Medical Journal of the Islamic Republic of Iran最新文献

{"title":"Schroth and Asymmetric Spinal Stabilization Exercises' Effectiveness on Back Pain and Trunk Muscle Endurance in Adolescents' Idiopathic Scoliosis: A Randomized Controlled Trial.","authors":"Arash Khaledi, Hooman Minoonejad, Hassan Daneshmandi, Mahdieh Akoochakian, Mehdi Gheitasi","doi":"10.47176/mjiri.38.90","DOIUrl":"10.47176/mjiri.38.90","url":null,"abstract":"<p><strong>Background: </strong>Millions of people worldwide suffer from back pain and muscle weakness due to adolescent idiopathic scoliosis (AIS). It has been found that Schroth exercises (SE) are the most effective treatment for AIS. However, it is still not clear how combining SE with asymmetric spinal stabilization exercises (ASSE) can impact back pain and trunk extensor muscle endurance (TE). This study aims to compare the effects of SE with and without ASSE on back pain and TE in AIS.</p><p><strong>Methods: </strong>A randomized controlled trial was conducted with 40 boys aged 10 to 18 years who had AIS. They were divided into three groups: SE+ASSE (n = 15), SE only (n = 15), and a waitlist control (n = 10). The participants underwent exercise training for 50-70 minutes three times a week for up to 12 weeks. The study evaluated two variables, namely, back pain (measured with a Visual Analog Scale or VAS) and TE (measured with the Biering-Sorensen test), before and after the interventions. For statistical analysis, a post-hoc Bonferroni test following analysis of covariance (ANCOVA) was used at α = 0.05.</p><p><strong>Results: </strong>According to a study, patients who underwent a combination of SE and ASSE experienced a significant reduction in back pain (VAS score = 2.9±0.8 to 0.1±0.4) as compared to those who only underwent SE (VAS = 2.7±0.9 to 1.5±1.2) and the control group. No significant difference was found between the SE group and the control group in terms of back pain reduction. Furthermore, there was no significant difference in TE among the three groups. However, the combined exercises showed a numerical improvement (75.6±52.5 sec to 119.2±62.6 sec) compared to the other groups (<i>P</i> = 0.311).</p><p><strong>Conclusion: </strong>The combination of SE and ASSE is more effective in reducing back pain in AIS than SE alone or control. Although there was no significant difference between the three groups in terms of improving the TE, the SE and ASSE groups showed better results numerically.</p>","PeriodicalId":18361,"journal":{"name":"Medical Journal of the Islamic Republic of Iran","volume":"38 ","pages":"90"},"PeriodicalIF":0.0,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11644102/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142828793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What Could Lead to the Production of Anti-Rheumatoid Antibodies in Patients with Brucellosis Spondylodiscitis: Possible Causes.","authors":"Yulduz Khaidarova, Gaukhar Kurmanova, Gulzada Nurgaliyeva, Madina Omarova","doi":"10.47176/mjiri.38.89","DOIUrl":"10.47176/mjiri.38.89","url":null,"abstract":"<p><strong>Background: </strong>High titers of specific antibodies to cyclic citrulline peptide (ACCP) are often present in the serum of patients with rheumatoid arthritis (RA) and, together with rheumatoid factor (RF), are a diagnostic marker of RA. Brucellosis is a zoonotic infection in which osteoarticular involvement occurs in 10-85% of patients. RF in brucellosis patients is significantly higher than in healthy people.</p><p><strong>Methods: </strong>We presented 2 cases of brucellosis spondylodiscitis with positive results for RF and ACCP, which aroused great interest among the rheumatologists of our center.</p><p><strong>Results: </strong>Both patients described were men (27 and 60 years old) with arthritis, back pain, and high levels of rheumatoid arthritis-specific antibodies. These patients were suspected of having tuberculous spondylitis, but the tuberculous process was excluded using specific tests. During antibacterial therapy, there is a dynamic decrease in antirheumatoid antibodies. X-rays of the hand joints revealed no signs of erosive arthritis.</p><p><strong>Conclusion: </strong>All cases of arthritis, spondylitis, and spondylodiscitis in endemic areas require careful analysis and comparison of patients' clinical and laboratory-instrumental data to prevent misdiagnosis. With brucellosis infection, against the background of adequate antibacterial therapy, inflammation of the joints and spine is reversible.</p>","PeriodicalId":18361,"journal":{"name":"Medical Journal of the Islamic Republic of Iran","volume":"38 ","pages":"89"},"PeriodicalIF":0.0,"publicationDate":"2024-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11644106/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142828956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcutaneous Lower Blepharoplasty with Midface Lift by Malar Fat Suspension to Lateral Part of Infraorbital Wall.","authors":"Mahmoud Abdelhamid Elhendawy, Ahmed M Omran, Sherif Hamdeno, Hazem Dahshan, Ahmed Abu Elsoud, Ahmed Salem, Mohamed Ali Abdelaziz, Khallad Sholkamy, Saber M Abdelmaksoud","doi":"10.47176/mjiri.38.88","DOIUrl":"10.47176/mjiri.38.88","url":null,"abstract":"<p><strong>Background: </strong>The anatomy of the eyelid changes with age. Multiple changes were observed in the eyelids and the surrounding structures including the malar region. Aging affects the appearance of eyelids and midface by the formation of tear trough deformity and malar flattening and ptosis. To define the effect of malar fat suspension on the lateral part of the infraorbital wall and orbital fat transposition in tear-trough and malar flattening and ptosis.</p><p><strong>Methods: </strong>A retrospective study was carried out on 15 patients who had surgeries between January 2020 and January 2022. This technique combines orbital fat transposition to the medial side of the infraorbital wall and malar fat suspension to the lateral side of the infraorbital wall. The average follow-up period was 12 months. Values were compared by paired samples student or Wilcoxon signed rank test for quantitative and qualitative data respectively.</p><p><strong>Results: </strong>There was a significant improvement in tear trough deformity, malar ptosis, and midface lift (<i>P</i> < 0.5). No recurrence was observed on follow-up of 12 months. One patient experienced minor postoperative complications in the form of prolonged ecchymosis for 2 months.</p><p><strong>Conclusion: </strong>The transcutaneous lower blepharoplasty with orbital fat transposition and malar fat suspension to the lateral part of the infraorbital wall can be considered a safe and effective intervention with improved aesthetic outcome. Thus, it is recommended in patients with tear trough deformity and malar ptosis.</p>","PeriodicalId":18361,"journal":{"name":"Medical Journal of the Islamic Republic of Iran","volume":"38 ","pages":"88"},"PeriodicalIF":0.0,"publicationDate":"2024-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11644108/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142828728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Parenting Styles and Sedation Efficacy in Pediatric Dental Care; A Study in Uncooperative Children Aged 4 to 6 Years: Structural Equation Modeling Approach.","authors":"Matine Gharavi, Katayoun Salem, Elham Shirazi","doi":"10.47176/mjiri.38.87","DOIUrl":"10.47176/mjiri.38.87","url":null,"abstract":"<p><strong>Background: </strong>Behavioral problems in children contribute significantly to non-compliance and lack of cooperation with dentists.This study aimed to assess the impact of parenting styles on the success of conscious sedation with midazolam in uncooperative children aged 4 to 6 years.</p><p><strong>Methods: </strong>This short-term longitudinal study included ninety-six children aged 4-6 years who were classified as uncooperative according to the Frankl Behavior Rating Scale (Frankl I, II), requiring pulp treatment and Stainless-Steel Crown (SSC) restoration. Midazolam was orally administered at 0.25 mg/kg. Parenting Styles and Dimensions Questionnaire (PSDQ), Strengths and Difficulties Questionnaire (SDQ), and Children's Fear Survey Schedule-Dental Subscale (CFSS-DS). Treatment began at least thirty minutes post-drug administration. Vital signs were monitored using a pulse oximeter. Sedation effectiveness was assessed with the Houpt scale at local anesthesia injection (T0), cavity preparation (T1), restoration (T2), and treatment conclusion (T3). Statistical analysis used Mann-Whitney U test (<i>P</i> < 0.05).</p><p><strong>Results: </strong>Most parents (69, 71.9%) had an authoritative parenting style, while 10 (10.4%) were authoritarian, and 17 (17.7%) were permissive. Authoritative parenting is associated significantly with sedation success (<i>P</i> = 0.001) and reduced dental fear (<i>P</i> = 0.008). Conversely, authoritarian (<i>P</i> = 0.031) and permissive (<i>P</i> = 0.001) parenting styles are associated with sedation failure. Authoritarian parenting is associated positively with increased dental fear (<i>P</i> = 0.001). No significant association was found between permissive parenting style and dental fear (<i>P</i> > 0.05). No significant association existed between behavioral problems and parenting styles (<i>P</i> > 0.05). There was no significant association observed between permissive parenting style and dental fear (<i>P</i> = 0.279). Similarly, no significant associations were found between behavioral problems and specific parenting styles: authoritative (<i>P</i> = 0.625), authoritarian (<i>P</i> = 0.050), and permissive (<i>P</i> = 0.522).</p><p><strong>Conclusion: </strong>Understanding parenting styles aids in predicting conscious sedation success with midazolam and assisting in managing uncooperative children during dental procedures.</p>","PeriodicalId":18361,"journal":{"name":"Medical Journal of the Islamic Republic of Iran","volume":"38 ","pages":"87"},"PeriodicalIF":0.0,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11644105/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142828639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Policy Options for Reducing Defensive Medicine Behaviors: A Multi-Method Study.","authors":"Ehsan Zarei, Iman Yousefi, Saba Shiranirad, Tahmineh Poursaki, Mohamad Mehdi Zahmatkesh, Pouria Farrokhi","doi":"10.47176/mjiri.38.86","DOIUrl":"10.47176/mjiri.38.86","url":null,"abstract":"<p><strong>Background: </strong>Defensive medicine (DM) refers to taking or not taking clinical actions, mainly to prevent legal or reputational consequences. It increases patient and health system costs and threatens patient safety. This study aimed to provide policy options to reduce DM behaviors and was conducted in two phases.</p><p><strong>Methods: </strong>First, a scoping review was conducted by searching the Web of Science, PubMed, ProQuest, and Scopus databases in 2000-2023, and interventions and strategies to control DM behaviors were identified. To recognize the advantages, disadvantages, and implementation considerations, one session of focus group discussion (FGD) with experts was designed. Finally, the policies, strategies, advantages, disadvantages, and implementation considerations were refined and categorized during two expert panel sessions.</p><p><strong>Results: </strong>During the search, 1774 articles were retrieved. Finally, after the screening process, 58 articles were included in the study. Four main policy options were formulated: \"evidence-based medicine,\" \"legal reforms,\" \"promotion of professional ethics and a supportive environment,\" and \"improving the doctor-patient relationship.\" In the following, 13 interventions and strategies, 18 advantages, 18 disadvantages, and 21 implementation considerations were identified.</p><p><strong>Conclusion: </strong>To manage and reduce the effects of DM behaviors, different interventions at macro, organizational, and individual levels are needed. At the micro and individual levels, the enhancement of knowledge and skills is valuable. Organizational interventions that create a supportive culture and promote ethical behavior are also important.</p>","PeriodicalId":18361,"journal":{"name":"Medical Journal of the Islamic Republic of Iran","volume":"38 ","pages":"86"},"PeriodicalIF":0.0,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11644114/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142828785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation of Spiritual Health and Stress Related to the COVID-19 Pandemic in Cancer Patients.","authors":"Ali Arash Anoushirvani, Seidamir Pasha Tabaeian, Minoo Maarefi, Samira Basir Shabestari","doi":"10.47176/mjiri.38.85","DOIUrl":"10.47176/mjiri.38.85","url":null,"abstract":"<p><strong>Background: </strong>Both coronavirus disease-2019 (COVID-19) and cancer place a heavy burden on the society and mental health of patients. Spiritual health may play a prominent role in coping with stressful conditions. Considering the existing controversy regarding the correlation between spiritual health and stress related to the COVID-19 pandemic in cancer patients, this study aimed to assess the correlation between spiritual health and COVID-19 stress in cancer patients.</p><p><strong>Methods: </strong>This cross-sectional study was conducted on cancer patients presenting to Rasoul and Firouzgar Hospitals, affiliated with Iran University of Medical Sciences, in 2022. After obtaining written informed consent, eligible patients filled out the spiritual health questionnaire and COVID Stress Scale (CSS). Data were analyzed by the Pearson and Spearman correlation coefficients and one-way ANOVA.</p><p><strong>Results: </strong>The mean (SD) levels of COVID-19 stress and spiritual health were equal to 106.5 (44.5) and 26.2 (10.9), respectively, which are regarded as moderate levels. An inverse correlation of -0.48 was found between spiritual health and COVID-19 stress (<i>P</i> < 0.001). Spiritual health decreased by an increase in the stage of cancer (<i>P</i> < 0.001). The mean COVID-19 total stress score and its domain scores [except for the post-traumatic stress syndrome (PTSD) domain] were significantly higher in patients with poor spiritual health compared with those with good spiritual health. However, the difference in this regard was not significant between patients with poor and moderate spiritual health (<i>P</i> > 0.05).</p><p><strong>Conclusion: </strong>This study confirmed the prominent role of spiritual health in the reduction of COVID-19 stress. Promotion of spiritual health in cancer patients should be considered as an inseparable part of patient care to prevent disease aggravation and decrease the stress level of cancer patients, particularly during the COVID-19 pandemic.</p>","PeriodicalId":18361,"journal":{"name":"Medical Journal of the Islamic Republic of Iran","volume":"38 ","pages":"85"},"PeriodicalIF":0.0,"publicationDate":"2024-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11644030/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142829264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors Required to Develop Strategic Purchasing for Diagnostic Imaging Services: An Expert Opinion.","authors":"Abdollah Soltan-Tajian, Alireza Jabbari, Nasrin Shaarbafchizadeh, Peivand Bastani","doi":"10.47176/mjiri.38.84","DOIUrl":"10.47176/mjiri.38.84","url":null,"abstract":"<p><strong>Background: </strong>In recent decades, healthcare purchasing has been continuously searching for new approaches to improve performance. The pressure of expensive services resulting from more advanced health technology has increased the necessity of these changes. Strategic purchasing of health services, as a recommended approach, remains unknown in diagnostic imaging services. This study explores the potential determinants of strategic purchasing in the context of diagnostic imaging services.</p><p><strong>Methods: </strong>This was a qualitative study conducted through framework analysis (applying five stages of familiarization, identifying a thematic framework, indexing, mapping, and interpretation) in 2023 based on the World Health Organization for strategic purchasing. This framework includes 5 questions: what to buy? From whom to buy? For whom to buy? what mechanism to buy? At what price to buy? A dimension of what structure to buy? Data were gathered through semi-structured interviews with key informants in which data saturation was reached in 18 interviews. After transcribing each interview, data were analyzed using MAXQDA software.</p><p><strong>Results: </strong>A total of 32 factors were identified to be influencing the strategic purchasing of diagnostic imaging services. Development of an evidence-based service package using a prospective combined payment system, consideration of the burden of disease and health needs, implementation of a referral system and family physician program integrated with the electronic health record, and most importantly, political belief and technical capacity are the most important identified factors.</p><p><strong>Conclusion: </strong>The implementation of a strategic purchasing policy requires a systemic approach to the factors affecting it. A number of specific and sometimes interconnected activities must be carried out in different areas of strategic purchasing. Governance of purchasing is the foundation of strategic purchasing. It is suggested that this item should be investigated more in countries like Iran.</p>","PeriodicalId":18361,"journal":{"name":"Medical Journal of the Islamic Republic of Iran","volume":"38 ","pages":"84"},"PeriodicalIF":0.0,"publicationDate":"2024-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11644203/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142829271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"BRAF^V600E Mutation Analysis in Fine-Needle Aspiration Cytology of Fixed Slide Specimens in Patients with Papillary Thyroid Carcinoma.","authors":"Sara Cheraghi, Maryam Honardoost, Fereshteh Abdolmaleki, Mohammad E Khamseh","doi":"10.47176/mjiri.38.83","DOIUrl":"10.47176/mjiri.38.83","url":null,"abstract":"<p><strong>Background: </strong>Papillary thyroid carcinoma is the most frequent type of thyroid cancer. The BRAF^V600E mutation is associated with tumor progression. We explored the utility of the BRAF molecular testing on fine needle aspiration fixed specimens of patients with confirmed diagnoses of papillary thyroid carcinoma.</p><p><strong>Methods: </strong>Fixed thyroid cytology slide specimens of 19 patients with Bethesda II to VI reports were used to detect BRAF^V600E mutation by pyrosequencing of extracted DNA.</p><p><strong>Results: </strong>BRAF^V600E mutation was detected in 25% of the specimens with Bethesda category III and IV nodules and in 73% of the nodules with Bethesda category V and VI.</p><p><strong>Conclusion: </strong>BRAF mutation analysis can be performed on fixed fine needle aspiration cytology specimens. Although the frequency of the mutation is higher in specimens with higher Bethesda category scores, it could support clinical decision-making in thyroid nodules with intermediate Bethesda category scores.</p>","PeriodicalId":18361,"journal":{"name":"Medical Journal of the Islamic Republic of Iran","volume":"38 ","pages":"83"},"PeriodicalIF":0.0,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11644031/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142829258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring Co-expression Modules-Traits Correlation through Weighted Gene Co-expression Network Analysis: A Promising Approach in Wound Healing Research.","authors":"Mansoureh Farhangniya, Ali Samadikuchaksaraei, Farzaneh Mohamadi Farsani","doi":"10.47176/mjiri.38.82","DOIUrl":"10.47176/mjiri.38.82","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;The skin is the biggest organ in the body and has several important functions in protection and regulation. However, wound development can disrupt the natural healing process, leading to challenges such as chronic wounds, persistent infections, and impaired angiogenesis. These issues not only affect individuals' well-being but also pose significant economic burdens on healthcare systems. Despite advancements in wound care research, managing chronic wounds remains a pressing concern, with obstacles such as persistent infection and impaired angiogenesis hindering the healing process. Understanding the complex genetic pathways involved in wound healing is crucial for developing effective therapeutic strategies and reducing the socio-economic impact of chronic wounds. Weighted Gene Co-Expression Network Analysis (WGCNA) offers a promising approach to uncovering key genes and modules associated with different stages of wound healing, providing valuable insights for targeted interventions to enhance tissue repair and promote efficient wound healing.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Data collection involved retrieving microarray gene expression datasets from the Gene Expression Omnibus website, with 65 series selected according to inclusion and exclusion criteria. Preprocessing of raw data was performed using the Robust MultiArray Averaging approach for background correction, normalization, and gene expression calculation. Weighted Gene Co-Expression Network Analysis was employed to identify co-expression patterns among genes associated with wound healing processes. This involved steps such as network construction, topological analysis, module identification, and association with clinical traits. Functional analysis included enrichment analysis and identification of hub genes through gene-gene functional interaction network analysis using the GeneMANIA database.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;The analysis using WGCNA indicated significant correlations between wound healing and the black, brown, and light green modules. These modules were further examined for their relevance to wound healing traits and subjected to functional enrichment analysis. A total of 16 genes were singled out as potential hub genes critical for wound healing. These hub genes were then scrutinized, revealing a gene-gene functional interaction network within the module network based on the KEGG enrichment database. Noteworthy pathways such as MAPK, EGFR, and ErbB signaling pathways, as well as essential cellular processes including autophagy and mitophagy, emerged as the most notable significant pathways.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;We identified consensus modules relating to wound healing across nine microarray datasets. Among these, 16 hub genes were uncovered within the brown and black modules. KEGG enrichment analysis identified co-expression genes within these modules and highlighted pathways most closely associated with the development of","PeriodicalId":18361,"journal":{"name":"Medical Journal of the Islamic Republic of Iran","volume":"38 ","pages":"82"},"PeriodicalIF":0.0,"publicationDate":"2024-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11644100/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142829270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case of Primary Ovarian Primitive Neuroectodermal Tumor.","authors":"Sara Parviz, Fahimeh Zeinalkhani, Masoumeh Gity, Hamidreza Saligheh Rad, Anahita Fathi Kazerooni, Fatemeh Nili, Peyman Kamali Hakim, Hadise Zeinalkhani","doi":"10.47176/mjiri.38.81","DOIUrl":"10.47176/mjiri.38.81","url":null,"abstract":"<p><p>Primitive neuroectodermal tumors (PNET) are a family of poorly differentiated malignant neoplasms of neuroectodermal origin. According to the location of origin, PNETs could be further categorized as central or peripheral. Peripheral PNET (pPNET) is an uncommon type that accounts for 1% of all soft tissue sarcomas and occurs outside the central and sympathetic nervous systems. Ovarian PNET is a very rare tumor with a high mortality rate. We report a case of pPNET originating from the pelvic cavity of a young woman. Ultrasound and Magnetic Resonance Imaging (MRI) findings demonstrated the presence of a high-grade malignant ovarian tumor. On microscopic evaluation, the tumor was composed of solid nests and sheets of small rounded cells, and on Immunohistochemical (IHC) evaluation, the tumor cells showed intense cell-membranous immunoactivity for MIC2 protein (CD99). In the differential diagnosis of any invasive pelvic tumor in young women, pPNET should be considered.</p>","PeriodicalId":18361,"journal":{"name":"Medical Journal of the Islamic Republic of Iran","volume":"38 ","pages":"81"},"PeriodicalIF":0.0,"publicationDate":"2024-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11644198/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142829254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}