Medical mycology journal最新文献

A Silkworm Infection Model for Evaluating In Vivo Biofilm Formation by Pathogenic Fungi. 用于评估致病真菌体内生物膜形成的蚕感染模型

IF 1

Medical mycology journal Pub Date : 2024-01-01 DOI: 10.3314/mmj.24.001

Yasuhiko Matsumoto, Shintaro Eshima, Sanae Kurakado, Takashi Sugita

引用次数: 0

Skin Manifestations of Micafungin Breakthrough Disseminated Trichosporonosis in Acute Megakaryoblastic Leukemia. 急性巨核细胞白血病患者米卡芬突破性播散性三孢子菌病的皮肤表现。

IF 1

Medical mycology journal Pub Date : 2024-01-01 DOI: 10.3314/mmj.23-00009

Yukiro Matsumoto, Sayuka Arakawa, Ken Sadahira, Tomotaka Sato, Kazuto Yamazaki, Shuhei Nishimoto

{"title":"Skin Manifestations of Micafungin Breakthrough Disseminated Trichosporonosis in Acute Megakaryoblastic Leukemia.","authors":"Yukiro Matsumoto, Sayuka Arakawa, Ken Sadahira, Tomotaka Sato, Kazuto Yamazaki, Shuhei Nishimoto","doi":"10.3314/mmj.23-00009","DOIUrl":"10.3314/mmj.23-00009","url":null,"abstract":"Disseminated trichosporonosis is a rare fungal infection whose risk factors are hematological malignancies and neutropenia. Recently, breakthrough Trichosporon infections after administration of micafungin, the first-line systemic antifungal agent in compromised hosts, have been widely recognized. A man in his seventies about 1 month into chemotherapy for acute megakaryoblastic leukemia presented with a worsening fever and dyspnea. The patient was being administered with empirical micafungin therapy for suspected candidiasis. As the symptoms progressed, scattered erythema appeared on the trunk, some with a dark red vesicle at the center. Blood cultures identified Trichosporon asahii, as did the specimen of the skin biopsy. On the basis also of the presence of pneumonia on chest computed tomography, we confirmed the diagnosis of disseminated trichosporonosis and changed the antifungal agent from micafungin to voriconazole. Blood culture turned out to be negative 1 month after administrating voriconazole. However, the patient died of the leukemia. Our review of previous reports on cutaneous manifestations of disseminated trichosporonosis revealed that despite their morphological diversity, erythema with a red papule or vesicle at the center, implying necrosis, was also observed in previous cases. Our case report suggests that dermatologists should be aware of skin manifestations of disseminated trichosporonosis after micafungin administration, especially in cases of hematological malignancies.","PeriodicalId":18325,"journal":{"name":"Medical mycology journal","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139990556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploratory Research for New Diagnostic Markers of Mucormycosis. 粘孢子菌病新诊断标记的探索性研究。

IF 1

Medical mycology journal Pub Date : 2024-01-01 DOI: 10.3314/mmj.24.002

Hiroshi Kakeya

引用次数: 0

Optimized Antifungal Therapy for Chronic Pulmonary Aspergillosis. 优化慢性肺曲霉菌病的抗真菌疗法。

IF 1.4

Medical mycology journal Pub Date : 2024-01-01 DOI: 10.3314/mmj.24.005

Yusuke Yagi, Yuka Yamagishi, Yukihiro Hamada

{"title":"Optimized Antifungal Therapy for Chronic Pulmonary Aspergillosis.","authors":"Yusuke Yagi, Yuka Yamagishi, Yukihiro Hamada","doi":"10.3314/mmj.24.005","DOIUrl":"https://doi.org/10.3314/mmj.24.005","url":null,"abstract":"Chronic pulmonary aspergillosis (CPA) represents a spectrum of lung disorders caused by local proliferation of Aspergillus hyphae in individuals with non-systemic or mildly systemic immunodepression or altered pulmonary integrity due to underlying disease. While long-term systemic antifungal treatment is still the mainstay for management, surgery is considered mainly in rarer invasive disease manifestations such as sinusitis and osteomyelitis. Optimal application of existing antifungal agents with suitable pharmacokinetic properties is important for the treatment of diseases such as CPA, which requires long-term use. Appropriate management of side effects by therapeutic drug monitoring, maintenance of adherence, and assessment of drug resistance to Aspergillus can provide safe and effective treatment in the future. Most available antifungal agents for the management of mycoses in humans have disadvantages that can limit their use in clinical practice. By contrast, second generation antifungals such as triazoles have advantages of extended antifungal spectrum and availability in both oral and intravenous formulations. Isavuconazole, a new extended spectrum triazole, has been shown to be effective against Aspergillus. The safety profile and excellent pharmacokinetic characteristics of isavuconazole make it an attractive option for treatment of invasive fungal infections including CPA. With this drug now available in Japan, new evidence is expected to expand treatment options. This review focuses on the selection of antifungal agents based on national and international guidelines and the characteristics of each agent for their appropriate use in CPA.","PeriodicalId":18325,"journal":{"name":"Medical mycology journal","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142109196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification of Familial Infections Using Multilocus Microsatellite Typing in Tinea Corporis due to Microsporum canis. 利用多焦点微卫星分型鉴定犬小孢子菌所致体癣的家族感染。

IF 1

Medical mycology journal Pub Date : 2024-01-01 DOI: 10.3314/mmj.23-00013

Chiaki Takahashi, Ryohei Asakura, Ayaka Chaya, Michi Ota, Kazutoshi Harada, Tatsuya Inukai, Shigeki Nakamura, Yasuki Hata, Emiko Watanabe-Okada

{"title":"Identification of Familial Infections Using Multilocus Microsatellite Typing in Tinea Corporis due to Microsporum canis.","authors":"Chiaki Takahashi, Ryohei Asakura, Ayaka Chaya, Michi Ota, Kazutoshi Harada, Tatsuya Inukai, Shigeki Nakamura, Yasuki Hata, Emiko Watanabe-Okada","doi":"10.3314/mmj.23-00013","DOIUrl":"10.3314/mmj.23-00013","url":null,"abstract":"Microsporum canis is a type of dermatophyte that causes zoonotic dermatophytosis in cats and dogs. We report three cases of tinea corporis due to M. canis from a single household with a domestic cat as a pet. The cases included a woman in her thirties (mother), a girl in her teens (older sister), and a girl in her teens (younger sister). Following sudden hair loss in the domestic cat, annular erythema with pruritus and scales appeared on the face, neck, and limbs of the older sister, younger sister, and mother, sequentially; they subsequently visited our hospital. Potassium hydroxide direct microscopy revealed filamentous fungi on all three women. In addition, short-haired colonies with a white to yellowish-white color and extending in a radial manner were found in cultures using a flat plate agar medium. A slide culture with the same medium indicated pointed spindle-shaped macroconidia with 7-8 septa. Therefore, the cases were diagnosed as tinea corporis due to M. canis. Genetic analysis of the cells of the cat and the mother, older sister, and younger sister using multilocus microsatellite typing (MLMT) indicated that all cases were classified into the same genotype, suggesting that the transmission route of these cases was familial. Here, we show that MLMT is useful in identifying the infection route in cases of tinea corporis due to M. canis.","PeriodicalId":18325,"journal":{"name":"Medical mycology journal","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139990554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Most Azole-Susceptible Isolates of Aspergillus fumigatus in Hokkaido, Japan are Clustered with Worldwide Strains That Do Not Have Tandem Repeats in Cyp51A Promoter. 日本北海道大多数对唑类敏感的烟曲霉分离株与 Cyp51A Promoter 中没有串联重复的全球菌株聚集在一起。

IF 1

Medical mycology journal Pub Date : 2024-01-01 DOI: 10.3314/mmj.23-00007

Takuya Fujiwara, Megumi Itoh, Naoya Matsumoto, Yusuke Koshizaki, Syunpei Saitou, Kazutaka Yamada, Takahito Toyotome

引用次数: 0

Status and Challenge of Antifungal Stewardship at the Osaka Metropolitan University Hospital. 大阪都立大学医院抗真菌管理的现状与挑战。

IF 1

Medical mycology journal Pub Date : 2024-01-01 DOI: 10.3314/mmj.24.003

Koichi Yamada, Hiroshi Kakeya

引用次数: 0

Basic Research on Candida Species. 念珠菌的基础研究

IF 1.4

Medical mycology journal Pub Date : 2024-01-01 DOI: 10.3314/mmj.24.006

Masahiro Abe, Yuki Kinjo, Takuro Koshikawa, Yoshitsugu Miyazaki

{"title":"Basic Research on Candida Species.","authors":"Masahiro Abe, Yuki Kinjo, Takuro Koshikawa, Yoshitsugu Miyazaki","doi":"10.3314/mmj.24.006","DOIUrl":"https://doi.org/10.3314/mmj.24.006","url":null,"abstract":"Candida species are common human pathogens that cause a wide range of diseases ranging from superficial to invasive candidiasis. However, basic studies focusing on the mechanisms underlying these diseases are limited. This article reviews our previous research on the mechanisms of superficial and invasive candidiasis, the virulence of Candida species, and Candida species fitness to hosts. Regarding invasive candidiasis, we focused on two types of infections: ocular candidiasis and endogenous candidiasis from the gastrointestinal tract. Using an established ocular candidiasis mouse model, along with retrospective epidemiological research, we found a strong association between Candida albicans and ocular candidiasis. Regarding endogenous candidiasis, research using Candida auris indicated that invasive strains had a higher capability for gastrointestinal tract colonization and showed greater dissemination compared with non-invasive strains. In terms of superficial candidiasis, we focused on the defense mechanism in vulvovaginal candidiasis. The results suggested that stimulated invariant natural killer T cells played a protective role against C. albicans vaginal infection and might be a therapeutic target for vulvovaginal candidiasis. Concerning Candida species fitness, we focused on environmental factors, particularly oxygen concentration, and evaluated biofilm formation under various oxygen concentrations, revealing that each Candida species favored different oxygen concentrations. In particular, Candida tropicalis showed greater biofilm formation under hypoxic conditions. Our research revealed several insights for understanding the exact mechanisms of candidiasis, which might lead to better control of Candida species infections and appropriate treatment.","PeriodicalId":18325,"journal":{"name":"Medical mycology journal","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142109195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antimicrobial Tolerance in Cross-Kingdom Dual-Species Biofilms Formed by Fungi and Bacteria. 真菌和细菌形成的跨王国双物种生物膜的抗菌耐受性

IF 1.4

Medical mycology journal Pub Date : 2024-01-01 DOI: 10.3314/mmj.24.004

Sanae Kurakado, Yasuhiko Matsumoto, Shintaro Eshima, Takashi Sugita

引用次数: 0

Retrospective Comparison of Two Aspergillus IgG Enzyme Immunoassays for Diagnosing Pulmonary Aspergillosis. 两种诊断肺曲霉菌病的曲霉菌 IgG 酶免疫测定的回顾性比较

IF 1.4

Medical mycology journal Pub Date : 2024-01-01 DOI: 10.3314/mmj.24.00004

Ikumi Yamagishi, Yuuki Bamba, Hiroshi Moro, Naoto Kanno, Hayato Tsuruma, Mariko Hakamata, Hideyuki Ogata, Satoshi Shibata, Nobumasa Aoki, Yasuyoshi Ohshima, Satoshi Watanabe, Toshiyuki Koya, Toshiaki Kikuchi

{"title":"Retrospective Comparison of Two Aspergillus IgG Enzyme Immunoassays for Diagnosing Pulmonary Aspergillosis.","authors":"Ikumi Yamagishi, Yuuki Bamba, Hiroshi Moro, Naoto Kanno, Hayato Tsuruma, Mariko Hakamata, Hideyuki Ogata, Satoshi Shibata, Nobumasa Aoki, Yasuyoshi Ohshima, Satoshi Watanabe, Toshiyuki Koya, Toshiaki Kikuchi","doi":"10.3314/mmj.24.00004","DOIUrl":"https://doi.org/10.3314/mmj.24.00004","url":null,"abstract":"Aspergillus-specific antibodies are diagnostic indicators of allergic bronchopulmonary aspergillosis (ABPA) and chronic pulmonary aspergillosis (CPA). Tests for detecting Aspergillus-specific antibodies were not used clinically in Japan, and the production of the Aspergillus precipitin test was discontinued. Thus, alternative tests for diagnosing aspergillosis are urgently needed. We retrospectively evaluated 64 patients with suspected ABPA and CPA who underwent precipitin antibody testing. Serum Aspergillus IgG levels were measured and compared using the Bordier Aspergillus fumigatus ELISA and the Platelia Aspergillus IgG (Bio-Rad) kits. Of the participants, 18 were diagnosed with CPA, and 8 were diagnosed with ABPA. Both the Bordier and Bio-Rad kits showed high sensitivity and specificity for CPA and ABPA. The area under the receiver operating characteristic curves for the Bordier and Bio-Rad kits were 0.97 and 0.95, respectively, for CPA, and 0.89 and 0.91, respectively, for ABPA. In contrast to the Bordier kit, the Bio-Rad kit showed relatively low anti-Aspergillus IgG levels and lower sensitivity to non-fumigatus Aspergillus infections. The Aspergillus-specific IgG ELISA tests showed sufficient diagnostic accuracy. Therefore, these assays are recommended as alternatives to the precipitin kit for diagnosing aspergillosis in clinical settings in Japan.","PeriodicalId":18325,"journal":{"name":"Medical mycology journal","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142109197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0