F. Sendrasoa, V. Ratovonjanahary, T. Rasamoelina, L. Ramarozatovo, F. R. Rabenja
{"title":"马达加斯加伊曲康唑对嗜铬菌病患者的治疗效果。","authors":"F. Sendrasoa, V. Ratovonjanahary, T. Rasamoelina, L. Ramarozatovo, F. R. Rabenja","doi":"10.1093/mmy/myac086","DOIUrl":null,"url":null,"abstract":"INTRODUCTION\nChromoblastomycosis is a chronic fungal infection of the skin and subcutaneous tissue caused by several pigmented fungi. It is frequently found in tropical and subtropical areas like Madagascar. This study primarily discusses the effects of antifungal therapy while also describing the epidemiological, clinical, and pathological features of CBM in our patients.\n\n\nMETHODS\nFrom March 2013 to January 2019, a descriptive prospective study on chromoblastomycosis patients was undertaken. The study included patients with CBM who had received antifungal treatment for at least 3 months. Itraconazole 200 mg was given to patients every day for more than 3 months. Results were assessed at the 6th and 12th months, and classified as improvement, cure, or failure.\n\n\nRESULTS\n29 cases of chromoblastomycosis were included. The mean age of patients was 42.02 years. They primarily worked in rural areas. Infected men were more prevalent. At the end of the 12th month of itraconazole therapy, 3 patients presented major responses, 14 patients had minor responses to treatment, and 12 had been lost to follow up. The clinical response of CBM to treatment was correlated to the severity and the long course of CBM. When compared to CBM caused by Cladophialophora, CBM caused by Fonsecaea showed a greater clinical response.\n\n\nCONCLUSION\nThese findings demonstrated that chromoblastomycosis lesions are recalcitrant and difficult to treat.","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":null,"pages":null},"PeriodicalIF":16.4000,"publicationDate":"2022-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Treatment responses in patients with chromoblastomycosis to itraconazole in Madagascar.\",\"authors\":\"F. Sendrasoa, V. Ratovonjanahary, T. Rasamoelina, L. Ramarozatovo, F. R. Rabenja\",\"doi\":\"10.1093/mmy/myac086\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"INTRODUCTION\\nChromoblastomycosis is a chronic fungal infection of the skin and subcutaneous tissue caused by several pigmented fungi. It is frequently found in tropical and subtropical areas like Madagascar. This study primarily discusses the effects of antifungal therapy while also describing the epidemiological, clinical, and pathological features of CBM in our patients.\\n\\n\\nMETHODS\\nFrom March 2013 to January 2019, a descriptive prospective study on chromoblastomycosis patients was undertaken. The study included patients with CBM who had received antifungal treatment for at least 3 months. Itraconazole 200 mg was given to patients every day for more than 3 months. Results were assessed at the 6th and 12th months, and classified as improvement, cure, or failure.\\n\\n\\nRESULTS\\n29 cases of chromoblastomycosis were included. The mean age of patients was 42.02 years. They primarily worked in rural areas. Infected men were more prevalent. At the end of the 12th month of itraconazole therapy, 3 patients presented major responses, 14 patients had minor responses to treatment, and 12 had been lost to follow up. The clinical response of CBM to treatment was correlated to the severity and the long course of CBM. When compared to CBM caused by Cladophialophora, CBM caused by Fonsecaea showed a greater clinical response.\\n\\n\\nCONCLUSION\\nThese findings demonstrated that chromoblastomycosis lesions are recalcitrant and difficult to treat.\",\"PeriodicalId\":1,\"journal\":{\"name\":\"Accounts of Chemical Research\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":16.4000,\"publicationDate\":\"2022-10-26\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Accounts of Chemical Research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1093/mmy/myac086\",\"RegionNum\":1,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Accounts of Chemical Research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1093/mmy/myac086","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
Treatment responses in patients with chromoblastomycosis to itraconazole in Madagascar.
INTRODUCTION
Chromoblastomycosis is a chronic fungal infection of the skin and subcutaneous tissue caused by several pigmented fungi. It is frequently found in tropical and subtropical areas like Madagascar. This study primarily discusses the effects of antifungal therapy while also describing the epidemiological, clinical, and pathological features of CBM in our patients.
METHODS
From March 2013 to January 2019, a descriptive prospective study on chromoblastomycosis patients was undertaken. The study included patients with CBM who had received antifungal treatment for at least 3 months. Itraconazole 200 mg was given to patients every day for more than 3 months. Results were assessed at the 6th and 12th months, and classified as improvement, cure, or failure.
RESULTS
29 cases of chromoblastomycosis were included. The mean age of patients was 42.02 years. They primarily worked in rural areas. Infected men were more prevalent. At the end of the 12th month of itraconazole therapy, 3 patients presented major responses, 14 patients had minor responses to treatment, and 12 had been lost to follow up. The clinical response of CBM to treatment was correlated to the severity and the long course of CBM. When compared to CBM caused by Cladophialophora, CBM caused by Fonsecaea showed a greater clinical response.
CONCLUSION
These findings demonstrated that chromoblastomycosis lesions are recalcitrant and difficult to treat.
期刊介绍:
Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance.
Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.