Journal of Blood Disorders and Transfusion最新文献_第4页

Vascular Disease in Multiple Sclerosis: A Real Thing? 多发性硬化症中的血管疾病是真的吗?

Journal of Blood Disorders and Transfusion Pub Date : 2016-10-14 DOI: 10.4172/2155-9864.1000370

M. G. Caprio, M. Mancini

引用次数: 0

TRALI in a Patient with Hematological Malignancy: Complexities in the Critically Ill 恶性血液病患者的TRALI:危重病人的复杂性

Journal of Blood Disorders and Transfusion Pub Date : 2016-10-04 DOI: 10.4172/2155-9864.1000369

Rajeswari Subramaniyan

引用次数: 1

Possible Haematological Abnormalities Induced by Herbal Tea Consumption: A Review 饮用凉茶可能引起的血液学异常:综述

Journal of Blood Disorders and Transfusion Pub Date : 2016-09-23 DOI: 10.4172/2155-9864.1000367

R. Reis, E. Sipahi, A. Aydın

{"title":"Possible Haematological Abnormalities Induced by Herbal Tea Consumption: A Review","authors":"R. Reis, E. Sipahi, A. Aydın","doi":"10.4172/2155-9864.1000367","DOIUrl":"https://doi.org/10.4172/2155-9864.1000367","url":null,"abstract":"Nowadays, a vast majority of herbal products used in traditional medicine are consumed in the form of tea due to their aromas, favourable tastes, and health-boosting effects arising from the antioxidant activity of the phenolic content. Even though people are advised to include these herbal teas in their daily diet as health promoters, the articles in the literature often present conflicting findings on the relationship between herbal tea consumption and haematological parameters. In this review, we recompiled the limited research on the possible relationship between herbal tea consumption and haematological alterations. We suggest that the contributions of active ingredients in the herbal tea products may affect haematological parameters such as the degree of iron absorption, serum ferritin concentration, thrombocyte level, aggregation rate, and lymphocyte mediated immunity. Populations, especially pregnant women and patients under the risk of haematological diseases, should consume these products under the control of physicians or other healthcare professionals. Furthermore, online marketing of these products or via TV commercials should be restricted due to the increasing misusage and related haematological alterations.","PeriodicalId":182392,"journal":{"name":"Journal of Blood Disorders and Transfusion","volume":"150 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132859667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

RHD Zygosity Determination from Whole Genome Sequencing Data 基于全基因组测序数据的RHD合子性测定

Journal of Blood Disorders and Transfusion Pub Date : 2016-09-19 DOI: 10.4172/2155-9864.1000365

J Jotautas Baronas, C. Westhoff, S. Vege, H. Mah, M. Aguad, Robin Smel, Wagman, R. Kaufman, H. Rehm, L. Silberstein, R. Green, W. Lane

引用次数: 15

Nanomedicine: Will it be able to Overcome Multidrug Resistance in Cancers? 纳米医学:它能克服癌症的多药耐药性吗?

Journal of Blood Disorders and Transfusion Pub Date : 2016-09-19 DOI: 10.4172/2155-9864.1000368

S. Friberg

引用次数: 1

Anaemia in Pregnant Women of Sokoto Residents in North Western Nigeria 尼日利亚西北部索科托居民孕妇贫血

Journal of Blood Disorders and Transfusion Pub Date : 2016-09-19 DOI: 10.4172/2155-9864.1000366

Buhari H, Imoru M, Erhabor O

{"title":"Anaemia in Pregnant Women of Sokoto Residents in North Western Nigeria","authors":"Buhari H, Imoru M, Erhabor O","doi":"10.4172/2155-9864.1000366","DOIUrl":"https://doi.org/10.4172/2155-9864.1000366","url":null,"abstract":"Background: In developing countries, anaemia is a cause of serious concern as it contributes significantly to high maternal mortality. The aim of this study was to assess the prevalence of anaemia among pregnant women in Sokoto, Northern Nigeria due to scanty information in this region. \u0000Materials and Methods: The study was conducted on 273 pregnant women at Usmanu Danfodio University Teaching Hospital (UDUTH), Sokoto between June and November, 2015. Socio-demographic characteristics of the pregnant women were collected using structured questionnaire while the red cell parameters of each subject were determined using haematology analyser. \u0000Results: Overall prevalence of anaemia was 39.2% while the prevalence of anaemia with respect to pregnant women less than 19 years, 20-24 years, 25-29 years, 30-34 years, 35-39 years and ≤ 40 years were 50.0%, 46.8%, 38.9%, 37.5%, 23.3%, and 100.0%, respectively. Out of all the anaemic pregnant women, 86.0% had mild anaemia, 14.0% had moderate anaemia and none had severe anaemia. The means and standard deviations of haemoglobin and haematocrit for the pregnant women were 11.1 ± 1.27 g/dL and 33.5 ± 3.2%, respectively. \u0000Conclusion: The study has revealed an overall prevalence of anaemia in pregnant women of 39.2% with the highest prevalence amongst those above 40 years. The high prevalence of pregnant women with mild anaemia may be associated with proper antenatal care at UDUTH and good dietary habit. Early booking and improvement on health and nutritional education are recommended.","PeriodicalId":182392,"journal":{"name":"Journal of Blood Disorders and Transfusion","volume":"68 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130838366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Discrepancies in ABO and Rh Grouping in Southeast Iran, an Analysis of 3 Years' Experience 伊朗东南部ABO血型与Rh血型差异的3年经验分析

Journal of Blood Disorders and Transfusion Pub Date : 2016-08-31 DOI: 10.4172/2155-9864.1000364

Esmaeil Sanei Moghaddam, S. Khosravi, A. Dorgalaleh

{"title":"Discrepancies in ABO and Rh Grouping in Southeast Iran, an Analysis of 3 Years' Experience","authors":"Esmaeil Sanei Moghaddam, S. Khosravi, A. Dorgalaleh","doi":"10.4172/2155-9864.1000364","DOIUrl":"https://doi.org/10.4172/2155-9864.1000364","url":null,"abstract":"Background: ABO and Rh blood grouping discrepancies are significant causes of transfusion-related morbidity and mortality. Most of these errors occur when blood grouping standards are unavailable or misinterpreted. This study determined the rate of such errors among hospitals in Zahedan, a city in southeast Iran. We also assessed the prevalence of ABO and Rh grouping errors in the Iranian Blood Transfusion Organization (IBTO) in Zahedan. \u0000Method: During the study, 30,254 blood bags were sent to five of Zahedan's hospitals. Pre-transfusion ABO and Rh blood grouping was carried out by slide method. Any sample showing a discrepancy between IBTO and hospital laboratory was returned to IBTO for identification of the error by the American Association of Blood Banking (AABB) standards protocol. \u0000Results: We observed 420 discrepancies in the pre-transfusion ABO and Rh blood grouping of 30,254 units, a 1.4 percent error, among Zahedan hospitals. The most common error was misidentification of group A as O (62 cases), while group B was misidentified as O in 41 cases. We discovered critical errors, such as misdiagnosis of A as B and vice versa, which could endanger the patient’s life. We also noted 20 misidentifications in routine IBTO laboratory testing, a 0.02 percent error. \u0000Conclusion: The high incidence of pre-transfusion blood grouping errors emphasizes the necessity of always using standard forward and reverse grouping tests in hospitals.","PeriodicalId":182392,"journal":{"name":"Journal of Blood Disorders and Transfusion","volume":"46 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116443828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Molecular basis of acute myeloid leukemia 急性髓性白血病的分子基础

Journal of Blood Disorders and Transfusion Pub Date : 2016-08-27 DOI: 10.4172/2155-9864.C1.015

K. Mills

{"title":"Molecular basis of acute myeloid leukemia","authors":"K. Mills","doi":"10.4172/2155-9864.C1.015","DOIUrl":"https://doi.org/10.4172/2155-9864.C1.015","url":null,"abstract":"The 2016 WHO-CMP classification proposal defines a broad spectrum of JAK2 V617F mutated MPN phenotypes: normocellular ET, hypercellular ET due to increased erythropoiesis (prodromal PV), hypercellular ET with megakaryocytic-granulocytic myeloproliferation and splenomegaly (EMGM or masked PV), erythrocythemic PV, early and overt classical PV, advanced PV with MF and post-PV MF. ET heterozygous for the JAK2 V617F mutation is associated with low JAK2 mutation load and normal life expectance. PV patients are hetero-homozygous versus homozygous for the JAK2 V617F mutation in their early versus advanced stages with increasing JAK2 mutation load from less than 50% to 100% and increase of MPN disease burden during life long follow-up in terms of symptomatic splenomegaly, constitutional symptoms, bone marrow hypercellularity and secondary MF. Pretreatment bone marrow biopsy in prefibrotic MPNs is of diagnostic and prognostic importance. JAK2 exon 12 mutated MPN is a distinct benign early stage PV. CALR mutated hypercellular thrombocythemia show distinct PMGM bone marrow characteristics of clustered larged immature dysmorphic megakaryocytes with bulky (bulbous) hyperchromatic nuclei, which are not seen in JAK2 mutated ET and PV. MPL mutated normocellular thrombocythemia is featured by clustered giant megakaryocytes with hyperlobulated stag-horn-like nuclei without features of PV in blood and bone marrow. Myeloproliferative disease burden in each of the JAK2, CALR and MPL MPNs is best reflected by the degree of anemia, splenomegaly, mutation allele burden, bone marrow cellularity and myelofibrosis.","PeriodicalId":182392,"journal":{"name":"Journal of Blood Disorders and Transfusion","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121512006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Hemophagocytic Lymphohistiocytosis: A Review 噬血细胞性淋巴组织细胞病:综述

Journal of Blood Disorders and Transfusion Pub Date : 2016-08-03 DOI: 10.4172/2155-9864.1000363

Sirisharani Siddaiahgari, Shirali Agarwal, Pallavi Madukuri, L. Moodahadu

{"title":"Hemophagocytic Lymphohistiocytosis: A Review","authors":"Sirisharani Siddaiahgari, Shirali Agarwal, Pallavi Madukuri, L. Moodahadu","doi":"10.4172/2155-9864.1000363","DOIUrl":"https://doi.org/10.4172/2155-9864.1000363","url":null,"abstract":"Hemophagocytic lymphohistiocytosis (HLH) is a disorder charecterised by immune dysregulation. Though it was underdiagnosed earlier now it is increasingly being diagnosed across the world with better awareness among physicians. “Hypercytokinemia” which is the hallmark of HLH can result in end organ damage and even death in some cases if there is delay in diagnosis. It has a wide array of presentation but commonly presents as fever with organomegaly and bicytopenia. A vast majority of cases are acquired due to secondary causes but primary HLH is also not uncommon which also intern gets triggered by infection as suggested by recent studies. Laboratory parameters like Ferritin, triglycerides and fibrinogen along with bicytopenia/pancytopernia aid in further confirmation of this diagnosis. Bone marrow may or may not show evidence of HLH, Hence absence of involvement should not exclude the diagnosis of HLH. Newer modalities like flow cytometry and genetic analysis have contirbuted for widespread recognition of its pathogenesis and etiology. Like various other emergencies, timely diagnosis remains one of the key stones of its management. Management is largely based on HLH-2004 protocol for secondary cases and almost all cases of primary HLH require Hematopeitic Stem Cell transplantation after initial treatment with HLH 2004 protocol. Recent advances have been made in exploring other modalities of treatment like immunomodulatory agents and monoclonal antibodies (ATG, Alemtuzumab, IFN-y) for resistant/refractory cases to achieve desirable outcomes. Our article aims to summarize the new advances in the diagnosis and management of HLH and also gives comprehensive review of the pathophysiology, clinical observations and modern laboratory methods for HLH diagnosis. Early and prompt recognition remains the gold standard to decrease the mortality related to this condition","PeriodicalId":182392,"journal":{"name":"Journal of Blood Disorders and Transfusion","volume":"88 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126807886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Hypervitaminia B12: A Useful Additional Biomarker for the Diagnosis and Monitoring of Liver Diseases 维生素B12过多:肝脏疾病诊断和监测的一个有用的额外生物标志物

Journal of Blood Disorders and Transfusion Pub Date : 2016-07-22 DOI: 10.4172/2155-9864.1000362

A. Zulfiqar, Assia El Adli, J. Doucet, N. Kadri, E. Andrès

引用次数: 1