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Phytochemical screening of Nigerian medicinal plants II. 尼日利亚药用植物的植物化学筛选2。
Lloydia Pub Date : 1978-05-01
O O Odebiyi, E A Sofowora
{"title":"Phytochemical screening of Nigerian medicinal plants II.","authors":"O O Odebiyi,&nbsp;E A Sofowora","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A total of 47 plant extracts representing 132 genera and 172 species of plants distributed over 59 families were collected from various parts of Nigeria. The plant extracts were screened for the presence of alkaloids, saponins, tannins, phlobatannins and anthraquinones. The number of positive tests obtained was 176 (32.18%) for alkaloids, 242 (44.24%) for saponins, and 435 (79.52) for tannins. A few were positive for phlobatannins and anthraquinones.</p>","PeriodicalId":18256,"journal":{"name":"Lloydia","volume":"41 3","pages":"234-46"},"PeriodicalIF":0.0,"publicationDate":"1978-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11874255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Alkaloids of Thalictrum XXVI. New hypotensive and other alkaloids from Thalictrum minus race B. 海芋生物碱。新的降压药和其他生物碱从Thalictrum负B种。
Lloydia Pub Date : 1978-05-01
W T Liao, J L Beal, W N Wu, R W Doskotch
{"title":"Alkaloids of Thalictrum XXVI. New hypotensive and other alkaloids from Thalictrum minus race B.","authors":"W T Liao,&nbsp;J L Beal,&nbsp;W N Wu,&nbsp;R W Doskotch","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The roots of T. minus race B have yielded 9 alkaloids, thalirabine (1), thaliracebine (13), thalfine (19), thalfinine (20), thalrugosaminine (22), thalidasine (13), obaberine (24), thaliglucinone (25) and (S)-reticuline (26). The first two, possessing marked hypotensive activity, were assigned complete structures by physical and chemical methods. Thalfine (19) was given S-configuration at its one asymmetric center and was converted to thalfinine (20) and epithalfinine (21), thus the stereochemistry was established at one of the two optically active positions. The other alkaloids were identified by direct comparison with known samples. Antimicrobial testing showed thalirabine, thaliracebine, thalfine, and thalfinine to be active against Mycobacterium smegmatis.</p>","PeriodicalId":18256,"journal":{"name":"Lloydia","volume":"41 3","pages":"257-70"},"PeriodicalIF":0.0,"publicationDate":"1978-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11873281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In vitro methods used in detection and quantitation of antitumor drugs produced by microbial fermentations. 微生物发酵产生的抗肿瘤药物的体外检测和定量方法。
Lloydia Pub Date : 1978-03-01
L J Hanka, D G Martin, G L Neil
{"title":"In vitro methods used in detection and quantitation of antitumor drugs produced by microbial fermentations.","authors":"L J Hanka,&nbsp;D G Martin,&nbsp;G L Neil","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":18256,"journal":{"name":"Lloydia","volume":"41 2","pages":"85-97"},"PeriodicalIF":0.0,"publicationDate":"1978-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11856017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The occurrence of psilocybin in Gymnopilus species. 裸盖菇素在裸子茅属植物中的存在。
Lloydia Pub Date : 1978-03-01
G M Hatfield, L J Valdes
{"title":"The occurrence of psilocybin in Gymnopilus species.","authors":"G M Hatfield,&nbsp;L J Valdes","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>An accidental case of mushroom poisoning led to the detection of psilocybin in Gymnopilus validipes (Cortinariaceae). This compound was subsequently isolated (0.12% yield) by anion exchange and cellulose chromatography. Eighteen additional species of Gymnopilus were screened by a method capable of detecting 0.0004% psilocybin in dried carpophores. Psilocybin was detected in G. aeruginosus, G. luteus, G. viridans and G. spectabilis. The latter species has been previously reported to be hallucinogenic. This is the first report of psilocybin from this genus.</p>","PeriodicalId":18256,"journal":{"name":"Lloydia","volume":"41 2","pages":"140-4"},"PeriodicalIF":0.0,"publicationDate":"1978-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11768874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antimicrobial activities of constituents of Uvaria chamae. 鼠耳草各成分的抗菌活性研究。
Lloydia Pub Date : 1978-03-01
C D Hufford, W L Lasswell
{"title":"Antimicrobial activities of constituents of Uvaria chamae.","authors":"C D Hufford,&nbsp;W L Lasswell","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The antimicrobial activities of a number of cytotoxic C-benzylated flavonoids from Uvaria chamae have been determined. The minimum inhibitory concentration values of these flavonoids and certain of their derivatives against Straphylococcus aureus, Bacillus subtilis, and Mycobacterium smegmatis compare favorably with those of streptomycin sulfate.</p>","PeriodicalId":18256,"journal":{"name":"Lloydia","volume":"41 2","pages":"156-60"},"PeriodicalIF":0.0,"publicationDate":"1978-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11856015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antimicrobial agents from higher plants. An investigation of Hunnemannia fumariaefolia pseudoalcoholates of sanguinarine and chelerythrine. 来自高等植物的抗菌剂。假血碱和车车菊碱假醇的研究。
Lloydia Pub Date : 1978-03-01
L A Mitscher, Y H Park, D Clark, G W Clark, P D Hammesfahr, W N Wu, J L Beal
{"title":"Antimicrobial agents from higher plants. An investigation of Hunnemannia fumariaefolia pseudoalcoholates of sanguinarine and chelerythrine.","authors":"L A Mitscher,&nbsp;Y H Park,&nbsp;D Clark,&nbsp;G W Clark,&nbsp;P D Hammesfahr,&nbsp;W N Wu,&nbsp;J L Beal","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The antimicrobial activity seen in extracts of Hunnemmania fumariaefolia S. resides in the alkaloids. The activity seen in the non-polar fractions had been shown by chromatography, physicochemical measurements, and comparisons with authentic samples to be due to apparently artifactual formation of the pseudomethanolates and pseudoethanolates of the alkaloids sanguinarine and chelerythrine, which are abundant in the plant. The enhanced potency of the pseudoalcoholates of sanguinarine over the parent benzophenanthridine is discussed in comparison with the in vitro biopotencies of other analogs prepared for the purpose. It appears that the pseudoalcoholates may be useful prodrugs.</p>","PeriodicalId":18256,"journal":{"name":"Lloydia","volume":"41 2","pages":"145-50"},"PeriodicalIF":0.0,"publicationDate":"1978-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11856014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antineoplastic agents. 52. Baileya multiradiata. 抗肿瘤药物。52.Baileya multiradiata。
Lloydia Pub Date : 1978-01-01
G R Pettit, C L Herald, G F Judd, G Bolliger, L D Vanell, E Lehto, C P Pase
{"title":"Antineoplastic agents. 52. Baileya multiradiata.","authors":"G R Pettit,&nbsp;C L Herald,&nbsp;G F Judd,&nbsp;G Bolliger,&nbsp;L D Vanell,&nbsp;E Lehto,&nbsp;C P Pase","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The desert-marigold Baileya multiradiata Harv. and Gray (Compositae) has been found to produce a series of sesquiterpenes that markedly inhibit growth of the murine lymphocytic leukemia P388 and the corresponding in vitro cell line. Separation guided by bioassay led to the isolation of baileyin (1), fastigilins B and C (3a and 2a), radiatin (3b), pleniradin (4a), and the new pseudoguaianolide multiradiatin (2b). The most significant antitumor activity was displayed by fastigilin C (2a) and radiation (3b).</p>","PeriodicalId":18256,"journal":{"name":"Lloydia","volume":"41 1","pages":"29-36"},"PeriodicalIF":0.0,"publicationDate":"1978-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11769404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Determination of epimeric 1-(3-indolyl) propane -1,2,3-triol isolated from Balansia epichloe. 白莲中1-(3-吲哚基)丙烷-1,2,3-三醇的含量测定。
Lloydia Pub Date : 1978-01-01
J K Porter, J D Robbins, C W Bacon, D S Himmelsbach, A F Haeberer
{"title":"Determination of epimeric 1-(3-indolyl) propane -1,2,3-triol isolated from Balansia epichloe.","authors":"J K Porter,&nbsp;J D Robbins,&nbsp;C W Bacon,&nbsp;D S Himmelsbach,&nbsp;A F Haeberer","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Investigations into diseases in cattle grazing on grass pastures infected with clavicipitaceous fungi have resulted in the isolation and characterization of erythro and threo 1-(3-indolyl) propane-1,2,3-triol from cultures of Balansia epichloë (Weese). Gas chromatography-mass spectroscopy analyses of synthetic and natural epimers as their trimethylsilyl derivatives is described. Toxicity studies with fertile chicken eggs demonstrated that the threo epimer was the more active compound. The ratio of erythro to threo was calculated at 3:2 in the natural isolate.</p>","PeriodicalId":18256,"journal":{"name":"Lloydia","volume":"41 1","pages":"43-9"},"PeriodicalIF":0.0,"publicationDate":"1978-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11768313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A note on the isolation and identification of two pharmacologically active constituents of Euphorbia pilulifera. 大戟两种药理活性成分的分离鉴定。
Lloydia Pub Date : 1978-01-01
L el-Naggar, J L Beal, L M Parks, K N Salman, P Patil
{"title":"A note on the isolation and identification of two pharmacologically active constituents of Euphorbia pilulifera.","authors":"L el-Naggar,&nbsp;J L Beal,&nbsp;L M Parks,&nbsp;K N Salman,&nbsp;P Patil","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":18256,"journal":{"name":"Lloydia","volume":"41 1","pages":"73-5"},"PeriodicalIF":0.0,"publicationDate":"1978-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11844174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Muscle-relaxant activity in Asian Strychnos species. A re-examination of two western Malaysian dart poisons. 亚洲马钱子属植物的肌肉松弛活性。对马来西亚西部两种飞镖毒素的重新检查。
Lloydia Pub Date : 1977-11-01
N G Bisset, K H Baser, J D Phillipson, L Bohlin, F Sandberg
{"title":"Muscle-relaxant activity in Asian Strychnos species. A re-examination of two western Malaysian dart poisons.","authors":"N G Bisset,&nbsp;K H Baser,&nbsp;J D Phillipson,&nbsp;L Bohlin,&nbsp;F Sandberg","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Two supposedly Strychnos-based Semai Senoi dart poisons from Western Malaysia, ipoh akar and lampong, and their accompanying plant materials have been re-investigated botanically, chemically, and pharmacologically. The two poisons contained tertiary and quaternary alkaloids, including strychnine and bis-quaternary dimeric bases, and also cardiotonic glycosides. The dominant pharmacological activity of the highly toxic ipoh akar poison was convulsant. The weaker lampong poison had muscle-relaxant activity of the curarizing type. The alkaloids of the two poisons were almost certainly derived from Strychnosignatii Berg. (S. ovalifolia Wall. ex G. Don) and not from S. vanprukii Craib to which the accompanying plant materials probably belong, while the cardiotonic glycosides of the two poisons came from Antiaris toxicaria Lesch. The quaternary alkaloids of both S. ignatii and S. vanprukii have muscle relaxant activity.</p>","PeriodicalId":18256,"journal":{"name":"Lloydia","volume":"40 6","pages":"546-60"},"PeriodicalIF":0.0,"publicationDate":"1977-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11803263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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