Macromolecular Materials and Engineering最新文献_第6页

Direct Lithography for Regulating Multiple Properties of Organic Semiconductors via Photo-Crosslinkers 利用光交联剂调节有机半导体多种特性的直接光刻技术

IF 4.6 3区材料科学

Macromolecular Materials and Engineering Pub Date : 2025-04-08 DOI: 10.1002/mame.202500062

Yueping Lai, Liang-Wen Feng

{"title":"Direct Lithography for Regulating Multiple Properties of Organic Semiconductors via Photo-Crosslinkers","authors":"Yueping Lai, Liang-Wen Feng","doi":"10.1002/mame.202500062","DOIUrl":"https://doi.org/10.1002/mame.202500062","url":null,"abstract":"Photo-crosslinkers, as materials with negative photoresist characteristics, are applied in the direct lithography process of organic semiconductor devices. Compared to commonly used organic lithography processes, the direct lithography process only requires three steps: spin-coating, exposure, and development, to achieve optical patterning of the organic semiconductor channel, eliminating the need for complex procedures such as protection, baking, etching, and transfer. Furthermore, during this process, the photo-crosslinker remains in the blended film, subsequently influencing the crystalline structure and morphology of the semiconductor film. These alterations will further impact multiple properties of the organic film. By utilizing this characteristic, the design of photo-crosslinker can effectively regulate and enhance the tensile properties, charge carrier mobility, stability, and dielectric properties of the device. This approach effectively enables high-precision patterning of organic integrated circuits while synchronously enhancing their various performance attributes. Although there are some relevant reports, a systematic summary and organization of the impact of these photo-crosslinkers on semiconductors remains absent. For the future development of direct lithography, systematic organization is crucial. Therefore, this review systematically classifies and summarizes the functions of photo-crosslinkers in organic thin film devices, providing guidance for the design of novel photo-crosslinkers in direct lithography and improve multiple properties of semiconductor devices.","PeriodicalId":18151,"journal":{"name":"Macromolecular Materials and Engineering","volume":"310 8","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mame.202500062","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144869207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Innovative Thermosensitive Composite Materials: Merging Poloxamer PF-127 and Polysaccharides for Enhanced Functional Properties 创新的热敏复合材料：合并波洛沙姆PF-127和增强功能性能的多糖

IF 4.2 3区材料科学

Macromolecular Materials and Engineering Pub Date : 2025-04-08 DOI: 10.1002/mame.202400457

Marcos Blanco-López, Inmaculada de Dios-Pérez, Álvaro González-Garcinuño, Antonio Tabernero, Eva Martín del Valle

{"title":"Innovative Thermosensitive Composite Materials: Merging Poloxamer PF-127 and Polysaccharides for Enhanced Functional Properties","authors":"Marcos Blanco-López, Inmaculada de Dios-Pérez, Álvaro González-Garcinuño, Antonio Tabernero, Eva Martín del Valle","doi":"10.1002/mame.202400457","DOIUrl":"https://doi.org/10.1002/mame.202400457","url":null,"abstract":"Currently, new cancer treatment options are being developed following tumor resection surgery, with a focus on minimizing invasiveness and reducing systemic toxicity to lower the risk of recurrence. In this context, the thermosensitive poloxamer Pluronic Acid F-127 (PF-127) is modified by incorporating polysaccharides with varying structures—xanthan gum (XG), alginate (ALG), gellan gum (GG), and levan (LEV). Hydrogels are synthesized using different ratios of polysaccharides and PF-127. Rheological results reveal that adding polysaccharides to the hydrogel matrix increases storage moduli from 8 to 11–18 kPa and viscosity from 4.5 to 6.1–7.1 Pa s. Additionally, the micellar aggregation capacity (MAC) and gelation temperature shift from 34 °C to between 22 and 31 °C. Studies on 5-fluorouracil (5-FU) release from these composites indicate that enhanced MAC prolongs drug release 4 times longer compared to the hydrogel made with PF-127 alone. A mathematical model is applied to analyze these experimental results, taking into account polymer chain release. Hydrogel's degradation rate and viscosity are primary determinants of drug release duration. Thus, by modifying the hydrogel composition, MAC, thermosensitivity, and drug release profile can be finely controlled based on the polysaccharide used.","PeriodicalId":18151,"journal":{"name":"Macromolecular Materials and Engineering","volume":"310 7","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mame.202400457","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144647066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Poly(Butylene Adipate-Co-Terephthalate)/Silane-Treated Wollastonite-Based Blown Film for Sustainable Packaging Application: Studying the Impact of Uniaxial Stretching on the Final Properties 聚己二酸丁二酯/硅烷处理硅灰石基可持续包装吹膜：单轴拉伸对最终性能的影响研究

IF 4.2 3区材料科学

Macromolecular Materials and Engineering Pub Date : 2025-04-07 DOI: 10.1002/mame.202400434

Matias Menossi, Manjusri Misra, Amar Kumar Mohanty

{"title":"Poly(Butylene Adipate-Co-Terephthalate)/Silane-Treated Wollastonite-Based Blown Film for Sustainable Packaging Application: Studying the Impact of Uniaxial Stretching on the Final Properties","authors":"Matias Menossi, Manjusri Misra, Amar Kumar Mohanty","doi":"10.1002/mame.202400434","DOIUrl":"https://doi.org/10.1002/mame.202400434","url":null,"abstract":"The demand for biodegradable packaging is rising due to plastic pollution corncerns. This study develops biodegradable composites based on poly (butylene adipate-co-terephthalate) (PBAT) and silane-treated wollastonite (S-W) at two concentrations (15 and 25 wt%) through a combination of melt extrusion and blow-film extrusion techniques. Next, the PBAT/S-W composite films underwent uniaxial stretching in the machine direction (MD) to study the effects on their morphology, mechanical and thermal properties, barrier performance, contact angle, and X-ray diffraction (XRD) at different stretch ratios (SR). The incorporation of S-W at 15 wt% increased the mechanical properties, achieving ≈500% for tensile strength and 1000% for Young's modulus for SR6. Thermal and XRD analyses demonstrated that uniaxial stretching significantly enhanced film crystallinity because of strain-induced crystallization. Morphological analysis indicated two opposing effects at high SR: a pronounced alignment of molecular chains in the MD and weak adhesion between the filler and polymer matrix, which can impact the material's structural integrity. The water vapor barrier properties of the PBAT/S-W25% blown film at SR6 exhibited a remarkable 42% improvement compared to the unstretched version. This advancement, resulting from the elevated crystallinity, establishes PBAT/S-W as a viable eco-friendly substitute for single-use plastics in the field of biodegradable packaging.","PeriodicalId":18151,"journal":{"name":"Macromolecular Materials and Engineering","volume":"310 7","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mame.202400434","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144646869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of Electroconductive Polypyrrole-Polycaprolactone and Poly(3,4-Ethylenedioxythiophene)-poly(Styrenesulfonate)-Polyethylene Oxide Fibrous Scaffolds by Pressurised Gyration for Cardiac Tissue Engineering Applications 心脏组织工程用导电聚吡啶-聚己内酯和聚（3,4-乙烯二氧噻吩）-聚苯乙烯磺酸盐-聚氧聚乙烯纤维支架的加压旋转研究

IF 4.6 3区材料科学

Macromolecular Materials and Engineering Pub Date : 2025-04-07 DOI: 10.1002/mame.202500031

Juan Grano de Oro Fernandez, Manul Amarakoon, Mohan Edirisinghe, Rupy Kaur Matharu

{"title":"Development of Electroconductive Polypyrrole-Polycaprolactone and Poly(3,4-Ethylenedioxythiophene)-poly(Styrenesulfonate)-Polyethylene Oxide Fibrous Scaffolds by Pressurised Gyration for Cardiac Tissue Engineering Applications","authors":"Juan Grano de Oro Fernandez, Manul Amarakoon, Mohan Edirisinghe, Rupy Kaur Matharu","doi":"10.1002/mame.202500031","DOIUrl":"https://doi.org/10.1002/mame.202500031","url":null,"abstract":"Cardiac patches, typically made from non-conductive polymers, are a promising treatment for myocardial infarction (MI). Introducing electroconductive fibres in these patches improves clinical outcomes, but current production methods are limited. This study aims to design and manufacture electroconductive polymeric cardiac scaffolds that closely match native tissue, using pressurised gyration (PG) and conductive polymers (CP). In this study, for the first time, fibres from polypyrrole (PPy) with polycaprolactone (PCL) in chloroform and Poly(3,4-ethylenedioxythiophene)-poly(styrenesulfonate) (PEDOT:PSS) with polyethylene oxide (PEO) in water, are pressure spun with varying CP concentrations (5–10% w/v) and applied pressures (0–0.2 MPa). SEM shows fibres resemble the thickness and uniformity of natural cardiac fibres, as PEDOT:PSS 5%, 0 MPa matched endomysium, PEDOT:PSS 10%, 0 MPa aligned with perimysium, and PPy 7.5%, 0 MPa mimicked epimysium fibres, with diameters of 0.38, 1.02, and 3.88 µm, respectively. Four-point probe testing reveals the closest electrical conductivity measurement to the reported cardiac chambers values is 0.22 S m−1, achieved by PPy 10%, 0.2MPa. FTIR verified the absence of residual solvent, confirming conductivity is due to polymer bonds. The study confirms the produced fibres have ideal electroconductive and physicochemical properties for cardiac tissue engineering, demonstrating PG's potential as a scalable technique for electroconductive fibres manufacturing, advancing cardiac patch development and MI treatment.","PeriodicalId":18151,"journal":{"name":"Macromolecular Materials and Engineering","volume":"310 8","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mame.202500031","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144869280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bioelectronic Hydrogels: Exemplifying the Synergy Between Biopolymers and Conjugated Polymers 生物电子水凝胶：举例说明生物聚合物和共轭聚合物之间的协同作用

IF 4.6 3区材料科学

Macromolecular Materials and Engineering Pub Date : 2025-04-07 DOI: 10.1002/mame.202500019

Thanh Nhi Tra, Kristina Fidanovski, Damia Mawad

{"title":"Bioelectronic Hydrogels: Exemplifying the Synergy Between Biopolymers and Conjugated Polymers","authors":"Thanh Nhi Tra, Kristina Fidanovski, Damia Mawad","doi":"10.1002/mame.202500019","DOIUrl":"https://doi.org/10.1002/mame.202500019","url":null,"abstract":"Conductive hydrogels are a potential platform for 3D cell culture, especially in bioelectronic interfaces, enabling the integration of electronic and mechanical signals as biological cues. Biopolymer-based conductive hydrogels offer significant advantages thanks to their inherent flexibility and their renewable and biocompatible properties, in combination with the conductivity of the hydrogel network. However, hydrogels' vulnerability to mechanical failure limits their durability in bioelectronic applications. To address this, self-healing conductive hydrogels with reversible dynamic networks have emerged. These materials are capable of repairing themselves after damage and closely mimic the healing characteristics of living tissues. This self-healing capability thus promotes the reliable and long-lasting use of bioelectronic devices. This review first examines the individual characteristics of conductive hydrogels, namely electrical conductivity from the conjugated polymer and mechanical cues from the biopolymer, in terms of their influence on cellular activities. Subsequently, recent advancements in biopolymer-based conductive hydrogels are discussed, with a focus on their fabrication method and ability to modulate specific cell functions. Finally, the advancements in self-healing hydrogel bioelectronics are summarized, focusing on the variety of self-healing mechanisms and the corollaries for enhanced bioelectronic longevity.","PeriodicalId":18151,"journal":{"name":"Macromolecular Materials and Engineering","volume":"310 8","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mame.202500019","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144869281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Plasma Immersion Ion Implantation Increases Adhesive Bond Strength of PEK and PEEK to Dental Composites and Enables Hydrolysis Resistance 等离子体浸泡离子注入提高了聚醚醚酮和聚醚醚酮与牙科复合材料的粘合强度，并增强了抗水解能力

IF 4.6 3区材料科学

Macromolecular Materials and Engineering Pub Date : 2025-04-04 DOI: 10.1002/mame.202500007

William T Lewin, Hedi Verena Kruse, Eva Tomaskovic-Crook, Mahdi Shahmoradi, Dale Howes, David R McKenzie

{"title":"Plasma Immersion Ion Implantation Increases Adhesive Bond Strength of PEK and PEEK to Dental Composites and Enables Hydrolysis Resistance","authors":"William T Lewin, Hedi Verena Kruse, Eva Tomaskovic-Crook, Mahdi Shahmoradi, Dale Howes, David R McKenzie","doi":"10.1002/mame.202500007","DOIUrl":"https://doi.org/10.1002/mame.202500007","url":null,"abstract":"The additive manufacturing technology known as selective-laser-sintering is available for the poly-aryl-ether-ketone (PAEK) family of high-strength polymers, enabling the rapid production of personalized dental and mandibular reconstructions at or near the point-of-care. PAEK mandibular segmental replacements, bridges, and abutments are transitioning to clinical use. There remains a need for improved adhesion between PAEK polymers and dental adhesives including dental composite resin cements. Without surface modification, there is a weak bond to PAEK polymers, especially when the surface of the polymer is smooth. Plasma-immersion-ion-implantation (PIII) is applied to demonstrate a significant increase in the bond strength between Polyether–ether–ketone (PEEK) and Poly–ether–ketone (PEK) polymers and a commonly used dental composite resin cement, for multiple levels of interface roughness. A validated predictive model for the bond strength as a function of surface roughness expressed as a surface area ratio is presented that demonstrates the relative effect of PIII and mechanical interlocking. The results show that the bond strength achieved using PIII is retained even when the primer step is omitted, an important advance as the primer has been associated with hydrolysis-induced weakening. A long-term water immersion test shows that the PIII-assisted primer-free bond retains its strength while all primer-assisted bonds are weakened.","PeriodicalId":18151,"journal":{"name":"Macromolecular Materials and Engineering","volume":"310 8","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mame.202500007","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144869397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Light Based 3D Printable Photochromic WO3 Polymer Gel Nanocomposites for Heat Management and Decorative Applications 用于热管理和装饰应用的光基3D打印光致变色WO3聚合物凝胶纳米复合材料

IF 4.2 3区材料科学

Macromolecular Materials and Engineering Pub Date : 2025-04-04 DOI: 10.1002/mame.202400449

Alister Urain, Ilaria Abdel Aziz, Naroa Lopez-Larrea, Iñigo Calvo, Ana M. Conde, Miryam Criado-Gonzalez, Nerea Casado, David Mecerreyes

{"title":"Light Based 3D Printable Photochromic WO3 Polymer Gel Nanocomposites for Heat Management and Decorative Applications","authors":"Alister Urain, Ilaria Abdel Aziz, Naroa Lopez-Larrea, Iñigo Calvo, Ana M. Conde, Miryam Criado-Gonzalez, Nerea Casado, David Mecerreyes","doi":"10.1002/mame.202400449","DOIUrl":"https://doi.org/10.1002/mame.202400449","url":null,"abstract":"Materials with functionalities such as photochromicity are needed to extend the palette of materials for additive manufacturing. Herein, gel nanocomposites (gel NCs) with photochromic properties are designed for light-induced 3D printing. The photochromic resin is prepared by using a photocurable acrylic formulation, containing tungsten oxide nanoparticles (WO3 NPs) in the presence of aqueous and alcohol plasticizers. After photopolymerization, gel NCs transition reversibly from a highly transparent colorless state to a dark blue-colored state when exposed to UV light. The addition of ethylene glycol to water as a co-plasticizer and a lithium salt improves the gels coloration kinetics while providing anti-freezing and anti-drying capabilities. The gels demonstrate high luminous transmission (Tlum) of 89.24% and optical modulations (ΔTsol) of up to 75.96%, with a coloration speed of less than 1 min. Energy-saving simulations show that the WO3 gel NCs can be used for heat management applications. The preparation of costume-made 3D designs using the photocurable resin with a digital light processing (DLP) 3D printer, demonstrates that the resin can be used for the additive manufacturing of photochromic gels.","PeriodicalId":18151,"journal":{"name":"Macromolecular Materials and Engineering","volume":"310 7","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mame.202400449","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144647052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sustainable Shell Formulations as Alternative to the Conventional Soft Gelatin Capsules in Pharmaceutical and Nutraceutical Applications. A Review. 可持续壳配方替代传统软明胶胶囊在制药和营养保健应用。复习一下。

IF 4.6 3区材料科学

Macromolecular Materials and Engineering Pub Date : 2025-04-03 DOI: 10.1002/mame.202500003

Francisco Javier Palomero-Hernández, María Ángela Caballo-González, Francisco Javier de la Mata, Sandra García-Gallego

{"title":"Sustainable Shell Formulations as Alternative to the Conventional Soft Gelatin Capsules in Pharmaceutical and Nutraceutical Applications. A Review.","authors":"Francisco Javier Palomero-Hernández, María Ángela Caballo-González, Francisco Javier de la Mata, Sandra García-Gallego","doi":"10.1002/mame.202500003","DOIUrl":"https://doi.org/10.1002/mame.202500003","url":null,"abstract":"Gelatin is the traditional gelling agent used to produce softgels. In recent years, different products have progressively emerged on the market based on other alternative polymers such as starch, carrageenan and pectin. Its use, alone or in combination with other gelling agents, conditions the softgel production and modifies the properties of shell cover material, and therefore, the softgel capsules. In addition, the use of new alternative materials such as alginate, pullulan, cellulose and its derivates, PVA, chitosan, gellan gum and agar have been explored and are becoming more important. Their market inclusion has not only led to improvements in terms of compatibility, manufacture, stability, drug release control, cost and sustainability; but also, has enabled to extend the softgel portfolio offering to the consumers friendlier products with vegetal origin. This review provides an updated overview on the alternative options to traditional gelatin shell cover for pharmaceutical and nutraceutical products. Additionally, it evaluates the impact of this change on the shell material behavior over the production and stability of these pharmaceutical forms. This will help to select the best gelling agent, alone or in combination, depending on the defined specification during the design and development phase of the softgel product.","PeriodicalId":18151,"journal":{"name":"Macromolecular Materials and Engineering","volume":"310 8","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mame.202500003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144869475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rapid Screening of Vapor Uptake by Ultra-Thin Polymer Films Using Surface Plasmon Resonance and Quartz Crystal Microbalance with Dissipation Monitoring 利用表面等离子体共振和耗散监测的石英晶体微天平快速筛选超薄聚合物薄膜的蒸汽吸收

IF 4.2 3区材料科学

Macromolecular Materials and Engineering Pub Date : 2025-03-27 DOI: 10.1002/mame.202400405

Ana Corres, José I. Santos, Alba Gonzalez, Thomas Schäfer

引用次数: 0

Fabrication of Carbon Nanodots/Platinum Functionalized Nanocomposite Hydrogel Formulation for Near-Infrared Responsive Delivery of Doxorubicin to Promote Necroptosis for Mitigating Lung Cancer Cells: In Vitro Photodynamic Therapy 碳纳米点/铂功能化纳米复合水凝胶配方的制备，用于近红外响应递送阿霉素促进肺癌细胞坏死：体外光动力治疗

IF 4.2 3区材料科学

Macromolecular Materials and Engineering Pub Date : 2025-03-26 DOI: 10.1002/mame.202400442

Xiaoqin An, Junjun Bai, Yuan Li

{"title":"Fabrication of Carbon Nanodots/Platinum Functionalized Nanocomposite Hydrogel Formulation for Near-Infrared Responsive Delivery of Doxorubicin to Promote Necroptosis for Mitigating Lung Cancer Cells: In Vitro Photodynamic Therapy","authors":"Xiaoqin An, Junjun Bai, Yuan Li","doi":"10.1002/mame.202400442","DOIUrl":"https://doi.org/10.1002/mame.202400442","url":null,"abstract":"Lung cancer remains one of the deadliest cancers, marked by uncontrolled cell growth in the lungs and often diagnosed at later stages. This study presents a novel hydrogel-embedded nanocomposite responsive to Near-Infrared (NIR) light (CN-Pt-DOX@CS+NIR) to induce necroptosis in lung cancer cells. The composite, created by combining Carbon Nanodots (CNs), Platinum Nanoparticles (PtNPs), and Doxorubicin (DOX) within a Chitosan (CS)-based hydrogel, demonstrated favorable properties for sustained drug release. Upon NIR irradiation, the CNs increase oxidative stress and initiate apoptosis due to the generation of reactive oxygen species (ROS) and caspase activation (3, 8, and 9). The PtNPs enhance ROS production and disrupt mitochondrial membrane potential (MMP), further promoting cell death. DOX, a well-known chemotherapeutic, intercalates DNA and inhibits topoisomerase II, leading to apoptosis. These combined effects result in significant cytotoxicity under NIR stimulation, as shown in vitro on A549 and H1299 cells, confirmed through various assays including AO/EB and DAPI staining, flow cytometry, and RT-PCR. Additionally, the hydrogel matrix provides a controlled release of the therapeutic agents and improves localized delivery. Combining CNs, PtNPs, and DOX with NIR enhanced in vitro cytotoxic effects, apoptosis, ROS generation, and potential for targeted lung cancer therapy.","PeriodicalId":18151,"journal":{"name":"Macromolecular Materials and Engineering","volume":"310 7","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mame.202400442","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144647766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0