Journal of Blood Disorders and Transfusion最新文献_第5页

Legal Medicine Evaluation of a Laboratory Error at the Blood Transfusion Center of Iran: A Case Report 伊朗输血中心实验室错误的法医学评价:一例报告

Journal of Blood Disorders and Transfusion Pub Date : 2016-07-05 DOI: 10.4172/2155-9864.1000361

Naimeh Farhidnia, A. Memarian, F. Fallah

引用次数: 0

Estimation of Iron Overload-Implications of its Non-linear Correlation 铁超载的估计及其非线性相关性

Journal of Blood Disorders and Transfusion Pub Date : 2016-06-30 DOI: 10.4172/2155-9864.1000360

P. Chowdhury, M. Saha, S. Karpurkayastha, D. Chowdhury, R. Jena

{"title":"Estimation of Iron Overload-Implications of its Non-linear Correlation","authors":"P. Chowdhury, M. Saha, S. Karpurkayastha, D. Chowdhury, R. Jena","doi":"10.4172/2155-9864.1000360","DOIUrl":"https://doi.org/10.4172/2155-9864.1000360","url":null,"abstract":"Thalassaemias and haemoglobinopathies contribute the highest number of cases, as far as single gene disorders are concerned, where blood transfusion and iron chelation remain the mainstays of therapy. Depending upon the requirement of transfusion, thalassaemias have been classified into two categories: 1) Transfusion dependent, 2) Non-transfusion dependent. \u0000Non-transfusion dependent thalassaemia patients, contrary to previous belief, suffer from iron overload. If this iron is estimated by the level of ferritin in serum, it does not linearly correlate to hepatic and/or cardiac iron. It was noted during our study that serum ferritin levels up to 300 ng/ml correlated with hepatic iron load of up to 3 mg/g of DLT almost linearly, within +0.5 SD of mean. \u0000There were a few patients in whom the serum ferritin level compared to the corresponding hepatic iron content (as measured by MRI) was more than +1.0 SD, and in some patients it was even ≥ 2.5 SD. In addition to serum ferritin, which is also a marker of acute inflammation, CRP was also estimated. It was seen that in these patients, CRP was also high. They were investigated for Hepatitis B, C and work ups were done for Tuberculosis. Out of the 350 such patients who were examined, 18 patients (5.14%) had their level of serum ferritin ≥ 1.0 SD, 08 tested positive for Tuberculosis, and 05 tested Positive for Hepatitis C and 01 for Hepatitis B. 14 patients out of the 18 (77.77%), who were screened to be out of the limits of SD had some infectious pathology in addition to their primary disorder, which was detected due to this observed discrepancy. They are undergoing treatment as appropriate for the diagnosis. \u0000In conclusion, in the range where the level of serum ferritin is linearly correlated to the corresponding hepatic iron, the value was >1.0 SD of mean, clinical investigations should be done to exclude possibilities of infections like Hepatitis and Tuberculosis.","PeriodicalId":182392,"journal":{"name":"Journal of Blood Disorders and Transfusion","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117091921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Megaloblastic Anemia: A Drug-Induced Disorder 巨幼细胞性贫血:一种药物引起的疾病

Journal of Blood Disorders and Transfusion Pub Date : 2016-06-13 DOI: 10.4172/2155-9864.1000359

Satadal Barik

{"title":"Megaloblastic Anemia: A Drug-Induced Disorder","authors":"Satadal Barik","doi":"10.4172/2155-9864.1000359","DOIUrl":"https://doi.org/10.4172/2155-9864.1000359","url":null,"abstract":"Megaloblastic anemia is categorized by distinguished hematopoietic cell morphology, unproductive hematopoiesis, induced by folic acid and/or vitamin B12 deficiency [1]. Ineffective DNA synthesis in hematopoietic progenitor cells or myelodysplastic syndrome leading to congenital disorders is commonly responsible for the megaloblastic anemia. In western populations, cobalamin (vitamin B12) deficiency is a common factor to cause the megaloblastic anemia. The complexity of the clinical manifestations of megaloblastic anemia often leads to a misdiagnosis in the geriatric population. Bone marrow aspirate examination and bone marrow core biopsy can aid in the morphologic diagnosis of this disorder. The diagnosis of megaloblastic anemia is quite excellent and uptake of folic acid and/or vitamin B12 with a simple regimen is effective for the treatment [2]. In a case report, a 31year old army soldier with both vitamin B12 and folic acid deficiency in his blood, showed a typical megaloblastic anaemia with oval macrocytes and hypersegmented neutrophils. Three months later, the patient revealed a further reduction in his neutrophil count and a mild thrombocytopaenia. The repeat bone marrow examination exposed a considerable (33%) plasma cell penetratation with erythroid dysplasia and further investigations confirmed a non secretory multiple myeloma (NSMM). The initial presentation was megaloblastic anaemia but the patient was diagnosed with NSMM later [3].","PeriodicalId":182392,"journal":{"name":"Journal of Blood Disorders and Transfusion","volume":"31 11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134286479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Interleukin-4 Intron 3 VNTR Polymorphism Gene in Leukemic Patients 白血病患者白细胞介素-4内含子3 VNTR多态性基因

Journal of Blood Disorders and Transfusion Pub Date : 2016-05-31 DOI: 10.4172/2155-9864.1000357

A. Ahmed, R. Abdelgadir, A. M. Muddathir, E. Elshibli, imad Mohamed Fadl Elmula

{"title":"Interleukin-4 Intron 3 VNTR Polymorphism Gene in Leukemic Patients","authors":"A. Ahmed, R. Abdelgadir, A. M. Muddathir, E. Elshibli, imad Mohamed Fadl Elmula","doi":"10.4172/2155-9864.1000357","DOIUrl":"https://doi.org/10.4172/2155-9864.1000357","url":null,"abstract":"Background: Leukemia is a group of chronic malignant disorders of White blood cells and its precursor. Interleukin-4 (IL-4) is inflammatory cytokine that determines the activation and differentiation of B-cells, mast cells, erythroid progenitors. Several studies have investigated the association between IL-4 intron 3 variable number of tandem repeats (VNTR) polymorphism and cancer risk in humans; however, this association is not investigated among patients with leukemia. \u0000Material and Methods: The present study aimed to investigate genotype and allele frequencies of IL-4 gene intron 3(VNTR) polymorphism in patients with leukemia compared to healthy control. The study included 231 patients with leukemia and 163 healthy controls. Genomic DNA was isolated from 3 ml of anticoagulated venous blood samples by modified salting out method. IL-4 intron 3 VNTR polymorphism determined by using polymerase chain reaction (PCR) with specific primers. The data were analysed using SPSS software program version 21. P value, Odds ratio (OR) and corresponding 95% confidence interval (CI) were used to estimate the strength of the association. \u0000Results: The allele frequency was showed in 25.9% (60/231) leukemic patients while 74.1% (171/231) showed absence of allele compared with the presence of allele in all control group with significance differences of P value=0.00 and risk factor of 4.617 times for leukemia. The frequencies of P1P1, P2P2, and P1P2 genotypes of intron 3 VNTR polymorphism in leukemic patients were significantly different from control group P value=0.00.The result showed, P1P1 and P1P2 allele were highly risk for developing leukemia than P2P2 (OR: P1P1 1.24, 95% CI: 0.675-2.279; OR P1P2: 1.24, 95% CI: 0.568-2.7; OR P2P2:0.72, 95% CI: 0.398-1.3). \u0000Conclusion: IL-4 intron 3 VNTR polymorphism could influences in the risk of leukemia; this could be used as early prognostic marker in the course of the disease.","PeriodicalId":182392,"journal":{"name":"Journal of Blood Disorders and Transfusion","volume":"353 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114746450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Pre Donation Deferral a Single Centre Experience 捐赠前延后单一中心体验

Journal of Blood Disorders and Transfusion Pub Date : 2016-05-30 DOI: 10.4172/2155-9864.1000356

R. Vasudev, S. Kaur, Abhishek Kumar, Balraj Singh, N. Paul, U. Rampal, T. Raina

{"title":"Pre Donation Deferral a Single Centre Experience","authors":"R. Vasudev, S. Kaur, Abhishek Kumar, Balraj Singh, N. Paul, U. Rampal, T. Raina","doi":"10.4172/2155-9864.1000356","DOIUrl":"https://doi.org/10.4172/2155-9864.1000356","url":null,"abstract":"It is well known that quite a large number of apparently healthy donors are not able to donate blood successfully because of varied reasons. These donors are deferred temporarily or permanently. The aim of the study was to analyze the Incidence of Blood Donor deferral and its various causes and use this information as a guide for promoting Voluntary Blood donation. All the Blood donors reporting at our Blood Bank in last 6 months period were analyzed retrospectively. Data of all the donors deferred due to various causes was analyzed at our Transfusion Medicine Centre. There were 7253 donors, of which 524 donors were deferred (7.22%) for various reasons. Of the 7253 donors registered for donation, females constituted only 8.6%. And deferral rate was about six times more for female (29.05%) compared to male (5.18%). The three most common reasons for deferral low hemoglobin levels, chronic diseases and medication. More studies should be done at state and national level so that enough data can be collected and national policies formulated and western parameters for deferral should not be followed as regional differences cause unnecessary deferrals of already limited donors. Moreover analysis of donor deferral pattern will help blood banks to formulate more focused donor screening approach.","PeriodicalId":182392,"journal":{"name":"Journal of Blood Disorders and Transfusion","volume":"145 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131679743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Effects of Preoperative Platelet Count on Blood Loss for Splenectomy with Esophagogastric Devascularization 术前血小板计数对脾切除术食管胃断流术出血量的影响

Journal of Blood Disorders and Transfusion Pub Date : 2016-05-26 DOI: 10.4172/2155-9864.1000355

G. Bo, P. Mishra, Luo Chen, Yang Mo, Ting Yan, S. Luo

{"title":"Effects of Preoperative Platelet Count on Blood Loss for Splenectomy with Esophagogastric Devascularization","authors":"G. Bo, P. Mishra, Luo Chen, Yang Mo, Ting Yan, S. Luo","doi":"10.4172/2155-9864.1000355","DOIUrl":"https://doi.org/10.4172/2155-9864.1000355","url":null,"abstract":"Objective: To investigate whether low preoperative platelet count increased blood loss in splenectomy and esophagogastric devascularization for hepatitis B cirrhosis patients, and to discuss the necessity of prophylactic platelet transfusion in patients with platelet count less than 50 × 109 /L. \u0000Methods: 105 patients who received splenectomy from January 2008 to July 2014 were divided into three groups based on their preoperative platelet counts: 50 × 109 /L (group 3). Their operation time, blood loss, postoperative platelet count of 1st and 3rd day, drainage volume, postoperative hospital stay and operation associated complications were compared between the 3 groups. \u0000Results: Compared with patients in group 3, patients in group 1 and 2 experienced more blood loss, but the difference was not statistically significant (P>0.05). There were no significant differences among 3 groups in terms of operative time, postoperative drainage, postoperative hospital stay and operation-associated complications (P>0.05). Compared with preoperative results, PLT count increased significantly after the operation between the 3 groups (P<0.05). \u0000Conclusion: It is safe to perform splenectomy and esophagogastric de-vascularization in hepatitis B cirrhosis patients with PLT count less than 50 × 109 /L, and also in patients with platelet count lower than 30 × 109 /L, it is not necessary to give prophylactic platelet transfusion until patient has any risk of bleeding.","PeriodicalId":182392,"journal":{"name":"Journal of Blood Disorders and Transfusion","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114455577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Abnormal Fibrinogens: Almost a Century from the First Case Reported. Is it Time for Guidelines? 纤维蛋白原异常:距第一例报道近一个世纪。是时候制定指导方针了吗?

Journal of Blood Disorders and Transfusion Pub Date : 2016-05-20 DOI: 10.4172/2155-9864.1000354

R. M. Cappelletti

引用次数: 0

Beta-thalassemia Major and Non-Hodgkin Lymphoma -地中海贫血和非霍奇金淋巴瘤

Journal of Blood Disorders and Transfusion Pub Date : 2016-05-16 DOI: 10.4172/2155-9864.1000352

P. Patir, N. Soyer, G. Saydam

引用次数: 3

Non Hodgkins Lymphoma Masquerading as Tuberculosis 伪装成肺结核的非霍奇金淋巴瘤

Journal of Blood Disorders and Transfusion Pub Date : 2016-05-11 DOI: 10.4172/2155-9864.1000349

R. Jhamb, S. Madhu, A. Juneja

引用次数: 4

The Preterm Effect of Antiretroviral Drugs on Total Lymphocyte Cells and CD4 Cells in HIV-Infected Pregnant Women 抗逆转录病毒药物对hiv感染孕妇总淋巴细胞和CD4细胞的早产影响

Journal of Blood Disorders and Transfusion Pub Date : 2016-05-11 DOI: 10.4172/2155-9864.1000353

O. C. Udoka, Ukibe Solomon Nwabueze, H. Brown, Ezeiruaku Ferdin

{"title":"The Preterm Effect of Antiretroviral Drugs on Total Lymphocyte Cells and CD4 Cells in HIV-Infected Pregnant Women","authors":"O. C. Udoka, Ukibe Solomon Nwabueze, H. Brown, Ezeiruaku Ferdin","doi":"10.4172/2155-9864.1000353","DOIUrl":"https://doi.org/10.4172/2155-9864.1000353","url":null,"abstract":"Background: HIV infected pregnant women are placed on antiretroviral drugs for treatment and to avoid maternal to child transmission of HIV. This study was carried out to investigate the effects of the antiretroviral drugs (ARD) on CD4 and Total Lymphocyte cell count (TLC) among these women. \u0000Method: A total of 120 women participated in this study at Bori General Hospital Nigeria. Sixty (60) of them were seropositive to HIV while 60 were seronegative. Blood sample was collected from both groups of women at 2nd and 3rd trimester. The seropositve group was placed on ARD (Nevirapine, Zidovudine) after initial collection of sample at 2 nd trimester. CD4 count and TLC were estimated in these samples using Cyflow machine and manual method respectively. \u0000Result: CD4 count and TLC were significantly (p 0.05) difference. \u0000Conclusion: Reduction of CD4 cell count and TLC at 2nd trimester in HIV- infected pregnant women showed that HIV infection depleted these immunologic markers in pregnancy. The administration of ARD from second trimester boosted the CD4 cell count and TLC among these infected pregnant women before delivery. Progressive increase in TLC alongside CD4 cell count among the women on ARD suggests that TLC could be used as a surrogate to monitor progress of treatment among HIV-infected pregnant women in resource limited settings.","PeriodicalId":182392,"journal":{"name":"Journal of Blood Disorders and Transfusion","volume":"62 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125062566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5