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Screening of higher plants for biological activities. II. Antiviral activity. 高等植物生物活性筛选。2抗病毒活性。
Lloydia Pub Date : 1978-09-01
D A Van Den Berghe, M Ieven, F Mertens, A J Vlietinck
{"title":"Screening of higher plants for biological activities. II. Antiviral activity.","authors":"D A Van Den Berghe,&nbsp;M Ieven,&nbsp;F Mertens,&nbsp;A J Vlietinck","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Extracts prepared from 100 samples of higher plants were evaluated for antiviral activity against several viruses, including Semliki forest, coxsackie, measles, poliomyelitis, herpes, and adeno viruses. The plants were chosen from 73 genera and 43 families on the basis of literature data and medicinal reports on antimicrobial activity. The results of the antiviral testing showed that eight of these extracts exhibited a pronounced activity against one or more of the test viruses. Another three plant extracts showed a moderate level of antiviral activity against some of the test viruses.</p>","PeriodicalId":18256,"journal":{"name":"Lloydia","volume":"41 5","pages":"463-71"},"PeriodicalIF":0.0,"publicationDate":"1978-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11914956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Shikimic acid and quinic acid are not mutagenic in the Ames assay. 莽草酸和奎宁酸在艾姆斯试验中不具有诱变性。
Lloydia Pub Date : 1978-09-01
L B Jacobsen, C L Richardson, H G Floss
{"title":"Shikimic acid and quinic acid are not mutagenic in the Ames assay.","authors":"L B Jacobsen,&nbsp;C L Richardson,&nbsp;H G Floss","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Shikimic acid, reported to cause tumors in mice, and its close structural analog, quinic acid, both ubiquitous constituents of higher plants, were found not be be mutagenic in the Ames assay when tested with and without the rat liver microsomal activation system.</p>","PeriodicalId":18256,"journal":{"name":"Lloydia","volume":"41 5","pages":"450-2"},"PeriodicalIF":0.0,"publicationDate":"1978-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11572287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The anticancer activity of Semecarpus anacardium. I. 9KB active pentadecylcatechols. 心菖蒲的抗癌活性。1 . 9KB活性十六烷基儿茶酚。
Lloydia Pub Date : 1978-09-01
J A Hembree, C J Chang, J L McLaughlin, G Peck, J M Cassady
{"title":"The anticancer activity of Semecarpus anacardium. I. 9KB active pentadecylcatechols.","authors":"J A Hembree,&nbsp;C J Chang,&nbsp;J L McLaughlin,&nbsp;G Peck,&nbsp;J M Cassady","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":18256,"journal":{"name":"Lloydia","volume":"41 5","pages":"491-3"},"PeriodicalIF":0.0,"publicationDate":"1978-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11913778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Behavioral and toxicological studies of cyclopentanoid monoterpenes from Nepeta cataria. 荆芥环戊类单萜的行为学和毒理学研究。
Lloydia Pub Date : 1978-07-01
J W Harney, I M Barofsky, J D Leary
{"title":"Behavioral and toxicological studies of cyclopentanoid monoterpenes from Nepeta cataria.","authors":"J W Harney,&nbsp;I M Barofsky,&nbsp;J D Leary","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Two samples of catnip oil were analyzed by tic, gc, and hplc; the results indicated the presence of 23 components. Fractionation of the commercial sample of catnip oil by either distillation or gc yielded 40% nepetalactone and 43% nepetalic acid. Catnip oil, nepetalic acid, and a nepetalactone-enriched fraction were evaluated for toxicological and behavioral effects in mice and rats. The LD50 of catnip oil, the nepetalactone-enriched fraction, and nepetalic acid were found in mice to be: 1300 mg/kg, 1550 mg/kg and 1050 mg/kg, respectively. Catnip oil (500 mg/kg) and nepetalic acid (62.5 mg/kg) were found to significantly increase hexobarbital sleeping time in mice. Rats trained on a Sidman avoidance schedule showed a significant decrease in performance following intraperitoneal injections of catnip oil (500--750 mg/kg), nepetalic acid (125--250 mg/kg), and the nepetalactone-enriched fraction (500--750 mg/kg). Rats trained on the same avoidance schedule developed behavioral tolerance after daily injections of 750 mg/kg catnip oil.</p>","PeriodicalId":18256,"journal":{"name":"Lloydia","volume":"41 4","pages":"367-74"},"PeriodicalIF":0.0,"publicationDate":"1978-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11873285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Glycyrrhiza in old and new perspectives. 新旧视角下的甘草。
Lloydia Pub Date : 1978-07-01
M R Gibson
{"title":"Glycyrrhiza in old and new perspectives.","authors":"M R Gibson","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A chronological, documented summary of the reputed uses of glycyrrhiza since 2100 B.C. to the present with correlations made to modern pharmacological research. Many early claims for a broad spectrum of uses for this drug appear to be borne out by conclusions from modern research.</p>","PeriodicalId":18256,"journal":{"name":"Lloydia","volume":"41 4","pages":"348-54"},"PeriodicalIF":0.0,"publicationDate":"1978-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11562130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The effects of selected fungicides and insecticides on growth and thebaine production of Papaver bracteatum. 选定杀菌剂和杀虫剂对罂粟生长和产碱的影响。
Lloydia Pub Date : 1978-07-01
F F Wu, R H Dobberstein, R W Morris
{"title":"The effects of selected fungicides and insecticides on growth and thebaine production of Papaver bracteatum.","authors":"F F Wu,&nbsp;R H Dobberstein,&nbsp;R W Morris","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The fungicides benlate, maneb, and captan depressed plant growth, thebaine concentration, and thebaine yield per plant when administered chronically to Papaver bracteatum. The chronic administration of dicofol inhibited plant growth and thebaine yield per plant, but did not affect thebaine concentration. Malathion and pyrethrins had no adverse effects on either plant growth or thebaine content.</p>","PeriodicalId":18256,"journal":{"name":"Lloydia","volume":"41 4","pages":"355-60"},"PeriodicalIF":0.0,"publicationDate":"1978-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11873284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Arthur E. Schwarting--an appreciation. Arthur E. Schwarting——感谢。
Lloydia Pub Date : 1978-07-01
V E Tyler
{"title":"Arthur E. Schwarting--an appreciation.","authors":"V E Tyler","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":18256,"journal":{"name":"Lloydia","volume":"41 4","pages":"292-6"},"PeriodicalIF":0.0,"publicationDate":"1978-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11562127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Semisynthetic derivatives of pyrrolizidine alkaloids of pharmacodynamic importance: a review. 吡咯利西啶类生物碱半合成衍生物的药效学研究进展。
Lloydia Pub Date : 1978-07-01
C K Atal
{"title":"Semisynthetic derivatives of pyrrolizidine alkaloids of pharmacodynamic importance: a review.","authors":"C K Atal","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Pyrrolizidine alkaloids occur in more than 40 genera. Among these are two important genera, Senecio and Crotalaria, which have been responsible for heavy losses of livestock and poisoning in man due to their hepatotoxicity. Pyrrolizidine alkaloids are also reported to possess a number of other biological activities. Attempts have been made to convert the pyrrolizidine alkaloids to new structures by synthetic modifications. One hundred and twenty semisynthetic compounds were developed and investigated pharmacologically. The range of activity exhibited was hypotensive, local anesthetic, ganglion blocking, neuromuscular blocking and antispasmodic. The five most promising compounds of these series were subjected to detailed pharmacological investigations.</p>","PeriodicalId":18256,"journal":{"name":"Lloydia","volume":"41 4","pages":"312-26"},"PeriodicalIF":0.0,"publicationDate":"1978-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11251353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Alkaloids of Thalictrum XXVII. New hypotensive aporphine-benzylisoquinoline derived dimeric alkaloids from Thalictrum minus race B. 海芋生物碱。从Thalictrum - B种中提取的新型降压aporphine-benzylisoquinoline二聚体生物碱。
Lloydia Pub Date : 1978-05-01
W T Liao, J L Beal, W N Wu, R W Doskotch
{"title":"Alkaloids of Thalictrum XXVII. New hypotensive aporphine-benzylisoquinoline derived dimeric alkaloids from Thalictrum minus race B.","authors":"W T Liao,&nbsp;J L Beal,&nbsp;W N Wu,&nbsp;R W Doskotch","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The roots of T. minus race B have yielded, in addition to adiantifoline (1) previously isolated from this source, two new related alkaloids, thaliadine (2) and thaliadanine (5). Both were assigned complete structures by spectral methods and by chemical interconversion to adiantifoline or its product. O-Desmethyladiantifoline should have structure 14, rather than the previously reported 5. All three isolated alkaloids show hypotensive activity in rabbits, and thaliadanine (5) has antimicrobial activity against Mycobacterium smegmatis.</p>","PeriodicalId":18256,"journal":{"name":"Lloydia","volume":"41 3","pages":"271-6"},"PeriodicalIF":0.0,"publicationDate":"1978-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11873282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The tigliane, daphnane and ingenane diterpenes, their chemistry, distribution and biological activities. A review. 丁烷、萘烷和烯烷二萜及其化学、分布和生物活性。复习一下。
Lloydia Pub Date : 1978-05-01
F J Evans, C J Soper
{"title":"The tigliane, daphnane and ingenane diterpenes, their chemistry, distribution and biological activities. A review.","authors":"F J Evans,&nbsp;C J Soper","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":18256,"journal":{"name":"Lloydia","volume":"41 3","pages":"193-233"},"PeriodicalIF":0.0,"publicationDate":"1978-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11874254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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