Medical mycology journal最新文献_第3页

Kerion Celsi due to Microsporum canis in an Adult Woman, Treated Successfully with Fosravuconazole. 成年女性犬小孢子虫引起的角状细胞瘤用福司伐康唑治疗成功。

IF 1

Medical mycology journal Pub Date : 2023-01-01 DOI: 10.3314/mmj.22-00025

Harunari Shimoyama, Haruka Taira, Kazuo Satoh, Takashi Tamura, Ayaka Yo, Yoshihiro Sei, Koichi Makimura, Yoshihiro Kuwano

{"title":"Kerion Celsi due to Microsporum canis in an Adult Woman, Treated Successfully with Fosravuconazole.","authors":"Harunari Shimoyama, Haruka Taira, Kazuo Satoh, Takashi Tamura, Ayaka Yo, Yoshihiro Sei, Koichi Makimura, Yoshihiro Kuwano","doi":"10.3314/mmj.22-00025","DOIUrl":"https://doi.org/10.3314/mmj.22-00025","url":null,"abstract":"A 64-year-old woman presented with a fist-sized, severely painful lesion with scales, crusts, pustules, erythema with subcutaneous abscess, and hair loss on the left temporal region. Direct microscopic examination revealed a large number of spores around the hair, which indicated ectothrix hair invasion, and some hyphae were also found. Histopathological examination showed significant inflammatory cell infiltration from the dermis to the subcutaneous tissues and into the hair follicles, destruction of the hair follicles with granulomatous reactions, and fungal masses along the hair within the hair follicles. Microsporum canis was identified based on morphological features via culture method and molecular biological analysis of the internal transcribed spacer region DNA sequence. The patient was diagnosed with kerion celsi caused by M. canis. For treatment of kerion celsi, we chose an oral antifungal agent, fosravuconazole (FRVCZ), which has been available since 2018 only in Japan. Clinical symptoms were cured in 12 weeks without scarring. No side effects were observed during oral administration of FRVCZ. The results of our case and several previous reports suggest that FRVCZ is effective in treating various types of dermatomycoses.","PeriodicalId":18325,"journal":{"name":"Medical mycology journal","volume":"64 2","pages":"37-43"},"PeriodicalIF":1.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9615222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Trichophyton tonsurans Infection]. [毛癣菌感染]。

IF 1

Medical mycology journal Pub Date : 2023-01-01 DOI: 10.3314/mmj.23-001

Taketoshi Futatsuya, Kazushi Anzawa, Takashi Mochizuki, Akira Shimizu

{"title":"[Trichophyton tonsurans Infection].","authors":"Taketoshi Futatsuya, Kazushi Anzawa, Takashi Mochizuki, Akira Shimizu","doi":"10.3314/mmj.23-001","DOIUrl":"https://doi.org/10.3314/mmj.23-001","url":null,"abstract":"Trichophyton tonsurans infection has been prevalent among individuals involved in contact sports in Japan since about 2000. The present review focuses on its diagnosis, molecular epidemiology, drug susceptibility, and infection control. The most commonly observed lesions of T. tonsurans, an anthropogenic dermatophyte, are tinea corporis and tinea capitis. However, the presence of asymptomatic carriers must be considered for infection control. Genotypic epidemiology using restriction fragment length polymorphisms (RFLP) in the non-transcribed spacer (NTS) region of the ribosomal RNA gene showed a lack of diversity of genotypes, and only the NTS I genotype is detected at present. In regard to drug susceptibility, terbinafine drug resistance has not been found to be associated with the RFLP genotypes, and it is assumed that there are no terbinafine-resistant strains in Japan. T. tonsurans coexisted with other fungi and bacteria in the scalp of asymptomatic carriers without affecting species diversity. T. tonsurans is an anthropogenic dermatophyte and may be difficult for the human immune system to eliminate. During an infection outbreak, screening of infection and treatment including asymptomatic carriers are essential to eradicate the infection.","PeriodicalId":18325,"journal":{"name":"Medical mycology journal","volume":"64 3","pages":"49-54"},"PeriodicalIF":1.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10127438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

A Case of Nail Yellow Discoloration due to Topical Treatment of Onychomycosis with Luliconazole 5% Nail Solution. 5%吕立康唑甲液局部治疗甲真菌病甲变黄1例。

IF 1

Medical mycology journal Pub Date : 2023-01-01 DOI: 10.3314/mmj.22-00030

Tomotaka Sato, Norihito Fukada, Akihiko Kinjo, Ryuta Akimoto, Hisashi Kobayashi, Satoshi Fukuzumi

引用次数: 0

Invasive Malassezia Infections. 侵袭性马拉色菌感染。

IF 1

Medical mycology journal Pub Date : 2023-01-01 DOI: 10.3314/mmj.23-003

Masato Tashiro, Takahiro Takazono, Koichi Izumikawa

{"title":"Invasive Malassezia Infections.","authors":"Masato Tashiro, Takahiro Takazono, Koichi Izumikawa","doi":"10.3314/mmj.23-003","DOIUrl":"https://doi.org/10.3314/mmj.23-003","url":null,"abstract":"The Malassezia species are dimorphic fungi that require lipids such as olive oil for their growth. They are constituents of the normal human skin microbiota and can affix to the host or other surfaces through the establishment of biofilms. Malassezia species are accountable for superficial mycoses like folliculitis. Additionally, they are capable of causing invasive infections, such as of the bloodstream, in neonates and immunocompromised patients, albeit infrequently. Catheter-associated bloodstream infections in neonates are the most commonly reported invasive cases. Remarkably, unlike other invasive fungal infections, neutropenia and the use of broad-spectrum antibiotics do not seem to contribute to the risk of invasive Malassezia infections. Nosocomial outbreaks of Malassezia infections have been reported. While most cases of invasive Malassezia infection are fungemia, they seldom give rise to disseminated lesions in various organs. The diagnosis can be confirmed by the visualization of characteristic yeasts through histologic or cytologic examination of a biopsy or needle aspiration specimen, or via positive culture results from sterile sites. The prognosis for invasive Malassezia infection is generally favorable, with few reports of treatment failure. Nevertheless, due to the limited number of cases, evidence-based treatment recommendations are wanting. Management of invasive Malassezia infections linked to central venous catheters includes removal of the catheter, cessation of intravenous lipid emulsion, and intravenous administration of appropriate antifungal agents.","PeriodicalId":18325,"journal":{"name":"Medical mycology journal","volume":"64 4","pages":"79-83"},"PeriodicalIF":1.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138460788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

A Case of Kerion Celsi due to Trichophyton tonsurans. 由毛癣菌引起的角膜炎1例。

IF 1

Medical mycology journal Pub Date : 2023-01-01 DOI: 10.3314/mmj.22-00032

Risa Ikutama, Yumi Ogawa, Takasuke Ogawa, Rui Kano, Masataro Hiruma, Shigaku Ikeda

引用次数: 1

Antifungal Susceptibility Testing for Microsporum canis from Cats in Japan. 日本猫源犬小孢子菌的药敏试验。

IF 1

Medical mycology journal Pub Date : 2023-01-01 DOI: 10.3314/mmj.22-00014

Rui Kano, Mai Watanabe, Hitoshi Tsuchihashi, Takasuke Ogawa, Yumi Ogawa, Etsuko Komiyama, Yusuke Hirasawa, Masataro Hiruma, Shigaku Ikeda

引用次数: 1

Mycobiome and Mycobiome-Associated Diseases. 真菌组和真菌组相关疾病。

IF 1

Medical mycology journal Pub Date : 2023-01-01 DOI: 10.3314/mmj.23-002

Mao Hagihara, Hideo Kato, Yuichi Shibata, Takumi Umemura, Tadashi Ariyoshi, Jun Hirai, Nobuhiro Asai, Nobuaki Mori, Hiroshige Mikamo

引用次数: 0

In vitro Azole Susceptibility Testing of Japanese Isolates of Terbinafine-Resistant Trichophyton indotineae and Trichophyton rubrum. 耐特比萘芬日本分离株吲哚毛癣菌和红毛癣菌体外唑类药敏试验。

IF 1

Medical mycology journal Pub Date : 2023-01-01 DOI: 10.3314/mmj.22-00021

Junichiro Hiruma, Utako Kimura, Hiromitsu Noguchi, Masataro Hiruma, Kazutoshi Harada, Rui Kano

引用次数: 0

Treatment responses in patients with chromoblastomycosis to itraconazole in Madagascar. 马达加斯加伊曲康唑对嗜铬菌病患者的治疗效果。

IF 1

Medical mycology journal Pub Date : 2022-10-26 DOI: 10.1093/mmy/myac086

F. Sendrasoa, V. Ratovonjanahary, T. Rasamoelina, L. Ramarozatovo, F. R. Rabenja

{"title":"Treatment responses in patients with chromoblastomycosis to itraconazole in Madagascar.","authors":"F. Sendrasoa, V. Ratovonjanahary, T. Rasamoelina, L. Ramarozatovo, F. R. Rabenja","doi":"10.1093/mmy/myac086","DOIUrl":"https://doi.org/10.1093/mmy/myac086","url":null,"abstract":"INTRODUCTION\u0000Chromoblastomycosis is a chronic fungal infection of the skin and subcutaneous tissue caused by several pigmented fungi. It is frequently found in tropical and subtropical areas like Madagascar. This study primarily discusses the effects of antifungal therapy while also describing the epidemiological, clinical, and pathological features of CBM in our patients.\u0000\u0000\u0000METHODS\u0000From March 2013 to January 2019, a descriptive prospective study on chromoblastomycosis patients was undertaken. The study included patients with CBM who had received antifungal treatment for at least 3 months. Itraconazole 200 mg was given to patients every day for more than 3 months. Results were assessed at the 6th and 12th months, and classified as improvement, cure, or failure.\u0000\u0000\u0000RESULTS\u000029 cases of chromoblastomycosis were included. The mean age of patients was 42.02 years. They primarily worked in rural areas. Infected men were more prevalent. At the end of the 12th month of itraconazole therapy, 3 patients presented major responses, 14 patients had minor responses to treatment, and 12 had been lost to follow up. The clinical response of CBM to treatment was correlated to the severity and the long course of CBM. When compared to CBM caused by Cladophialophora, CBM caused by Fonsecaea showed a greater clinical response.\u0000\u0000\u0000CONCLUSION\u0000These findings demonstrated that chromoblastomycosis lesions are recalcitrant and difficult to treat.","PeriodicalId":18325,"journal":{"name":"Medical mycology journal","volume":"29 24 1","pages":""},"PeriodicalIF":1.0,"publicationDate":"2022-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73097727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

P305 Cirrhosis and fungal infections-a cocktail for catastrophe: a systematic review and meta-analysis with machine learning 肝硬化和真菌感染——灾难的鸡尾酒:系统回顾和机器学习的荟萃分析

IF 1

Medical mycology journal Pub Date : 2022-09-01 DOI: 10.1093/mmy/myac072.P305

N. Verma, Shreya Singh, Akash Roy, A. Valsan, P. Garg, Pranita Pradhan, Arunaloke Chakrabarti, Meenu Singh

{"title":"P305 Cirrhosis and fungal infections-a cocktail for catastrophe: a systematic review and meta-analysis with machine learning","authors":"N. Verma, Shreya Singh, Akash Roy, A. Valsan, P. Garg, Pranita Pradhan, Arunaloke Chakrabarti, Meenu Singh","doi":"10.1093/mmy/myac072.P305","DOIUrl":"https://doi.org/10.1093/mmy/myac072.P305","url":null,"abstract":"Abstract Poster session 2, September 22, 2022, 12:30 PM - 1:30 PM Objectives We evaluated the magnitude and factors contributing to poor outcomes among cirrhosis patients with fungal infections (FIs). Methods We searched PubMed, Embase, Ovid, and WOS and included articles reporting mortality in cirrhosis with FIs. We pooled the point and relative-risk (RR) estimates of mortality on random-effects meta-analysis and explored their heterogeneity (I2) on subgroups, meta-regression, and machine learning (ML). We assessed the study quality through New-Castle-Ottawa-Scale and estimate-asymmetry through Eggers regression (CRD42019142782). Results Of 4345, 34 studies (2134 patients) were included (good/fair/poor quality: 12/21/1). Pooled mortality of FIs was 64.1% (95%CI: 55.4-72.0, 12: 87%, P <.01), which was 2.1 times higher than controls (95%CI: 1.8-2.5, 12:89%, P <.01). Higher CTP (MD: +0.52, 95%CI: 0.27-0.77), MELD (MD: +2.75, 95% CI: 1.21-4.28), organ failures, and increased hospital stay (30 vs. 19 days) was reported among cases with FIs. Patients with ACLF (76.6%, RR: 2.3), and ICU-admission (70.4%, RR: 1.6) had the highest mortality. The risk was maximum for pulmonary-FIs (79.4%, RR: 1.8), followed by peritoneal-FIs (68.3%, RR: 1.7) and fungemia (55%, RR: 1.7). The mortality was higher in FIs than bacterial (RR: 1.7) or no-infections (RR: 2.9). Estimate-asymmetry was evident (P <.05). Up to 8 clusters and 5 outlier studies were identified on ML, and the estimate-heterogeneity was eliminated on excluding such studies. Conclusions A substantially worse prognosis, poorer than bacterial infections in cirrhosis patients with FIs indicates an unmet need for improving fungal diagnostics and therapeutics in this population. ACLF and ICU admission should be included in host criteria for defining IFIs.","PeriodicalId":18325,"journal":{"name":"Medical mycology journal","volume":"1 1","pages":""},"PeriodicalIF":1.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90248010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0