{"title":"Alkaloids of Thalictrum XXVI. New hypotensive and other alkaloids from Thalictrum minus race B.","authors":"W T Liao, J L Beal, W N Wu, R W Doskotch","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>The roots of T. minus race B have yielded 9 alkaloids, thalirabine (1), thaliracebine (13), thalfine (19), thalfinine (20), thalrugosaminine (22), thalidasine (13), obaberine (24), thaliglucinone (25) and (S)-reticuline (26). The first two, possessing marked hypotensive activity, were assigned complete structures by physical and chemical methods. Thalfine (19) was given S-configuration at its one asymmetric center and was converted to thalfinine (20) and epithalfinine (21), thus the stereochemistry was established at one of the two optically active positions. The other alkaloids were identified by direct comparison with known samples. Antimicrobial testing showed thalirabine, thaliracebine, thalfine, and thalfinine to be active against Mycobacterium smegmatis.</p>","PeriodicalId":18256,"journal":{"name":"Lloydia","volume":"41 3","pages":"257-70"},"PeriodicalIF":0.0000,"publicationDate":"1978-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Lloydia","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
The roots of T. minus race B have yielded 9 alkaloids, thalirabine (1), thaliracebine (13), thalfine (19), thalfinine (20), thalrugosaminine (22), thalidasine (13), obaberine (24), thaliglucinone (25) and (S)-reticuline (26). The first two, possessing marked hypotensive activity, were assigned complete structures by physical and chemical methods. Thalfine (19) was given S-configuration at its one asymmetric center and was converted to thalfinine (20) and epithalfinine (21), thus the stereochemistry was established at one of the two optically active positions. The other alkaloids were identified by direct comparison with known samples. Antimicrobial testing showed thalirabine, thaliracebine, thalfine, and thalfinine to be active against Mycobacterium smegmatis.
T. minus B种的根中有9种生物碱，分别是thalirabine(1)、thaliracebine(13)、thalfine(19)、thalfinine(20)、thalrugosaminine(22)、thalidasine(13)、obaberine(24)、thaliglucinone(25)和(S)-reticuline(26)。前两种具有明显的降压活性，通过物理和化学方法确定了完整的结构。Thalfine(19)在其一个不对称中心被赋予s构型，并被转化为thalfinine(20)和上皮finine(21)，因此立体化学在两个光学活性位置之一建立。其他生物碱通过与已知样品的直接比较进行鉴定。抗菌试验结果表明，thalrabine、thalracebine、thalfinine和thalfinine对耻垢分枝杆菌有活性。
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