Magnetic Resonance in Medical Sciences最新文献

{"title":"Functional Connectivity Pattern Using Resting-state fMRI as an Assessment Tool for Spatial Neglect during the Recovery Stage of Stroke: A Pilot Study.","authors":"Toshihiko Ebisu,&nbsp;Masaki Fukunaga,&nbsp;Tomokazu Murase,&nbsp;Toyoshi Matsuura,&nbsp;Naoya Tomura,&nbsp;Yasuhiro Miyazaki,&nbsp;Shinpei Osaki,&nbsp;Tsutomu Okada,&nbsp;Toshihiro Higuchi,&nbsp;Masahiro Umeda","doi":"10.2463/mrms.mp.2022-0010","DOIUrl":"https://doi.org/10.2463/mrms.mp.2022-0010","url":null,"abstract":"<p><strong>Purpose: </strong>To determine if functional connectivity measured with resting-state functional MRI could be used as a tool to assess unilateral spatial neglect during stroke recovery.</p><p><strong>Methods: </strong>Resting-state functional MRI was performed on 13 stroke patients with lesions in the right cerebral hemisphere and 31 healthy subjects. The functional connectivity score was defined as a correlation of a target region with the right inferior parietal lobule. Spatial neglect was measured with a behavioral inattention test.</p><p><strong>Results: </strong>First, the functional connectivity scores between the right inferior parietal lobule and right inferior frontal gyrus, including the opercular and triangular parts, were significantly decreased in stroke patients with unilateral spatial neglect compared with patients without unilateral spatial neglect and were significantly correlated with the behavioral inattention test score. Second, the functional connectivity scores between the bilateral inferior parietal lobules were also significantly decreased in patients with unilateral spatial neglect compared with patients without unilateral spatial neglect and were significantly correlated with the behavioral inattention test score. Third, negative functional connectivity scores between the right inferior parietal lobule and bilateral medial orbitofrontal cortexes, which are related to the default mode network, were detected in patients without unilateral spatial neglect in contrast to a reduction of this negative tendency in patients with unilateral spatial neglect. The functional connectivity scores between these regions were significantly different between patients with and without unilateral spatial neglect and were negatively correlated with the behavioral inattention test score.</p><p><strong>Conclusion: </strong>Though still in the pilot research stage and using a small number of cases, our findings are consistent with the hypothesis that functional connectivity maps generated with resting-state functional MRI may be used as a tool to evaluate unilateral spatial neglect during stroke recovery.</p>","PeriodicalId":18119,"journal":{"name":"Magnetic Resonance in Medical Sciences","volume":"22 3","pages":"313-324"},"PeriodicalIF":3.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/38/3c/mrms-22-313.PMC10449554.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10072982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Motility Mapping Quantification Using the Classical Optical Flow Algorithm for Small Bowel Crohn's Disease: Comparison with Balloon-assisted Enteroscopy Findings.","authors":"Yoshio Kitazume,&nbsp;Kento Takenaka,&nbsp;Kazuo Ohtsuka,&nbsp;Yasuo Ozawa,&nbsp;Koichiro Kimura,&nbsp;Ryosuke Watanabe,&nbsp;Junichi Tsuchiya,&nbsp;Toshimitsu Fujii,&nbsp;Masakazu Nagahori,&nbsp;Mamoru Watanabe,&nbsp;Ukihide Tateishi","doi":"10.2463/mrms.mp.2021-0037","DOIUrl":"https://doi.org/10.2463/mrms.mp.2021-0037","url":null,"abstract":"<p><strong>Purpose: </strong>To quantify bowel motility shown on cine MRI using the classical optical flow algorithm and compare it with balloon-assisted enteroscopy (BAE) findings in patients with Crohn's disease (CD).</p><p><strong>Methods: </strong>This retrospective study included 29 consecutive patients with CD who had undergone MR enterocolonography (MREC) and BAE between March and May 2017. We developed computer software to present motion vector magnitudes between consecutive cine MR images as bowel motility maps via a classical optical flow algorithm using the Horn-Schunck method. Cine MR images were acquired with a balanced steady-state free precession sequence in the coronal direction to capture small bowel motility. The small bowels were divided into three segments. In total, 63 bowel segments were assessed via BAE and MREC. Motility scores on the maps, simplified MR index of activity (sMaRIA), and MREC score derived from a 5-point MR classification were assessed independently by two radiologists and compared with the CD endoscopic index of severity (CDEIS). Correlations were assessed using Spearman's rank coefficient. The areas under the receiver-operating characteristic curve (AUCs) of motility score for differentiating CDEIS was calculated; a P value < 0.05 was considered statistically significant.</p><p><strong>Results: </strong>Motility score was negatively correlated with CDEIS (r = -0.59 [P < 0.001] and -0.54 [P < 0.001]), and the AUCs of motility scores for detecting CDEIS ≥ 3 were 88.2% and 78.6% for observers 1 and 2, respectively. There were no significant differences in the AUC for detecting CDEIS ≥ 3 and CDEIS ≥ 12 between motility and sMaRIA or MREC score.</p><p><strong>Conclusion: </strong>The motility map was feasible for locally quantifying the bowel motility. In addition, the motility score on the map reflected the endoscopic inflammatory activity of each small bowel segment in patients with CD; hence, it could be used as a tool in objectively interpreting cine MREC to predict inflammatory activity in CD.</p>","PeriodicalId":18119,"journal":{"name":"Magnetic Resonance in Medical Sciences","volume":"22 3","pages":"325-334"},"PeriodicalIF":3.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/27/3a/mrms-22-325.PMC10449560.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10072989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Commercially Available Deep-learning-reconstruction of MR Imaging of the Knee at 1.5T Has Higher Image Quality Than Conventionally-reconstructed Imaging at 3T: A Normal Volunteer Study.","authors":"Hiroyuki Akai,&nbsp;Koichiro Yasaka,&nbsp;Haruto Sugawara,&nbsp;Taku Tajima,&nbsp;Masaaki Akahane,&nbsp;Naoki Yoshioka,&nbsp;Kuni Ohtomo,&nbsp;Osamu Abe,&nbsp;Shigeru Kiryu","doi":"10.2463/mrms.mp.2022-0020","DOIUrl":"https://doi.org/10.2463/mrms.mp.2022-0020","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to evaluate whether the image quality of 1.5T magnetic resonance imaging (MRI) of the knee is equal to or higher than that of 3T MRI by applying deep learning reconstruction (DLR).</p><p><strong>Methods: </strong>Proton density-weighted images of the right knee of 27 healthy volunteers were obtained by 3T and 1.5T MRI scanners using similar imaging parameters (21 for high resolution image and 6 for normal resolution image). Commercially available DLR was applied to the 1.5T images to obtain 1.5T/DLR images. The 3T and 1.5T/DLR images were compared subjectively for visibility of structures, image noise, artifacts, and overall diagnostic acceptability and objectively. One-way ANOVA and Friedman tests were used for the statistical analyses.</p><p><strong>Results: </strong>For the high resolution images, all of the anatomical structures, except for bone, were depicted significantly better on the 1.5T/DLR compared with 3T images. Image noise scored statistically lower and overall diagnostic acceptability scored higher on the 1.5T/DLR images. The contrast between lateral meniscus and articular cartilage of the 1.5T/DLR images was significantly higher (5.89 ± 1.30 vs. 4.34 ± 0.87, P < 0.001), and also the contrast between medial meniscus and articular cartilage of the 1.5T/DLR images was significantly higher (5.12 ± 0.93 vs. 3.87 ± 0.56, P < 0.001). Similar image quality improvement by DLR was observed for the normal resolution images.</p><p><strong>Conclusion: </strong>The 1.5T/DLR images can achieve less noise, more precise visualization of the meniscus and ligaments, and higher overall image quality compared with the 3T images acquired using a similar protocol.</p>","PeriodicalId":18119,"journal":{"name":"Magnetic Resonance in Medical Sciences","volume":"22 3","pages":"353-360"},"PeriodicalIF":3.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d0/b2/mrms-22-353.PMC10449552.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10071335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pitfalls of Using T2-contrast Enhancement Techniques in 3D-FLAIR to Detect Endolymphatic Hydrops.","authors":"Yutaka Kato,&nbsp;Shinji Naganawa,&nbsp;Toshiaki Taoka,&nbsp;Tadao Yoshida,&nbsp;Michihiko Sone","doi":"10.2463/mrms.mp.2022-0017","DOIUrl":"https://doi.org/10.2463/mrms.mp.2022-0017","url":null,"abstract":"Purpose To determine whether T2-contrast enhancement techniques can be used to diagnose endolymphatic hydrops, we compared fluid signal artifacts with and without T2-contrast enhancement techniques in 3D fluid-attenuated inversion recovery (3D-FLAIR). Methods We prepared a custom-made phantom consisting of eight tubes half-filled with saline. Images were obtained using four 3D-FLAIR: without T2-contrast enhancement (Normal), with non-selective T2-inversion recovery (T2-IR), and two with non-selective T2 preparation IR (T2-prep). Scans were performed with and without rice covering the phantom to simulate minimal and severe B0-inhomogeneity conditions. The average signal intensity (SI) values of eight saline tubes were compared between the four sequences and between each other. Comparisons were performed for all measurement slices and the central 10 slices. The images using T2-contrast enhancement technique were obtained from a volunteer and a patient suspected of Meniere’s disease. Results The Normal sequence SI for all slices was significantly lower than that for the other sequences, with smaller standard deviation (SD) and no outliers. Several outliers were detected in the other sequences. The SDs and outliers were larger without rice than with rice. When the central 10 slices with rice, the T2-IR had a significantly higher SI with more outliers compared with the Normal sequence. The T2-prep had no outliers and SIs that were comparable to those of the Normal sequence. However, without rice, the T2-IR and T2-prep sequences had significantly higher SIs with outliers and larger SDs compared to the Normal sequence. In the corresponding images, the Normal sequence achieved excellent fluid suppression, whereas the T2-IR and T2-prep sequences showed high-signal artifacts. Imperfect fluid suppressions were observed in the volunteer image and the endolymphatic hydrops on the post-gadolinium image differed in size and shape in the non-injected T2-IR in the patient image. Conclusion T2-contrast enhancement techniques should be used with caution in 3D-FLAIR for diagnosing endolymphatic hydrops.","PeriodicalId":18119,"journal":{"name":"Magnetic Resonance in Medical Sciences","volume":"22 3","pages":"335-344"},"PeriodicalIF":3.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e3/5b/mrms-22-335.PMC10449551.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10072990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of a Car-mounted Mobile MR Imaging System for Diagnosis of Sports-related Wrist Injury.","authors":"Tomoki Miyasaka,&nbsp;Michiru Kajiwara,&nbsp;Akito Kawasaki,&nbsp;Yoshikazu Okamoto,&nbsp;Yasuhiko Terada","doi":"10.2463/mrms.tn.2021-0158","DOIUrl":"https://doi.org/10.2463/mrms.tn.2021-0158","url":null,"abstract":"<p><p>Portable MRI scanners, in which a permanent magnet with a low magnetic field is mounted on a small car, have enabled the performance of MRI examinations in various remote environments. Here, we have modified the portable MRI system to enable the early diagnosis of wrist sports injuries among tennis players. A RF probe specifically designed for the human wrist was developed, and a power supply scheme using a small generator was introduced. The portable MRI system was located at a tennis school and imaging of the wrists of junior tennis players was performed. To demonstrate clinical feasibility, image quality was assessed by a radiologist and clinical evaluations were performed. In most cases, the image quality was sufficient for diagnosis, and triangular fibrocartilage complex damage could be detected. The results indicated that the modified portable MRI system could be applied for an early diagnosis of wrist injuries.</p>","PeriodicalId":18119,"journal":{"name":"Magnetic Resonance in Medical Sciences","volume":"22 3","pages":"379-387"},"PeriodicalIF":3.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b1/4c/mrms-22-379.PMC10449548.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10125241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Using Dictionary Matching to Improve the Accuracy of MOLLI Myocardial T1 Analysis and Measurements of Heart Rate Variability.","authors":"Yuta Endo,&nbsp;Kuninori Kobayashi,&nbsp;Haruna Shibo,&nbsp;Makoto Amanuma,&nbsp;Shigehide Kuhara","doi":"10.2463/mrms.tn.2022-0013","DOIUrl":"https://doi.org/10.2463/mrms.tn.2022-0013","url":null,"abstract":"<p><p>We analyzed modified Look-Locker inversion recovery (MOLLI) T1 measurements by applying a dictionary matching strategy and aimed to acquire T1 measurements more accurately than those acquired by the conventional three-parameter matching analysis. We particularly clarified the robustness of this method for measuring heart rate (HR) variability. A phantom experiment using a 3T MRI system was performed for various HRs. The ideal MOLLI signal corresponding to the scan parameter in the MRI experiment was simulated over a wide range of T1 values according to the dictionary. The unknown T1 values were determined by finding the simulated signals in the dictionary corresponding to the measured signals using pattern matching. The measured T1 values showed that the proposed analysis improved the accuracy of T1 measurements compared to those acquired by traditional analysis by up to 10%. In addition, the variability of measurements at several HRs was reduced by up to 100 ms.</p>","PeriodicalId":18119,"journal":{"name":"Magnetic Resonance in Medical Sciences","volume":"22 3","pages":"389-399"},"PeriodicalIF":3.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/48/ad/mrms-22-389.PMC10449558.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10445595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rapid MR Angiography Using 3D Gradient-echo Imaging and the Two-point Dixon Method to Evaluate Carotid Plaque.","authors":"Ryusuke Irie,&nbsp;Shiori Amemiya,&nbsp;Tsuyoshi Ueyama,&nbsp;Yuichi Suzuki,&nbsp;Hidemasa Takao,&nbsp;Osamu Abe","doi":"10.2463/mrms.tn.2022-0002","DOIUrl":"https://doi.org/10.2463/mrms.tn.2022-0002","url":null,"abstract":"<p><p>Liver acquisition with volume acceleration-flex (LAVA-Flex) acquires out-of-phase and in-phase echo images and automatically generates water-only and fat-only images from one single acquisition. The scan time of carotid MR angiography (MRA) using LAVA-Flex (LAVA MRA) is about one-fifth that of conventional time-of-flight MRA (cTOF MRA). We aimed to investigate whether LAVA MRA could provide useful information for the diagnosis of carotid plaque by utilizing the ability to acquire multiple sequences simultaneously. Comparing LAVA MRA and cTOF MRA images for carotid plaque, low-intensity plaques were more clearly identified in the in-phase images, and high-intensity plaques were more clearly identified in the water-only or out-of-phase images. None of the plaques exhibited superior visualization with the cTOF sequence. We concluded that LAVA MRA can provide more useful information on plaque evaluation using multiple sequences than cTOF MRA.</p>","PeriodicalId":18119,"journal":{"name":"Magnetic Resonance in Medical Sciences","volume":"22 3","pages":"373-378"},"PeriodicalIF":3.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/47/e6/mrms-22-373.PMC10449555.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10059707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Using Spin-labeled MR Imaging to Depict Slow Pancreatic Juice Flow.","authors":"Hideki Hoshi,&nbsp;Reiji Sugita,&nbsp;Yoshio Machida","doi":"10.2463/mrms.tn.2022-0018","DOIUrl":"https://doi.org/10.2463/mrms.tn.2022-0018","url":null,"abstract":"<p><p>This study evaluated the dependence of the signal characteristics of time-spatial labeling inversion pulse (time-SLIP) on flow velocity and tag thickness to depict the pancreatic juice flow by analyzing signal profile using a tube phantom study. The tag edge property was evaluated by edge rise distance (ERD). For various slow flow velocities and tag thicknesses, the signal profile characteristics were evaluated using two indices: the tag center value (R_TCV) reduction rate and the total signal value along the tube (T_SVT). ERD, which was about 10% of the tag thickness, was higher for thicker tags, making slow flow detection difficult. T_SVT was proportional to the thickness of the tag and was preserved irrespective of the flow velocity. R_TCV became lower with higher flow velocity and decreased significantly with thinner tags. These results suggest that the visualization of pancreatic juice flow might improve stability by considering the appropriate tag thickness.</p>","PeriodicalId":18119,"journal":{"name":"Magnetic Resonance in Medical Sciences","volume":"22 3","pages":"361-371"},"PeriodicalIF":3.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a0/0c/mrms-22-361.PMC10449553.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10072977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Utility of Arterial Transit Time Measurement for Evaluating the Hemodynamic Perfusion State of Patients with Chronic Cerebrovascular Stenosis or Occlusive Disease: Correlative Study between MR Imaging and ¹⁵O-labeled H₂O Positron Emission Tomography.","authors":"Kayo Takeuchi, Makoto Isozaki, Yoshifumi Higashino, Nobuyuki Kosaka, Ken-Ichiro Kikuta, Shota Ishida, Masayuki Kanamoto, Naoyuki Takei, Hidehiko Okazawa, Hirohiko Kimura","doi":"10.2463/mrms.mp.2020-0123","DOIUrl":"10.2463/mrms.mp.2020-0123","url":null,"abstract":"<p><strong>Purpose: </strong>To verify whether arterial transit time (ATT) mapping can correct arterial spin labeling-cerebral blood flow (ASL-CBF) values and to verify whether ATT is a parameter that correlates with positron emission tomography (PET)-oxygen extraction fraction (OEF) and PET-mean transit time (MTT).</p><p><strong>Methods: </strong>Eleven patients with unilateral major cerebral artery stenosis or occlusion underwent MRI and PET in the chronic or asymptomatic phase. ASL-MRI acquisitions were conducted with each of two post-label delay (PLD) settings (0.7s and 2.0s) using a pseudo-continuous ASL pulse sequence and 3D-spin echo spiral readout with vascular crusher gradient. ATT maps were obtained using a low-resolution pre-scan approach with five PLD settings. Using the ASL perfusion images and ATT mapping, ATT-corrected ASL-CBF images were obtained. Four kinds of ASL-CBF methods (PLD 0.7s with or without ATT correction and PLD 2.0s with or without ATT correction) were compared to PET-CBF, using vascular territory ROIs. ATT and OEF were compared for all ROIs, unaffected side ROIs, and affected side ROIs, respectively. ATT and MTT were compared by the ratio of the affected side to the unaffected side. Transit time-based ROIs were used for the comparison with ATT.</p><p><strong>Results: </strong>Comparing ASL-CBF and PET-CBF, the correlation was higher with ATT correction than without correction, and for a PLD of 2.0s compared with 0.7s. The best correlation was for PLD of 2.0s with ATT correction (R² = 0.547). ROIs on the affected side showed a low but significant correlation between ATT and PET-OEF (R² = 0.141). There was a low correlation between the ATT ratio and the MTT ratio (R² = 0.133).</p><p><strong>Conclusion: </strong>Low-resolution ATT correction may increase the accuracy of ASL-CBF measurements in patients with unilateral major cerebral artery stenosis or occlusion. In addition, ATT itself might have a potential role in detecting compromised hemodynamic state.</p>","PeriodicalId":18119,"journal":{"name":"Magnetic Resonance in Medical Sciences","volume":"22 3","pages":"289-300"},"PeriodicalIF":2.5,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/65/db/mrms-22-289.PMC10449557.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10072992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Creatine Chemical Exchange Saturation Transfer (Cr-CEST) Imaging Can Evaluate Cisplatin-induced Testicular Damage.","authors":"Sohei Kuribayashi,&nbsp;Shigeyoshi Saito,&nbsp;Reika Sawaya,&nbsp;Yusuke Takahashi,&nbsp;Hidetaka Kioka,&nbsp;Kentaro Takezawa,&nbsp;Hiroshi Kiuchi,&nbsp;Shinichiro Fukuhara,&nbsp;Norio Nonomura","doi":"10.2463/mrms.mp.2021-0125","DOIUrl":"https://doi.org/10.2463/mrms.mp.2021-0125","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to investigate the ability of creatine-chemical exchange saturation transfer (Cr-CEST) technique assessed through 7-T MRI to evaluate cisplatin-induced testicular damage.</p><p><strong>Methods: </strong>We used 8-10 weeks C57BL/6 mice (n = 10) that were divided into a control group (n = 5) and a cisplatin-treated group (n = 5). The cisplatin group received cisplatin at a dose of 15 mg/kg, via intraperitoneal injection, while the control group received saline. MR images of mouse testes were acquired under anesthesia 18 days after the injection using a horizontal 7-T scanner. The pulse sequence consisted of rapid acquisition with a relaxation enhancement (RARE) with magnetization transfer. The Z-spectra were collected using a 2000-ms saturation pulse at a B₁ amplitude of 1.2 μT, with frequencies varying from -4.8 to +4.8 parts per million (ppm). Maps of magnetization transfer ratio with asymmetric analysis (MTR_asym) were reconstructed at a Cr metabolite concentration of 1.8 ppm.</p><p><strong>Results: </strong>The Cr-CEST effect was significantly reduced in the cisplatin-treated group compared to the control group (MTR_asym of control mice vs. cisplatin-treated mice: 6.9 [6-7.5] vs. 5.2 [4-5.5], P = 0.008). Correlation analysis revealed a strong correlation between the Cr-CEST effect and the pathological score (ρ = 0.93, P < 0.001).</p><p><strong>Conclusion: </strong>Cr-CEST MRI can be useful for the evaluation of cisplatin-induced testicular damage in mice.</p>","PeriodicalId":18119,"journal":{"name":"Magnetic Resonance in Medical Sciences","volume":"22 3","pages":"345-351"},"PeriodicalIF":3.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a2/98/mrms-22-345.PMC10449556.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10066710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}