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Plants used against cancer. A survey. 用于抗癌的植物。一项调查。
Lloydia Pub Date : 1984-11-01 DOI: 10.2307/1220819
J. Hartwell
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引用次数: 2
(+)Nortrachelogenin, a new pharmacologically active lignan from Wikstroemia indica. (+)Nortrachelogenin，一种新的具有药理活性的木脂素。
Lloydia Pub Date : 1979-03-01
A Kato, Y Hashimoto, M Kidokoro
{"title":"(+)Nortrachelogenin, a new pharmacologically active lignan from Wikstroemia indica.","authors":"A Kato,&nbsp;Y Hashimoto,&nbsp;M Kidokoro","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A new lignan, (+)-nortrachelogenin (I), and a known compound, daphnoretin were isolated from Wikstroemia indica C.A. Meyer (Thymelaeaceae). The structure of (+)-nortrachelogenin was established as 8(R)8'-4,4',8'-trihydroxy-3,3'-dimethoxylignan-olid, (9,9') on the basis of spectroscopic evidence and comparison with its enantiomer, (-)-nortrachelogenin. +-nortrachelogenin(I) showed effects on the central nervous system producing depression in rabbits.</p>","PeriodicalId":18256,"journal":{"name":"Lloydia","volume":"42 2","pages":"159-62"},"PeriodicalIF":0.0,"publicationDate":"1979-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11655436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inhibition of reverse transcriptase activity by benzophenanthridine alkaloids. 苯并苯胺生物碱对逆转录酶活性的抑制作用。
Lloydia Pub Date : 1979-03-01
M L Sethi
{"title":"Inhibition of reverse transcriptase activity by benzophenanthridine alkaloids.","authors":"M L Sethi","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Benzophenanthridine alkaloids, fagaronine 4, O-methylfagaronine 5,nitidine 1, allonitidine 3 and methoxydihydronitidine 2 have been shown to possess inhibitory activity against reverse transcriptase of RNA tumor viruses. The enzyme inhibition (50%) by these alkaloids was found in the range of 6-60 microgram per milliliter of the reaction mixture when polynucleotide-oligodeoxynucleotide complexes were used as template primers. The results suggested that the benzophenanthridine alkaloids interacted with the template primers (particularly of the A:T base pairs) and not with the enzyme proteins. Kinetics reaction of the reverse transciptase inhibition showed that the alkaloids stopped the DNA polymerase synthesis instantly, probably by interacting with the template primer.</p>","PeriodicalId":18256,"journal":{"name":"Lloydia","volume":"42 2","pages":"187-96"},"PeriodicalIF":0.0,"publicationDate":"1979-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11308909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Proceedings of the 19th Annual Meeting of the American Society of Pharmacognosy held with the Phytochemical Society of North America, August 14-17, 1978, Oklahoma State University, Stillwater, Oklahoma. 第19届美国生药学学会年会论文集与北美植物化学学会于1978年8月14-17日在俄克拉何马州立大学举行。
Lloydia Pub Date : 1978-11-01
{"title":"Proceedings of the 19th Annual Meeting of the American Society of Pharmacognosy held with the Phytochemical Society of North America, August 14-17, 1978, Oklahoma State University, Stillwater, Oklahoma.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":18256,"journal":{"name":"Lloydia","volume":"41 6","pages":"642-63"},"PeriodicalIF":0.0,"publicationDate":"1978-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11254660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Plant antitumor agents. XVI. 6alpha-Senecioyloxy-chaparrinone, a new antileukemic quassinoid from Simaba multiflora. 植物抗肿瘤剂。十六。一种新的抗白血病类西米藤素。
Lloydia Pub Date : 1978-11-01
M C Wani, H L Taylor, J B Thompson, M E Wall
{"title":"Plant antitumor agents. XVI. 6alpha-Senecioyloxy-chaparrinone, a new antileukemic quassinoid from Simaba multiflora.","authors":"M C Wani,&nbsp;H L Taylor,&nbsp;J B Thompson,&nbsp;M E Wall","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Fractionation of Simaba multiflora A. Juss. guided by bioassay has resulted in the isolation of a new antileukemic quassinoid 6alpha-senecioyloxychaparrinone (2) and the previously reported quassinoid chaparrinone (3). The structure of the former has been established by spectral and chemical methods. Compound 2 has high anti-neoplastic activity against several mouse leukemia systems (P-388, L-1210 and in solid-tumor B-16 melanoma). This demonstrates for the first time that the presence of a C-15 ester function is not required for antineoplastic activity in the quassinoids.</p>","PeriodicalId":18256,"journal":{"name":"Lloydia","volume":"41 6","pages":"578-83"},"PeriodicalIF":0.0,"publicationDate":"1978-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11932469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Potential anticancer agents IX. Isolation of a new simaroubolide, 6alpha-tigloyloxychaparrinone, from Ailanthus integrifolia ssp. calycina (Simaroubaceae). 潜在的抗癌剂臭椿中6 α - tigloyloxychaparinone的分离。calycina(苦木科)。
Lloydia Pub Date : 1978-11-01
A A Seida, A D Kinghorn, G A Cordell, N R Farnsworth
{"title":"Potential anticancer agents IX. Isolation of a new simaroubolide, 6alpha-tigloyloxychaparrinone, from Ailanthus integrifolia ssp. calycina (Simaroubaceae).","authors":"A A Seida,&nbsp;A D Kinghorn,&nbsp;G A Cordell,&nbsp;N R Farnsworth","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Chaparrinone (1) and 6alpha-tigloyoxychaparrinone (2) were shown to be responsible for the antitumor and cytotoxic activities of the root bark of Ailanthus integrifolia ssp. calycina. The structure of the latter compound was established by analysis of spectral data. Compound 2 exhibited a more pronounced biological activity than chaparrinone (1) and demonstrates, for the first time, anticancer activity of a simaroubolide ester substituted at only the 6-position.</p>","PeriodicalId":18256,"journal":{"name":"Lloydia","volume":"41 6","pages":"584-7"},"PeriodicalIF":0.0,"publicationDate":"1978-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11932473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Marine cardioactive agents. Adenosine and 2'-deoxyadenosine from Dasychalina cyathina. 海洋心脏活性药物。水杨花中的腺苷和2'-脱氧腺苷。
Lloydia Pub Date : 1978-09-01
A J Weinheimer, C W Chang, J A Matson, P N Kaul
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引用次数: 0
Alkaloid N-oxides. A review of recent developments. 生物碱N-oxides。对最近事态发展的回顾。
Lloydia Pub Date : 1978-09-01
J D Phillipson, S S Handa
{"title":"Alkaloid N-oxides. A review of recent developments.","authors":"J D Phillipson,&nbsp;S S Handa","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The preparation, characterization and chemistry of alkaloid N-oxides is reviewed. Because the literature on amine N-oxides is more extensive for animals than for plants, a brief resumé of the pharmacology, metabolism, and toxicity of N-oxides is given. Some 64 naturally occuring N-oxides representing pyrrolidine-piperidine-, pyrrolizidine-, quinolizidine-, tropane-, isoquinoline-, morphinane-, indole- and miscellaneous-type alkaloids are reviewed. These alkaloid N-oxides are additional to and, in the main, have been isolated since those described in a 1971 review. The earlier review dealt with some 56 naturally occurring N-oxides which represented mainly pyrrolizidine and indole types. The role of N-oxides in plants is discussed.</p>","PeriodicalId":18256,"journal":{"name":"Lloydia","volume":"41 5","pages":"385-431"},"PeriodicalIF":0.0,"publicationDate":"1978-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11572285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Plant anticancer agents. VIII. Constituents of Inga punctata. 植物抗癌剂。8印加的成分。
Lloydia Pub Date : 1978-09-01
D G Kingston, R C Munjal
{"title":"Plant anticancer agents. VIII. Constituents of Inga punctata.","authors":"D G Kingston,&nbsp;R C Munjal","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":18256,"journal":{"name":"Lloydia","volume":"41 5","pages":"499-500"},"PeriodicalIF":0.0,"publicationDate":"1978-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11914955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antitumor Plants. V. Constituents of Cinchona pubescens. 抗肿瘤植物。五。金鸡纳短毛的成分。
Lloydia Pub Date : 1978-09-01
R F Raffauf, P W Le Quesne, P C Ghosh
{"title":"Antitumor Plants. V. Constituents of Cinchona pubescens.","authors":"R F Raffauf,&nbsp;P W Le Quesne,&nbsp;P C Ghosh","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The stem bark and stem wood of Cinchona pubescens were found to owe their weak cytotoxic activity to the presence of quinovic acid. This acid and its 3-rhamnoside were isolated and characterized through several derivatives, all of which were assayed for their cytotoxicity.</p>","PeriodicalId":18256,"journal":{"name":"Lloydia","volume":"41 5","pages":"432-4"},"PeriodicalIF":0.0,"publicationDate":"1978-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11913774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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