日本北海道大多数对唑类敏感的烟曲霉分离株与 Cyp51A Promoter 中没有串联重复的全球菌株聚集在一起。

IF 1.4 Q4 MYCOLOGY

Medical mycology journal Pub Date : 2024-01-01 DOI:10.3314/mmj.23-00007

Takuya Fujiwara, Megumi Itoh, Naoya Matsumoto, Yusuke Koshizaki, Syunpei Saitou, Kazutaka Yamada, Takahito Toyotome

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引用次数: 0

摘要

在这项研究中，我们分析了从室外空气、临床标本和日本患有曲霉菌病的国王企鹅（Aptenodytes patagonicus）中分离出的 106 株烟曲霉短串联重复模式，并将其与来自 AfumID 的 668 株（包括来自日本的 6 株）进行了比较。结果表明，分离菌株被分为三大类。第二组包含了大部分对唑类耐药的菌株，这些菌株在 cyp51A 启动子中具有 34 和 46 个 bp 的串联重复。与我们之前的研究一样，OKH50 和 Env1 菌株被归入第二组。在日本获得的大多数对唑敏感的菌株被归入第 III 组。

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Most Azole-Susceptible Isolates of Aspergillus fumigatus in Hokkaido, Japan are Clustered with Worldwide Strains That Do Not Have Tandem Repeats in Cyp51A Promoter.

In this study, we analyzed Aspergillus fumigatus short tandem repeat patterns of 106 strains isolated from the outdoor air, clinical specimens, and king penguins (Aptenodytes patagonicus) with aspergillosis in Japan, and compared them with those of 668 strains from AfumID (including six isolates from Japan). The results showed that the isolates were classified into three major groups. Group II contained most of the azole-resistant strains with 34- and 46-bp tandem repeats in cyp51A promoter. As in our previous study, OKH50 and Env1 strains were classified in Group II. Most of the azole-susceptible strains obtained in Japan were classified in Group III.

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来源期刊

Medical mycology journal Medicine-Infectious Diseases

CiteScore

1.80

自引率

10.00%

发文量

期刊介绍： The Medical Mycology Journal is published by and is the official organ of the Japanese Society for Medical Mycology. The Journal publishes original papers, reviews, and brief reports on topics related to medical and veterinary mycology.