Macromolecular Materials and Engineering最新文献

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Nanofibrous Biomaterial Containing Raw-Propolis Particles Encapsulated by PLA/PBS for Wound Dressing Application 由聚乳酸/PBS包封的含有原蜂胶颗粒的纳米纤维生物材料用于伤口敷料
IF 4.2 3区 材料科学
Macromolecular Materials and Engineering Pub Date : 2025-01-02 DOI: 10.1002/mame.202400321
Ecem Özdilek, Sema Samatya Yilmaz, Hüseyin Uzuner, Ayse Aytac
{"title":"Nanofibrous Biomaterial Containing Raw-Propolis Particles Encapsulated by PLA/PBS for Wound Dressing Application","authors":"Ecem Özdilek,&nbsp;Sema Samatya Yilmaz,&nbsp;Hüseyin Uzuner,&nbsp;Ayse Aytac","doi":"10.1002/mame.202400321","DOIUrl":"https://doi.org/10.1002/mame.202400321","url":null,"abstract":"<p>The hollow nanofibrous materials were obtained by successfully encapsulating different rate raw-propolis particles (5%, 10%, and 15%) with hydrophobic polylactic acid/polybutylene succinate (PLA/PBS, 93/7, w/w) blend. No purification process such as extraction was applied to raw propolis and propolis was used as raw. High liquid absorbing capacity values between 400 and 600% were observed owing to the hollow core of the nanofiber. Scanning electron microscopy (SEM) surface images of hollow nanofibers became transparent, and it was seen that the fiber diameters were thickened. The tensile stress of 5% propolis-encapsulated biomaterial exhibited the highest value of 1.25 MPa. High antibacterial activity was observed especially against <i>Staphylococcus aureus (</i><i>S. aureus)</i> at the end of the 24<sup>th</sup> and 48<sup>th</sup> h with the dispersion of raw-propolis particles in the core of propolis-encapsulated all fibrous materials. However, it was seen that the use of propolis in its raw form caused the emergence of toxic effects. It was reported that hollow biomaterials containing raw-propolis particles encapsulated by PLA/PBS could not be used as wound dressings due to insufficient fibroblast cell viability. So, it was suggested that pure hollow PLA/PBS fibrous mats could be used as skin tissue scaffolds.</p>","PeriodicalId":18151,"journal":{"name":"Macromolecular Materials and Engineering","volume":"310 4","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mame.202400321","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143831141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Design Optimization of Pressurized Gyration Technology: Orifice Height Level Effects on Production Rate and Fiber Morphology 加压回转工艺的优化设计:孔口高度对生产率和纤维形态的影响
IF 4.2 3区 材料科学
Macromolecular Materials and Engineering Pub Date : 2025-01-02 DOI: 10.1002/mame.202400317
Ahmed Alneyadi, Angelo Delbusso, Anthony Harker, Mohan Edirisinghe
{"title":"Design Optimization of Pressurized Gyration Technology: Orifice Height Level Effects on Production Rate and Fiber Morphology","authors":"Ahmed Alneyadi,&nbsp;Angelo Delbusso,&nbsp;Anthony Harker,&nbsp;Mohan Edirisinghe","doi":"10.1002/mame.202400317","DOIUrl":"https://doi.org/10.1002/mame.202400317","url":null,"abstract":"<p>Electrospinning and pressurized gyration are two widely adopted methods for polymeric fiber production, valued for their simplicity, versatility, and relatively low environmental impact. Despite its advantages, electrospinning has notable limitations, including low production efficiency and significant safety concerns. Pressurized gyration, however, offers greater productivity and a safer, more sustainable process, making it an excellent candidate for industrial scaling. To fully realize this potential, optimizing the pressurized gyration process is essential for enhancing efficiency and achieving sustainable large-scale fiber production. In this study, the effects of vessel orifice height on the production rate and fiber morphology in pressurized gyration are explored. A series of experiments is conducted using a 15 wt.% polycaprolactone (PCL) solution, with vessels of identical diameter but differing orifice heights 7.5, 15, and 22.5 mm tested under pressures of 0, 0.1, 0.2, and 0.3 MPa, all at a constant rotational speed of 13 000 rpm. The 7.5 mm orifice height demonstrates the highest production rate under pressure while increasing orifice height led to finer fiber diameters, better alignment, and smaller beads. These findings underscore the importance of optimizing vessel design, along with process and solution parameters, for scaling up pressurized gyration fiber manufacturing to meet industrial demands.</p>","PeriodicalId":18151,"journal":{"name":"Macromolecular Materials and Engineering","volume":"310 3","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mame.202400317","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143602540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Self-Assembled Supramolecular Materials for Substrate Transport by External Stimuli 自组装超分子材料在外界刺激下的基底运输
IF 4.2 3区 材料科学
Macromolecular Materials and Engineering Pub Date : 2024-12-27 DOI: 10.1002/mame.202400395
Xue Li, Yuichiro Kobayashi, Akira Harada, Hiroyasu Yamaguchi
{"title":"Self-Assembled Supramolecular Materials for Substrate Transport by External Stimuli","authors":"Xue Li,&nbsp;Yuichiro Kobayashi,&nbsp;Akira Harada,&nbsp;Hiroyasu Yamaguchi","doi":"10.1002/mame.202400395","DOIUrl":"https://doi.org/10.1002/mame.202400395","url":null,"abstract":"<p>Substrate transport within biological tissues is diverse, with the most fundamental process being transport across cell membranes, which plays a crucial role in sustaining life. In this study, an artificial substrate transport system based on hydrogels by utilizing molecular recognition and stimuli-responsive substrates is developed. α- and β-Cyclodextrins are selected as host molecules, while adamantane serves as the guest molecule, enabling the adhesion of two hydrogels through self-assembly. Under light stimulation, the light-responsive dye, azobenzene derivative, is transported between the two hydrogels. This research provides new insights into the development of light-controlled substance transport systems, which can be applied to biological substance delivery and the creation of smart materials.</p>","PeriodicalId":18151,"journal":{"name":"Macromolecular Materials and Engineering","volume":"310 6","pages":""},"PeriodicalIF":4.2,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mame.202400395","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144300426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring Cross-Link Density and Additive Effects on Mechanical and Morphological Behaviors of Cross-Linked Polymers 探讨交联密度和加性对交联聚合物力学和形态行为的影响
IF 4.2 3区 材料科学
Macromolecular Materials and Engineering Pub Date : 2024-12-27 DOI: 10.1002/mame.202400383
Kamrun N. Keya, Zhaofan Li, Lan Xu, Wenjie Xia
{"title":"Exploring Cross-Link Density and Additive Effects on Mechanical and Morphological Behaviors of Cross-Linked Polymers","authors":"Kamrun N. Keya,&nbsp;Zhaofan Li,&nbsp;Lan Xu,&nbsp;Wenjie Xia","doi":"10.1002/mame.202400383","DOIUrl":"https://doi.org/10.1002/mame.202400383","url":null,"abstract":"<p>Cross-linked thermoset polymeric materials are widely used in various engineering applications due to their excellent mechanical properties, thermal stability, and chemical resistance. Recent research highlights the role of cross-link density and additives in influencing segmental dynamics and thermomechanical behavior of polymers. This study employs coarse-grained molecular dynamics (CG-MD) simulations to explore the thermomechanical and morphologic behaviors of cross-linked polymers with molecular additives. Specifically, it is systematically investigated how cross-link density (<i>c</i>) and different additive concentrations (<i>m</i>) affect key glass-forming characteristics, along with the resulting changes in mechanical and morphologic properties of network materials as they approach their glass transition temperatures (<i>T<sub>g</sub></i>). Relatively weaker interaction between the polymer network and additives can lead to additive aggregation, significantly affecting the morphology and <i>T<sub>g</sub></i> as the <i>m</i> increases. Increasing <i>c</i> leads to an increase in both <i>T<sub>g</sub></i> and fragility while increasing <i>m</i> decreases them. The simulation reveals that both <i>c</i> and <i>m</i> moderately influence the mechanical properties (i.e., shear and tensile modulus) of cross-linked polymers with additives. This study provides valuable insights into how cross-link density and additive concentrations influence glass-forming and morphological behaviors, offering a molecular design strategy for developing advanced cross-linked thermosets.</p>","PeriodicalId":18151,"journal":{"name":"Macromolecular Materials and Engineering","volume":"310 5","pages":""},"PeriodicalIF":4.2,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mame.202400383","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144074718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Polycondensation-Derived High-Molecular Weight Lignin as Nonblended Precursor for Carbon Fibers 缩聚衍生的高分子量木质素作为碳纤维的非共混前驱体
IF 4.2 3区 材料科学
Macromolecular Materials and Engineering Pub Date : 2024-12-23 DOI: 10.1002/mame.202400388
Manuel M. Clauss, Erik Frank, Volker Bauch, Lisa Kuske, Michael R. Buchmeiser
{"title":"Polycondensation-Derived High-Molecular Weight Lignin as Nonblended Precursor for Carbon Fibers","authors":"Manuel M. Clauss,&nbsp;Erik Frank,&nbsp;Volker Bauch,&nbsp;Lisa Kuske,&nbsp;Michael R. Buchmeiser","doi":"10.1002/mame.202400388","DOIUrl":"https://doi.org/10.1002/mame.202400388","url":null,"abstract":"<p>A new concept for the controlled chain-extension of lignin has been developed. A mixture of trioxane as formaldehyde source, resorcinol as chain extender, and lignin allows to prepare high molecular weight precursor fibers by melt-spinning, which can be spun on a semitechnical scale. Chain extension with resorcinol bridged by methylene groups is achieved during the stabilization process of the precursor fiber. After carbonization, carbon fibers (CFs) with an average diameter of 18 µm show an average tensile strength of 0.78 GPa and a Young's modulus of 106 GPa. A maximum tensile strength of 2.44 GPa and a Young's modulus of 294 GPa are reached with fibers 9.7 µm in diameter.</p>","PeriodicalId":18151,"journal":{"name":"Macromolecular Materials and Engineering","volume":"310 5","pages":""},"PeriodicalIF":4.2,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mame.202400388","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144074350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Femtosecond Laser Transmission Joining of Fused Silica and Polymethyl Methacrylate 熔融二氧化硅与聚甲基丙烯酸甲酯的飞秒激光传输连接
IF 4.2 3区 材料科学
Macromolecular Materials and Engineering Pub Date : 2024-12-23 DOI: 10.1002/mame.202400354
Felice Alberto Sfregola, Raffaele De Palo, Caterina Gaudiuso, Pietro Patimisco, Antonio Ancona, Annalisa Volpe
{"title":"Femtosecond Laser Transmission Joining of Fused Silica and Polymethyl Methacrylate","authors":"Felice Alberto Sfregola,&nbsp;Raffaele De Palo,&nbsp;Caterina Gaudiuso,&nbsp;Pietro Patimisco,&nbsp;Antonio Ancona,&nbsp;Annalisa Volpe","doi":"10.1002/mame.202400354","DOIUrl":"https://doi.org/10.1002/mame.202400354","url":null,"abstract":"<p>In this study, polymethyl methacrylate (PMMA) is joined with fused silica using pulsed femtosecond laser transmission micro-welding. This technique enables the welding of transparent materials to each other without the need for intermediate opaque layers, through localized energy deposition. The laser parameters – peak fluence, scanning speed, and hatch distance – are systematically optimized to maximize joint shear strength. The ATR-FTIR spectroscopic analysis has proven that mechanical interlocking is the primary mechanism of joint formation between the two materials. An analytical model based on heat accumulation is developed to describe the joining process, with a good predictive quality confirmed by comparison with the experimental results. This joining approach is applied to seal a hybrid PMMA-fused silica microfluidic chip. The device has successfully passed a static leakage test by withstanding pressures up to the full-scale value of the employed microfluidic pump at 2 bar, demonstrating the effectiveness of femtosecond laser transmission welding for fabricating robust and reliable joints in hybrid microfluidic devices.</p>","PeriodicalId":18151,"journal":{"name":"Macromolecular Materials and Engineering","volume":"310 4","pages":""},"PeriodicalIF":4.2,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mame.202400354","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143831140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Electrospun Thermoplastic Polyurethane Fibrous Membrane Decorated with MXene/Carbon Black for Dual-Mode Human Movement Monitoring and Energy Harvesting MXene/炭黑装饰电纺热塑性聚氨酯纤维膜用于人体运动监测和能量收集
IF 4.2 3区 材料科学
Macromolecular Materials and Engineering Pub Date : 2024-12-19 DOI: 10.1002/mame.202400357
Qingsen Gao, Xin Wang, Dirk W. Schubert, Xianhu Liu
{"title":"Electrospun Thermoplastic Polyurethane Fibrous Membrane Decorated with MXene/Carbon Black for Dual-Mode Human Movement Monitoring and Energy Harvesting","authors":"Qingsen Gao,&nbsp;Xin Wang,&nbsp;Dirk W. Schubert,&nbsp;Xianhu Liu","doi":"10.1002/mame.202400357","DOIUrl":"https://doi.org/10.1002/mame.202400357","url":null,"abstract":"<p>Conductive fiber membranes have received widespread attention due to their excellent physical and chemical properties. However, developing conductive fiber membranes for both strain sensing and energy harvesting remains a challenge. Herein, a novel thermoplastic polyurethane (TPU)/polydopamine (PDA)/MXene/carbon black (CB) (TPMC) conductive fibrous membrane is developed by combining electrospinning and layer-by-layer dip-coating processes. The TPMC fibrous membrane can be used as a component of strain sensors and triboelectric nanogenerators (TENG) to achieve dual-mode human motion detection and energy harvesting. The strain sensor boasts a wide operating range (0.5%-195%), excellent sensitivity (with a gauge factor (GF) up to 54 at 50% strain and maximum GF of 6.5×10<sup>4</sup>), fast response (80 ms) and excellent cycle durability (over 10 000 cycles), making it possible to detect slight or heavy human activities under various conditions effectively. Additionally, a single-electrode TENG utilizing the TPMC membrane achieves an output voltage of 115 V, a current of 0.8 µA, and a power density of 68 mW m⁻<sup>2</sup>, also serving as a self-powered sensor for various movements. The excellent dual-mode sensing and energy harvesting properties make it promising for future high-performance wearable devices.</p>","PeriodicalId":18151,"journal":{"name":"Macromolecular Materials and Engineering","volume":"310 4","pages":""},"PeriodicalIF":4.2,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mame.202400357","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143831469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In Situ Forming Hypoxia-Induced Exosome-Loaded Hydrogel for Enhanced Diabetic Wound Healing 原位形成缺氧诱导的外泌体负载水凝胶促进糖尿病伤口愈合
IF 4.2 3区 材料科学
Macromolecular Materials and Engineering Pub Date : 2024-12-18 DOI: 10.1002/mame.202400402
Yong-fei Wang, Gang Zhao, Sigen A, Qian Xu, Xiao-li Wu, Wen-Xin Wang, Yong-jun Rui
{"title":"In Situ Forming Hypoxia-Induced Exosome-Loaded Hydrogel for Enhanced Diabetic Wound Healing","authors":"Yong-fei Wang,&nbsp;Gang Zhao,&nbsp;Sigen A,&nbsp;Qian Xu,&nbsp;Xiao-li Wu,&nbsp;Wen-Xin Wang,&nbsp;Yong-jun Rui","doi":"10.1002/mame.202400402","DOIUrl":"https://doi.org/10.1002/mame.202400402","url":null,"abstract":"<p>Diabetic wound healing presents unique challenges, including impaired angiogenesis, prolonged inflammation, and delayed re-epithelialization. Advancements in tissue engineering offer promising solutions through cell/drug-based therapies. Exosomes (Exo) derived from hypoxia-preconditioned adipose-derived stem cells (ADSCs) have gained attention for their potential to address these complex issues in diabetic wounds. Existing strategies for Exo delivery aim to overcome drawbacks associated with conventional administration methods, including rapid loss of activity, frequent dosing, and off-target effects. However, complexities in fabrication, undesirable components within the delivery system, and unforeseen outcomes have hindered the efficacy of these approaches. Thus, an in situ formed hydrogel is engineered using click chemistry to facilitate the convenient encapsulation of hypoxia-induced Exo. The hydrogel swiftly transitioned into a gel state upon mixing and facilitated the controlled release of Exo at various loading dosages. Through systematic screening of Exo-hydrogel formulations, it is demonstrated that the encapsulated Exo retained their bioactivity, exhibits therapeutic efficacy in vitro via scratch and tube formation assays. Further, the optimal Exo-hydrogel promotes accelerated wound healing while preventing scar formation in a diabetic rat wound model. The Exo-loaded hydrogel represents a promising approach for efficient Exo delivery in wound healing applications and holds potential for broader applications in diverse medical fields.</p>","PeriodicalId":18151,"journal":{"name":"Macromolecular Materials and Engineering","volume":"310 5","pages":""},"PeriodicalIF":4.2,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mame.202400402","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144074289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Additive Manufacturing of Watertight ABS Parts and Its Use for Chemical Metal Plating ABS水密件的增材制造及其在化学金属电镀中的应用
IF 4.2 3区 材料科学
Macromolecular Materials and Engineering Pub Date : 2024-12-18 DOI: 10.1002/mame.202400367
Philipp Zimmermann, Christoph Schammel, Jürgen Nagel
{"title":"Additive Manufacturing of Watertight ABS Parts and Its Use for Chemical Metal Plating","authors":"Philipp Zimmermann,&nbsp;Christoph Schammel,&nbsp;Jürgen Nagel","doi":"10.1002/mame.202400367","DOIUrl":"https://doi.org/10.1002/mame.202400367","url":null,"abstract":"<p>One of the most frequently used polymers in the galvanic industry as well as for Fused Filament Fabrication (FFF) is the terpolymer of acrylonitrile butadiene styrene (ABS). Its surface is etched in chromosulfuric acid to enable the chemical deposition of a metal. The use of chromium (Cr)(VI) compounds is restricted in the European Union (EU) since 2017. A new plating process is proposed here that does not rely on etching. Instead, double bonds on the ABS surface are converted to epoxides, followed by grafting of a polyethylenimine (PEI) to the surface. The so modified plastic is an ideal starting point for metal plating. Printing often leads to the formation of voids between strands and layers, which hinders subsequent wet processing. The plating process introduced here requires high demands on the water tightness of parts. The proposed printing procedure reduces the degree of penetration of water from 50% to less than 0.1% at 2 bar water pressure. The combination of the new printing procedure with the new plating process results in the deposition of industrial relevant nickel (Ni) layers. The cross-hatch test followed by a peel test exhibits values of zero, pointing to the high adhesion of Ni to ABS.</p>","PeriodicalId":18151,"journal":{"name":"Macromolecular Materials and Engineering","volume":"310 4","pages":""},"PeriodicalIF":4.2,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mame.202400367","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143831121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development and Evaluation of Poly(Lactic-Co-Glycolic Acid) Encapsulated Betulinic Acid Nanocarrier for Improved Anti-Tumor Efficacy 聚乳酸-羟基乙酸包封白桦酸纳米载体的研制及抗肿瘤效果评价
IF 4.2 3区 材料科学
Macromolecular Materials and Engineering Pub Date : 2024-12-17 DOI: 10.1002/mame.202400283
Cyril Tlou Selepe, Khanyisile Sheer Dhlamini, Lesego Tshweu, Lusisizwe Kwezi, Bathabile Ramalapa, Suprakas Sinha Ray
{"title":"Development and Evaluation of Poly(Lactic-Co-Glycolic Acid) Encapsulated Betulinic Acid Nanocarrier for Improved Anti-Tumor Efficacy","authors":"Cyril Tlou Selepe,&nbsp;Khanyisile Sheer Dhlamini,&nbsp;Lesego Tshweu,&nbsp;Lusisizwe Kwezi,&nbsp;Bathabile Ramalapa,&nbsp;Suprakas Sinha Ray","doi":"10.1002/mame.202400283","DOIUrl":"https://doi.org/10.1002/mame.202400283","url":null,"abstract":"<p>Betulinic acid (BA) is a promising natural anti-tumor agent renowned for its activity against various tumor cell types. Despite its favorable profile of low cytotoxicity to normal cells, BA's inherent hydrophobic nature and relatively short systematic half-life impose hurdles for clinical application. This study introduces a strategy to surmount these obstacles by developing a drug delivery system employing poly(lactic-co-glycolic acid) (PLGA)-encapsulated BA nanoparticles (PLGA-BA NPs). Rigorous characterization techniques such as dynamic light scattering (DLS), x-ray diffraction (XRD), and scanning electron microscopy (SEM) analyses are employed to confirm the integrity of the drug within the nanocarriers. The PLGA-BA NPs demonstrated a mean particle size of 196 ± 6.80 nm. XRD analysis demonstrated the amorphous state of the PLGA-BA formulation, a characteristic vital for sustained drug release and enhanced bioavailability. The PLGA-BA NPs exhibited spherical morphology with encapsulation and loading efficiency of 83 ± 9.24% and 7.0 ± 0.4%, respectively, highlighting efficient encapsulation of the drug within the PLGA NPs. In vitro, cytotoxicity assessments demonstrated enhanced anti-proliferative efficacy against breast and lung tumor cells when utilizing PLGA-BA NPs in comparison to free BA. This research underlines the potential of employing the developed PLGA-based nanocarrier to optimize the therapeutic efficacy of BA.</p>","PeriodicalId":18151,"journal":{"name":"Macromolecular Materials and Engineering","volume":"310 2","pages":""},"PeriodicalIF":4.2,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mame.202400283","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143404316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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