{"title":"帕金森病、进行性核上性麻痹和多系统萎缩伴或不伴痴呆患者视网膜神经纤维层的变化","authors":"Peyman Daraei, Morteza Taheri","doi":"10.47176/mjiri.39.33","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Several studies have evaluated RNFL thickness in PD, with only a few on other Parkinsonian syndromes. There is insufficient information on the pattern of changes in these patients who have dementia. Therefore, the present study examined the RNFL thickness in Parkinsonism patients with and without dementia.</p><p><strong>Methods: </strong>In this cross-sectional study, all patients diagnosed with PD, MSA, and PSP from March 2017 to February 2019 were evaluated. The severity of the disease and the presence of dementia were determined using the UPDRS and MMSE tests, respectively. The thickness of the RNFL was measured in the superior, inferior, nasal, and temporal quadrants using the 3D-OCT 1000 Mark II. Statistical methods, including the independent t-test, one-way analysis of variance (ANOVA), and the Pearson correlation coefficient, were used to analyze the data at a significance level of 0.05 using SPSS statistical software.</p><p><strong>Results: </strong>Fifty-three patients were examined. The mean age and mean UPDRS showed a significant difference between the groups, while gender and disease duration did not show. The mean RNFL thickness in the nasal sector had a significant difference among the three groups, with a thinner thickness in patients with MSA (<i>P</i><0.05). Patients with PD, PSP, and MSA with dementia showed a significantly greater reduction in RNFL thickness in the upper and temporal quadrants, nasal quadrant, and upper and temporal quadrants compared to PD, PSP, and MSA without dementia, respectively (<i>P</i><0.05).</p><p><strong>Conclusion: </strong>Evaluating RNFL can be useful in predicting ocular involvement. Once validated in further studies, OCT may serve as a biomarker for predicting the presence or progression of movement disorders. OCT may also assist in predicting the presence of dementia in these patients by reflecting a more significant reduction in RNFL thickness compared to patients without dementia.</p>","PeriodicalId":18361,"journal":{"name":"Medical Journal of the Islamic Republic of Iran","volume":"39 ","pages":"33"},"PeriodicalIF":0.0000,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12138753/pdf/","citationCount":"0","resultStr":"{\"title\":\"Changes In The Retinal Nerve Fiber Layer In Patients With Parkinson's Disease, Progressive Supranuclear Palsy, And Multiple System Atrophy With And Without Dementia.\",\"authors\":\"Peyman Daraei, Morteza Taheri\",\"doi\":\"10.47176/mjiri.39.33\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Several studies have evaluated RNFL thickness in PD, with only a few on other Parkinsonian syndromes. There is insufficient information on the pattern of changes in these patients who have dementia. Therefore, the present study examined the RNFL thickness in Parkinsonism patients with and without dementia.</p><p><strong>Methods: </strong>In this cross-sectional study, all patients diagnosed with PD, MSA, and PSP from March 2017 to February 2019 were evaluated. The severity of the disease and the presence of dementia were determined using the UPDRS and MMSE tests, respectively. The thickness of the RNFL was measured in the superior, inferior, nasal, and temporal quadrants using the 3D-OCT 1000 Mark II. Statistical methods, including the independent t-test, one-way analysis of variance (ANOVA), and the Pearson correlation coefficient, were used to analyze the data at a significance level of 0.05 using SPSS statistical software.</p><p><strong>Results: </strong>Fifty-three patients were examined. The mean age and mean UPDRS showed a significant difference between the groups, while gender and disease duration did not show. The mean RNFL thickness in the nasal sector had a significant difference among the three groups, with a thinner thickness in patients with MSA (<i>P</i><0.05). Patients with PD, PSP, and MSA with dementia showed a significantly greater reduction in RNFL thickness in the upper and temporal quadrants, nasal quadrant, and upper and temporal quadrants compared to PD, PSP, and MSA without dementia, respectively (<i>P</i><0.05).</p><p><strong>Conclusion: </strong>Evaluating RNFL can be useful in predicting ocular involvement. Once validated in further studies, OCT may serve as a biomarker for predicting the presence or progression of movement disorders. OCT may also assist in predicting the presence of dementia in these patients by reflecting a more significant reduction in RNFL thickness compared to patients without dementia.</p>\",\"PeriodicalId\":18361,\"journal\":{\"name\":\"Medical Journal of the Islamic Republic of Iran\",\"volume\":\"39 \",\"pages\":\"33\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-03-03\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12138753/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Medical Journal of the Islamic Republic of Iran\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.47176/mjiri.39.33\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Medical Journal of the Islamic Republic of Iran","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.47176/mjiri.39.33","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
摘要
背景：一些研究已经评估了PD患者的RNFL厚度，但只有少数研究涉及其他帕金森综合征。关于这些痴呆症患者的变化模式的信息不足。因此，本研究检测了伴有和不伴有痴呆的帕金森病患者的RNFL厚度。方法：在这项横断面研究中，对2017年3月至2019年2月期间诊断为PD、MSA和PSP的所有患者进行评估。分别使用UPDRS和MMSE测试确定疾病的严重程度和痴呆的存在。使用3D-OCT 1000 Mark II测量上、下、鼻和颞象限的RNFL厚度。统计学方法采用独立t检验、单因素方差分析（ANOVA）和Pearson相关系数，采用SPSS统计软件在0.05的显著性水平上对数据进行分析。结果：共检查53例患者。组间平均年龄和平均UPDRS差异有统计学意义，性别和病程差异无统计学意义。三组患者鼻部RNFL的平均厚度差异有统计学意义，MSA （ppsa）患者的RNFL厚度更薄。结论：评估RNFL可用于预测眼部受累。一旦在进一步的研究中得到验证，OCT可以作为预测运动障碍存在或进展的生物标志物。OCT也可以通过反映与无痴呆患者相比RNFL厚度更显著的减少来帮助预测这些患者是否存在痴呆。
Changes In The Retinal Nerve Fiber Layer In Patients With Parkinson's Disease, Progressive Supranuclear Palsy, And Multiple System Atrophy With And Without Dementia.
Background: Several studies have evaluated RNFL thickness in PD, with only a few on other Parkinsonian syndromes. There is insufficient information on the pattern of changes in these patients who have dementia. Therefore, the present study examined the RNFL thickness in Parkinsonism patients with and without dementia.
Methods: In this cross-sectional study, all patients diagnosed with PD, MSA, and PSP from March 2017 to February 2019 were evaluated. The severity of the disease and the presence of dementia were determined using the UPDRS and MMSE tests, respectively. The thickness of the RNFL was measured in the superior, inferior, nasal, and temporal quadrants using the 3D-OCT 1000 Mark II. Statistical methods, including the independent t-test, one-way analysis of variance (ANOVA), and the Pearson correlation coefficient, were used to analyze the data at a significance level of 0.05 using SPSS statistical software.
Results: Fifty-three patients were examined. The mean age and mean UPDRS showed a significant difference between the groups, while gender and disease duration did not show. The mean RNFL thickness in the nasal sector had a significant difference among the three groups, with a thinner thickness in patients with MSA (P<0.05). Patients with PD, PSP, and MSA with dementia showed a significantly greater reduction in RNFL thickness in the upper and temporal quadrants, nasal quadrant, and upper and temporal quadrants compared to PD, PSP, and MSA without dementia, respectively (P<0.05).
Conclusion: Evaluating RNFL can be useful in predicting ocular involvement. Once validated in further studies, OCT may serve as a biomarker for predicting the presence or progression of movement disorders. OCT may also assist in predicting the presence of dementia in these patients by reflecting a more significant reduction in RNFL thickness compared to patients without dementia.
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