Lipids最新文献_第8页

IF 1.6 4区医学

Lipids Pub Date : 2026-02-11

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IF 1.6 4区医学

Lipids Pub Date : 2026-02-08

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IF 1.6 4区医学

Lipids Pub Date : 2026-02-03

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IF 1.6 4区医学

Lipids Pub Date : 2026-01-28

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IF 1.6 4区医学

Lipids Pub Date : 2026-01-19

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IF 1.6 4区医学

Lipids Pub Date : 2026-01-10

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Associations Between Fatty Acid Levels in Human Blood and Trigeminovascular Tissues 人体血液中脂肪酸水平与三叉神经血管组织之间的关系。

IF 1.6 4区医学

Lipids Pub Date : 2026-01-07 Epub Date: 2025-09-21 DOI: 10.1002/lipd.70010

Daisy Zamora, Mark S. Horowitz, Sharon F. Majchrzak-Hong, Katherine Ness Shipley, Nicholas M. Salem, Ann I. Scher, Matthew R. Sapio, Michael J. Iadarola, Christopher E. Ramsden

{"title":"Associations Between Fatty Acid Levels in Human Blood and Trigeminovascular Tissues","authors":"Daisy Zamora, Mark S. Horowitz, Sharon F. Majchrzak-Hong, Katherine Ness Shipley, Nicholas M. Salem, Ann I. Scher, Matthew R. Sapio, Michael J. Iadarola, Christopher E. Ramsden","doi":"10.1002/lipd.70010","DOIUrl":"10.1002/lipd.70010","url":null,"abstract":"Omega-3 and omega-6 polyunsaturated fatty acids (PUFAs) are precursors to oxylipins that modulate pain and inflammation. We previously demonstrated that (1) a dietary intervention increasing omega-3 and reducing omega-6 PUFAs alters the concentration of these oxylipin precursors in blood, and (2) these changes are associated with reduced headache pain in humans. However, the extent to which blood levels reflect trigeminovascular tissues remains unclear. We sought to determine whether oxylipin precursor PUFA levels in blood reflect those in the meninges, cranial arteries, and trigeminal ganglia. Precursor PUFA compositions of post-mortem blood and trigeminovascular tissue specimens from 70 individuals, procured from the Human Brain Collection Core at the National Institute of Mental Health, were quantified. Regression models adjusted for confounders examined relationships between blood and tissue PUFA levels. Eicosapentaenoic acid in blood was associated with levels in cranial arteries, meninges, and trigeminal ganglia [logged coefficients (p value): 0.29 (0.019); 0.37 (< 0.001); 0.25 (0.009)]. Other PUFAs, including linoleic acid, arachidonic acid, n-6 docosapentaenoic acid, and docosahexaenoic acid, also showed significant associations between blood and meninges and/or trigeminal ganglia levels. These findings support using blood measurements of certain PUFAs as a proxy for their concentration in tissues directly involved in headache pathogenesis.","PeriodicalId":18086,"journal":{"name":"Lipids","volume":"61 1","pages":"55-63"},"PeriodicalIF":1.6,"publicationDate":"2026-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://aocs.onlinelibrary.wiley.com/doi/epdf/10.1002/lipd.70010","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145113649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Sterol Metabolism in Ovariectomized Rats: Potential Roles of Campesterol and 4β-Hydroxycholesterol in Osteoporosis 去卵巢大鼠的固醇代谢：油菜甾醇和4β-羟胆固醇在骨质疏松症中的潜在作用。

IF 1.6 4区医学

Lipids Pub Date : 2026-01-07 Epub Date: 2025-10-29 DOI: 10.1002/lipd.70006

Wenzhao He, Sayuri Eguchi, Sen Wang, Yasutake Tanaka, Masao Sato

{"title":"Sterol Metabolism in Ovariectomized Rats: Potential Roles of Campesterol and 4β-Hydroxycholesterol in Osteoporosis","authors":"Wenzhao He, Sayuri Eguchi, Sen Wang, Yasutake Tanaka, Masao Sato","doi":"10.1002/lipd.70006","DOIUrl":"10.1002/lipd.70006","url":null,"abstract":"Osteoporosis is characterized by low bone mass and microarchitectural deterioration of bone tissue. Lipid metabolism disorders may contribute to osteoporosis in postmenopausal women. Phytosterols and oxysterols (OC) are involved in lipid metabolism. However, their roles in bone metabolism and in the development of osteoporosis remain unclear. This study used ovariectomized (OVX) rats, commonly used to study osteoporosis, to analyze the levels of sterols, including phytosterols, cholesterol, and oxysterols in the humerus, femur, femoral bone marrow, blood, and liver. Sterol levels were measured through gas chromatography. We observed that campesterol and cholesterol exhibited similar patterns of change in the blood, liver, and bone marrow. Conversely, cholesterol and campesterol levels in the femur did not change significantly, while bone marrow cholesterol levels decreased. The similar changes in campesterol and cholesterol levels suggest that these sterols are derived from the blood and taken up by the bone marrow. Significant increases in 4β-hydroxycholesterol were found in the humerus, plasma, and liver of OVX rats. The ratio of 4β-hydroxycholesterol to cholesterol in the bone marrow was significantly increased in OVX rats. These findings suggest that 4β-hydroxycholesterol is associated with OVX-induced osteoporosis and contributes to the decline in bone density.","PeriodicalId":18086,"journal":{"name":"Lipids","volume":"61 1","pages":"151-162"},"PeriodicalIF":1.6,"publicationDate":"2026-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://aocs.onlinelibrary.wiley.com/doi/epdf/10.1002/lipd.70006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145390696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Metabolomics Investigation of a Multi-Ingredient Supplements-Modulated Changes in Metabolism in Mice After Endurance Exercise 多成分补充剂对耐力运动后小鼠代谢变化的代谢组学研究。

IF 1.6 4区医学

Lipids Pub Date : 2026-01-07 Epub Date: 2025-09-04 DOI: 10.1002/lipd.70007

Xu Haixia, Chen Hui

{"title":"Metabolomics Investigation of a Multi-Ingredient Supplements-Modulated Changes in Metabolism in Mice After Endurance Exercise","authors":"Xu Haixia, Chen Hui","doi":"10.1002/lipd.70007","DOIUrl":"10.1002/lipd.70007","url":null,"abstract":"<div>\u0000 \u0000 Energy metabolism manipulation strategy, enhancing fat metabolism while reducing the dependence on glucose, is beneficial to improve exercise performance. The multi-ingredient supplements (MIS) mixed with valine, isoleucine, leucine, β-alanine, creatine, L-carnitine, quercetin, and betaine were found to be able to improve the endurance performance of mice, which was associated with a shift of energy substrates from glucose to fatty acids. Thus, we hypothesized that the MIS regulating lipid metabolism contributes to enhancing exercise endurance in mice. The present study aimed to explore the alterations in the biochemical composition of mice treated with the MIS using a metabolomics strategy after they were subjected to endurance exercise. The serum metabolite profile was investigated using ultrahigh performance liquid chromatography tandem mass spectrometry. Results showed that significant changes in lipid metabolism were observed in the MIS-treated mice during endurance exercise compared with the vehicle control. Specifically, the MIS treatment reduced glycerophospholipids, glycerolipids, long-chain fatty acids, and inflammatory signaling arachidonic acid derivatives, and increased medium-long-chain acylcarnitine levels relative to the exercised group. Furthermore, the levels of dimethylglycine (DMG), citrate (CA), glycerol, creatine, and corticosterone were also increased after the MIS supplementation, which was associated with the changes in the pathways of serotoninergic synapses, CA cycles, and amino acid metabolisms. In conclusion, the MIS tested in this study effectively alters serum metabolomics profiles, which provides further evidence to support a shift in energy substrate utilization contributing to the ability of the MIS to improve exercise performance.\u0000 </div>","PeriodicalId":18086,"journal":{"name":"Lipids","volume":"61 1","pages":"3-12"},"PeriodicalIF":1.6,"publicationDate":"2026-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144992921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Association Between Per- and Polyfluoroalkyl Substances (PFAS) Exposure and LDL Cholesterol in US Adults: Evidence From NHANES 美国成人全氟和多氟烷基物质（PFAS）暴露与低密度脂蛋白胆固醇之间的关系：来自NHANES的证据

IF 1.6 4区医学

Lipids Pub Date : 2026-01-07 Epub Date: 2025-09-06 DOI: 10.1002/lipd.70008

Akshaya Srikanth Bhagavathula, Dhwani Krishnan, Melinda B. Chu

{"title":"Association Between Per- and Polyfluoroalkyl Substances (PFAS) Exposure and LDL Cholesterol in US Adults: Evidence From NHANES","authors":"Akshaya Srikanth Bhagavathula, Dhwani Krishnan, Melinda B. Chu","doi":"10.1002/lipd.70008","DOIUrl":"10.1002/lipd.70008","url":null,"abstract":"<div>\u0000 \u0000 Per- and polyfluoroalkyl substances (PFAS) are persistent environmental pollutants increasingly implicated in cardiometabolic risk. This study evaluates the association between serum PFAS exposure and lipid dysregulation, focusing on low-density lipoprotein cholesterol (LDL-C), a key cardiovascular risk factor. We analyzed 998 adults from the 2017 to 2020 National Health and Nutrition Examination Survey (NHANES), representing a weighted sample of 240 million US adults. Serum concentrations of nine PFAS compounds including perfluorooctanoic acid (PFOA), perfluorooctane sulfonic acid (PFOS), perfluoroundecanoic acid (PFUnDA), and perfluorohexane sulfonic acid (PFHxS) were measured. Double/debiased machine learning (DML) estimated the association between PFAS exposure and LDL-C and triglyceride levels, adjusting for demographics, clinical, and behavioral covariates. The median total PFAS concentration was 9.23 ng/mL (interquartile range: 9.67 ng/mL). The weighted mean LDL-C and triglyceride levels were 112.5 mg/dL (95% CI: 112.5–112.5) and 115.6 mg/dL (95% CI: 115.6–115.6), respectively. Total PFAS exposure was significantly associated with higher LDL-C (β = 0.30; 95% CI: 0.05–0.54; p = 0.016). Perfluoroundecanoic acid (PFUnDA), linear PFOS, and methyl-perfluorooctane sulfonic acid (Sm-PFOS) were also significantly associated with elevated LDL-C (β = 12.1, 0.44, 2.83; all p < 0.05). PFHxS was inversely associated with triglycerides (β = −2.26; p = 0.031). In this representative sample of US adults, PFAS exposure is independently associated with lipid dysregulation, particularly elevated LDL-C. However, results should be interpreted with caution given the cross-sectional design, modest effect sizes, and potential residual confounding from unmeasured environmental or dietary factors.\u0000 </div>","PeriodicalId":18086,"journal":{"name":"Lipids","volume":"61 1","pages":"13-18"},"PeriodicalIF":1.6,"publicationDate":"2026-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145006347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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