Mass Spectrometry Letters最新文献

Effect of Ginsenoside Rc on the Pharmacokinetics of Mycophenolic Acid, a UGT1A9 Substrate, and its Glucuronide Metabolite in Rats 人参皂苷Rc对UGT1A9底物霉酚酸及其葡萄糖醛酸代谢产物在大鼠体内药动学的影响

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Mass Spectrometry Letters Pub Date : 2021-06-01 DOI: 10.5478/MSL.2021.12.2.53

So-Young Park, Ji-Hyeon Jeon, Su-Nyeong Jang, I. Song, Kwang-Hyeon Liu

引用次数: 1

Estimation of Phosphorus Concentration in Silicon Thin Film on Glass Using ToF-SIMS 利用ToF-SIMS估算玻璃上硅薄膜中磷的浓度

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Mass Spectrometry Letters Pub Date : 2021-06-01 DOI: 10.5478/MSL.2021.12.2.47

M. Hossion, M. Karthick, B. Arora

引用次数: 0

Screening of Nitrosamine Impurities in Sartan Pharmaceuticals by GC-MS/MS GC-MS/MS法筛选沙坦类药物中亚硝胺类杂质

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Mass Spectrometry Letters Pub Date : 2021-06-01 DOI: 10.5478/MSL.2021.12.2.31

Shu-Han Chang, Hui-yu Ho, Chi-Zong Zang, Y. Hsu, Mei-Chih Lin, S. Tseng, Der-Yuan Wang

引用次数: 4

Statistical Characterization of the Multi-Charged Fragment Ions in the CID and HCD Spectrum CID和HCD光谱中多电荷碎片离子的统计表征

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Mass Spectrometry Letters Pub Date : 2021-06-01 DOI: 10.5478/MSL.2021.12.2.41

Sangeetha Ramachandran, T. Thomas

引用次数: 0

Liquid Chromatography-Tandem Mass Spectrometric Analysis of Nannozinone A and Its Application to Pharmacokinetic Study in Mice 纳米氮酮A的液相色谱-串联质谱分析及其在小鼠体内药动学研究中的应用

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Mass Spectrometry Letters Pub Date : 2021-01-01 DOI: 10.5478/MSL.2021.12.1.000

C. Lee, S. Kim, Jaehyeok Lee, Ji-Hyeon Jeon, I. Song, Y. Han, Min‐Koo Choi

{"title":"Liquid Chromatography-Tandem Mass Spectrometric Analysis of Nannozinone A and Its Application to Pharmacokinetic Study in Mice","authors":"C. Lee, S. Kim, Jaehyeok Lee, Ji-Hyeon Jeon, I. Song, Y. Han, Min‐Koo Choi","doi":"10.5478/MSL.2021.12.1.000","DOIUrl":"https://doi.org/10.5478/MSL.2021.12.1.000","url":null,"abstract":"We aimed to develop and validate a sensitive analytical method of nannozinone A, active metabolite of Nannochelins A extracted from the Myxobacterium Nannocytis pusilla, in mouse plasma using a liquid chromatography-tandem mass spectrometry (LC-MS/MS). Mouse plasma samples containing nannozinone A and C-caffeine (internal standard) were extracted using a liquid-liquid extraction (LLE) method with methyl tert-butyl ether. Standard calibration curves were linear in the concentration range of 1 1000 ng/mL (r > 0.998) with the interand intra-day accuracy and precision results less than 15%. LLE method gave results in the high and reproducible extraction recovery in the range of 78.00–81.08% with limited matrix effect in the range of 70.56-96.49%. The pharmacokinetics of nannozinone A after intravenous injection (5 mg/kg) and oral administration (30 mg/kg) of nannozinone A were investigated using the validated LC-MS/MS analysis of nannozinone A. The absolute oral bioavailability of nannozinone A was 8.82%. Plasma concentration of nannozinone A after the intravenous injection sharply decreased for 4 h but plasma concentration of orally administered nannozinone A showed fast distribution and slow elimination for 24 h. In conclusion, we successfully applied this newly developed sensitive LC-MS/MS analytical method of nannozinone A to the pharmacokinetic evaluation of this compound. This method can be useful for further studies on the pharmacokinetic optimization and evaluating the druggability of nannozinone A including its efficacy and toxicity.","PeriodicalId":18238,"journal":{"name":"Mass Spectrometry Letters","volume":"84 2 1","pages":"21-25"},"PeriodicalIF":0.5,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87660586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Determination of Nitarsone in Pork, Egg, Milk, Halibut, Shrimp, and Eel Using QuEChERS and LC-MRM 用QuEChERS和LC-MRM法测定猪肉、鸡蛋、牛奶、大比目鱼、虾和鳗鱼中的尼塔酮

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Mass Spectrometry Letters Pub Date : 2021-01-01 DOI: 10.5478/MSL.2021.12.1.11

Jin Hee Kim, Y. Jang, Dong Yoon Kim, H. Lee, Y. S. Choi

引用次数: 0

A Dilute-and-Shoot LC–MS/MS Method for Screening of 43 Cardiovascular Drugs in Human Urine 稀释-射击LC-MS /MS法筛选人尿中43种心血管药物

IF 0.5

Mass Spectrometry Letters Pub Date : 2021-01-01 DOI: 10.5478/MSL.2021.12.1.1

T. Pham, Gunhee Lee, X. Mai, Thi-Anh-Tuyet Le, Thi-Ngoc-Van Nguyen, Jongki Hong, K. Kim

{"title":"A Dilute-and-Shoot LC–MS/MS Method for Screening of 43 Cardiovascular Drugs in Human Urine","authors":"T. Pham, Gunhee Lee, X. Mai, Thi-Anh-Tuyet Le, Thi-Ngoc-Van Nguyen, Jongki Hong, K. Kim","doi":"10.5478/MSL.2021.12.1.1","DOIUrl":"https://doi.org/10.5478/MSL.2021.12.1.1","url":null,"abstract":"A simple, specific, and economical LC–MS/MS method was investigated for the screening of 43 prescribed antihypertensive and related drugs in human urine. The urine samples were simply prepared by diluting and mixing with internal standard before directly introduced to the LC-MS/MS system, which is fast, straightforward, and cost-effective. Fractional factorial, Box-Behnken, and I-optimal design were applied to screen and optimize the mass spectrometric and chromatographic factors. The analysis was carried out on a triple quadrupole mass spectrometer system utilizing multiple reaction monitoring with positive and negative electrospray ionization method. Chromatographic separation was performed on a Thermo Scientific Accucore RP-MS column (50 × 3.0 mm ID., 2.6 μm) using two separate gradient elution programs established with the same mobile phases. Chromatographic separation was performed within 12 min. The optimal method was validated based on FDA guideline. The results indicated that the assay was specific, reproducible, and sensitive with the limit of detection from 0.1 to 50.0 μg/L. The method was linear for all analytes with coefficient of determination ranging from 0.9870 to 0.9981. The intra-assay precision was from 1.44 to 19.87% and the inter-assay precision was between 2.69 and 18.54% with the recovery rate ranges from 84.54 to 119.78% for all drugs measured. All analytes in urine samples were stable for 24 h at 25oC, and for 2 weeks at -60oC. The developed method improves on currently existing methods by including larger number of cardiovascular medications and better sensitivity of 12 analytes.","PeriodicalId":18238,"journal":{"name":"Mass Spectrometry Letters","volume":"12 1","pages":"1-10"},"PeriodicalIF":0.5,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78878702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

A Study on the Reduction of Inorganic Arsenic in Hijiki and Rice Using the Various Pretreatments and Inductively Coupled Plasma Mass Spectrometry 不同预处理和电感耦合等离子体质谱法对羊栖菜和水稻中无机砷的还原研究

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Mass Spectrometry Letters Pub Date : 2021-01-01 DOI: 10.5478/10.5478/MSL.2021.12.3.106

S. Nam, Dong-Chan Lee

引用次数: 0

Serum Proteomic Analysis of Scrub Typhus Patients for Screening Antigenic Proteins Originating from Orientia tsutsugamushi 筛选恙虫病东方体抗原蛋白的恙虫病恙虫病患者血清蛋白质组学分析

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Mass Spectrometry Letters Pub Date : 2021-01-01 DOI: 10.5478/10.5478/MSL.2021.12.3.76

Sang-Yeop Lee, S. Yun, G. Bang, Chang-Seop Lee, Seung Il Kim

引用次数: 0

Correlation between the Content and Pharmacokinetics of Ginsenosides from Four Different Preparation of Panax Ginseng C.A. Meyer in Rats 四种不同炮制法人参皂苷在大鼠体内含量及药动学的相关性研究

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Mass Spectrometry Letters Pub Date : 2021-01-01 DOI: 10.5478/MSL.2021.12.1.16

Ji-Hyeon Jeon, Jaehyeok Lee, C. Lee, Min‐Koo Choi, I. Song

{"title":"Correlation between the Content and Pharmacokinetics of Ginsenosides from Four Different Preparation of Panax Ginseng C.A. Meyer in Rats","authors":"Ji-Hyeon Jeon, Jaehyeok Lee, C. Lee, Min‐Koo Choi, I. Song","doi":"10.5478/MSL.2021.12.1.16","DOIUrl":"https://doi.org/10.5478/MSL.2021.12.1.16","url":null,"abstract":"We aimed to compare the content of ginsenosides and the pharmacokinetics after the oral administration of four different ginseng products at a dose of 1 g/kg in rats. The four different ginseng products were fresh ginseng extract, red ginseng extract, white ginseng extract, and saponin enriched white ginseng extract prepared from the radix of Panax ginseng C.A. Meyer. The ginsenoside concentrations in the ginseng product and the rat plasma samples were determined using a liquid chromatography-tandem mass spectrometry (LC-MS/MS). Eight or nine ginsenosides of the 15 tested ginsenosides were detected; however, the content and total ginsenosides varied depending on the preparation method. Moreover, the content of triglycosylated ginsenosides was higher than that of diglycosylated ginsenosides, and deglycosylated ginsenosides were not present in any preparation. After the single oral administrations of four different ginseng products in rats, only four ginsenosides, such as 20(S)ginsenosides Rb1 (GRb1), GRb2, GRc, and GRd, were detected in the rat plasma samples among the 15 ginsenosides tested. The plasma concentrations of GRb1, GRb2, GRc, and GRd were different depends on the preparation method but pharmacokinetic features of the four ginseng products were similar. In conclusion, a good correlation between the area under the concentration curve and the content of GRb1, GRb2, and GRc, but not GRd, in the ginseng products was identified and it might be the result of their higher content and intestinal biotransformation of the ginseng product.","PeriodicalId":18238,"journal":{"name":"Mass Spectrometry Letters","volume":"43 1","pages":"16-20"},"PeriodicalIF":0.5,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73487635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2