Medical Journal of the Islamic Republic of Iran最新文献

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Comparison of the Pauda and the Autar DVT Risk Assessment Scales in Prediction of Venous Thromboembolism in ICU Patients. 保达和 Autar 深静脉血栓风险评估量表在预测重症监护病房患者静脉血栓栓塞方面的比较。
Medical Journal of the Islamic Republic of Iran Pub Date : 2024-04-30 eCollection Date: 2024-01-01 DOI: 10.47176/mjiri.38.48
Foruzan Orak, Maryam Saadat, Amal Saki Malehi, Amin Behdarvandan, Fateme Esfandiarpour
{"title":"Comparison of the Pauda and the Autar DVT Risk Assessment Scales in Prediction of Venous Thromboembolism in ICU Patients.","authors":"Foruzan Orak, Maryam Saadat, Amal Saki Malehi, Amin Behdarvandan, Fateme Esfandiarpour","doi":"10.47176/mjiri.38.48","DOIUrl":"https://doi.org/10.47176/mjiri.38.48","url":null,"abstract":"<p><strong>Background: </strong>The evaluation of VTE risk using risk assessment scales for each hospitalized patient is recommended by the National Institute for Health and Care Excellence. The purpose of this study was to compare the predictive accuracy of two common assessment scales, the Autar and Padua deep vein thrombosis (DVT) risk assessment scales.</p><p><strong>Methods: </strong>This prospective cohort study was conducted on 228 ICU hospitalized patients. The risk of VTE was estimated using the Autar and Padua scales during the first 48 hours after admission. The predictive accuracy of the above two risk assessment scales for VTE in ICU patients was compared based on the area under the receiver operating curve (ROC).</p><p><strong>Results: </strong>Results of ROC analysis indicated the area under the curve (AUC) values for the Autar (0.61 ± 0.05) and Pauda (0.53 ± 0.06). Log-rank test showed no difference in AUCs (<i>P</i> = 0.19). Moreover, the accuracy of the Autar scale and Padua obtained 24% and 14% respectively. Both scales had 100% sensitivity but their specificity was low (Autar 14% and Padua 3%). The positive likelihood ratios (LR+) were 1.17 for Autar and 1.03 for Padua. The negative likelihood ratios (LR-) were 0 for Autar and 0.89 for Padua. Inter-rater agreement values obtained 0.99 and 0.95 respectively for the the Autar and Padua scales.</p><p><strong>Conclusion: </strong>The AUC, accuracy, and LR+ of the Autar risk assessment scale were higher than the Padua scale in predicting VTE. However, both scales had excellent reliability, high sensitivity and low specificity. It is recommended that the risk of VTE is recorded by the Autar scale for patients admitted to ICUs. It can help the healthcare team in the use of prophylaxis for those that are at high risk for VTE.</p>","PeriodicalId":18361,"journal":{"name":"Medical Journal of the Islamic Republic of Iran","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11469705/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142469498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of the Relationship between QT Interval in ECG and GRACE Score Amount of Hospitalized Patients with NSTEMI. 评估心电图 QT 间期与 NSTEMI 住院患者 GRACE 评分量之间的关系
Medical Journal of the Islamic Republic of Iran Pub Date : 2024-04-29 eCollection Date: 2024-01-01 DOI: 10.47176/mjiri.38.47
Fatemeh Goodarzi, Mohammad Mahdi Daei, Samira Dodangeh, Elham Kia Lashaki, Zohreh Yazdi, Majid Hajikarimi
{"title":"Evaluation of the Relationship between QT Interval in ECG and GRACE Score Amount of Hospitalized Patients with NSTEMI.","authors":"Fatemeh Goodarzi, Mohammad Mahdi Daei, Samira Dodangeh, Elham Kia Lashaki, Zohreh Yazdi, Majid Hajikarimi","doi":"10.47176/mjiri.38.47","DOIUrl":"https://doi.org/10.47176/mjiri.38.47","url":null,"abstract":"<p><strong>Background: </strong>Non-ST-elevation myocardial infarction (NSTEMI) is a significant component of acute coronary syndrome (ACS) and typically exhibits a relative incidence that is more than double that of ST-segment elevation myocardial infarction (STEMI). Data obtained from the International Long QT Syndrome Registry indicate that the risk of developing malignant arrhythmias in individuals with long QT syndrome is exponentially associated with the duration of the QTc interval. Therefore, the aim of this study was to assess the potential inclusion of prolonged QTc as a prognostic risk factor in NSTEMI patients.</p><p><strong>Methods: </strong>A cross-sectional study was conducted on patients with NSTEMI diagnosis admitted to the Bu-Ali Hospital of Qazvin between April 2021 and September 2021 by census method. The QT interval was measured in the electrocardiogram at admission. The documented grace score was calculated and its relationship with the corrected QTc interval was estimated using the Hodges formula. Finally, the relationship between QTc and GRACE score was investigated as a prognostic factor in ACS patients. Relationships were assessed by using both the T-test and the chi-square test.</p><p><strong>Results: </strong>A total of 60 patients (31.7% females, 63.8% males) with a mean age of 63 ± 12.7 years were evaluated. Most of the patients (68.3%) were at low risk regarding the Grace score category. In evaluating the relationship between QTc in the electrocardiogram at admission with total GRACE score, the Pearson correlation results were significant and there was a positive relationship between these two factors (r = 0.497, <i>P</i> < 0.001).</p><p><strong>Conclusion: </strong>This study revealed a significant relationship between the QTc interval of patients and the GRACE Score. It was shown patients' QTc can be a predictive factor of patients' mortality.</p>","PeriodicalId":18361,"journal":{"name":"Medical Journal of the Islamic Republic of Iran","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11469722/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142469460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correlation of the Apgar Score with Dental Caries in 3- to 5-year-old Iranian Children. 伊朗 3-5 岁儿童阿普加评分与龋齿的相关性。
Medical Journal of the Islamic Republic of Iran Pub Date : 2024-04-24 eCollection Date: 2024-01-01 DOI: 10.47176/mjiri.38.46
Amin Keykhaie Afusi, Marzieh Salehi Shahrabi, Mehrsa Paryab, Mohammad Javad Kharrazi Fard
{"title":"Correlation of the Apgar Score with Dental Caries in 3- to 5-year-old Iranian Children.","authors":"Amin Keykhaie Afusi, Marzieh Salehi Shahrabi, Mehrsa Paryab, Mohammad Javad Kharrazi Fard","doi":"10.47176/mjiri.38.46","DOIUrl":"https://doi.org/10.47176/mjiri.38.46","url":null,"abstract":"<p><strong>Background: </strong>Dental caries is a serious health condition in children. Poor diet, poor oral hygiene, and unique anatomy of the primary teeth can all contribute to the development of caries in primary teeth. Developmental structural defects in teeth during the fetal period and the first year after birth are believed to increase caries susceptibility. This study aimed to assess the correlation of the Apgar score with dental caries in 3- to 5-year-old Iranian children.</p><p><strong>Methods: </strong>This retrospective, descriptive, cross-sectional study was conducted at the Pediatric Dental Clinic of Tehran Dental School in 2022. A total of 123 eligible children between 3-5 years were enrolled. The parents were requested to fill out a checklist regarding the information of demographics, birth and infancy condition and Apgar score of children. The children underwent clinical dental examination, and their dmft was recorded. Data were analyzed by the Pearson and regression tests. <i>P</i> values < 0.1 were considered statistically significant.</p><p><strong>Results: </strong>The Pearson test showed that the 1-minute (<i>P</i> = 0.000) and 5-minute (<i>P</i> = 0.000) Apgar scores had a significant correlation with dmft. The regression analysis of demographic and birth factors revealed significant correlations between duration of breastfeeding (<i>P</i> = 0.066) and age of initiation of toothbrushing (<i>P</i> = 0.019) with dmft. Also, birth weight (<i>P</i> = 0.026) and mother's educational level (<i>P</i> = 0.090) had significant correlations with the Apgar score.</p><p><strong>Conclusion: </strong>The results indicated a significant correlation between the Apgar score and dental caries. Thus, newborns with lower Apgar scores are recommended to receive more regular oral and dental care services.</p>","PeriodicalId":18361,"journal":{"name":"Medical Journal of the Islamic Republic of Iran","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11469694/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142469499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Study of Pragmatic Skills of Persian-speaking Adults with Autism Spectrum Disorder Based on the Persian Version of Montreal Protocol for the Evaluation of Communication (P.M.E.C.). 根据波斯语版《蒙特利尔交流评估协议》(P.M.E.C.)研究波斯语自闭症谱系障碍成人的语用能力。
Medical Journal of the Islamic Republic of Iran Pub Date : 2024-04-23 eCollection Date: 2024-01-01 DOI: 10.47176/mjiri.38.45
Shahed Zandiehrad, Shahla Raghibdoust, Mohammad Taghi Joghataei, Arsalan Golfam
{"title":"Study of Pragmatic Skills of Persian-speaking Adults with Autism Spectrum Disorder Based on the Persian Version of Montreal Protocol for the Evaluation of Communication (P.M.E.C.).","authors":"Shahed Zandiehrad, Shahla Raghibdoust, Mohammad Taghi Joghataei, Arsalan Golfam","doi":"10.47176/mjiri.38.45","DOIUrl":"https://doi.org/10.47176/mjiri.38.45","url":null,"abstract":"<p><strong>Background: </strong>Various studies have shown that individuals with autism spectrum disorder (ASD) experience significant cognitive impairments during childhood. Individuals often experience various language disorders that can manifest in different ways. There are also studies indicating that these impairments persist into adulthood for individuals with ASD. This study aimed to evaluate and identify cognitive impairments among Persian-speaking adults with ASD.</p><p><strong>Methods: </strong>This research is of a quantitative nature and has been conducted using an experimental method in which two subtests from the Persian Version of the Montreal Protocol for the Evaluation of Communication (P.M.E.C.), including the Metaphor Interpretation and Speech Act Interpretation subtests, were utilized. Thirteen Persian-speaking men with ASD participated in this research, with ages ranging from 25 to 44 years (mean age 32.84, standard deviation 4.17), whose educational levels varied from primary school to 20 years of formal education. The control group consisted of 26 healthy Persian-speaking men who were matched in terms of age and educational level with the ASD group. The Kolmogorov-Smirnov test and a paired t-test were used to compare the two groups.</p><p><strong>Results: </strong>The results indicated that the ASD group performed significantly poorer in both the Metaphor Interpretation subtest (<i>P</i> < 0.001) and the Speech Act Interpretation subtest (<i>P</i> = 0.033) compared to the healthy control group, suggesting cognitive impairments in their abilities.</p><p><strong>Conclusion: </strong>The findings of this research can be valuable for assessment and intervention purposes in rehabilitation centers, as well as in academic and research settings.</p>","PeriodicalId":18361,"journal":{"name":"Medical Journal of the Islamic Republic of Iran","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11469710/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142469503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association Between Lumbar Spine Disorder and Genovarum: A Population-Based Cross-Sectional Study. 腰椎疾病与 Genovarum 之间的关系:一项基于人群的横断面研究。
Medical Journal of the Islamic Republic of Iran Pub Date : 2024-04-22 eCollection Date: 2024-01-01 DOI: 10.47176/mjiri.38.44
Ali Yeganeh, Ava Parvandi, Mohammadreza Mehri, Hamed Tayyebi, Javad KhajeMozafari
{"title":"Association Between Lumbar Spine Disorder and Genovarum: A Population-Based Cross-Sectional Study.","authors":"Ali Yeganeh, Ava Parvandi, Mohammadreza Mehri, Hamed Tayyebi, Javad KhajeMozafari","doi":"10.47176/mjiri.38.44","DOIUrl":"https://doi.org/10.47176/mjiri.38.44","url":null,"abstract":"<p><strong>Background: </strong>It is becoming increasingly important to study pathology at the knee and spine because of their role in causing pain and deformity in one another. Compression of the lumbar nerve root can disrupt innervation to the thigh muscles, cause an imbalance of muscle and result in varus deformity. In this study, we try to figure out the relation between lumbar spine disorders and genu varum and realize if lumbar spine disorders can cause varus deformity in a patient.</p><p><strong>Methods: </strong>In this cross-sectional study, the number of 53 patients with knee varus greater than 20 degrees who visited the orthopedic clinics of Rasoul Akram and Moheb Mehr hospitals affiliated to Iran University of Medical Sciences between 2020 and 2022 were investigated in terms of association with lumbar disorders. The demographic characteristics and clinical findings of the patients were recorded and collected using a checklist by referring to the patient's medical profiles. Radiographic findings were evaluated by referring to the imaging department and using the Pacs system. The diagnosis of the patients was based on the history and findings of the knee graph, which was measured with a goniometer to measure the knee angle. The frequency of lumbar disorders caused by pressure on the lumbar nerves in patients with genu varum deformity including canal stenosis, osteoarthritis, spondylolisthesis, and disc herniation was investigated. To investigate lumbar problems, patients' history and radiographic images as well as lumbosacral and knee MRI of patients were used.</p><p><strong>Results: </strong>The mean age was 66.3 ± 7.66 years. 40 (75.5%) cases were female and 13 (24.5%) cases were male. Lumbar canal stenosis with 28(52.8%) and disc herniation with 32(60.4%) were the most common lumbar disorders in patients with knee varus more than 20 degrees. The mean age of patients with varus of more than 20 degrees with lumbar disorders was significantly higher than that of patients without lumbar disorders. (<i>P</i>: 0.001) There was no significant difference between gender distribution and lumbar disorders in patients with varus more than 20 degrees. Significant positive correlation between genu varum with lumbar canal stenosis (r: 0.53, <i>P</i>: 0.001), osteoarthritis (r: 0.38, <i>P</i>: 0.004), spondylolisthesis (r: 0.39, <i>P</i>: 0.002) and disc herniation (r: 0.46, <i>P</i>: 0.001) was reported2.</p><p><strong>Conclusion: </strong>An association between lumbar disorders and varus more than 20 degrees was found to be considerable.</p>","PeriodicalId":18361,"journal":{"name":"Medical Journal of the Islamic Republic of Iran","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11469699/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142469483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparing Medical Training Costs Internationally: A Systematic Review. 比较国际医学培训成本:系统回顾。
Medical Journal of the Islamic Republic of Iran Pub Date : 2024-04-17 eCollection Date: 2024-01-01 DOI: 10.47176/mjiri.38.43
Asgar Aghaei Hashjin, Kamran Irandoust, Hanie Gholampoor, Claudia Fischer, Masoud Maleki Birjandi, Aireza Mazdaki, Hossein Abdolali, Hediye Seval Akgün
{"title":"Comparing Medical Training Costs Internationally: A Systematic Review.","authors":"Asgar Aghaei Hashjin, Kamran Irandoust, Hanie Gholampoor, Claudia Fischer, Masoud Maleki Birjandi, Aireza Mazdaki, Hossein Abdolali, Hediye Seval Akgün","doi":"10.47176/mjiri.38.43","DOIUrl":"https://doi.org/10.47176/mjiri.38.43","url":null,"abstract":"<p><strong>Background: </strong>Acquiring a thorough understanding of the expenses linked to the education of health sciences students is crucial for effective university planning, budgeting, and overall preparedness. This systematic review aimed to identify and compare the per capita costs associated with educating medical and other health science students internationally-particularly emphasizing the context of Iran.</p><p><strong>Methods: </strong>A systematic review was conducted in 2023 according to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. The search covered the period from January 1, 2000, to November 11, 2022, using MeSH and EMTREE terms. Databases such as PubMed, Scopus, Web of Science, Embase, and Iranian databases were searched. Manual searches were performed using Google and Google Scholar.</p><p><strong>Results: </strong>The study retrieved 1336 publications from bibliometric databases and, following thorough screening, included 8 relevant articles from 5 countries (Australia, Iran, United States, Thailand, and Vietnam). An additional 17 relevant articles from Iranian databases were also included. Based on USD purchasing power parity (PPP) 2019, the results show that the mean per capita cost of training a medical student for 1 academic year in Iran is $61,493.86 (range, $28,102-$133,603; standard deviation, $35,476.03). In comparison, the cost of training a medical student for 1 year is $263,305 in the United States and $44,674 in Australia. In Thailand and Vietnam, a 6-year medical program costs is $284,058 and $69,323, respectively. Moreover, according to most studies, training students in other health sciences in Iran for 1 academic year generally costs ˂$20,000 (PPP 2019).</p><p><strong>Conclusion: </strong>The study reveals that the costs associated with medical student education in Iran exceed that of most countries, second only to the United States. These findings highlight the importance of such data in improving the efficiency, sustainability, and informed resource allocation of global medical education programs for future planning and budgeting.</p>","PeriodicalId":18361,"journal":{"name":"Medical Journal of the Islamic Republic of Iran","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11469735/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142469494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Factors Related to the Choice of Place of Death in Deceased Patients due to Cancer from 2011 to 2017 with Hospitalization Background in Firoozgar Hospital. 2011 年至 2017 年在 Firoozgar 医院住院的癌症死亡患者选择死亡地点的相关因素。
Medical Journal of the Islamic Republic of Iran Pub Date : 2024-04-16 eCollection Date: 2024-01-01 DOI: 10.47176/mjiri.38.42
Raha Tabahfar, Fatemeh Oskouie, Hamid Haghani
{"title":"Factors Related to the Choice of Place of Death in Deceased Patients due to Cancer from 2011 to 2017 with Hospitalization Background in Firoozgar Hospital.","authors":"Raha Tabahfar, Fatemeh Oskouie, Hamid Haghani","doi":"10.47176/mjiri.38.42","DOIUrl":"https://doi.org/10.47176/mjiri.38.42","url":null,"abstract":"<p><strong>Background: </strong>Death in the place that the patient has selected and feels comfortable remaining in for the remainder of their life is one of the main objectives of palliative care for terminally ill cancer patients. Nevertheless, this problem is constantly disregarded. The goal of the present study was to look at variables that affected cancer patients' decisions about their place of death.</p><p><strong>Methods: </strong>A descriptive cross-sectional study was conducted from May to August 2018. Using a continuous sampling method, 631 patients who had passed away between 2011 and 2017 were selected among the patients with a history of cancer and hospitalization at the Firoozgar Hospital in Tehran. A self-made 3-section questionnaire with 21 questions was completed by phone calls made to the families who confirmed their patients' deaths due to cancer. Data were managed by SPSS software Version 13, and descriptive statistics were used in data analysis.</p><p><strong>Results: </strong>Based on the results, among 631 deceased patients, only 157 (24.9%) chose their place of death, and 474 (75.1%) had not spoken about it during their lifetime. Among the examined variables, age, sex, education, insurance status, duration of disease, activities of daily living, awareness of disease progression, and receiving home care had a significant association with this choice in people who died of cancer.</p><p><strong>Conclusion: </strong>Despite the importance of the choice of place of death by the patient in the final days of life, the possibility of having an option is not provided for most cancer patients. Patients who understand how their disease is progressing at this point are probably going to want to select where they pass away. Consequently, the healthcare system must be ready to grant cancer patients the option to choose their final resting place and ensure a comfortable and respectable passing. Future research can be built upon the results of this study.</p>","PeriodicalId":18361,"journal":{"name":"Medical Journal of the Islamic Republic of Iran","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11469707/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142469462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Investigating the Effectiveness of Melatonin in the Treatment of Critically Ill Patients with COVID-19 Hospitalized in the Intensive Care Unit: A Double-Blind Randomized Clinical Trial. 研究褪黑素治疗重症监护病房 COVID-19 重症患者的效果:双盲随机临床试验。
Medical Journal of the Islamic Republic of Iran Pub Date : 2024-04-15 eCollection Date: 2024-01-01 DOI: 10.47176/mjiri.38.41
Atefe Tirkan, Delaram Eskandari, Maryam Roham, Oldooz Aloosh, Tayeb Ramim, Hale Afshar
{"title":"Investigating the Effectiveness of Melatonin in the Treatment of Critically Ill Patients with COVID-19 Hospitalized in the Intensive Care Unit: A Double-Blind Randomized Clinical Trial.","authors":"Atefe Tirkan, Delaram Eskandari, Maryam Roham, Oldooz Aloosh, Tayeb Ramim, Hale Afshar","doi":"10.47176/mjiri.38.41","DOIUrl":"https://doi.org/10.47176/mjiri.38.41","url":null,"abstract":"<p><strong>Background: </strong>Melatonin, a tryptophan product, has anti-inflammatory and virucidal effects. A study evaluated whether melatonin is more effective than placebo in critically ill COVID-19 patients.</p><p><strong>Methods: </strong>The present study used a double-blind, randomized clinical trial in patients with COVID-19 hospitalized in the intensive care unit of Rasool Akram Hospital, Tehran. Iran. Melatonin 10 mg and placebo were given to the patients at night before bed. Patients were randomly divided into 2 groups. The first group was given melatonin with a therapeutic dose of 10 mg daily, and the second group was given a placebo with the same dose of 10 mg daily. Patients received melatonin or placebo for 7 days.The chi-square or Fisher exact test was used to compare qualitative variables. The study analyzed the mean of the variables under investigation by conducting a 2-factor repeated measures analysis of variance at 3 different time intervals in those administered medication or placebo.</p><p><strong>Results: </strong>The study analyzed 44 melatonin patients and 42 placebo groups. The mean intensive care unit (ICU) hospitalization days were 11.23 ± 4.73 days in the melatonin group and 11.90 ± 6.52 days in the placebo group (<i>P</i> = 0.582). The mean days of hospitalization in the melatonin group were 19.70 ± 8.77 days and 21.48 ± 10.85 days in the placebo group (<i>P</i> = 0.407). The mean oxygen saturation before and after discharge from ICU in the melatonin group was 81 ± 6.73%, 91.02 ± 1.17%, and in the placebo group, 83.36 ± 8.27%, 91.21 ± 1.26, respectively (<i>P</i> = 0.467 and <i>P</i> = 0.150).</p><p><strong>Conclusion: </strong>Melatonin can significantly reduce inflammation and oxidative stress markers in patients, making it a promising therapeutic option for COVID-19 patients. Further research is needed to determine the optimal treatment dosage and duration. Nonetheless, these results offer a promising avenue for future research and clinical practice.</p>","PeriodicalId":18361,"journal":{"name":"Medical Journal of the Islamic Republic of Iran","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11480672/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142469486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A 12-year Life History of a Girl with Profound Intellectual Disability and Leukoencephalopathy: A Rare Clinical Presentation of X Chromosome Pentasomy. 患有严重智力障碍和白质脑病的女孩的 12 年生活史:X染色体五体综合征的罕见临床表现。
Medical Journal of the Islamic Republic of Iran Pub Date : 2024-04-10 eCollection Date: 2024-01-01 DOI: 10.47176/mjiri.38.40
Akmaral Izbassarova, Aisulu Zholdybayeva, Galiya Kadrzhanova, Khadisha Kashikova, Asel Izbassarova, Natalya Petrova, Alima Tolybekova
{"title":"A 12-year Life History of a Girl with Profound Intellectual Disability and Leukoencephalopathy: A Rare Clinical Presentation of X Chromosome Pentasomy.","authors":"Akmaral Izbassarova, Aisulu Zholdybayeva, Galiya Kadrzhanova, Khadisha Kashikova, Asel Izbassarova, Natalya Petrova, Alima Tolybekova","doi":"10.47176/mjiri.38.40","DOIUrl":"10.47176/mjiri.38.40","url":null,"abstract":"<p><p>This paper presents a unique 12-year case analysis of a girl with Penta-X syndrome, a chromosomal abnormality characterized by five X chromosomes instead of the normal two in healthy women. Pentasomy of X is a genetic, but not a hereditary disease affecting only women. Our patient demonstrated delayed mental, speech, and motor development along with physical anomalies such as craniofacial deformities, and eye pathology and was diagnosed with pentasomy of the X chromosome at the age of 3 after a cytogenetic examination. She developed epileptic seizures at the age of nine. Magnetic resonance imaging(MRI) revealed leukoencephalopathy with ventriculomegaly. The peculiarity of this observation is that the polysomy 49, XXXXX detected in the patient is characterized by a typical phenotypic presentation combined with demyelinating leukoencephalopathy, which has not been a typical feature of the disorder.</p>","PeriodicalId":18361,"journal":{"name":"Medical Journal of the Islamic Republic of Iran","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11230594/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141559082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Three-Year Investigation on Corpses Referred to Legal Medicine Organization from An Iranian General Hospital: A Cross-Sectional Study. 关于伊朗一家综合医院移交给法医组织的尸体的三年调查:一项横断面研究。
Medical Journal of the Islamic Republic of Iran Pub Date : 2024-04-09 eCollection Date: 2024-01-01 DOI: 10.47176/mjiri.38.39
Saba Dahaghin, Ava Aghakhani, Azadeh Memarian, Pardis Monjezi, Kamran Aghakhani
{"title":"A Three-Year Investigation on Corpses Referred to Legal Medicine Organization from An Iranian General Hospital: A Cross-Sectional Study.","authors":"Saba Dahaghin, Ava Aghakhani, Azadeh Memarian, Pardis Monjezi, Kamran Aghakhani","doi":"10.47176/mjiri.38.39","DOIUrl":"10.47176/mjiri.38.39","url":null,"abstract":"<p><strong>Background: </strong>A Medical Certificate of Cause of Death (MCCD) is a legal and enforceable document issued by the attending physician. However, according to the instructions, in many cases such as sudden, unexplained, and extraordinary deaths, along with some uncommon causes, such as cases suspicious of murder, the deceased patient must be referred to the Iranian Legal Medicine Organization (ILMO). Moreover, the unnecessary referral of corpses to ILMO can increase the workload of the staff, finally confronting the family of the deceased with high emotional and financial costs.</p><p><strong>Methods: </strong>In this cross-sectional study, the medical records of all deceased patients referred from Hazrat Rasool Hospital to the ILMO (565 cases) in a three-year period from April 2016 to March 2019 were investigated and analyzed using SPSS22 software with chi-squared and T-test.</p><p><strong>Results: </strong>Among all the patients who passed away during this time (4,239 patients), 565 were referred to ILMO, accounting for 13.3% of deaths. The most common causes of referral were car and motorcycle accidents, with a total prevalence of 27.1%, dead-on-arrival (DOA) prevalence of 21.3%, and death with an unknown cause prevalence of 15.3%. Significant correlation was also detected between causes of referral with gender, time of death, and age. For example, Car accidents and lawsuits against medical staff were more common in men and women, respectively.</p><p><strong>Conclusion: </strong>Car and motorcycle accidents, DOA, and unknown causes were the most prevalent causes of referral in this study. In general, few studies have been conducted regarding the causes of referral of the deceased to the Legal Medicine Organization. In this study, we collected relevant variables to investigate this issue thoroughly.</p>","PeriodicalId":18361,"journal":{"name":"Medical Journal of the Islamic Republic of Iran","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11230593/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141559134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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