Mass Spectrometry Letters最新文献_第6页

Preparation and Characterization of Quercetin-Loaded Solid Dispersion by Solvent Evaporation and Freeze-Drying Method 溶剂蒸发-冷冻干燥法制备槲皮素负载固体分散体及表征

IF 0.5

Mass Spectrometry Letters Pub Date : 2016-09-30 DOI: 10.5478/MSL.2016.7.3.79

S. H. Park, I. Song, Min‐Koo Choi

{"title":"Preparation and Characterization of Quercetin-Loaded Solid Dispersion by Solvent Evaporation and Freeze-Drying Method","authors":"S. H. Park, I. Song, Min‐Koo Choi","doi":"10.5478/MSL.2016.7.3.79","DOIUrl":"https://doi.org/10.5478/MSL.2016.7.3.79","url":null,"abstract":"We prepared solid dispersion formulations of quercetin to enhance its solubility and dissolution rate. Various quercetinloaded solid dispersion were tested with quercetin, poloxamer 407, and carrier such as hydroxypropyl methyl cellulose (HPMC), polyethylene glycol 8000 (PEG 8000), and polyvinylpyrrolidone K40 (PVP K40) using solvent evaporation and freeze drying methods in terms of both the aqueous solubility and the dissolution rates of quercetin. The solubility of quercetin as its solid dispersion formulations was markedly improved compared with that of quercetin powder. Especially, highest solubility of quercetin was observed when HPMC was used as a carrier. The cumulative dissolution of quercetin within 360 min from solid dispersion composed of quercetin, poloxamer 407, and HPMC was 8.8-fold higher than the dissolution of pure quercetin. The results of powder Xray diffraction (XRD) and scanning electron microscope (SEM) indicated that quercetin transformed from a crystalline to an amorphous form through the solid dispersion formulation process. These results suggest that the solid dispersion formulation of quercetin with poloxamer 407 and HPMC could be a promising option for enhancing the solubility and dissolution rate of quercetin.","PeriodicalId":18238,"journal":{"name":"Mass Spectrometry Letters","volume":"16 1","pages":"79-83"},"PeriodicalIF":0.5,"publicationDate":"2016-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73262985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Identification of ML106 Phase 1 Metabolites in Human Liver Microsomes Using High-Resolution Quadrupole-Orbitrap Mass Spectrometry 用高分辨率四极轨道阱质谱法鉴定人肝微粒体中ML106 1期代谢物

IF 0.5

Mass Spectrometry Letters Pub Date : 2016-09-30 DOI: 10.5478/MSL.2016.7.3.69

J. Jo, W. Nam, Sunjoo Kim, Doohyun Lee, K. Min, Taeho Lee, Sangkyu Lee

引用次数: 0

LC-MS/MS Method for Simultaneous Analysis of Growth Hormone-Releasing Peptides and Secretagogues in Human Urine LC-MS/MS同时分析人尿中生长激素释放肽和分泌物的方法

IF 0.5

Mass Spectrometry Letters Pub Date : 2016-09-30 DOI: 10.5478/MSL.2016.7.3.55

H. Min, Boyoung Han, Changmin Sung, K. Lee, H. Kim, Ki Hun Kim, J. Son, Jaeick Lee

引用次数: 5

Differentiation of Glycan Diversity with Serial Affinity Column Set (SACS) 序列亲和柱集(SACS)对多糖多样性的鉴别

IF 0.5

Mass Spectrometry Letters Pub Date : 2016-09-30 DOI: 10.5478/MSL.2016.7.3.74

Jihoon Shin, W. Cho

引用次数: 1

Complete Simultaneous Analysis of Uranium Isotopes in NUSIMEP-7 Microparticles Using SEM-TIMS 用SEM-TIMS同时分析NUSIMEP-7微粒中的铀同位素

IF 0.5

Mass Spectrometry Letters Pub Date : 2016-09-30 DOI: 10.5478/MSL.2016.7.3.64

Jong-Ho Park, Kahee Jeong

引用次数: 3

Recent Developments in Nuclear Forensic and Nuclear Safeguards Analysis Using Mass Spectrometry 质谱法在核法医和核保障分析中的最新进展

IF 0.5

Mass Spectrometry Letters Pub Date : 2016-06-30 DOI: 10.5478/MSL.2016.7.2.31

K. Song, Jong-Ho Park, Chi-Gyu Lee, Sun-ho Han

引用次数: 3

UHPLC-ESI-qTOF-MS Analysis of Cyclopeptide Alkaloids in the Seeds of Ziziphus jujuba var. spinosa UHPLC-ESI-qTOF-MS分析酸枣种子中环肽生物碱

IF 0.5

Mass Spectrometry Letters Pub Date : 2016-06-30 DOI: 10.5478/MSL.2016.7.2.45

K. Kang, D. Jang, Jinwoong Kim, S. Sung

引用次数: 7

Improvement of Measurement Precisions for Uranium Isotopes at Ultra Trace Levels by Modification of the Sample Introduction System in MC-ICP-MS MC-ICP-MS样品导入系统改进对超痕量铀同位素测量精度的影响

IF 0.5

Mass Spectrometry Letters Pub Date : 2016-06-30 DOI: 10.5478/MSL.2016.7.2.50

Ranhee Park, S. Lim, Sun-ho Han, Min Young Lee, Jinkyu Park, Chi-Gyu Lee, K. Song

{"title":"Improvement of Measurement Precisions for Uranium Isotopes at Ultra Trace Levels by Modification of the Sample Introduction System in MC-ICP-MS","authors":"Ranhee Park, S. Lim, Sun-ho Han, Min Young Lee, Jinkyu Park, Chi-Gyu Lee, K. Song","doi":"10.5478/MSL.2016.7.2.50","DOIUrl":"https://doi.org/10.5478/MSL.2016.7.2.50","url":null,"abstract":": Multi-collector inductively coupled plasma mass spectrometry (MC-ICP-MS) is currently used in our laboratory for isotopic and quantitative analyses of nuclear materials at ultra-trace levels in environmental swipe samples, which is a very useful for monitoring undeclared nuclear activities. In this study, to improve measurement precisions of uranium isotopes at ultra-trace levels, we adopted a desolvating nebulizer system (Aridus-II, CETAC., USA), which can improve signal sensitivity and reduce formation of uranium hydride. A peristaltic pump was combined with Aridus-II in the sample introduction system of MC-ICP-MS to reduce long-term signal fluctuations by maintaining a constant flow rate of the sample solution. The signal sensitivity in the presence of Aridus-II was improved more than 10-fold and the formation ratio of UH/U decreased by 16- to 17-fold compared to a normal spray chamber. Long-term signal fluctuations were significantly reduced by using the peristaltic pump. Detailed optimizations and evaluations with uranium standards are also discussed in this paper.","PeriodicalId":18238,"journal":{"name":"Mass Spectrometry Letters","volume":"6 1","pages":"50-54"},"PeriodicalIF":0.5,"publicationDate":"2016-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80783590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Uranium Particle Identification with SEM-EDX for Isotopic Analysis by Secondary Ion Mass Spectrometry 二次离子质谱法鉴定铀粒子的SEM-EDX

IF 0.5

Mass Spectrometry Letters Pub Date : 2016-06-30 DOI: 10.5478/MSL.2016.7.2.41

F. Esaka, M. Magara

{"title":"Uranium Particle Identification with SEM-EDX for Isotopic Analysis by Secondary Ion Mass Spectrometry","authors":"F. Esaka, M. Magara","doi":"10.5478/MSL.2016.7.2.41","DOIUrl":"https://doi.org/10.5478/MSL.2016.7.2.41","url":null,"abstract":": Secondary ion mass spectrometry (SIMS) is a promising tool to measure isotope ratios of individual uranium particles in environmental samples for nuclear safeguards. However, the analysis requires prior identification of a small number of uranium particles that coexist with a large number of other particles without uranium. In the present study, this identification was performed by scanning electron microscopy - energy dispersive X-ray analysis with automated particle search mode. The analytical results for an environmental sample taken at a nuclear facility indicated that the observation of backscattered electron images with × 1000 magnification was appropriate to efficiently identify uranium particles. Lower magnification (less than × 500) made it difficult to detect smaller particles of approximately 1 µ m diameter. After identification, each particle was manipulated and transferred for subsequent isotope ratio analysis by SIMS. Consequently, the isotope ratios of individual uranium particles were successfully determined without any molecular ion interference. It was demonstrated that the proposed technique provides a powerful tool to measure individual particles not only for nuclear safeguards but also for environmental sciences.","PeriodicalId":18238,"journal":{"name":"Mass Spectrometry Letters","volume":"11 1","pages":"41-44"},"PeriodicalIF":0.5,"publicationDate":"2016-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73242180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Dual Nano-Electrospray and Mixing in the Taylor Cone 双纳米电喷雾与泰勒锥混合

IF 0.5

Mass Spectrometry Letters Pub Date : 2016-03-31 DOI: 10.5478/MSL.2016.7.1.21

A. Radionova, D. Greenwood, G. Willmott, P. Derrick

{"title":"Dual Nano-Electrospray and Mixing in the Taylor Cone","authors":"A. Radionova, D. Greenwood, G. Willmott, P. Derrick","doi":"10.5478/MSL.2016.7.1.21","DOIUrl":"https://doi.org/10.5478/MSL.2016.7.1.21","url":null,"abstract":"Abstract : Dual-channel nano-electrospray has recently become an ionization technique of great promise especially in biologi-cal mass spectrometry. This unique approach takes advantage of the mixing processes that occurs during electrospray. Under-standing in more detail the fundamental principles influencing spray formation further study of the origins of the mixingprocesses: (1) in a Taylor cone region, (2) in charged droplets or (3) in both environments. The dual-channel emitters were mad efrom borosilicate theta-shape glass tubes (O.D. 1.2 mm) and had a tip diameters of less than 4µm. Electrical contact wasachived by deposition of a thin film of an appropriate metal onto the surface of the emitter. The experimental investigation ofthe Taylor cone formation in a dual-channel electrospray emitter has been carried out by injection of polystyrene beads(diameter 3µm) at very low concentrations into one of the channels of the non-tapered theta-glass tubes. High-speed cameraexperiments were set up to visualize the mixing processes in Taylor cone regions for dual-channel emitters. Mass spectra fromdual nano-electrospray are presented.Keywords : nano-electrospray, theta-shaped dual channel emitters, Taylor cone, mass spectrometry","PeriodicalId":18238,"journal":{"name":"Mass Spectrometry Letters","volume":"31 1","pages":"21-25"},"PeriodicalIF":0.5,"publicationDate":"2016-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74716084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4