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Potential anticancer agents vi. Constituents of Ailanthus excelsa (Simaroubaceae). 潜在的抗癌剂vi.臭椿科臭椿的成分。
Lloydia Pub Date : 1977-11-01
M Ogura, G A Cordell, A D Kinghorn, N R Farnsworth
{"title":"Potential anticancer agents vi. Constituents of Ailanthus excelsa (Simaroubaceae).","authors":"M Ogura,&nbsp;G A Cordell,&nbsp;A D Kinghorn,&nbsp;N R Farnsworth","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Ailanthione (1), glaucarubinone (2) and a mixture of glaucarubol 15-isovalerate (3) and 13,18-dehydroglaucarubol 15-isovalerate (4) were found to be the compounds responsible for the antitumor and cytotoxic activities of extracts of the root bark of Ailanthus excelsa (Simaroubaceae). The latter compound, 4, is new.</p>","PeriodicalId":18256,"journal":{"name":"Lloydia","volume":"40 6","pages":"579-84"},"PeriodicalIF":0.0,"publicationDate":"1977-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11803270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diosgenin and yomogenin from solanum incanum. 茄中的薯蓣皂苷元和yomogenin。
Lloydia Pub Date : 1977-11-01
R Segal, I Milo-Goldzweig, D V Zaitschek
{"title":"Diosgenin and yomogenin from solanum incanum.","authors":"R Segal,&nbsp;I Milo-Goldzweig,&nbsp;D V Zaitschek","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":18256,"journal":{"name":"Lloydia","volume":"40 6","pages":"604"},"PeriodicalIF":0.0,"publicationDate":"1977-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11803277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Baeocystin in psilocybe, conocybe and panaeolus. 裸盖菇、黄曲霉和人参中的黄曲霉素。
Lloydia Pub Date : 1977-11-01
D B Repke, D T Leslie, G Guzmán
{"title":"Baeocystin in psilocybe, conocybe and panaeolus.","authors":"D B Repke,&nbsp;D T Leslie,&nbsp;G Guzmán","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Sixty collections of ten species referred to three families of the Agaricales have been analyzed for the presence of baeocystin by thin-layer chromatography. Baeocystin was detected in collections of Psilocybe, Conocybe, and Panaeolus from the U.S.A., Canada, Mexico, and Peru. Laboratory cultivated fruitbodies of Psilocybe cubensis, P. semilanceata, and P. cyanescens were also studied. Intra-species variation in the presence of decay rate of baeocystin, psilocybin and psilocin are discussed in terms of age and storage factors. In addition, evidence is presented to support the presence of 4-hydroxytryptamine in collections of P. baeocystis and P. cyanescens. The possible significance of baeocystin and 4-hydroxytryptamine in the biosynthesis of psilocybin in these organisms is discussed.</p>","PeriodicalId":18256,"journal":{"name":"Lloydia","volume":"40 6","pages":"566-78"},"PeriodicalIF":0.0,"publicationDate":"1977-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11803265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metabolites from Pyrenomycetes VIII. Identification of three metabolites from Nectria lucida as antibiotic triprenyl phenols. pyrenomytes VIII的代谢物。三烯丙基酚类抗生素的鉴定。
Lloydia Pub Date : 1977-11-01
S T Carey, M S Nair
{"title":"Metabolites from Pyrenomycetes VIII. Identification of three metabolites from Nectria lucida as antibiotic triprenyl phenols.","authors":"S T Carey,&nbsp;M S Nair","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":18256,"journal":{"name":"Lloydia","volume":"40 6","pages":"602-3"},"PeriodicalIF":0.0,"publicationDate":"1977-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11803273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Constituents of West African medicinal plants. XXI. Tiliafunimine, a new imino bisbenzylisoquinoline alkaloid from Tiliacora funifera. 西非药用植物的成分。第二十一章。tilafunimine是一种新的亚胺双苄基异喹啉生物碱。
Lloydia Pub Date : 1977-11-01
J S Ayim, D Dwuma Badu, N Y Fiagbe, A M Ateya, D J Slatkin, J E Knapp, P L Schiff
{"title":"Constituents of West African medicinal plants. XXI. Tiliafunimine, a new imino bisbenzylisoquinoline alkaloid from Tiliacora funifera.","authors":"J S Ayim,&nbsp;D Dwuma Badu,&nbsp;N Y Fiagbe,&nbsp;A M Ateya,&nbsp;D J Slatkin,&nbsp;J E Knapp,&nbsp;P L Schiff","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Tiliacora funifera (Menispermaceae) is a woody climber of Ghana and West Africa that has been used natively as a medicinal in the treatment of numerous ailments. Chromatography of an extract of the leaves of T. funifera afforded tiliafunimine (13) whose ir, uv, nmr, and mass spectra were characteristic of a trimethoxylated phenolic iminobisbenzylisoquinoline alkaloid. Reduction of tiliafunimine with sodium borohydride afforded the dihydro-derivative (14) which upon treatment with formalin gave thalrugosine (12). The final structural assignment of tiliafunimine (13) as an iminobisbenzylisoquinoline alkaloid was made by nmr and mass spectral considerations. Other alkaloids isolated from the same extract include the bisbenzylisoquinoline bases isotetrandrine (11) and thalrugosine (12).</p>","PeriodicalId":18256,"journal":{"name":"Lloydia","volume":"40 6","pages":"561-5"},"PeriodicalIF":0.0,"publicationDate":"1977-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11803266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antimicrobial properties of some West African medicinal plants iv. Antimicrobial activity of xylopic acid and other constituente of the fruits of Xylopia aethiopica (Annonaceae). 一些西非药用植物的抗菌特性iv.埃塞俄比亚木香果实中木香酸和其他成分的抗菌活性。
Lloydia Pub Date : 1977-11-01
K Boakye-Yiadom, N I Fiagbe, J S Ayim
{"title":"Antimicrobial properties of some West African medicinal plants iv. Antimicrobial activity of xylopic acid and other constituente of the fruits of Xylopia aethiopica (Annonaceae).","authors":"K Boakye-Yiadom,&nbsp;N I Fiagbe,&nbsp;J S Ayim","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Xylopic acid and four other isolates from the fresh ripe fruits of Xylopia aethiopica a common ingredient in several Ghanaian folklore medicines and foods, have been examined for antimicrobial activity against five micro-organisms, Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa and Candida albicans. Xylopic acid and two other diterpene isolates were found to have antimicrobial properties.</p>","PeriodicalId":18256,"journal":{"name":"Lloydia","volume":"40 6","pages":"543-5"},"PeriodicalIF":0.0,"publicationDate":"1977-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11803261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cephalosporins and other beta-lactam antibiotics. 头孢菌素和其他-内酰胺类抗生素。
Lloydia Pub Date : 1977-11-01
W J Wheeler
{"title":"Cephalosporins and other beta-lactam antibiotics.","authors":"W J Wheeler","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":18256,"journal":{"name":"Lloydia","volume":"40 6","pages":"519-42"},"PeriodicalIF":0.0,"publicationDate":"1977-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11803262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cactus alkaloids. XXXVI. Mescaline and related compounds from Trichocereus peruvianus. 仙人掌生物碱。38。秘鲁毛蜡虫中的美斯卡灵及其相关化合物。
Lloydia Pub Date : 1977-11-01
J H Pardanani, J L McLaughlin, R W Kondrat, R G Cooks
{"title":"Cactus alkaloids. XXXVI. Mescaline and related compounds from Trichocereus peruvianus.","authors":"J H Pardanani,&nbsp;J L McLaughlin,&nbsp;R W Kondrat,&nbsp;R G Cooks","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Agurell has previously detected (tlc, glc-ms) tyramine, 3-methoxytyramine, and two unknown alkaloids in the Peruvian cactus, Trichocereus peruvianus Br. and R. The presence of mescaline in other similar Trichocereus species prompted us to reinvestigate this species, which is commercially available in the United States. The nonphenolic alkaloid extracts yielded an abundance of crystalline mescaline hydrochloride (0.82% yield) and a trace of 3,4-dimethoxyphenethylamine (tlc-ms). Crystalline tyramine hydrochloride, 3-methoxytyramine hydrochloride, and 3,5 dimethoxy-4-hydroxphenethylamine hydrochloride were isolated from the phenolic alkaloid extracts; the last compound has not been previously crystallized from nature, although it is the immediate biosynthetic precursor of mescaline. Crystalline 2-chloromescaline hydrochloride was isolated drom the nonphenolic extracts; but, as determined by mass-analyzed ion kinetic energy spectrometry, this new compound is an extraction artifact. Both 2-chloromescaline and 2.6-dichloromescaline hydrochlorides were prepared synthetically from mescaline. This cactus species has a mescaline content equal or superior to peyote and should be legally controlled as an item of drug abuse.</p>","PeriodicalId":18256,"journal":{"name":"Lloydia","volume":"40 6","pages":"585-90"},"PeriodicalIF":0.0,"publicationDate":"1977-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11803268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The C-flavonosides of Sarothamnus scoparius. Isolation of a new compound, the 6"-O-acetylscoparoside]. 石蜡中c -黄酮苷。新化合物6′- o -乙酰天冬苷的分离。
Lloydia Pub Date : 1977-11-01
M Brum-Bousquet, F Tillequin, R R Paris
{"title":"[The C-flavonosides of Sarothamnus scoparius. Isolation of a new compound, the 6\"-O-acetylscoparoside].","authors":"M Brum-Bousquet,&nbsp;F Tillequin,&nbsp;R R Paris","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":18256,"journal":{"name":"Lloydia","volume":"40 6","pages":"591-2"},"PeriodicalIF":0.0,"publicationDate":"1977-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11803271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ultraviolet-mediated antibiotic activity of species of Compositae caused by polyacetylenic compounds. 紫外光介导的聚乙基化合物对菊科植物的抗菌活性研究。
Lloydia Pub Date : 1977-09-01
G H Towers, C K Wat, E A Graham, R J Bandoni, G Q Chan, J C Mitchell, J Lam
{"title":"Ultraviolet-mediated antibiotic activity of species of Compositae caused by polyacetylenic compounds.","authors":"G H Towers,&nbsp;C K Wat,&nbsp;E A Graham,&nbsp;R J Bandoni,&nbsp;G Q Chan,&nbsp;J C Mitchell,&nbsp;J Lam","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A survey of North, Central, and South American composites, and of certain polyacetylenic compounds occurring in them, confirmed that the ultraviolet-mediated antibiotic activity against Candida albicans can be ascribed to the presence of particular polyacetylenes and their thiophene derivatives. Leaves, stems, roots, and achenes were assayed separately. An attempt was made to relate the phototoxic activity of specific compounds to their chemical structures. Most composites tested were not phototoxic against Candida, but many were antibiotic. The antibiotic activity also appears to be caused by polyacetylenes. Of 65 sequiterpene lactones assayed, only a few were found to be antibiotic, and only one, glaucolide G, was phototoxic.</p>","PeriodicalId":18256,"journal":{"name":"Lloydia","volume":"40 5","pages":"487-98"},"PeriodicalIF":0.0,"publicationDate":"1977-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11292967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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