The maximum conductivity is observed for 5% LDH. The average activation energy for conductivity amounts to 0.20 ± 0.01 eV in fully humidified conditions and >50% RH. Thermogravimetric analysis of membranes before and after alkaline degradation tests (2 M KOH @ 80 °C, 48 h) reveals that the sample with 5% LDH has improved stability (19% vs. 36% of degradation). The stability tests are also investigated, measuring the ionic conductivity and the water uptake. A protective effect of LDH on the alkaline degradation of quaternary ammonium groups is clearly evidenced and opens the way to the use of different compounds and exfoliation methods in the LDH family.","PeriodicalId":18410,"journal":{"name":"Membranes","volume":"14 12","pages":""},"PeriodicalIF":3.3,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11678257/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142895908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anti-Inflammatory Properties of Novel 1,2-Benzothiazine Derivatives and Their Interaction with Phospholipid Model Membranes. 新型1,2-苯并噻唑衍生物的抗炎特性及其与磷脂模型膜的相互作用。

IF 3.3 4区工程技术

Membranes Pub Date : 2024-12-18 DOI: 10.3390/membranes14120274

Berenika M Szczęśniak-Sięga, Jadwiga Maniewska, Benita Wiatrak, Tomasz Janek, Paulina Nowotarska, Żaneta Czyżnikowska

{"title":"Anti-Inflammatory Properties of Novel 1,2-Benzothiazine Derivatives and Their Interaction with Phospholipid Model Membranes.","authors":"Berenika M Szczęśniak-Sięga, Jadwiga Maniewska, Benita Wiatrak, Tomasz Janek, Paulina Nowotarska, Żaneta Czyżnikowska","doi":"10.3390/membranes14120274","DOIUrl":"10.3390/membranes14120274","url":null,"abstract":"The design of novel anti-inflammatory drugs remains a critical area of research in the development of effective treatments for inflammatory diseases. In this study, a series of 1,2-benzothiazine was evaluated through a multifaceted approach. In particular, we investigated the potential interactions of the potential drugs with lipid bilayers, an important consideration for membrane permeability and overall pharmacokinetics. In addition, we evaluated their ability to inhibit cyclooxygenase 1 and cyclooxygenase 2 activity and selectivity using both a cyclooxygenase inhibition assay and molecular docking simulations. To evaluate their therapeutic potential, we performed in vitro assays to measure cytokine mRNA expression in inflamed cells. The antioxidant activity was evaluated using both in vitro assays, such as 2,2-diphenyl-1-picrylhydrazyl and 2,2-azino-bis-3-ethylbenzothiazoline-6-sulphonic acid scavenging, to determine the compounds' capacity to neutralize free radicals and reduce oxidative stress. Theoretical calculations, including density functional theory, were used to predict the reactivity profiles of the compounds.","PeriodicalId":18410,"journal":{"name":"Membranes","volume":"14 12","pages":""},"PeriodicalIF":3.3,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11678778/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142895890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0