马达加斯加伊曲康唑对嗜铬菌病患者的治疗效果。

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
F. Sendrasoa, V. Ratovonjanahary, T. Rasamoelina, L. Ramarozatovo, F. R. Rabenja
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引用次数: 1

摘要

成色菌病是由几种色素真菌引起的皮肤和皮下组织的慢性真菌感染。它经常出现在马达加斯加等热带和亚热带地区。本研究主要讨论抗真菌治疗的效果,同时也描述了我们患者中CBM的流行病学,临床和病理特征。方法2013年3月至2019年1月,对成色菌病患者进行描述性前瞻性研究。该研究包括接受抗真菌治疗至少3个月的CBM患者。每日给予伊曲康唑200 mg,疗程超过3个月。在第6个月和第12个月对结果进行评估,并将其分为改善、治愈或失败。结果共纳入29例成色菌病。患者平均年龄42.02岁。他们主要在农村地区工作。受感染的男性更为普遍。在伊曲康唑治疗12个月结束时,3例患者出现主要反应,14例患者出现次要反应,12例患者失访。CBM对治疗的临床反应与CBM的严重程度和病程长短有关。与Cladophialophora引起的CBM相比,Fonsecaea引起的CBM表现出更大的临床反应。结论:成色菌病病变顽固性强,治疗难度大。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Treatment responses in patients with chromoblastomycosis to itraconazole in Madagascar.
INTRODUCTION Chromoblastomycosis is a chronic fungal infection of the skin and subcutaneous tissue caused by several pigmented fungi. It is frequently found in tropical and subtropical areas like Madagascar. This study primarily discusses the effects of antifungal therapy while also describing the epidemiological, clinical, and pathological features of CBM in our patients. METHODS From March 2013 to January 2019, a descriptive prospective study on chromoblastomycosis patients was undertaken. The study included patients with CBM who had received antifungal treatment for at least 3 months. Itraconazole 200 mg was given to patients every day for more than 3 months. Results were assessed at the 6th and 12th months, and classified as improvement, cure, or failure. RESULTS 29 cases of chromoblastomycosis were included. The mean age of patients was 42.02 years. They primarily worked in rural areas. Infected men were more prevalent. At the end of the 12th month of itraconazole therapy, 3 patients presented major responses, 14 patients had minor responses to treatment, and 12 had been lost to follow up. The clinical response of CBM to treatment was correlated to the severity and the long course of CBM. When compared to CBM caused by Cladophialophora, CBM caused by Fonsecaea showed a greater clinical response. CONCLUSION These findings demonstrated that chromoblastomycosis lesions are recalcitrant and difficult to treat.
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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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